A revision of the Neotropical predaceous midges of Brachypogon (Brachypogon) Kieffer (Diptera: Ceratopogonidae)

This revision of the Neotropical predaceous midges of the genus Brachypogon (Brachypogon) Kieffer, recognizes 18 extant species, including the following 12 new species: Brachypogon (B.) apunctipennis, bifidus, bimaculatus, ecuadorensis, ethelae, insularis, monicae, pseudoparaensis, schmitzi, spatuliformis, telesfordi, and woodruffi. Two species groups are recognized, the fuscivenosus and impar groups. The hitherto unknown male of B. paraensis Wirth & Blanton is described and illustrated, and the female of that species as well as both sexes of B. impar (Johannsen) and B. fuscivenosus (Lutz) are redescribed and illustrated. Diagnoses are provided for previously described species, as well as a key for the recognition of all Neotropical species. New records of B. impar are from Brazil, Colombia, and Argentina

The biting and predaceous midges of Guadeloupe (Diptera: Ceratopogonidae). I. Species of the subfamily Ceratopogoninae

We provide new records of biting and predaceous midges (Diptera: Ceratopogonidae) from Guadeloupe in the subfamily Ceratopogoninae, including descriptions and illustrations of three new predaceous species in the genera, Parabezzia Malloch, Stilobezzia Kieffer and Palpomyia Meigen, respectively, and the first records of the New World predaceous genus, Amerohelea Grogan and Wirth, from the Caribbean region. We also provide the first Guadeloupe records of the biting midges, Culicoides (Anilomyia) decor (Williston), C. (Avaritia) pusillus Lutz, C. (Drymodesmyia) bredini Wirth and Blanton, C. (D.) poikilonotus Macfie, C. (Haematomyidium) hoffmani Fox, C. (Hoffmania) insignis Lutz, C. rangeli Ortiz and Mirsa and C. trilineatus Fox, and the predaceous midges, Brachypogon (Brachypogon) bifidus Spinelli and Grogan, B. (B.) telesfordi Spinelli and Grogan, B. (B.) woodruffi Spinelli and Grogan, Monohelea maya Felippe-Bauer, Huerta and Ibáñez-Bernal, Stilobezzia (Stilobezzia) diminuta Lane and Forattini, S. (S.) thomsenae Wirth, Amerohelea galindoi Grogan and Wirth, Bezzia (Bezzia) flinti Spinelli and Wirth, B. (Homobezzia) venustula (Williston) and Palpomyia insularis Spinelli and Grogan

Double-stranded RNA elements associated with the MVX disease of Agaricus bisporus

Double-stranded RNA (dsRNA) has been isolated from Agaricus bisporus fruit bodies exhibiting a wide range of disease symptoms. The symptoms which occurred singularly or in combination included; bare cropping areas on commercial beds (primordia disruption), crop delay, premature veil opening, off- or brown-coloured mushrooms, sporophore malformations and loss of crop yield. All symptoms were associated with loss of yield and/or product quality. Collectively, these symptoms are described as mushroom virus X (MVX) disease. The dsRNA titre was much lower than that previously encountered with the La France viral disease of mushrooms and a modified cellulose CF11 protocol was used for their detection. A broad survey of cultivated mushrooms from the British industry identified dsRNA elements ranging between 640 bp and 20.2 kbp; the majority have not previously been described in A. bisporus. 26 dsRNA elements were identified with a maximum of 17, apparently non-encapsidated dsRNA elements, in any one sample. Three dsRNAs (16.2, 9.4 and 2.4 kbp) were routinely found in mushrooms asymptomatic for MVX. Previously, La France disease was effectively contained and controlled by minimising the on-farm production and spread of basidiospores. Our on-farm observations suggest that MVX could be spread by infected spores and/or mycelial fragments

Adaptability of Irrigation to a Changing Monsoon in India: How far can we go?

Agriculture and the monsoon are inextricably linked in India. A large part of the steady rise in agricultural production since the onset of the Green Revolution in the 1960’s has been attributed to irrigation. Irrigation is used to supplement and buffer crops against precipitation shocks, but water availability for such use is itself sensitive to the erratic, seasonal and spatially heterogeneous nature of the monsoon. Most attention in the literature is given to crop yields (Guiteras, 2009; Fishman, 2012; Auffhammer et al, 2011) and their ability to withstand precipitation shocks, in the presence of irrigation (Fishman, 2012). However, there remains limited evidence about how natural weather variability and realized irrigation outcomes are related. We provide new evidence on the relationship between monsoon changes, irrigation variability and water availability by linking a process based hydrology model with an econometric model for one of the world’s most water stressed countries. India uses more groundwater for irrigation than any other country, and there is substantial evidence that this has led to depletion of groundwater aquifers. First, we build an econometric model of historical irrigation decisions using detailed crop-wise agriculture and weather data spanning 35 years from 1970-2004 for 311 districts across 19 major agricultural states in India. The source of agricultural data comes from the Village Dynamics in South Asia database at the International Crop Research Institute for the Semi-Arid Tropics (ICRISAT). Weather data is sourced from the only long term continental scale daily observationally gridded precipitation and temperature dataset called APHRODITE (Asian Precipitation- Highly Resolved Observational Data Integration Towards Evaluation of the Water Resources), that captures the spatial extent of the monsoon across the Himalayas, South and South-East Asia, and the Middle East in great detail. We use panel data approaches to control for unobserved and omitted variables that can confound the true impacts of weather variability on irrigation. Exploiting the exogenous inter-annual variability in the monsoon, our multivariate regression models reveal that for crops grown in the wet season, irrigation is sensitive to distribution and total monsoon rainfall but not to ground or surface water availability. For crops grown in the dry season, total monsoon rainfall matters most, and its effect is sensitive to groundwater availability but differentially so for shallow dug wells and deep tube wells. The historical estimates from the econometric model are used to calculate future irrigated areas using three different bias-corrected climate model projections of monsoon climate for the years 2010 – 2050 under the strongest warming scenario ( business as usual scenario) RCP-8.5 from the CMIP5 (Coupled Model Intercomparison Project) models. These projections are then used as input to a physical hydrology model, such as the Water Balance Model, that tracks water use and exchange between the ground, atmosphere, runoff and stream networks. This enables us to quantify supply of water required to meet irrigation needs from sustainable sources such as rechargeable shallow groundwater, rivers and reservoirs, as well as unsustainable sources such as non- rechargeable groundwater. Preliminary results show that the significant variation in monsoon projections lead to very different results. Crops grown in the dry season show particularly divergent trends between model projections, leading to very different groundwater resource requirements. By combining the strengths of the economic and hydrology components, this work highlights potential sustainable or unsustainable water use trajectories that different regions within India will face

Propionibacterium acnes Induces an IL-17 Response in Acne Vulgaris that Is Regulated by Vitamin A and Vitamin D.

Acne vulgaris is the most common skin disorder affecting millions of people worldwide and inflammation resulting from the immune response targeting Propionibacterium acnes has a significant role in its pathogenesis. In this study, we have demonstrated that P. acnes is a potent inducer of T helper 17 (Th17) and Th1, but not Th2 responses in human peripheral blood mononuclear cells (PBMCs). P. acnes stimulated expression of key Th17-related genes, including IL-17A, RORα, RORc, IL-17RA, and IL-17RC, and triggered IL-17 secretion from CD4(+), but not from CD8(+) T cells. Supernatants from P. acnes-stimulated PBMCs were sufficient to promote the differentiation of naive CD4(+)CD45RA T cells into Th17 cells. Furthermore, we found that the combination of IL-1β, IL-6, and transforming growth factor-β-neutralizing antibodies completely inhibited P. acnes-induced IL-17 production. Importantly, we showed that IL-17-expressing cells were present in skin biopsies from acne patients but not from normal donors. Finally, vitamin A (all-trans retinoic acid) and vitamin D (1,25-dihydroxyvitamin D3) inhibited P. acnes-induced Th17 differentiation. Together, our data demonstrate that IL-17 is induced by P. acnes and expressed in acne lesions and that both vitamin A and D could be effective tools to modulate Th17-mediated diseases such as acne

How Observations of Circumstellar Disk Asymmetries Can Reveal Hidden Planets: Pericenter Glow and its Application to the HR 4796 Disk

Recent images of the disks of dust around the young stars HR 4796A and Fomalhaut show, in each case, a double-lobed feature that may be asymmetric (one lobe may be brighter than the other). A symmetric double-lobed structure is that expected from a disk of dust with a central hole that is observed nearly edge-on (i.e., close to the plane of the disk). This paper shows how the gravitational influence of a second body in the system with an eccentric orbit would cause a brightness asymmetry in such a disk by imposing a "forced eccentricity" on the orbits of the constituent dust particles, thus shifting the center of symmetry of the disk away from the star and causing the dust near the forced pericenter of the perturbed disk to glow. Dynamic modeling of the HR 4796 disk shows that its 5% brightness asymmetry could be the result of a forced eccentricity as small as 0.02 imposed on the disk by either the binary companion HR 4796B, or by an unseen planet close to the inner edge of the disk. Since it is likely that a forced eccentricity of 0.01 or higher would be imposed on a disk in a system in which there are planets, but no binary companion, the corresponding asymmetry in the disk's structure could serve as a sensitive indicator of these planets that might otherwise remain undetected.Comment: 61 pages, 10 figures, accepted for publication in the Astrophysical Journal (scheduled for January 10, 2000