The DAV and Periadriatic fault systems in the Eastern Alps south of the Tauern window

Alpine deformation of Austroalpine units south of the Tauern window is dominated by two kinematic regimes. Prior to intrusion of the main Periadriatic plutons at ~30Ma, the shear sense was sinistral in the current orientation, with a minor north-side-up component. Sinistral shearing locally overprints contact metamorphic porphyroblasts and early Periadriatic dykes. Direct Rb-Sr dating of microsampled synkinematic muscovite gave ages in the range 33-30Ma, whereas pseudotachylyte locally crosscutting the mylonitic foliation gave an interpreted 40Ar-39Ar age of ~46Ma. The transition from sinistral to dextral (transpressive) kinematics related to the Periadriatic fault occurred rapidly, between solidification of the earlier dykes and of the main plutons. Subsequent brittle-ductile to brittle faults are compatible with N-S to NNW-SSE shortening and orogen-parallel extension. Antithetic Riedel shears are distinguished from the previous sinistral fabric by their fine-grained quartz microstructures, with local pseudotachylyte formation. One such pseudotachylyte from Speikboden gave a 40Ar-39Ar age of 20Ma, consistent with pseudotachylyte ages related to the Periadriatic fault. The magnitude of dextral offset on the Periadriatic fault cannot be directly estimated. However, the jump in zircon and apatite fission-track ages establishes that the relative vertical displacement was ~4-5km since 24Ma, and that movement continued until at least 13M

The 7 May 2001 induced seismic event in the Ekofisk oil field, North Sea

A moderate size seismic event on 7 May 2001 was strongly felt on platforms in the Ekofisk oil field, in the southern North Sea, but did not cause damage to platforms or wells. We combined near- and far-field observations to develop a consistent source model and to determine whether the event was induced. Seismic data placed the epicenter inside the Ekofisk field and suggested a shallow source depth based on spectral and moment tensor analysis. GPS data from the Ekofisk platforms displayed permanent vertical and horizontal movement due to the event. A topographic bulge in the sea bottom, revealed by differential bathymetry data, and overpressure in the overburden in the northeastern part of the field, detected only after the event, had been caused by unintentional water injection that started in 1999. The injection pressure and rate were sufficient to raise the overburden. Pressure gauge and compaction data ruled out that the event occurred at reservoir level, which was further supported by unaffected production rates and absence of well failure. We therefore conclude that the event occurred in the overburden, at less than 3 km depth. Initially, this appeared unlikely on account of very low shear strength of the overburden clay-rich shale and mud rocks. The seismic event was induced owing to stress changes caused by water injection. The event possibly initiated on the northern flank of the field near the water injector and may have involved flexure of the overburden into the depression bowl in the rest of the field. Moment tensor analysis is consistent with a pure double-couple source. We suggest that slip occurred on the near-horizontal rather than along the near-vertical nodal plane. Stress drop was low, and owing to the low overburden shear strength, the event released less energy than a typical stress drop event with similar source dimensions

Aquaporin 1 and aquaporin 4 expression in human brain after subarachnoid hemorrhage and in peritumoral tissue.

Aquaporins (AQPs) are a protein family of water channels which facilitate the water flux through the plasmatic membranes. The expression of AQPs has been described in rat brain by several studies. Despite recent reports that have shown an over-expression of AQP1 and 4 in human tumoral cells, little is known about AQP expression in human brain. The purpose of this study was to investigate the expression of AQP1 and AQP4 in human brain after subarachnoid hemorrhage (SAH) and in peritumoral tissue by western blot and immunohistochemistry. The results showed a marked increase of the expression of AQP1 and AQP4. This over-expression occurred on the astrocytic processes and polarization on astrocytic end-feet was lost. No expression was observed on neuronal cells. This study is the first demonstration of the induction of AQP1 and AQP4 on reactive astrocytes in an acute brain injury, such as SAH. These results reinforce the hypothesis that AQPs may be involved in the dynamics of brain edema formation or resolution. Further studies are needed to understand their functional role

Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes

Specific metabolic features, such as glutamate reuptake, have been associated with normal functions of mature astrocytes. In this study, we examined whether these characteristics are acquired together with classical phenotypic markers of differentiated astrocytes. Differentiation of E14 mouse neurospheres into astrocytes was induced by the addition of fetal bovine serum (FBS). Degree of differentiation was assessed by reverse transcription-polymerase chain reaction (RT-PCR) and immunofluorescence for both GFAP and nestin. Neural stem cells expressed nestin but not GFAP, while differentiated astrocytes were immunopositive for GFAP but displayed low levels of nestin expression. A strong increase in the expression of the glutamate transporter GLAST and the monocarboxylate transporter MCT1 accompanied phenotypic changes. In addition, active glutamate transport appeared in differentiated astrocytes, as well as their capacity to increase aerobic glycolysis in response to glutamate. Leukemia inhibitory factor (LIF) and ciliary neurotrophic factor, but not interleukin-6, triggered the expression of phenotypic and morphological characteristics of astrocytes. In addition, exposure to LIF led to the appearance of metabolic features typically associated with astrocytes. Altogether, our results show that acquisition of some specific metabolic features by astrocytes occurs early in their differentiation process and that LIF represents a candidate signal to induce their expression

DAV and Periadriatic fault systems in the Eastern Alps south of the Tauern window

Alpine deformation of Austroalpine units south of the Tauern window is dominated by two kinematic regimes. Prior to intrusion of the main Periadriatic plutons at ~30 Ma, the shear sense was sinistral in the current orientation, with a minor north-side-up component. Sinistral shearing locally overprints contact metamorphic porphyroblasts and early Periadriatic dykes. Direct Rb–Sr dating of microsampled synkinematic muscovite gave ages in the range 33–30 Ma, whereas pseudotachylyte locally crosscutting the mylonitic foliation gave an interpreted ^(40)Ar–^(39)Ar age of ~46 Ma. The transition from sinistral to dextral (transpressive) kinematics related to the Periadriatic fault occurred rapidly, between solidification of the earlier dykes and of the main plutons. Subsequent brittle–ductile to brittle faults are compatible with N–S to NNW–SSE shortening and orogen-parallel extension. Antithetic Riedel shears are distinguished from the previous sinistral fabric by their fine-grained quartz microstructures, with local pseudotachylyte formation. One such pseudotachylyte from Speikboden gave a ^(40)Ar–^(39)Ar age of 20 Ma, consistent with pseudotachylyte ages related to the Periadriatic fault. The magnitude of dextral offset on the Periadriatic fault cannot be directly estimated. However, the jump in zircon and apatite fission-track ages establishes that the relative vertical displacement was ~4–5 km since 24 Ma, and that movement continued until at least 13 Ma

The DAV and Periadriatic fault systems in the Eastern Alps south of the Tauern window

ISSN:1437-3254ISSN:1437-326