Symplectic birational transformations of finite order on O'Grady's sixfolds

We prove that any symplectic automorphism of finite order on a manifold of type OG6 acts trivially on the Beauville--Bogomolov--Fujiki lattice and that any birational transformation of finite order acts trivially on its discriminant group. Moreover, we classify all possible invariant and coinvariant sublattices.Comment: Final version, to appear on Kyoto J. Mat

The Implicit Function as Squashing Time Model: A Novel Parallel Nonlinear EEG Analysis Technique Distinguishing Mild Cognitive Impairment and Alzheimer's Disease Subjects with High Degree of Accuracy

Objective. This paper presents the results obtained using a protocol based on special types of artificial neural networks (ANNs) assembled in a novel methodology able to compress the temporal sequence of electroencephalographic (EEG) data into spatial invariants for the automatic classification of mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. With reference to the procedure reported in our previous study (2007), this protocol includes a new type of artificial organism, named TWIST. The working hypothesis was that compared to the results presented by the workgroup (2007); the new artificial organism TWIST could produce a better classification between AD and MCI. Material and methods. Resting eyes-closed EEG data were recorded in 180 AD patients and in 115 MCI subjects. The data inputs for the classification, instead of being the EEG data, were the weights of the connections within a nonlinear autoassociative ANN trained to generate the recorded data. The most relevant features were selected and coincidently the datasets were split in the two halves for the final binary classification (training and testing) performed by a supervised ANN. Results. The best results distinguishing between AD and MCI were equal to 94.10% and they are considerable better than the ones reported in our previous study (∼92%) (2007). Conclusion. The results confirm the working hypothesis that a correct automatic classification of MCI and AD subjects can be obtained by extracting spatial information content of the resting EEG voltage by ANNs and represent the basis for research aimed at integrating spatial and temporal information content of the EEG

RFID Technologies: Emerging Issues, Challenges and Policy Options

Radio Frequency Identification (RFID) technology, an enabling technology for automatic identification based on radio waves, will impact the daily lives of European citizens in many different ways, as it is a bridge between the physical and the virtual world. RFID has enormous socio-economic potential but it also brings challenges, such as serious security threats and the potential danger of impinging on personal lives, which if not addressed properly may limit the foreseen benefits from the wide-spread deployment of this technology. This report gives an overview of established and emerging RFID technologies, RFID standards and spectrum allocation, presents RFID market parameters and forecast, privacy and security issues and social aspects of RFID. Five case studies from different application sectors (animal tracking, healthcare, ICT sector, identity cards and public transport) allow us to draw conclusions about both specific areas of development and the whole RFID market in Europe. In the final part, the likely role of Europe is presented, as are policy options for further initiatives.JRC.J.4-Information Societ

Standardization for Defence Procurement - European Handbook : CEN Workshop 10

The European Commission (EC), DG Enterprise, endeavours the competitiveness of the European Defence Industry. The plethora of (national) standards, more than 10.000, are recognised by the EC as a major constraint and cost driver. Electromagnetic Compatibility (EMC) or Electromagnetic Environmental Effects (EEE) are considered by the EC as a major topic, with 7 other topics such as environmental engineering, energetic materials, batteries, electrical interfaces. An EMC expert group with representatives from industry, including Aerotech Telub, Intellect, EADS, Ericsson Microwave, Fincantieri, MBDA, Thales, and national MoDs rationalized in 2004 a list of 329 EEE standards, implicitly abandoning national, including American, standards, and develop guidelines for the procurement process. A limited number of widely accepted and cost effective standards, suitable for use by MoD’s (acquisition) and industry (product development), has been defined after making comparisons. Comparisons were carried out on some standards against STANAG 4370 AECTP 500. The Expert Group agreed; That no one standard is better or worse than another in achieving an end goal. Differences are not sufficient to prevent the use of AECTP 500. There are sufficient similarities to AECTP 500 to adopt this as the fundamental replacement standard. There was sufficient agreement on NATO-, IEC- and EN-produced standards to make worthwhile agreement to use a number of standards as replacement for some (or some parts) of existing National Standards. This document gives recommendations on the use of the standards, the scope and \ud limitations. It also emphasizes the constraints with respect to the standardisation process of National MoD’s, NATO, Industry and EN/IEC

Construcción y ensayo de piranómetros fotovoltaicos de bajo costo desarrollados en la C.N.E.A.

Los piranómetros construidos utilizan como elemento sensor una celda fotovoltaica de silicio cristalino, con dos tipos de cubierta, una de vidrio transparente y otra de vidrio esmerilado. Se midió la respuesta angular de los piranómetros, variando el ángulo de incidencia de la luz en ±90°, y se la comparó con la ley del coseno. Se estudió en condiciones reales el comportamiento de uno de los sensores con difusor, comparándoselo con un piranómetro termoeléctrico de precisión, regularmente utilizado para la calibración de otros solarímetros. Se analizaron tanto las integrales diarias cuanto las horarias, determinándose la constante media diaria de calibración mediante el ajuste de una correlación lineal que arrojó un coeficiente de determinación de 0,99, comparable al obtenido para otros sensores fotovoltaicos ya comercializados en el exterior.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Identification and Somatic Characterization of the Germline PTEN Promoter Variant rs34149102 in a Family with Gastrointestinal and Breast Tumors

Genetic variants located in non-coding regions can affect processes that regulate protein expression, functionally contributing to human disease. Germline heterozygous mutations in the non-coding region of the PTEN gene have been previously identified in patients with PTEN hamartoma tumor syndrome (PHTS) diagnosed with breast, thyroid, and/or endometrial cancer. In this study, we report a PTEN promoter variant (rs34149102 A allele) that was identified by direct sequencing in an Italian family with a history of gastroesophageal junction (GEJ) adenocarcinoma and breast cancer. In order to investigate the putative functional role of the rs34149102 A allele variant, we evaluated the status of PTEN alterations at the somatic level. We found that PTEN protein expression was absent in the GEJ adenocarcinoma tissue of the index case. Moreover, we detected the occurrence of copy number loss involving the PTEN rs34149102 major C allele in tumor tissue, revealing that the second allele was somatically inactivated. This variant is located within an active regulatory region of the PTEN core promoter, and in silico analysis suggests that it may affect the binding of the nuclear transcription factor MAZ and hence PTEN expression. Overall, these results reveal the functional role of the PTEN promoter rs34149102 A allele variant in the modulation of PTEN protein expression and highlight its contribution to hereditary cancer risk

Comportamiento de un radiómetro par fabricado por CNEA respecto a un radiómetro par comercial Kipp & Zonen

Se estudia el comportamiento de un radiómetro PAR fabricado por el Grupo de Energía Solar de la Comisión Nacional de Energía Atómica (CNEA) frente a un radiómetro PAR comercial de la firma Kipp & Zonen. Se analizan las integrales diarias, horarias y cada diez minutos. Tras 215 días de medición se concluye que el desempeño del equipo de CNEA es comparable al comercial, mostrando una excelente estabilidad en su constante de calibración durante todo el período analizado.The behavior of a PAR radiometer made by CNEA is compared with a Kipp and Zonen commercial PAR radiometer. The integrals are analyzed daily, hourly and every ten minutes. After 215 days of measurement one concludes that the performance of the CNEA equipment is comparable, showing an excellent stability in his calibration constant during the whole analyzed period.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Comportamiento de un radiómetro par fabricado por CNEA respecto a un radiómetro par comercial Kipp & Zonen

Se estudia el comportamiento de un radiómetro PAR fabricado por el Grupo de Energía Solar de la Comisión Nacional de Energía Atómica (CNEA) frente a un radiómetro PAR comercial de la firma Kipp & Zonen. Se analizan las integrales diarias, horarias y cada diez minutos. Tras 215 días de medición se concluye que el desempeño del equipo de CNEA es comparable al comercial, mostrando una excelente estabilidad en su constante de calibración durante todo el período analizado.The behavior of a PAR radiometer made by CNEA is compared with a Kipp and Zonen commercial PAR radiometer. The integrals are analyzed daily, hourly and every ten minutes. After 215 days of measurement one concludes that the performance of the CNEA equipment is comparable, showing an excellent stability in his calibration constant during the whole analyzed period.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Comportamiento de un radiómetro par fabricado por CNEA respecto a un radiómetro par comercial Kipp & Zonen

Se estudia el comportamiento de un radiómetro PAR fabricado por el Grupo de Energía Solar de la Comisión Nacional de Energía Atómica (CNEA) frente a un radiómetro PAR comercial de la firma Kipp & Zonen. Se analizan las integrales diarias, horarias y cada diez minutos. Tras 215 días de medición se concluye que el desempeño del equipo de CNEA es comparable al comercial, mostrando una excelente estabilidad en su constante de calibración durante todo el período analizado.The behavior of a PAR radiometer made by CNEA is compared with a Kipp and Zonen commercial PAR radiometer. The integrals are analyzed daily, hourly and every ten minutes. After 215 days of measurement one concludes that the performance of the CNEA equipment is comparable, showing an excellent stability in his calibration constant during the whole analyzed period.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Crizotinib in MET-Deregulated or ROS1-Rearranged Pretreated Non-Small Cell Lung Cancer (METROS): A Phase II, Prospective, Multicenter, Two-Arms Trial.

PURPOSE: MET-deregulated NSCLC represents an urgent clinical need because of unfavorable prognosis and lack of specific therapies. Although recent studies have suggested a potential role for crizotinib in patients harboring MET amplification or exon 14 mutations, no conclusive data are currently available. This study aimed at investigating activity of crizotinib in patients harboring MET or ROS1 alterations. PATIENTS AND METHODS: Patients with pretreated advanced NSCLC and evidence of ROS1 rearrangements (cohort A) or MET deregulation (amplification, ratio MET/CEP7 >2.2 or MET exon 14 mutations, cohort B) were treated with crizotinib 250 mg twice daily orally. The coprimary endpoint was objective response rate in the two cohorts. RESULTS: From December 2014 to March 2017, 505 patients were screened and a total of 52 patients (26 patients per cohort) were enrolled onto the study. At data cutoff of September 2017, in cohort A, objective response rate was 65%, and median progression-free survival and overall survival were 22.8 months [95% confidence interval (CI) 15.2-30.3] and not reached, respectively. In cohort B, objective response rate was 27%, median progression-free survival was 4.4 months (95% CI 3.0-5.8), and overall survival was 5.4 months (95% CI, 4.2-6.5). No difference in any clinical endpoint was observed between MET-amplified and exon 14-mutated patients. No response was observed among the 5 patients with cooccurrence of a second gene alteration. No unexpected toxicity was observed in both cohorts. CONCLUSIONS: Crizotinib induces response in a fraction of MET-deregulated NSCLC. Additional studies and innovative therapies are urgently needed