Recognition and Comprehension of Speech in Noise in School-Aged Children with Unilateral Hearing Loss

Sentence recognition and auditory comprehension abilities of young adults with normal hearing (NH) and school-age children with NH and unilateral hearing loss (UHL) were tested in a mixed design. In Experiment 1, subjects’ sentence recognition abilities were measured in the presence of speech spectrum noise (SSN) and two-talker child babble (TTB) in co-located and spatially-separated target and masker configurations. In all conditions, reception thresholds for sentences (RTS) improved with age from six-to 12 years. Speech spectrum noise proved to be a more effective masker than TTB in all listening conditions, suggesting subjects were able to take advantage of temporal and spectral fluctuations in the masker. By 12 years of age, RTS appeared to be adult-like when children listened in the presence of SSN, but were still immature in TTB. Across all listening conditions, a majority of UHL subjects’ RTS fell outside ±1 standard deviation of the NH mean, indicating poorer performance for this group of listeners. Performance of UHL subjects heavily depended on spatial configuration and was poorest when the masker was directed towards their normal-hearing ear. In Experiment 2, subjects’ auditory comprehension abilities were measured in the presence of TTB at a variety of signal-to-noise ratios (SNRs). When averaged across age, NH subjects performed similarly across the different listening conditions. For most UHL subjects, performance was similar to NH subjects in all comprehension tasks suggesting like NH subjects they made use of story context to support understanding even when audibility was compromised and likely took advantage of gaps in the TTB and spatial separation of the target and masker to better glimpse/hear the target. The findings of the current study improve our understanding of both simple and complex auditory abilities of school-aged children with NH and UHL in classroom-like, noisy environments. Furthermore measurable auditory deficits were detected in the study’s sample of children with UHL

Evaluating Flood Forecasting System Performance in Cambodia During the 2019 Flood Season

Every year, Cambodia experiences both flash and prolonged riverine flooding as a result of monsoon rains and typhoons. Floods occur frequently in various parts of the region, and result in significant economic cost. Flood forecasting systems are designed to mitigate economic and social impacts, enabling people to prepare for extreme events. However, in order for forecasts to be used effectively, an assessment of the available forecasting systems is needed. In addition, following the onset of flooding, satellite imagery is used to generate flood maps to aid in response efforts. This study demonstrates the performance of regional and global flood forecasting systems over the 2019 flood season. To do this, we assess the flood forecast accuracy at different forecast lead times through a series of forecast verification metrics at gauge locations in Cambodia. We then compare the flood forecast performance to Sentinel 1 flood maps produced by the Hydrological Remote Sensing Analysis of Floods (HYDRAFloods) tool currently being co-developed by SERVIR-Mekong in collaboration with the Myanmar Department of Disaster Management. This assessment of the flood forecasting systems performance and comparison to generated flood maps helps provide context to forecasters and disaster managers as they make improvements to their models. Additionally, these results provide support to forecast users as they evaluate the strengths and weaknesses of different systems for taking action

Longitudinal examination of pathways to peer problems in middle childhood: a siblings-reared-apart design

To advance research from Dishion and others on associations between parenting and peer problems across childhood, we used a sample of 173 sibling pairs reared apart since birth (because of adoption of one of the siblings) to examine associations between parental hostility and children’s peer problems when children were ages 7 and 9.5 years (n = 326 children). We extended conventional cross-lagged parent–peer models by incorporating child inhibitory control as an additional predictor and examining genetic contributions via birth mother psychopathology. Path models indicated a cross-lagged association from parental hostility to later peer problems. When child inhibitory control was included, birth mother internalizing symptoms were associated with poorer child inhibitory control, which was associated with more parental hostility and peer problems. The cross-lagged paths from parental hostility to peer problems were no longer significant in the full model. Multigroup analyses revealed that the path from birth mother internalizing symptoms to child inhibitory control was significantly higher for birth parent–reared children, indicating the possible contribution of passive gene–environment correlation to this association. Exploratory analyses suggested that each child’s unique rearing context contributed to their inhibitory control and peer behavior. Implications for the development of evidence-based interventions are discussed

A T8.5 Brown Dwarf Member of the Xi Ursae Majoris System

The Wide-field Infrared Survey Explorer has revealed a T8.5 brown dwarf (WISE J111838.70+312537.9) that exhibits common proper motion with a solar-neighborhood (8 pc) quadruple star system - Xi Ursae Majoris. The angular separation is 8.5 arc-min, and the projected physical separation is about 4000 AU. The sub-solar metallicity and low chromospheric activity of Xi UMa A argue that the system has an age of at least 2 Gyr. The infrared luminosity and color of the brown dwarf suggests the mass of this companion ranges between 14 and 38 Jupiter masses for system ages of 2 and 8 Gyr respectively.Comment: AJ in press, 12 pages LaTeX with 6 figures. More astrometric data and a laser guide star adaptive optics image adde

Identification and manipulation of the pleuromutilin gene cluster from Clitopilus passeckerianus for increased rapid antibiotic production

Semi-synthetic derivatives of the tricyclic diterpene antibiotic pleuromutilin from the basidiomycete Clitopilus passeckerianus are important in combatting bacterial infections in human and veterinary medicine. These compounds belong to the only new class of antibiotics for human applications, with novel mode of action and lack of cross-resistance, representing a class with great potential. Basidiomycete fungi, being dikaryotic, are not generally amenable to strain improvement. We report identification of the seven-gene pleuromutilin gene cluster and verify that using various targeted approaches aimed at increasing antibiotic production in C. passeckerianus, no improvement in yield was achieved. The seven-gene pleuromutilin cluster was reconstructed within Aspergillus oryzae giving production of pleuromutilin in an ascomycete, with a significant increase (2106%) in production. This is the first gene cluster from a basidiomycete to be successfully expressed in an ascomycete, and paves the way for the exploitation of a metabolically rich but traditionally overlooked group of fungi

Regional Invasive Species & Climate Change Management Challenge: Gardening with climate-smart native plants in the Northeast

An estimated 80% of ornamental plants for sale are non-native. This means that the average yard does a poor job of supporting native flora and fauna. By shifting our plantings towards natives, we can dramatically increase the diversity of bees, butterflies, birds and other animals. In contrast, non-native plants do not support local food webs and can become invasive. Native plants increase biodiversity and reduce risks associated with invasive species, which supports resilient ecosystems in the face of climate change

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity

TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 restriction in New World owl monkeys and HIV-2 restriction in Old World rhesus macaques. Here we provide evidence that Asian macaque TRIMCyps have acquired changes that switch restriction specificity between different lentiviral lineages, resulting in species-specific alleles that target different viruses. Structural, thermodynamic and viral restriction analysis suggests that a single mutation in the Cyp domain, R69H, occurred early in macaque TRIMCyp evolution, expanding restriction specificity to the lentiviral lineages found in African green monkeys, sooty mangabeys and chimpanzees. Subsequent mutations have enhanced restriction to particular viruses but at the cost of broad specificity. We reveal how specificity is altered by a scaffold mutation, E143K, that modifies surface electrostatics and propagates conformational changes into the active site. Our results suggest that lentiviruses may have been important pathogens in Asian macaques despite the fact that there are no reported lentiviral infections in current macaque populations

Serum from COVID-19 patients early in the pandemic shows limited evidence of cross-neutralization against variants of concern

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in a variety of clinical symptoms ranging from no or mild to severe disease. Currently, there are multiple postulated mechanisms that may push a moderate to severe disease into a critical state. Human serum contains abundant evidence of the immune status following infection. Cytokines, chemokines, and antibodies can be assayed to determine the extent to which a patient responded to a pathogen. We examined serum and plasma from a cohort of patients infected with SARS-CoV-2 early in the pandemic and compared them to negative-control sera. Cytokine and chemokine concentrations varied depending on the severity of infection, and antibody responses were significantly increased in severe cases compared to mild to moderate infections. Neutralization data revealed that patients with high titers against an early 2020 SARS-CoV-2 isolate had detectable but limited neutralizing antibodies against the emerging SARS-CoV-2 Alpha, Beta and Delta variants. This study highlights the potential of re-infection for recovered COVID-19 patients

Promoting inclusive metrics of success and impact to dismantle a discriminatory reward system in science

“The most dangerous phrase in the language is: We’ve always done it this way.” —Rear Admiral Grace HopperSuccess and impact metrics in science are based on a system that perpetuates sexist and racist “rewards” by prioritizing citations and impact factors. These metrics are flawed and biased against already marginalized groups and fail to accurately capture the breadth of individuals’ meaningful scientific impacts. We advocate shifting this outdated value system to advance science through principles of justice, equity, diversity, and inclusion. We outline pathways for a paradigm shift in scientific values based on multidimensional mentorship and promoting mentee well-being. These actions will require collective efforts supported by academic leaders and administrators to drive essential systemic change.Peer reviewe