High-Tech Augmentative and Alternative Communication for Individuals with IDD and Complex Communication Needs: A Meta-Analysis (Variable Codes)

The attachment includes the operational definitions of the variable codes for the following article: The use of mobile technology is ubiquitous and is rapidly increasing in novel use. The use of mobile apps as augmentative and alternative communication (AAC) is rapidly expanding, both in the community and in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC with individuals with intellectual and developmental disabilities, including autism spectrum disorder. Following inclusion determination, including excluding studies with poor design quality, raw data from 24 publications were extracted and included 89 A-B phase contrasts. Tau-U nonparametric, non-overlap effect size was used to aggregate the results across all studies for an omnibus and moderator analyses. Kendall’s S was calculated for confidence intervals, p-values, and standard error. The omnibus analysis indicated overall low to moderate positive effects on social-communication outcomes for high-tech AAC with people with IDD.The contents of this manuscript were developed under the Preparation of Leaders in Autism Across the Lifespan grant awarded by the U.S. Department of Education, Office of Special Education Programs (Grant No. H325D110046)

High-Tech Augmentative and Alternative Communication for Individuals with IDD and Complex Communication Needs: A Meta-Analysis (Search Terms)

Search Terms used in this manuscriptSearch Terms attached for the following paper: The use of mobile technology is ubiquitous and is rapidly increasing in novel use. The use of mobile apps as augmentative and alternative communication (AAC) is rapidly expanding, both in the community and in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC with individuals with intellectual and developmental disabilities, including autism spectrum disorder. Following inclusion determination, including excluding studies with poor design quality, raw data from 24 publications were extracted and included 89 A-B phase contrasts. Tau-U nonparametric, non-overlap effect size was used to aggregate the results across all studies for an omnibus and moderator analyses. Kendall’s S was calculated for confidence intervals, p-values, and standard error. The omnibus analysis indicated overall low to moderate positive effects on social-communication outcomes for high-tech AAC with people with IDD.The contents of this manuscript were developed under the Preparation of Leaders in Autism Across the Lifespan grant awarded by the U.S. Department of Education, Office of Special Education Programs (Grant No. H325D110046)

High-Tech Augmentative and Alternative Communication for Individuals with IDD and Complex Communication Needs: A Meta-Analysis (Reference List)

The attached document lists the references for the following article: The use of mobile technology is ubiquitous and is rapidly increasing in novel use. The use of mobile apps as augmentative and alternative communication (AAC) is rapidly expanding, both in the community and in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC with individuals with intellectual and developmental disabilities, including autism spectrum disorder. Following inclusion determination, including excluding studies with poor design quality, raw data from 24 publications were extracted and included 89 A-B phase contrasts. Tau-U nonparametric, non-overlap effect size was used to aggregate the results across all studies for an omnibus and moderator analyses. Kendall’s S was calculated for confidence intervals, p-values, and standard error. The omnibus analysis indicated overall low to moderate positive effects on social-communication outcomes for high-tech AAC with people with IDD.The contents of this manuscript were developed under the Preparation of Leaders in Autism Across the Lifespan grant awarded by the U.S. Department of Education, Office of Special Education Programs (Grant No. H325D110046)

High-Tech Augmentative and Alternative Communication for Individuals with IDD and Complex Communication Needs: A Meta-Analysis (Design Quality Review)

The attachment includes the description of the design quality review for the following paper: The use of mobile technology is ubiquitous and is rapidly increasing in novel use. The use of mobile apps as augmentative and alternative communication (AAC) is rapidly expanding, both in the community and in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC with individuals with intellectual and developmental disabilities, including autism spectrum disorder. Following inclusion determination, including excluding studies with poor design quality, raw data from 24 publications were extracted and included 89 A-B phase contrasts. Tau-U nonparametric, non-overlap effect size was used to aggregate the results across all studies for an omnibus and moderator analyses. Kendall’s S was calculated for confidence intervals, p-values, and standard error. The omnibus analysis indicated overall low to moderate positive effects on social-communication outcomes for high-tech AAC with people with IDD.The contents of this manuscript were developed under the Preparation of Leaders in Autism Across the Lifespan grant awarded by the U.S. Department of Education, Office of Special Education Programs (Grant No. H325D110046)

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Despite the clinical significance of balanced chromosomal abnormalities (BCAs), their characterization has largely been restricted to cytogenetic resolution. We explored the landscape of BCAs at nucleotide resolution in 273 subjects with a spectrum of congenital anomalies. Whole-genome sequencing revised 93% of karyotypes and demonstrated complexity that was cryptic to karyotyping in 21% of BCAs, highlighting the limitations of conventional cytogenetic approaches. At least 33.9% of BCAs resulted in gene disruption that likely contributed to the developmental phenotype, 5.2% were associated with pathogenic genomic imbalances, and 7.3% disrupted topologically associated domains (TADs) encompassing known syndromic loci. Remarkably, BCA breakpoints in eight subjects altered a single TAD encompassing MEF2C, a known driver of 5q14.3 microdeletion syndrome, resulting in decreased MEF2C expression. We propose that sequence-level resolution dramatically improves prediction of clinical outcomes for balanced rearrangements and provides insight into new pathogenic mechanisms, such as altered regulation due to changes in chromosome topology

High-technology augmentative and alternative communication for individuals with intellectual and developmental disabilities and complex communication needs: a meta-analysis

<p>The use of mobile technology is ubiquitous in modern society and is rapidly increasing in novel use. The use of mobile devices and software applications (“apps”) as augmentative and alternative communication (AAC) is rapidly expanding in the community, and this is also reflected in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC, including mobile devices, by individuals with intellectual and developmental disabilities, including autism spectrum disorder. Following inclusion determination, and excluding studies with poor design quality, raw data from 24 publications were extracted and included 89 A-B phase contrasts. Tau-U nonparametric, non-overlap effect size was used to aggregate the results across all studies for an omnibus and moderator analyses. Kendall’s S was calculated for confidence intervals, <i>p</i>-values, and standard error. The omnibus analysis indicated overall low to moderate positive effects on social-communication outcomes for high-tech AAC use by individuals with intellectual and developmental disabilities.</p