Toward a unified PNT, Part 1: Complexity and context: Key challenges of multisensor positioning

The next generation of navigation and positioning systems must provide greater accuracy and reliability in a range of challenging environments to meet the needs of a variety of mission-critical applications. No single navigation technology is robust enough to meet these requirements on its own, so a multisensor solution is required. Known environmental features, such as signs, buildings, terrain height variation, and magnetic anomalies, may or may not be available for positioning. The system could be stationary, carried by a pedestrian, or on any type of land, sea, or air vehicle. Furthermore, for many applications, the environment and host behavior are subject to change. A multi-sensor solution is thus required. The expert knowledge problem is compounded by the fact that different modules in an integrated navigation system are often supplied by different organizations, who may be reluctant to share necessary design information if this is considered to be intellectual property that must be protected

Diagnosis and disclosure of HIV status: Implications for women’s risk of physical partner violence in the postpartum period

This study prospectively examined whether HIV leads to elevated risk for intimate partner violence (IPV) for women, and how this risk varies depending on HIV status disclosure to a partner

Fisher profiles and perceptions of sea turtle-fishery interactions: case study of East Coast Peninsular Malaysia

The paper focuses on coastal fisheries, particularly examining sea turtle-fishery interactions and determining the socioeconomic profile and perception of local fishers about sea turtle issues along the East Coast of Peninsular Malaysia.Turtle fisheries, Nature conservation, Coastal fisheries, Man-induced effects, ISEW, Malaysia, Malaya, Pahang, Malaysia, Malaya, Kelantan, Malaysia, Malaya, Terengganu,

The Contribution of the Pineal Gland on Daily Rhythms and Masking in Diurnal Grass Rats, Arvicanthis niloticus

Melatonin is a hormone rhythmically secreted at night by the pineal gland in vertebrates. In diurnal mammals, melatonin is present during the inactive phase of the rest/activity cycle, and in primates it directly facilitates sleep and decreases body temperature. However, the role of the pineal gland for the promotion of sleep at night has not yet been studied in non-primate diurnal mammalian species. Here, the authors directly examined the hypothesis that the pineal gland contributes to diurnality in Nile grass rats by decreasing activity and increasing sleep at night, and that this could occur via effects on circadian mechanisms or masking, or both. Removing the pineal gland had no effect on the hourly distribution of activity across a 12:12 light-dark (LD) cycle or on the patterns of sleep-like behavior at night. Masking effects of light at night on activity were also not significantly different in pinealectomized and control grass rats, as 1h pulses of light stimulated increases in activity of sham and pinealectomized animals to a similar extent. In addition, the circadian regulation of activity was unaffected by the surgical condition of the animals. Our results suggest that the pineal gland does not contribute to diurnality in the grass rat, thus highlighting the complexity of temporal niche transitions. The current data raise interesting questions about how and why genetic and neural mechanisms linking melatonin to sleep regulatory systems might vary among mammals that reached a diurnal niche via parallel and independent pathways

A grander challenge: the case of how Makerere University College of Health Sciences (MakCHS) contributes to health outcomes in Africa

<p>Abstract</p> <p>Background</p> <p>“Grand challenges” in global health have focused on discovery and development of technologies to save lives. The “grander challenge” involves building institutions, systems, capacity and demand to effectively deliver strategies to improve health. In 2008, Makerere University began a radical institutional change to bring together four schools under one College of Health Sciences. This paper’s objective is to demonstrate how its leadership in training, research, and services can improve health in Uganda and internationally, which lies at the core of the College’s vision.</p> <p>Methods</p> <p>A comprehensive needs assessment involved five task forces that identified MakCHS’s contribution to the Ugandan government health priorities. Data were collected through analysis of key documents; systematic review of MakCHS publications and grants; surveys of patients, students and faculty; and key informant interviews of the College’s major stakeholders. Four pilot projects were conducted to demonstrate how the College can translate research into policy and practice, extend integrated outreach community-based education and service, and work with communities and key stakeholders to address their priority health problems.</p> <p>Results</p> <p>MakCHS inputs to the health sector include more than 600 health professionals graduating per year through 23 degree programs, many of whom assume leadership positions. MakCHS contributions to processes include strengthened approaches to engaging communities, standardized clinical care procedures, and evidence-informed policy development. Outputs include the largest number of outpatients and inpatient admissions in Uganda. From 2005-2009, MakCHS also produced 837 peer-reviewed research publications (67% in priority areas). Outcomes include an expanded knowledge pool, and contributions to coverage of health services and healthy behaviors. Impacts include discovery and applications of global significance, such as the use of nevirapine to prevent HIV transmission in childbirth and male circumcision for HIV prevention. Pilot projects have applied innovative demand and supply incentives to create a rapid increase in safe deliveries (3-fold increase after 3 months), and increased quality and use of HIV services with positive collateral improvements on non-HIV health services at community clinics.</p> <p>Conclusion</p> <p>MakCHS has made substantial contributions to improving health in Uganda, and shows great potential to enhance this in its new transformational role – a model for other Universities.</p

Valuing Transgenic Cotton Technologies Using a Risk/Return Framework

Stochastic Efficiency with Respect to a Function (SERF) is used to rank transgenic cotton technology groups and place an upper and lower bound on their value. Yield and production data from replicated plot experiments are used to build cumulative distribution functions of returns for nontransgenic, Roundup Ready, Bollgard, and stacked gene cotton cultivars. Analysis of Arkansas data indicated that the stacked gene and Roundup Ready technologies would be preferred by a large number of risk neutral and risk averse producers as long as the costs of the technology and seed are below the lower bounds calculated in this manuscript.cotton, financial risk, market value, SERF, transgenic, Agribusiness, Crop Production/Industries, Risk and Uncertainty, Q12, Q16,

A Detailed Study of the Radio--FIR Correlation in NGC6946 with Herschel-PACS/SPIRE from KINGFISH

We derive the distribution of the synchrotron spectral index across NGC6946 and investigate the correlation between the radio continuum (synchrotron) and far-infrared (FIR) emission using the KINGFISH Herschel PACS and SPIRE data. The radio--FIR correlation is studied as a function of star formation rate, magnetic field strength, radiation field strength, and the total gas surface brightness. The synchrotron emission follows both star-forming regions and the so-called magnetic arms present in the inter-arm regions. The synchrotron spectral index is steepest along the magnetic arms ($\alpha_n \sim 1$), while it is flat in places of giant H{\sc ii} regions and in the center of the galaxy ($\alpha_n \sim 0.6-0.7$). The map of $\alpha_n$ provides an observational evidence for aging and energy loss of cosmic ray electrons propagating in the disk of the galaxy. Variations in the synchrotron--FIR correlation across the galaxy are shown to be a function of both star formation and magnetic fields. We find that the synchrotron emission correlates better with cold rather than with warm dust emission, when the interstellar radiation field is the main heating source of dust. The synchrotron--FIR correlation suggests a coupling between the magnetic field and the gas density. NGC6946 shows a power-law behavior between the total (turbulent) magnetic field strength B and the star formation rate surface density $\Sigma_{\rm SFR}$ with an index of 0.14\,(0.16)$\pm$0.01. This indicates an efficient production of the turbulent magnetic field with the increasing gas turbulence expected in actively star forming regions. The scale-by-scale analysis of the synchrotron--FIR correlation indicates that the ISM affects the propagation of old/diffused cosmic ray electrons, resulting in a diffusion coefficient of $D_0=4.6\times 10^{28}$\,cm$^2$\,s$^{-1}$ for 2.2\,GeV CREs.Comment: 23 pages, 13 figures, accepted for publication in Astronomy & Astrophysics Journa

A telephone survey of cancer awareness among frontline staff: informing training needs

Background: Studies have shown limited awareness about cancer risk factors among hospital-based staff. Less is known about general cancer awareness among community frontline National Health Service and social care staff. Methods: A cross-sectional computer-assisted telephone survey of 4664 frontline community-based health and social care staff in North West England. Results: A total of 671 out of 4664 (14.4%) potentially eligible subjects agreed to take part. Over 92% of staff recognised most warning signs, except an unexplained pain (88.8%, n=596), cough or hoarseness (86.9%, n=583) and a sore that does not heal (77.3%, n=519). The bowel cancer-screening programme was recognised by 61.8% (n=415) of staff. Most staff agreed that smoking and passive smoking ‘increased the chance of getting cancer.’ Fewer agreed about getting sunburnt more than once as a child (78.0%, n=523), being overweight (73.5%, n=493), drinking more than one unit of alcohol per day (50.2%, n=337) or doing less than 30 min of moderate physical exercise five times a week (41.1%, n=276). Conclusion: Cancer awareness is generally good among frontline staff, but important gaps exist, which might be improved by targeted education and training and through developing clearer messages about cancer risk factors

Replication Study of Candidate Genes Associated With Type 2 Diabetes Based On Genome-Wide Screening

OBJECTIVE—The present study was conducted to confirm possible associations between candidate genes from genome-wide association studies and type 2 diabetes in Japanese diabetic patients and a community-based general population. A total of 11 previously reported single-nucleotide polymorphisms (SNPs) from the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, and KCNJ11 genes were analyzed

The dust energy balance in the edge-on spiral galaxy NGC 4565

We combine new dust continuum observations of the edge-on spiral galaxy NGC 4565 in all Herschel/SPIRE (250, 350, 500 micron) wavebands, obtained as part of the Herschel Reference Survey, and a large set of ancillary data (Spitzer, SDSS, GALEX) to analyze its dust energy balance. We fit a radiative transfer model for the stars and dust to the optical maps with the fitting algorithm FitSKIRT. To account for the observed UV and mid-infrared emission, this initial model was supplemented with both obscured and unobscured star-forming regions. Even though these star-forming complexes provide an additional heating source for the dust, the far-infrared/submillimeter emission long wards of 100 micron is underestimated by a factor of 3-4. This inconsistency in the dust energy budget of NGC 4565 suggests that a sizable fraction (two-thirds) of the total dust reservoir (Mdust ~ 2.9e+8 Msun) consists of a clumpy distribution with no associated young stellar sources. The distribution of those dense dust clouds would be in such a way that they remain unresolved in current far-infrared/submillimeter observations and hardly comtribute to the attenuation at optical wavelengths. More than two-thirds of the dust heating in NGC 4565 is powered by the old stellar population, with localized embedded sources supplying the remaining dust heating in NGC 4565. The results from this detailed dust energy balance study in NGC 4565 is consistent with that of similar analyses of other edge-on spirals.Comment: 16 pages, 7 figures, accepted for publication in MNRA