Towards reproducible research of event detection techniques for Twitter

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Interactive Paper as a Mobile Client for a Multi-channel Web Information System

We describe how interactive paper can be used together with a multi-channel web information system to build a platform for experimenting with multi-modal context-aware mobile information services. As an application, we present a tourist guide for visitors to an international festival that was developed to investigate alternative modes of information delivery and interaction in mobile environments. The guide is based around a set of interactive paper documents—an event brochure, map and bookmark. The brochure and map are augmented with digital services by using a digital pen to activate links and a text-to-speech engine for information delivery. The digital pen is also used for data capture of event ratings and reviews. The bookmark provides access to advanced searches and ticket reservations. We describe the architecture and operation of the system, highlighting the challenges of extending a web information system to support both the generation of the paper documents and the interaction from these documents, alongside more traditional access channels. Finally, we discuss the range of context-aware interactions that is supported by our platfor

A platform to support object database research

Databases play a key role in an increasingly diverse range of applications and settings. New requirements are continually emerging and may differ substantially from one domain to another, sometimes even to the point of conflict. To address these challenges, database systems are evolving to cater for new application domains. Yet little attention has been given to the process of researching and developing database concepts in response to new requirements. We present a platform designed to support database research in terms of experimentation with different aspects of database systems ranging from the data model to the distribution architecture. Our platform is based on the notion of metamodel extension modules, inspired by proposals for adaptive and configurable database management systems. However, rather than building a tailored system from existing components, we focus on the process of designing new components. To qualitatively evaluate our platform, we present a series of case studies where our approach was used successfully to experiment with concepts designed to support a variety of novel application domains

Context-aware platform for mobile data management

Interaction design is a major issue for mobile information systems in terms of not only the choice of input/output channels and presentation of information, but also the application of context-awareness. To support experimentation with these factors, we have developed platforms to support the rapid prototyping of multi-channel, multi-modal, context-aware applications. The Java-based platform presented here is based on an integration of a cross-media link server and an object-oriented framework for advanced content publishing, along with a Client Controller and Context Engine. We also describe how this platform was used to develop a mobile tourist information system for an international arts festival where interaction was based on a combination of interactive paper and speech outpu

Chemotherapy Used to Halt Lower GI Bleeding in a Rare Case of Metastatic Choriocarcinoma to the GI Tract

Choriocarcinoma, a nonseminomatous germ cell tumor, is a rare type of testicular malignancy that tends to occur in young males. It is, however, exceedingly rare for choriocarcinoma to involve the GI tract. In this article, we present a rare case of a 31-year-old male, diagnosed with choriocarcinoma of the left testes, along with several metastases to distant sites. The patient presented with headaches and severe lower GI bleeding due to metastases to the GI tract, which was eventually controlled with systemic chemotherapy, while requiring several units of packed RBCs during his admission to the hospital. An extensive literature review found very few cases of the occurrence of GI bleeding as a consequence of choriocarcinoma due to metastases to the GI tract

Genetic subtraction profiling identifies genes essential for Arabidopsis reproduction and reveals interaction between the female gametophyte and the maternal sporophyte

Genetic subtraction and expression profiling of wild-type Arabidopsis and a sporophytic mutant lacking an embryo sac identified 1,260 genes expressed in the embryo sac; a total of 527 genes were identified for their expression in ovules of mutants lacking an embryo sac

SAHARA: Memory footprint reduction of cloud databases with automated table partitioning

Enterprises increasingly move their databases into the cloud. As a result, database-as-a-service providers are challenged to meet the performance guarantees assured in service-level agreements (SLAs) while keeping hardware costs as low as possible. Being cost-effective is particularly crucial for cloud databases where the provisioned amount of DRAM dominates the hardware costs. A way to decrease the memory footprint is to leverage access skew in the workload by moving rarely accessed cold data to cheaper storage layers and retaining only frequently accessed hot data in main memory. In this paper, we present SAHARA, an advisor that proposes a table partitioning for column stores with minimal memory footprint while still adhering to all performance SLAs. SAHARA collects lightweight workload statistics, classifies data as hot and cold, and calculates optimal or near-optimal range partitioning layouts with low optimization time using a novel cost model. We integrated SAHARA into a commercial cloud database and show in our experiments for real-world and synthetic benchmarks a memory footprint reduction of 2.5× while still fulfilling all performance SLAs provided by the customer or advertised by the DBaaS provider

Mouse Paneth cell antimicrobial function is independent of Nod2

ObjectiveAlthough polymorphisms of the NOD2 gene predispose to the development of ileal Crohn's disease, the precise mechanisms of this increased susceptibility remain unclear. Previous work has shown that transcript expression of the Paneth cell (PC) antimicrobial peptides (AMPs) α-defensin 4 and α-defensin-related sequence 10 are selectively decreased in Nod2−/− mice. However, the specific mouse background used in this previous study is unclear. In light of recent evidence suggesting that mouse strain strongly influences PC antimicrobial activity, we sought to characterise PC AMP function in commercially available Nod2−/− mice on a C57BL/6 (B6) background. Specifically, we hypothesised that Nod2−/− B6 mice would display reduced AMP expression and activity.DesignWild-type (WT) and Nod2−/− B6 ileal AMP expression was assessed via real-time PCR, acid urea polyacrylamide gel electrophoresis and mass spectrometry. PCs were enumerated using flow cytometry. Functionally, α-defensin bactericidal activity was evaluated using a gel-overlay antimicrobial assay. Faecal microbial composition was determined using 454-sequencing of the bacterial 16S gene in cohoused WT and Nod2−/− littermates.ResultsWT and Nod2−/− B6 mice displayed similar PC AMP expression patterns, equivalent α-defensin profiles, and identical antimicrobial activity against commensal and pathogenic bacterial strains. Furthermore, minimal differences in gut microbial composition were detected between the two cohoused, littermate mouse groups.ConclusionsOur data reveal that Nod2 does not directly regulate PC antimicrobial activity in B6 mice. Moreover, we demonstrate that previously reported Nod2-dependent influences on gut microbial composition may be overcome by environmental factors, such as cohousing with WT littermates

A simplified method to measure choroidal thickness using adaptive compensation in enhanced depth imaging optical coherence tomography

10.1371/journal.pone.0096661PLoS ONE95-POLN