Brownian Dynamics of a Sphere Between Parallel Walls

We describe direct imaging measurements of a colloidal sphere's diffusion between two parallel surfaces. The dynamics of this deceptively simple hydrodynamically coupled system have proved difficult to analyze. Comparison with approximate formulations of a confined sphere's hydrodynamic mobility reveals good agreement with both a leading-order superposition approximation as well as a more general all-images stokeslet analysis.Comment: 4 pages, 3 figures, REVTeX with PostScript figure

Guidance, flight mechanics and trajectory optimization. Volume 11 - Guidance equations for orbital operations

Mathematical formulation of guidance equations and solutions for orbital space mission

Guidance, Flight Mechanics and Trajectory Optimization. Volume 5 - State Determination And/or Estimation

Guidance, flight mechanics, and trajectory optimizatio

Weak Long-Ranged Casimir Attraction in Colloidal Crystals

We investigate the influence of geometric confinement on the free energy of an idealized model for charge-stabilized colloidal suspensions. The mean-field Poisson-Boltzmann formulation for this system predicts pure repulsion among macroionic colloidal spheres. Fluctuations in the simple ions' distribution provide a mechanism for the macroions to attract each other at large separations. Although this Casimir interaction is long-ranged, it is too weak to influence colloidal crystals' dynamics.Comment: 5 pages 2 figures ReVTe

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment. In the present study, we undertook two approaches to determine the significance of plasticity involving system xc−. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system xc−. Rats were trained to self-administer cocaine (1 mg/kg/200 μl, i.v.) under extended access conditions (6 h/day). After extinction training, cocaine (10 mg/kg, i.p.) primed reinstatement was assessed in rats pretreated with N-acetylcysteine (0–60 mg/kg, i.p.) in the presence or absence of the system xc− inhibitor (S)-4-carboxyphenylglycine (CPG; 0.5 μM; infused into the nucleus accumbens). N-acetylcysteine attenuated cocaine-primed reinstatement, and this effect was reversed by co-administration of CPG. Secondly, we examined whether reduced system xc− activity is necessary for cocaine-primed reinstatement. To do this, we administered N-acetylcysteine (0 or 90 mg/kg, i.p.) prior to 12 daily self-administration sessions (1 mg/kg/200 μl, i.v.; 6 h/day) since this procedure has previously been shown to prevent reduced activity of system xc−. On the reinstatement test day, we then acutely impaired system xc− in some of the rats by infusing CPG (0.5 μM) into the nucleus accumbens. Rats that had received N-acetylcysteine prior to daily self-administration sessions exhibited diminished cocaine-primed reinstatement; this effect was reversed by infusing the cystine–glutamate exchange inhibitor CPG into the nucleus accumbens. Collectively these data establish system xc− in the nucleus accumbens as a key mechanism contributing to cocaine-primed reinstatement

Anomalous interactions in confined charge-stabilized colloid

Charge-stabilized colloidal spheres dispersed in weak 1:1 electrolytes are supposed to repel each other. Consequently, experimental evidence for anomalous long-ranged like-charged attractions induced by geometric confinement inspired a burst of activity. This has largely subsided because of nagging doubts regarding the experiments' reliability and interpretation. We describe a new class of thermodynamically self-consistent colloidal interaction measurements that confirm the appearance of pairwise attractions among colloidal spheres confined by one or two bounding walls. In addition to supporting previous claims for this as-yet unexplained effect, these measurements also cast new light on its mechanism.Comment: 8 pages, 5 figures, RevTeX4. Conference proceedings for CODEF-04, Colloidal Dispersions in External Fields, March 29 - April 1, 200

C IV BAL disappearance in a large SDSS QSO sample

Broad absorption lines (BALs) in the spectra of quasi-stellar objects (QSOs) originate from outflowing winds along our line of sight; winds are thought to originate from the inner regions of the QSO accretion disk, close to the central supermassive black hole (SMBH). Winds likely play a role in galaxy evolution and aid the accretion mechanism onto the SMBH. BAL equivalent widths can change on typical timescales from months to years; such variability is generally attributed to changes in the covering factor and/or in the ionization level of the gas. We investigate BAL variability, focusing on BAL disappearance. We analyze multi-epoch spectra of more than 1500 QSOs -the largest sample ever used for such a study- observed by different programs from the Sloan Digital Sky Survey-I/II/III (SDSS), and search for disappearing C IV BALs. The spectra rest-frame time baseline ranges from 0.28 to 4.9 yr; the source redshifts range from 1.68 to 4.27. We detect 73 disappearing BALs in the spectra of 67 sources. This corresponds to 3.9% of disappearing BALs, and 5.1% of our BAL QSOs exhibit at least one disappearing BAL. We estimate the average lifetime of a BAL along our line of sight (~ 80-100 yr), which appears consistent with the accretion disk orbital time at distances where winds are thought to originate. We inspect properties of the disappearing BALs and compare them to the properties of our main sample. We also investigate the existence of a correlation in the variability of multiple troughs in the same spectrum, and find it persistent at large velocity offsets between BAL pairs, suggesting that a mechanism extending on a global scale is necessary to explain the phenomenon. We select a more reliable sample of disappearing BALs following Filiz Ak et al. (2012), where a subset of our sample was analyzed, and compare the findings from the two works, obtaining generally consistent results.Comment: 22 pages, 9 figures. Accepted for publication in A&

The Importance of Broad Emission-Line Widths in Single Epoch Black Hole Mass Estimates

Estimates of the mass of super-massive black holes (BHs) in distant active galactic nuclei (AGNs) can be obtained efficiently only through single-epoch spectra, using a combination of their broad emission-line widths and continuum luminosities. Yet the reliability and accuracy of the method, and the resulting mass estimates, M_BH, remain uncertain. A recent study by Croom using a sample of SDSS, 2QZ and 2SLAQ quasars suggests that line widths contribute little information about the BH mass in these single-epoch estimates and can be replaced by a constant value without significant loss of accuracy. In this Letter, we use a sample of nearby reverberation-mapped AGNs to show that this conclusion is not universally applicable. We use the bulge luminosity (L_Bulge) of these local objects to test how well the known M_BH - L_Bulge correlation is recovered when using randomly assigned line widths instead of the measured ones to estimate M_BH. We find that line widths provide significant information about M_BH, and that for this sample, the line width information is just as significant as that provided by the continuum luminosities. We discuss the effects of observational biases upon the analysis of Croom and suggest that the results can probably be explained as a bias of flux-limited, shallow quasar samples.Comment: 10 text pages + 4 Figures + 1 Table. Accepted for publication in ApJ Letter

The PS 80 MHz cavities

As part of the preparation of the PS as injector for LHC, two new 80 MHz cavities have been designed and built at CERN. Bunches spaced by 25 ns and less than 4 ns long are required at injection into t he SPS. The bunch spacing is obtained with a 40 MHz system installed in the PS in 1996, but the nominal small bunch length will only be obtained with the 80 MHz systems producing a total of 600 kV. Th ese systems also have the capability to accelerate leptons in the PS, providing a total of 400 kV with high duty cycle (25 %). The mechanical design is similar to that of the 40 MHz cavity with many c ommon parts, but cooling water circuits had to be added. The cavity is equipped with an efficient, pneumatically operated, coaxial short-circuit. The power coupling loop has the form of a wide strip t o minimize the ratio of self to mutual inductance. It has a DC insulation permitting multipactor suppression by a bias voltage. The final amplifier is mounted directly onto the cavity. A fast RF feedb ack with a loop gain of 44 dB reduces the Q to about 100. Higher-order-mode dampers designed and built at TRIUMF have been installed