297 research outputs found
Intraguild processes drive spaceâuse patterns in a largeâbodied marine predator community
ACKNOWLEDGEMENTS We dedicate this paper to the memory of Samuel (âDocâ) Gruber who passed away before the completion of this manuscript. This work was supported by the Bimini Biological Field Station Foundation staff and volunteers, and funded by Save Our Seas Foundation, Swiss Shark Foundation (Hai Stiftung) and Guy Harvey Ocean Foundation. We are grateful for the unwavering support provided by Bimini Scuba Center. We thank Volker Grimm, A. Bradley Duthie and an anonymous reviewer for their constructive feedback on earlier versions of the manuscript. This is publication # 1708 from the Institute of Environment at Florida International University.Peer reviewe
The BRST quantization and the no-ghost theorem for AdS_3
In our previous papers, we prove the no-ghost theorem without light-cone
directions (hep-th/0005002, hep-th/0303051). We point out that our results are
valid for more general backgrounds. In particular, we prove the no-ghost
theorem for AdS_3 in the context of the BRST quantization (with the standard
restriction on the spin). We compare our BRST proof with the OCQ proof and
establish the BRST-OCQ equivalence for AdS_3. The key in both approaches lies
in the certain structure of the matter Hilbert space as a product of two Verma
modules. We also present the no-ghost theorem in the most general form.Comment: 22 pages, JHEP and AMS-LaTeX; v2 & 3: minor improvement
Spontaneous light-mediated magnetism in cold atoms
Cold atom setups are now commonly employed in simulations of condensed matter phenomena. We present a novel approach to induce strong magnetic interactions between atoms on a self-organized lattice using diffraction of light. Diffractive propagation of structured light fields leads to an exchange between phase and amplitude modulated planes which can be used to couple atomic degrees of freedom via optical pumping nonlinearities. In the experiment a cold cloud of Rb atoms placed near a retro-reflecting mirror is driven by a detuned pump laser. We demonstrate spontaneous magnetic ordering in the Zeeman sublevels of the atomic ground state: anti-ferromagnetic structures on a square lattice and ferrimagnetic structures on a hexagonal lattice in zero and a weak longitudinal magnetic field, respectively. The ordered state is destroyed by a transverse magnetic field via coherent dynamics. A connection to the transverse (quantum) Ising model is drawn
Superstrings on NS5 backgrounds, deformed AdS3 and holography
We study a non-standard decoupling limit of the D1/D5-brane system, which
interpolates between the near-horizon geometry of the D1/D5 background and the
near-horizon limit of the pure D5-brane geometry. The S-dual description of
this background is actually an exactly solvable two-dimensional (worldsheet)
conformal field theory: {null-deformed SL(2,R)} x SU(2) x T^4 or K3. This model
is free of strong-coupling singularities. By a careful treatment of the
SL(2,R), based on the better-understood SL(2,R) / U(1) coset, we obtain the
full partition function for superstrings on SL(2,R) x SU(2) x K3. This allows
us to compute the partition functions for the J^3 and J^2 current-current
deformations, as well as the full line of supersymmetric null deformations,
which links the SL(2,R) conformal field theory with linear dilaton theory. The
holographic interpretation of this setup is a renormalization-group flow
between the decoupled NS5-brane world-volume theory in the ultraviolet (Little
String Theory), and the low-energy dynamics of super Yang--Mills string-like
instantons in six dimensions.Comment: JHEP style, 59 pages, 1 figure; v2: minor changes, to appear in JHE
Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimerâs disease
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimerâs disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study (MWAS) of AD-associated loci from GWASs using untargeted metabolic profiling (metabolomics) by ultraperformance liquid chromatographyâmass spectrometry (UPLC-MS). We identified an association of lactosylceramides (LacCer) with AD-related single-nucleotide polymorphisms (SNPs) in ABCA7 (P = 5.0 Ă 10â5 to 1.3 Ă 10â44). We showed that plasma LacCer concentrations are associated with cognitive performance and genetically modified levels of LacCer are associated with AD risk. We then showed that concentrations of sphingomyelins, ceramides, and hexosylceramides were altered in brain tissue from Abca7 knockout mice, compared with wild type (WT) (P = 0.049â1.4 Ă 10â5), but not in a mouse model of amyloidosis. Furthermore, activation of microglia increases intracellular concentrations of hexosylceramides in part through induction in the expression of sphingosine kinase, an enzyme with a high control coefficient for sphingolipid and ceramide synthesis. Our work suggests that the risk for AD arising from functional variations in ABCA7 is mediated at least in part through ceramides. Modulation of their metabolism or downstream signaling may offer new therapeutic opportunities for AD
Avoiding lodging in irrigated spring wheat. I. Stem and root structural requirements
A model of the lodging process has been successfully adapted for use on spring wheat grown in North-West Mexico (NWM). The lodging model was used to estimate the lodging-associated traits required to enable spring wheat grown in NWM with a typical yield of 6 t haâ1 and plant height of 0.7 m to achieve a lodging return period of 25 years. Target traits included a root plate spread of 51 mm and stem strength of the bottom internode of 268 N mm. These target traits increased to 54.5 mm and 325 N mm, respectively, for a crop yielding 10 t haâ1. Analysis of multiple genotypes across three growing seasons enabled relationships between both stem strength and root plate spread with structural dry matter to be quantified. A NWM lodging resistant ideotype yielding 6 t haâ1 would require 3.93 t haâ1 of structural stem biomass and 1.10 t haâ1 of root biomass in the top 10 cm of soil, which would result in a harvest index (HI) of 0.46 after accounting for chaff and leaf biomass. A crop yielding 10 t haâ1 would achieve a HI of 0.54 for 0.7 m tall plants or 0.41 for more typical 1.0 m tall plants. This study indicates that for plant breeders to achieve both high yields and lodging-proofness they must either breed for greater total biomass or develop high yielding germplasm from shorter crops
Diagnostic criteria and symptom grading for delayed gastric conduit emptying after esophagectomy for cancer: international expert consensus based on a modified Delphi process
Delayed gastric conduit emptying (DGCE) after esophagectomy for cancer is associated with adverse outcomes and troubling symptoms. Widely accepted diagnostic criteria and a symptom grading tool for DGCE are missing. This hampers the interpretation and comparison of studies. A modified Delphi process, using repeated web-based questionnaires, combined with live interim group discussions was conducted by 33 experts within the field, from Europe, North America, and Asia. DGCE was divided into early DGCE if present within 14Â days of surgery and late if present later than 14Â days after surgery. The final criteria for early DGCE, accepted by 25 of 27 (93%) experts, were as follows: >500Â mL diurnal nasogastric tube output measured on the morning of postoperative day 5 or later orâ>100% increased gastric tube width on frontal chest x-ray projection together with the presence of an air-fluid level. The final criteria for late DGCE accepted by 89% of the experts were as follows: the patient should have 'quite a bit' or 'very much' of at least two of the following symptoms; early satiety/fullness, vomiting, nausea, regurgitation or inability to meet caloric need by oral intake and delayed contrast passage on upper gastrointestinal water-soluble contrast radiogram or on timed barium swallow. A symptom grading tool for late DGCE was constructed grading each symptom as: 'not at all', 'a little', 'quite a bit', or 'very much', generating 0, 1, 2, or 3 points, respectively. For the five symptoms retained in the diagnostic criteria for late DGCE, the minimum score would be 0, and the maximum score would be 15. The final symptom grading tool for late DGCE was accepted by 27 of 31 (87%) experts. For the first time, diagnostic criteria for early and late DGCE and a symptom grading tool for late DGCE are available, based on an international expert consensus process
Role of miR-2392 in driving SARS-CoV-2 infection
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we design a miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters, and may potentially inhibit a COVID-19 disease state in humans
Remoção biolĂłgica de fenol por uso de reator contĂnuo com inĂłculo de Aspergillus niger
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