6 research outputs found
Reply With: Proactive Recommendation of Email Attachments
Email responses often contain items-such as a file or a hyperlink to an
external document-that are attached to or included inline in the body of the
message. Analysis of an enterprise email corpus reveals that 35% of the time
when users include these items as part of their response, the attachable item
is already present in their inbox or sent folder. A modern email client can
proactively retrieve relevant attachable items from the user's past emails
based on the context of the current conversation, and recommend them for
inclusion, to reduce the time and effort involved in composing the response. In
this paper, we propose a weakly supervised learning framework for recommending
attachable items to the user. As email search systems are commonly available,
we constrain the recommendation task to formulating effective search queries
from the context of the conversations. The query is submitted to an existing IR
system to retrieve relevant items for attachment. We also present a novel
strategy for generating labels from an email corpus---without the need for
manual annotations---that can be used to train and evaluate the query
formulation model. In addition, we describe a deep convolutional neural network
that demonstrates satisfactory performance on this query formulation task when
evaluated on the publicly available Avocado dataset and a proprietary dataset
of internal emails obtained through an employee participation program.Comment: CIKM2017. Proceedings of the 26th ACM International Conference on
Information and Knowledge Management. 201
Mechanisms of oxidative stress in human aortic aneurysms — association with clinical risk factors for atherosclerosis and disease severity
Aortic abdominal aneurysms (AAA) are important causes of cardiovascular morbidity and mortality. Oxidative stress may link multiple mechanisms of AAA including vascular inflammation and increased metalloproteinase activity. However, the mechanisms of vascular free radical production remain unknown. Accordingly, we aimed to determine sources and molecular regulation of vascular superoxide (O2radical dot−) production in human AAA.
Methods and results:
AAA segments and matched non-dilated aortic samples were obtained from 40 subjects undergoing AAA repair. MDA levels (determined by HPLC/MS) were greater in plasma of AAA subjects (n = 16) than in risk factor matched controls (n = 16). Similarly, superoxide production, measured by lucigenin chemiluminescence and dihydroethidium fluorescence, was increased in aneurysmatic segments compared to non-dilated aortic specimens. NADPH oxidases and iNOS are the primary sources of O2radical dot− in AAA. Xanthine oxidase, mitochondrial oxidases and cyclooxygenase inhibition had minor or no effect. Protein kinase C inhibition had no effect on superoxide production in AAA. NADPH oxidase subunit mRNA levels for p22phox, nox2 and nox5 were significantly increased in AAAs while nox4 mRNA expression was lower. Superoxide production was higher in subjects with increased AAA repair risk Vanzetto score and was significantly associated with smoking, hypercholesterolemia and presence of CAD in AAA cohort. Basal superoxide production and NADPH oxidase activity were correlated to aneurysm size.
Conclusions:
Increased expression and activity of NADPH oxidases are important mechanisms underlying oxidative stress in human aortic abdominal aneurysm. Uncoupled iNOS may link oxidative stress to inflammation in AAA. Oxidative stress is related to aneurysm size and major clinical risk factors in AAA patients
Endothelial dysfunction and vascular inflammation in atherosclerotic patients undergoing coronary artery bypass graft surgery
Investigation of the y´ Precipitates Dissolution in a Ni-Based Superalloy During Stress-Free Short-Term Annealing at High Homologous Temperatures
The equiaxed Ni-based superalloy Rene 108 was subjected to short-term annealing at five temperatures between 900 degrees C and 1100 degrees C. The phase composition, phase lattice parameters, microstructure, stereological parameters, and chemical composition of y´ precipitates were investigated by thermodynamic simulations, X-ray diffraction, scanning and transmission electron microscopy, and energy-dispersive X-ray spectroscopy. Analysis of the y and y´ lattice parameters using the Nelson-Riley extrapolation function showed that the misfit parameter for temperatures 900 degrees C to 1050 degrees C is positive (decreasing from 0.32 to 0.11 pct). At 1100 degrees C, the parameter becomes negative, delta = - 0.18 pct. During the short-term annealing, gamma ‘ precipitates dissolution occurred progressing more rapidly with increasing temperatures. The surface fraction of y´ precipitates decreased with increasing temperature from 0.52 to 0.34. The dissolution of gamma ‘ precipitates did not only proceed through uninterrupted thinning of each individual precipitate, but also included more complex mechanisms, including splitting. Based on transmission electron microscopy, it was shown that after y´ precipitates dissolution, the matrix close to the y/y interface is strongly enriched in Co and Cr and depleted in Al.This work was supported by the Polish National Science Centre (Preludium 13) under grant 2017/25/N/ST8/02368. The authors wish to express appreciation to prof. Wiktoria Ratuszek (AGH-UST) for supporting the XRD study.</p
Mechanisms of oxidative stress in human aortic aneurysms — Association with clinical risk factors for atherosclerosis and disease severity
Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF
BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes