9 research outputs found
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Future global mortality from changes in air pollution attributable to climate change
Ground-level ozone and fine particulate matter (PM2.5) are associated with premature human mortality1-4; their future concentrations depend on changes in emissions, which dominate the near-term5, and on climate change6,7. Previous global studies of the air quality-related health effects of future climate change8,9 used single atmospheric models. However, in related studies, mortality results differ among models10-12. Here we use an ensemble of global chemistry-climate models13 to show that premature mortality from changes in air pollution attributable to climate change, under the high greenhouse gas scenario RCP8.514, is likely positive. We estimate 3,340 (-30,300 to 47,100) ozone-related deaths in 2030, relative to 2000 climate, and 43,600 (-195,000 to 237,000) in 2100 (14% of the increase in global ozone-related mortality). For PM2.5, we estimate 55,600 (-34,300 to 164,000) deaths in 2030 and 215,000 (-76,100 to 595,000) in 2100 (countering by 16% the global decrease in PM2.5-related mortality). Premature mortality attributable to climate change is estimated to be positive in all regions except Africa, and is greatest in India and East Asia. Most individual models yield increased mortality from climate change, but some yield decreases, suggesting caution in interpreting results from a single model. Climate change mitigation will likely reduce air pollution-related mortality
The effects of the opioid pharmacotherapies methadone, LAAM and buprenorphine, alone and in combination with alcohol, on simulated driving
While methadone is currently the primary pharmacotherapy used in the treatment of heroin dependence in Australia, levo-alpha-acetyl-methodol (LAAM) and buprenorphine are new pharmacotherapies that are being examined as alternatives to methadone maintenance treatment. The aim of this research is to consider the effects of the methadone, buprenorphine and LAAM, as used in maintenance pharmacotherapy for heroin dependence, upon simulated driving. Clients stabilised in methadone, LAAM and buprenorphine treatment programs for 3 months, and a control group of non-drug-using participants, took part in this study which involved operating a driving simulator over a 75 min period.<br /
Short communication : using ambulance attendances to recruit people who have experienced non-fatal heroin overdose
Using ambulance attendances to recruit people who have experienced non-fatal heroin overdose
Aims: To trial two novel methods of recruiting people who experience non-fatal heroin overdose through the ambulance service. Setting: Melbourne and Sydney, Australia. Methods: In Melbourne potential participants were given numbered contact cards by ambulance paramedics after revival, while in Sydney potential participants were approached after revival by a researcher who travelled with ambulance paramedics to the overdose scene. Results: In Melbourne 281 cards were distributed during the period 1 June 1998-31 December 1998 and a subsequent contact rate of 24% was achieved with 14% attending a subsequent interview. In Sydney there were 170 initial contacts of which 139 (82%) answered a series of questions asked at the scene (the remainder either ineligible or incapable of answering questions) with 48 (35%) also attending for follow-up interviews. Conclusions: Recruitment through contact with ambulance services is a novel method of recruiting heroin users for research into non-fatal heroin overdose with advantages over other methods of sampling for research on non-fatal heroin overdose
Global premature mortality due to anthropogenic outdoor air pollution and the contribution of past climate change
International audienceIncreased concentrations of ozone and fine particulate matter (PM2.5) since preindustrial times reflect increased emissions, but also contributions of past climate change. Here we use modeled concentrations from an ensemble of chemistryâclimate models to estimate the global burden of anthropogenic outdoor air pollution on present-day premature human mortality, and the component of that burden attributable to past climate change. Using simulated concentrations for 2000 and 1850 and concentrationâresponse functions (CRFs), we estimate that, at present, 470â000 (95% confidence interval, 140â000 to 900â000) premature respiratory deaths are associated globally and annually with anthropogenic ozone, and 2.1 (1.3 to 3.0) million deaths with anthropogenic PM2.5-related cardiopulmonary diseases (93%) and lung cancer (7%). These estimates are smaller than ones from previous studies because we use modeled 1850 air pollution rather than a counterfactual low concentration, and because of different emissions. Uncertainty in CRFs contributes more to overall uncertainty than the spread of model results. Mortality attributed to the effects of past climate change on air quality is considerably smaller than the global burden: 1500 (â20â000 to 27â000) deaths yrâ1 due to ozone and 2200 (â350â000 to 140â000) due to PM2.5. The small multi-model means are coincidental, as there are larger ranges of results for individual models, reflected in the large uncertainties, with some models suggesting that past climate change has reduced air pollution mortali