SCHISTOSOMIASIS MANSONI IN THE MUNICIPALITY OF PEDRO-DE-TOLEDO (SAO-PAULO, BRAZIL) WHERE THE BIOMPHALARIA-TENAGOPHILA IS THE SNAIL HOST .1. PREVALENCE IN HUMAN-POPULATION

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Cell therapy in Chagas cardiomyopathy (Chagas arm of the multicenter randomized trial of cell therapy in cardiopathies study): a multicenter randomized trial

Santos, Ricardo Ribeiro dos; Soares, Milena Botelho Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2017-06-20T14:11:49Z No. of bitstreams: 1 Ribeiro SR Cell therapy in chagas....pdf: 818580 bytes, checksum: 1a0717f394e0ba0c45f0f5ff7fbfd663 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2017-06-20T14:29:16Z (GMT) No. of bitstreams: 1 Ribeiro SR Cell therapy in chagas....pdf: 818580 bytes, checksum: 1a0717f394e0ba0c45f0f5ff7fbfd663 (MD5)Made available in DSpace on 2017-06-20T14:29:16Z (GMT). No. of bitstreams: 1 Ribeiro SR Cell therapy in chagas....pdf: 818580 bytes, checksum: 1a0717f394e0ba0c45f0f5ff7fbfd663 (MD5) Previous issue date: 2012Hospital San Rafael. Salvador, BA, BrasilHospital das Clínicas de Goiania. Gioania, GO, BrasilHospital Santa Izabel. Salvador, BA, BrasilInstituto de Moléstias Cardiovasculares. São José do Rio Preto, SP, BrasilHospital do Coração Anis Rassi. Goiania, GO, BrasilInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, BrasilHospital Sírio-Libanes. São Paulo, SP, BrasilPontifícia Universidade Católica do Paraná. Curitiba, PR, BrasilPronto Socorro Cardiológico de Pernambuco. Recife, PE, BrasilInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, BrasilHospital San Rafael. Salvador, BA, BrasilInstituto Nacional de Cardiologia. Rio de Janeiro, RJ, BrasilPrevious studies suggested that transplantation of autologous bone marrow-derived mononuclear cells (BMNCs) improves heart function in chronic chagasic cardiomyopathy. We report the results of the first randomized trial of BMNC therapy in chronic chagasic cardiomyopathy. Methods and Results—Patients 18 to 75 years of age with chronic chagasic cardiomyopathy, New York Heart Association class II to IV heart failure, left ventricular ejection fraction (LVEF) 35%, and optimized therapy were randomized to intracoronary injection of autologous BMNCs or placebo. The primary end point was the difference in LVEF from baseline to 6 and 12 months after treatment between groups. Analysis was by intention to treat and powered to detect an absolute between-group difference of 5%. Between July 2005 and October 2009, 234 patients were enrolled. Two patients abandoned the study and 49 were excluded because of protocol violation. The remaining 183 patients, 93 in the placebo group and 90 in the BMNC group, had a trimmed mean age of 52.4 years (range, 50.8–54.0 years) and LVEF of 26.1% (range, 25.1%–27.1%) at baseline. Median number of injected BMNCs was 2.20 108 (range, 1.40–3.50 108). Change in LVEF did not differ significantly between treatment groups: trimmed mean change in LVEF at 6 months, 3.0 (1.3– 4.8) for BMNCs and 2.5 (0.6–4.5) for placebo (P 0.519); change in LVEF at 12 months, 3.5 (1.5–5.5) for BMNCs and 3.7 (1.5– 6.0) for placebo (P 0.850). Left ventricular systolic and diastolic volumes, New York Heart Association functional class, Minnesota quality-of-life questionnaire, brain natriuretic peptide concentrations, and 6-minute walking test did also not differ between groups. Conclusion—Intracoronary injection of autologous BMNCs does not improve left ventricular function or quality of life in patients with chronic chagasic cardiomyopath

Soroprevalência de infecção chagásica em área de Triatoma infestans após medidas de controle Seroprevalence of Chagas disease in an area of Triatoma infestans after vector control measures

INTRODUÇÃO: Como parte de projeto que busca resgatar informações sobre sorologia da infecção chagásica no Estado de São Paulo durante a vigência das atividades oficiais de controle de vetores, foram selecionados dados relativos ao município de Taquarituba, região de Sorocaba, de importante passado chagásico. A despeito da campanha de combate instituída na década de 50, ainda persistiam aí populações de triatomíneos vetores intradomiciliares na década de 70. MÉTODOS: De amostras das populações de cinco localidades do Município de Taquarituba, Estado de São Paulo, foram analisados os dados de idade, sexo, tempo de moradia na casa que ocupavam e naturalidade. A possível relação entre idade e soropositividade foi investigada utilizando-se o cálculo de probitos. De 1974 e 1976, a prevalência da infecção chagásica foi estimada por meio de reação de imunofluorescência indireta (RIFI) para a detecção de anticorpos anti-Trypanosoma cruzi. RESULTADOS: A proporção total de soropositivos foi de 13,6% (n = 2.784), sem diferença significativa entre os sexos (p = 0,538). Os naturais de Taquarituba contribuíram com 62,9% das amostras examinadas e 62,4% dos soropositivos (n = 380). Ausente em crianças de menos de 6 anos, a soropositividade aumentou de 2,7% no grupo etário de 6 a 9 anos para 30,3% no de 30 a 39 anos. Dentro desse intervalo encontrou-se, por meio do cálculo de probitos, associação positiva entre idade e soropositividade. CONCLUSÕES: Os resultados das provas sorológicas sugeriram haver associação entre as medidas contra Triatoma infestans e o declínio da transmissão da doença de Chagas durante os anos 60, seguido de ulterior controle. Sugere-se a realização de pesquisa para investigar a ocorrência de infecção congênita em população feminina com mais de 14 anos, sorologicamente positivas.<br>INTRODUCTION: The study is part of a project intended to retrieve information about the serology of the American trypanosomiasis in the state of São Paulo, Brazil, during the period when there was a state effort to control the vector. Data from the municipality of Taquarituba, administrative region of Sorocaba, which was then important in the epidemiology of Chagas disease in that region, were analyzed. Despite the government efforts started in the 1950s, domiciliary triatomines were still being captured in that region during the 1970s. METHODS: Population samples were selected from five localities of Taquarituba. Age, sex, birthplace, and time of residence in the house being occupied at the time of the interview, were recorded. Probit analysis is used to assess a possible relationship between age and seropositivity, the latter taken as indicative of the risk of transmission. RESULTS: Blood from Taquarituba native people represented 62.9% of the samples examined (n = 2.784) and 62.4% of all seropositives (n = 380). Overall proportion of seropositives was 13.6% with no significant difference between genders (p = 0.538). Children under 6 years of age were not seropovitive, Seropositivity increased from 2.7% in the age group 6-9 years to 30.6% in the age group 30-39 years. By using probit analysis, an age-seropositivity relationship was found within these groups. CONCLUSIONS: The results of serological tests pointed to an association between the actions taken against Triatoma infestans and the decline and eventual control of the transmission of Chagas disease in the late 1960s