Red and green make yellow: An Interactive multimedia tutorial designed to teach the basic concepts of additive and subtractive color

The division between designers and printers is becoming increasingly blurred as the capabilities of the desktop environment improve. Electronic imaging is one area where this disintegration is rapidly occurring. Abilities that were formerly the domain of the color separator, image assembler, and printer, such as scanning, color correction, and film separation, are available through many popular software programs. Unfortunately, the education required to allow the proper application of these software options is not as accessible as the tools themselves. Both printers and graphic designers will have to educate themselves about the emerging and changing technologies of the other. Eventually a common language will develop to facilitate the smooth production of designs created on the desktop. It is vital to the industry that students of design learn the terminology and technology of the printer, and that students of printing learn the terminology and technology of the designer. Educational institutes are one logical place for this process to begin. The purpose of this project was to develop a teaching tool addressing this need. The area of color was chosen as a focus because it is one of the areas where terminology and past learning experiences may conflict. A solid understanding of color is also becoming increasingly important as desktop systems operators prepare graphic designs directly for imagesetting. Interactive multimedia was determined to be the appropriate format for such a project and the subject matter was further defined. The result is a tutorial, created for beginning graphic and printing design students, which teaches the basic concepts of additive and subtractive color

Temperature effects on emergence time, proportion of males, and diapause in three species of Nasonia (Hymenoptera: Pteromalidae)

Temperature has been demonstrated to induce phenotypic plasticity in numerous insects for numerous traits. An organism of a specific genotype is said to exhibit phenotypic plasticity if it shows variation in a trait or traits that is dependant on changes in the external environment. A reaction norm is the function that relates the environments to which a particular genotype is exposed and the phenotypes that can be produced by that genotype. Genotype-by-environment interactions measure how genotypes vary in their· reaction norms. Trait responses to temperature can be examined with analyses that test for G by E interactions and display norms of reaction; thus telling us if different genotypes behave differently in different temperature environments. In the genus Nasonia, females produce large numbers of virtually identical offspring in a single clutch, making them ideal for a study of reaction norms. Nasonia vitripennis, N. giraulti and N. /ongicomis are parasitic wasps that parasitize various species of blow flies. I tested two strains of each of the three species for differences in emergence time, proportion of males and tendency to diapause due to different temperature environments. I also tested for genetic differences among the strains and any G by E interactions that might occur. I found that emergence time was the same for all species and all strains tested; as temperature increased the emergence time decreased. The proportion of males per clutch tended to have less of a plastic response, but there is evidence of a genetic response, with strains of the same species behaving differently. Diapause showed more genetic than temperature variation. In general, the G by E responses were modest

Qualitatively Assessing Background Factors of Criminal Captive-takers

Captive-taking is an inclusive category of criminal behavior that encompasses kidnapping, hostage situations, and certain acts of terrorism within both domestic and international contexts. To date, the existing research examining the individuals that commit captive-taking events and their backgrounds has been minimal. Gaining a deeper understanding of these individuals and their backgrounds may better prepare the individuals that are charged with intervening in captive-taking events including law enforcement, military personnel, and psychologists who assist in negotiation procedures.;This dissertation is drawn from a pilot study consisting of interviews with seven, incarcerated individuals convicted of captive-taking. The purpose of this dissertation was to qualitatively assess background factors among a captive-taking sample within a medium-high security, state correctional facility and to determine if those factors fall under two common theories that have been used to describe characteristics of other violent offender populations. Consensual qualitative analysis was employed to draw conclusions from the interview transcripts about background factors of these individuals.;Analysis yielded a total of 52 domains related to the backgrounds of these individuals, which were then grouped into 12 core ideas. Cross analysis was carried out with weighted labels being assigned to each of the domains/core ideas based on the frequency that each appeared across the seven transcripts. The results presented represent the subjective experience of individuals charged with captive-taking. Limitations, strengths, and future directions are also discussed

A study of the chelation of 1,3-BIS (tris (hydroxymethyl) Methylamino) 2-propanol with iron (III)

The element Iron is so important that a major era of history bore its name. Its magnetic and metallic properties have long been studied and used. It is also well known that iron. is the cental element in the oxygen-carrying compound hemo­ globin and therefore essential to life. Its biological importance is also evidenced by its presence in the cytochrome oxidases . These important biochemical compounds are iron chelates Fundamental research with iron chelates may therefore shed light on the operations of certain enzyme systems, drugs and poisons. Analytical chemistry and the dye industry have used chelate compounds for many years. Citrates and oxalates have also been used to tie up calcium ions and prevent coag­ ulation of blood, while polyphosphates have been used as water softeners. In recent years many new uses have been de­veloped and interest has grown accordingly

Prediction of patient outcomes through social determinants of health: The Pulmonary Hypertension Association Registry (PHAR) evaluation

Outcomes of patients with pulmonary arterial hypertension (PAH) may be associated with social determinants of health (SDOH) and other baseline patient characteristics. At present, there is no prognostic model to predict important patient outcomes in PAH based on SDOH. Utilizing information from the Pulmonary Hypertension Association Registry (PHAR), we derive a model (PHAR Evaluation or PHARE) to predict an important composite patient outcomes based on SDOH and other patient characteristics. Baseline data regarding SDOH from adult patients with PAH enrolled in the PHAR between 2015 and March 23, 2020, were included for analysis. We performed repeated measures logistic regression modeling with dichotomous outcome data (0 for no events, 1 for one or more events) to derive the PHARE. Here, 1275 consecutive adult patients enrolled in the PHAR from 47 participating centers were included. Variables included in our model are race, gender, ethnicity, household income, level of education, age, body mass index, drug use, alcohol use, marital status, and type of health insurance. Interaction effect between variables was analyzed and several interactions were also included in the PHARE. The PHARE shows

Intravenous Vitamin C Administered as Adjunctive Therapy for Recurrent Acute Respiratory Distress Syndrome

This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of recurrent acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and malabsorption. Prior to the episodes of sepsis, the patient was receiving nutrition via chronic hyperalimentation administered through a long-standing central venous catheter. The patient became recurrently septic with Gram positive cocci which led to two instances of ARDS. This report describes the broad-based general critical care of a septic patient with acute respiratory failure that includes fluid resuscitation, broad-spectrum antibiotics, and vasopressor support. Intravenous vitamin C infused at 50 mg per kilogram body weight every 6 hours for 96 hours was incorporated as an adjunctive agent in the care of this patient. Vitamin C when used as a parenteral agent in high doses acts “pleiotropically” to attenuate proinflammatory mediator expression, to improve alveolar fluid clearance, and to act as an antioxidant

Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?

<p>Abstract</p> <p>Background</p> <p>Pulmonary hypertension (PH) is a life-threatening disease with poor prognosis. Encouraging efforts have been made to target the main vasoproliferative aspects of the disease. Promising emerging therapeutics are tyrosine kinase inhibitors such as imatinib.</p> <p>Case presentation</p> <p>Here, we discuss the relevance of previously published cases and add another well-characterised patient who developed pre-capillary PH under long-term therapy with the multi-tyrosine kinase inhibitor dasatinib approved for therapy of chronic myeloic leukaemia (CML) and Philadelphia chromosome positive acute lymphocytic leukaemia (mean time of all patients on dasatinib: 26 months). Hence, we discuss the possibility of dasatinib itself causing PH after long-term therapy and turn specialist's attention to this possible severe side effect.</p> <p>At present, the true incidence of dasatinib-associated PH remains illusive and systematic data regarding haemodynamics are missing.</p> <p>Conclusion</p> <p>We therefore recommend systematic screening of dasatinib-treated patients for pulmonary hypertension and subsequent collection of haemodynamic data.</p

Right ventricular adaptation and failure in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is an obstructive pulmonary vasculopathy, characterized by excess proliferation, apoptosis resistance, inflammation, fibrosis, and vasoconstriction. Although PAH therapies target some of these vascular abnormalities (primarily vasoconstriction), most do not directly benefit the right ventricle (RV). This is suboptimal because a patient's functional state and prognosis are largely determined by the success of the adaptation of the RV to the increased afterload. The RV initially hypertrophies but might ultimately decompensate, becoming dilated, hypokinetic, and fibrotic. A number of pathophysiologic abnormalities have been identified in the PAH RV, including: ischemia and hibernation (partially reflecting RV capillary rarefaction), autonomic activation (due to G protein receptor kinase 2-mediated downregulation and desensitization of β-adrenergic receptors), mitochondrial-metabolic abnormalities (notably increased uncoupled glycolysis and glutaminolysis), and fibrosis. Many RV abnormalities are detectable using molecular imaging and might serve as biomarkers. Some molecular pathways, such as those regulating angiogenesis, metabolism, and mitochondrial dynamics, are similarly deranged in the RV and pulmonary vasculature, offering the possibility of therapies that treat the RV and pulmonary circulation. An important paradigm in PAH is that the RV and pulmonary circulation constitute a unified cardiopulmonary unit. Clinical trials of PAH pharmacotherapies should assess both components of the cardiopulmonary unit