355 research outputs found
POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models
The POWERLIB SAS/IML software provides convenient power calculations for a wide range of multivariate linear models with Gaussian errors. The software includes the Box, Geisser-Greenhouse, Huynh-Feldt, and uncorrected tests in the "univariate" approach to repeated measures (UNIREP), the Hotelling Lawley Trace, Pillai-Bartlett Trace, and Wilks Lambda tests in "multivariate" approach (MULTIREP), as well as a limited but useful range of mixed models. The familiar univariate linear model with Gaussian errors is an important special case. For estimated covariance, the software provides confidence limits for the resulting estimated power. All power and confidence limits values can be output to a SAS dataset, which can be used to easily produce plots and tables for manuscripts.
POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models
The POWERLIB SAS/IML software provides convenient power calculations for a wide range of multivariate linear models with Gaussian errors. The software includes the Box, Geisser-Greenhouse, Huynh-Feldt, and uncorrected tests in the "univariate" approach to repeated measures (UNIREP), the Hotelling Lawley Trace, Pillai-Bartlett Trace, and Wilks Lambda tests in "multivariate" approach (MULTIREP), as well as a limited but useful range of mixed models. The familiar univariate linear model with Gaussian errors is an important special case. For estimated covariance, the software provides confidence limits for the resulting estimated power. All power and confidence limits values can be output to a SAS dataset, which can be used to easily produce plots and tables for manuscripts
Computational and Biological Analogies for Understanding Fine-Tuned Parameters in Physics
In this philosophical paper, we explore computational and biological
analogies to address the fine-tuning problem in cosmology. We first clarify
what it means for physical constants or initial conditions to be fine-tuned. We
review important distinctions such as the dimensionless and dimensional
physical constants, and the classification of constants proposed by
Levy-Leblond. Then we explore how two great analogies, computational and
biological, can give new insights into our problem. This paper includes a
preliminary study to examine the two analogies. Importantly, analogies are both
useful and fundamental cognitive tools, but can also be misused or
misinterpreted. The idea that our universe might be modelled as a computational
entity is analysed, and we discuss the distinction between physical laws and
initial conditions using algorithmic information theory. Smolin introduced the
theory of "Cosmological Natural Selection" with a biological analogy in mind.
We examine an extension of this analogy involving intelligent life. We discuss
if and how this extension could be legitimated.
Keywords: origin of the universe, fine-tuning, physical constants, initial
conditions, computational universe, biological universe, role of intelligent
life, cosmological natural selection, cosmological artificial selection,
artificial cosmogenesis.Comment: 25 pages, Foundations of Science, in pres
Confidence trick: the interpretation of confidence intervals
The frequent misinterpretation of the nature of confidence intervals by students has been well documented. This article examines the problem as an aspect of the learning of mathematical definitions and considers the tension between parroting mathematically rigorous, but essentially uninternalized, statements on the one hand and expressing imperfect but developing understandings on the other. A small-scale study among schoolteachers sought comments on four definitions expressing differing understandings of confidence intervals, and these are examined and discussed. The article concludes that some student wordings could be regarded as less inaccurate than they might seem at first sight and presents a case for accepting a wider range of more intuitive understandings as a work in progress
Agency, qualia and life: connecting mind and body biologically
Many believe that a suitably programmed computer could act for its own goals and experience feelings. I challenge this view and argue that agency, mental causation and qualia are all founded in the unique, homeostatic nature of living matter. The theory was formulated for coherence with the concept of an agent, neuroscientific data and laws of physics. By this method, I infer that a successful action is homeostatic for its agent and can be caused by a feeling - which does not motivate as a force, but as a control signal. From brain research and the locality principle of physics, I surmise that qualia are a fundamental, biological form of energy generated in specialized neurons. Subjectivity is explained as thermodynamically necessary on the supposition that, by converting action potentials to feelings, the neural cells avert damage from the electrochemical pulses. In exchange for this entropic benefit, phenomenal energy is spent as and where it is produced - which precludes the objective observation of qualia
Pirfenidone in idiopathic pulmonary fibrosis:expert panel discussion on the management of drug-related adverse events
Pirfenidone is currently the only approved therapy for idiopathic pulmonary fibrosis, following studies demonstrating that treatment reduces the decline in lung function and improves progression-free survival. Although generally well tolerated, a minority of patients discontinue therapy due to gastrointestinal and skin-related adverse events (AEs). This review summarizes recommendations based on existing guidelines, research evidence, and consensus opinions of expert authors, with the aim of providing practicing physicians with the specific clinical information needed to educate the patient and better manage pirfenidone-related AEs with continued pirfenidone treatment. The main recommendations to help prevent and/or mitigate gastrointestinal and skin-related AEs include taking pirfenidone during (or after) a meal, avoiding sun exposure, wearing protective clothing, and applying a broad-spectrum sunscreen with high ultraviolet (UV) A and UVB protection. These measures can help optimize AE management, which is key to maintaining patients on an optimal treatment dose.Correction in: Advances in Therapy, Volume 31, Issue 5, pp 575-576 , doi: 10.1007/s12325-014-0118-8</p
POWERLIB : SAS/IML Software for Computing Power in Multivariate Linear Models
The POWERLIB SAS/IML software provides convenient power calculations for a wide range of multivariate linear models with Gaussian errors. The software includes the Box, Geisser-Greenhouse, Huynh-Feldt, and uncorrected tests in the âunivariateâ approach to repeated measures (UNIREP), the Hotelling Lawley Trace, Pillai-Bartlett Trace, and Wilks Lambda tests in âmultivariateâ approach (MULTIREP), as well as a limited but useful range of mixed models. The familiar univariate linear model with Gaussian errors is an important special case. For estimated covariance, the software provides confidence limits for the resulting estimated power. All power and confidence limits values can be output to a SAS dataset, which can be used to easily produce plots and tables for manuscripts
Falsification Of The Atmospheric CO2 Greenhouse Effects Within The Frame Of Physics
The atmospheric greenhouse effect, an idea that many authors trace back to
the traditional works of Fourier (1824), Tyndall (1861), and Arrhenius (1896),
and which is still supported in global climatology, essentially describes a
fictitious mechanism, in which a planetary atmosphere acts as a heat pump
driven by an environment that is radiatively interacting with but radiatively
equilibrated to the atmospheric system. According to the second law of
thermodynamics such a planetary machine can never exist. Nevertheless, in
almost all texts of global climatology and in a widespread secondary literature
it is taken for granted that such mechanism is real and stands on a firm
scientific foundation. In this paper the popular conjecture is analyzed and the
underlying physical principles are clarified. By showing that (a) there are no
common physical laws between the warming phenomenon in glass houses and the
fictitious atmospheric greenhouse effects, (b) there are no calculations to
determine an average surface temperature of a planet, (c) the frequently
mentioned difference of 33 degrees Celsius is a meaningless number calculated
wrongly, (d) the formulas of cavity radiation are used inappropriately, (e) the
assumption of a radiative balance is unphysical, (f) thermal conductivity and
friction must not be set to zero, the atmospheric greenhouse conjecture is
falsified.Comment: 115 pages, 32 figures, 13 tables (some typos corrected
Fractional anisotropy distributions in 2- to 6-year-old children with autism
Increasing evidence suggests that autism is a disorder of distributed neural networks that may exhibit abnormal developmental trajectories. Characterisation of white matter early in the developmental course of the disorder is critical to understanding these aberrant trajectories
Accelerated expansion from structure formation
We discuss the physics of backreaction-driven accelerated expansion. Using
the exact equations for the behaviour of averages in dust universes, we explain
how large-scale smoothness does not imply that the effect of inhomogeneity and
anisotropy on the expansion rate is small. We demonstrate with an analytical
toy model how gravitational collapse can lead to acceleration. We find that the
conjecture of the accelerated expansion being due to structure formation is in
agreement with the general observational picture of structures in the universe,
and more quantitative work is needed to make a detailed comparison.Comment: 44 pages, 1 figure. Expanded treatment of topics from the Gravity
Research Foundation contest essay astro-ph/0605632. v2: Added references,
clarified wordings. v3: Published version. Minor changes and corrections,
added a referenc
- âŠ