Safer Schools in an Age of Mass Violence: Back to the Basics of Public Health

Schools in the US are by and large safe environments where millions of our children are secure and thrive. Outbreaks of fatal violence like the recent shootings at Virginia Polytechnic Institute and State University (Virginia Tech) are, fortunately, rare. In fact, the odds of a student losing his or her life to homicide are 50 times more likely while off school grounds. Because of the extraordinary consequences and societal shock waves caused by a low-probability mass casualty disaster in a school, this becomes one of the “all hazards” that campuses must plan to face, albeit with limited budgets and resources. This is not to say that we should bypass the opportunity to learn from the lessons and unpredicted shortfalls that any crisis reveals. Within weeks of the lethal violence at Virginia Tech, the first round of meetings to analyze the catastrophe was organized in Washington, DC. Officials from the Departments of Justice, Education, and Health and Human Services, along with a range of key stakeholders, participated in the discussions that focused on conditions or gaps that may have contributed to or exacerbated the consequences of this particular incident. The result of this after-incident analysis was a series of specific actions that could reduce the risk for a similar occurrence

Space-Occupying Brain Lesions, Trauma-Related Tau Astrogliopathy, and ARTAG: A Report of Two Cases and a Literature Review

Astrocytes with intracellular accumulations of misfolded phosphorylated tau protein have been observed in advanced-stage chronic traumatic encephalopathy (CTE) and in other neurodegenerative conditions. There is a growing awareness that astrocytic tau inclusions are also relatively common in the brains of persons over 70 years of age-affecting approximately one-third of autopsied individuals. The pathologic hallmarks of aging-related tau astrogliopathy (ARTAG) include phosphorylated tau protein within thorn-shaped astrocytes (TSA) in subpial, subependymal, perivascular, and white matter regions, whereas granular-fuzzy astrocytes are often seen in gray matter. CTE and ARTAG share molecular and histopathologic characteristics, suggesting that trauma-related mechanism(s) may predispose to the development of tau astrogliopathy. There are presently few experimental systems to study the pathobiology of astrocytic-tau aggregation, but human studies have made recent progress. For example, leucotomy (also referred to as lobotomy) is associated with a localized ARTAG-like neuropathology decades after the surgical brain injury, suggesting that chronic brain injury of any type may predispose to later life ARTAG. To examine this idea in a different context, we report clinical and pathologic features of two middle-aged men who came to autopsy with large (\u3e 6 cm in greatest dimension) arachnoid cysts that had physically displaced and injured the subjects\u27 left temporal lobes through chronic mechanical stress. Despite the similarity of the size and location of the arachnoid cysts, these individuals had dissimilar neurologic outcomes and neuropathologic findings. We review the evidence for ARTAG in response to brain injury, and discuss how the location and molecular properties of astroglial tau inclusions might alter the physiology of resident astrocytes. These cases and literature review point toward possible mechanism(s) of tau aggregation in astrocytes in response to chronic brain trauma

Design and assembly sequence analysis of option 3 for CETF reference space station

A design and assembly sequence was conducted on one option of the Dual Keel Space Station examined by a NASA Critical Evaluation Task Force to establish viability of several variations of that option. A goal of the study was to produce and analyze technical data to support Task Force decisions to either examine particular Option 3 variations in more depth or eliminate them from further consideration. An analysis of the phasing assembly showed that use of an Expendable Launch Vehicle in conjunction with the Space Transportation System (STS) can accelerate the buildup of the Station and ease the STS launch rate constraints. The study also showed that use of an Orbital Maneuvering Vehicle on the first flight can significantly benefit Station assembly and, by performing Station subsystem functions, can alleviate the need for operational control and reboost systems during the early flights. In addition to launch and assembly sequencing, the study assessed stability and control, and analyzed node-packaging options and the effects of keel removal on the structural dynamics of the Station. Results of these analyses are presented and discussed

Förster Resonance Energy Transfer between Core/Shell Quantum Dots and Bacteriorhodopsin

An energy transfer relationship between core-shell CdSe/ZnS quantum dots (QDs) and the optical protein bacteriorhodopsin (bR) is shown, demonstrating a distance-dependent energy transfer with 88.2% and 51.1% of the QD energy being transferred to the bR monomer at separation distances of 3.5 nm and 8.5 nm, respectively. Fluorescence lifetime measurements isolate nonradiative energy transfer, other than optical absorptive mechanisms, with the effective QD excited state lifetime reducing from 18.0 ns to 13.3 ns with bR integration, demonstrating the Förster resonance energy transfer contributes to 26.1% of the transferred QD energy at the 3.5 nm separation distance. The established direct energy transfer mechanism holds the potential to enhance the bR spectral range and sensitivity of energies that the protein can utilize, increasing its subsequent photocurrent generation, a significant potential expansion of the applicability of bR in solar cell, biosensing, biocomputing, optoelectronic, and imaging technologies

Placing the spotted T Tauri star LkCa 4 on an HR diagram

Ages and masses of young stars are often estimated by comparing their luminosities and effective temperatures to pre-main-sequence stellar evolution tracks, but magnetic fields and starspots complicate both the observations and evolution. To understand their influence, we study the heavily spotted weak-lined T-Tauri star LkCa 4 by searching for spectral signatures of radiation originating from the starspot or starspot groups. We introduce a new methodology for constraining both the starspot filling factor and the spot temperature by fitting two-temperature stellar atmosphere models constructed from Phoenix synthetic spectra to a high-resolution near-IR IGRINS spectrum. Clearly discernable spectral features arise from both a hot photospheric component Thot ∼ 4100 K and a cool component Tcool ∼ 2700–3000 K, which covers ∼80% of the visible surface. This mix of hot and cool emission is supported by analyses of the spectral energy distribution, rotational modulation of colors and of TiO band strengths, and features in low-resolution optical/near-IR spectroscopy. Although the revised effective temperature and luminosity make LkCa 4 appear to be much younger and of much lower mass than previous estimates from unspotted stellar evolution models, appropriate estimates will require the production and adoption of spotted evolutionary models. Biases from starspots likely afflict most fully convective young stars and contribute to uncertainties in ages and age spreads of open clusters. In some spectral regions, starspots act as a featureless "veiling" continuum owing to high rotational broadening and heavy line blanketing in cool star spectra. Some evidence is also found for an anticorrelation between the velocities of the warm and cool components.Peer reviewe

Fast Steering Mirror Disturbance Effects on Overall System Optical Performance for the Large Ultraviolet/optical/infrared Surveyor (LUVOIR) Concept Using a Non-Contact Vibration Isolation and Precision Pointing System

As the optical performance requirements of space telescopes get more stringent, the need to analyze all possible error sources early in the mission design becomes critical. One large telescope with tight performance requirements is the Large Ultraviolet / Optical / Infrared Surveyor (LUVOIR) concept. The LUVOIR concept includes a 15-meter-diameter segmented-aperture telescope with a suite of serviceable instruments operating over a range of wavelengths between 100nm to 2.5um. Using an isolation architecture that involves no mechanical contact between the telescope and the host spacecraft structure allows for tighter performance metrics than current space-based telescopes being flown. Because of this separation, the spacecraft disturbances can be greatly reduced and disturbances on the telescope payload contribute more to the optical performance error. A portion of the optical performance error comes from the disturbances generated from the motion of the Fast Steering Mirror (FSM) on the payload. Characterizing the effects of this disturbance gives insight into the specifications on the FSM needed to achieve the tight optical performance requirements of the overall system. Through analysis of the LUVOIR finite element model and linear optical model given a range of input disturbances at the FSM, the optical performance of the telescope and recommendations for FSM specifications can be determined. The LUVOIR observatory control strategy consists of a multi-loop control architecture including the spacecraft Attitude Control System (ACS), Vibration Isolation and Precision Pointing System (VIPPS), and FSM. This paper focuses on the control loop containing the FSM disturbances and their effects on the telescope optical performance

Deep Extragalactic VLBI-Optical Survey (DEVOS): I. Pilot MERLIN and VLBI observations

We present the results of the pilot observations of the Deep Extragalactic VLBI-Optical Survey (DEVOS). Our ultimate aim is to collect information on compact structures in a large sample of extragalactic radio sources (~10000 objects) up to two orders of magnitude fainter than those studied in typical imaging Very Long Baseline Interferometry (VLBI) surveys up until now. This would lead to an unprecedented data base for various astrophysical, astrometric and cosmological studies. The first global VLBI observations of the DEVOS programme were successfully conducted in May 2002. We selected sources without any spectral criterion from the Very Large Array (VLA) Faint Images of the Radio Sky at Twenty-centimeters (FIRST) catalogue, that are also detected with the Multi-Element Radio Linked Interferometer Network (MERLIN). The DEVOS pilot sample sources are in the area of the sky that is covered by the Sloan Digital Sky Survey (SDSS). We describe the sample selection and present high resolution 5-GHz radio images of the sources. Based on the results of this pilot study, we estimate the outcome of and the resources needed for a full-scale DEVOS project.Comment: 19 pages, 8 figures, accepted by A&