There was something grotesque : The Application and Limits of Respectability in the Daughters of Bilitis

Living in both the “deviant” and “normal” worlds, the leadership of The Daughters of Bilitis generally adhered to a respectable and assimilationist public persona as evidenced through political activities and the publication of their periodical The Ladder. Due to this juxtaposition, the largely middle-class, white membership exhibited socially conservative views in order to make long-term social change, leading to an inherent contradiction between maintaining their middle-class identity and public respectability. Seen from the organization’s founding in 1955 until its collapse in 1970, these contradictions and the focus on respectability politics adds to the existing scholarship on the DOB. The fifteen-year long span of the San Francisco chaptersaw evolution from their initial conservativism, but the women who helmed the DOB did not understand the complexities of their membership and relied upon middle-class respectability. This respectability included policies of personal and public education, reversal of negative stereotyping, and private socialization. The disparities that arose within the organization resulted in an ideological and political schism between maintaining respectability and agitation for more open political action, including picketing and demonstrations. The Daughters left a legacy for lesbian activism, despite their downfall, and later organizations would move past respectability and, largely as a result of the changing social climate, concentrate less on the public perception of lesbians and more on social equality for homosexuals

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist

Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions

While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the contribution of somatic CNVs (sCNVs)—present in some but not all cells—remains unknown. We identified sCNVs using blood-derived genotype arrays from 12,834 SCZ cases and 11,648 controls, filtering sCNVs at loci recurrently mutated in clonal blood disorders. Likely early-developmental sCNVs were more common in cases (0.91%) than controls (0.51%, p = 2.68e−4), with recurrent somatic deletions of exons 1–5 of the NRXN1 gene in five SCZ cases. Hi-C maps revealed ectopic, allele-specific loops forming between a potential cryptic promoter and non-coding cis-regulatory elements upon 5′ deletions in NRXN1. We also observed recurrent intragenic deletions of ABCB11, encoding a transporter implicated in anti-psychotic response, in five treatment-resistant SCZ cases and showed that ABCB11 is specifically enriched in neurons forming mesocortical and mesolimbic dopaminergic projections. Our results indicate potential roles of sCNVs in SCZ risk

A Comparison of Rule-based Analysis with Regression Methods in Understanding the Risk Factors for Study Withdrawal in a Pediatric Study

Regression models are extensively used in many epidemiological studies to understand the linkage between specific outcomes of interest and their risk factors. However, regression models in general examine the average effects of the risk factors and ignore subgroups with different risk profiles. As a result, interventions are often geared towards the average member of the population, without consideration of the special health needs of different subgroups within the population. This paper demonstrates the value of using rule-based analysis methods that can identify subgroups with heterogeneous risk profiles in a population without imposing assumptions on the subgroups or method. The rules define the risk pattern of subsets of individuals by not only considering the interactions between the risk factors but also their ranges. We compared the rule-based analysis results with the results from a logistic regression model in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Both methods detected a similar suite of risk factors, but the rule-based analysis was superior at detecting multiple interactions between the risk factors that characterize the subgroups. A further investigation of the particular characteristics of each subgroup may detect the special health needs of the subgroup and lead to tailored interventions

Artropolis 90 : Lineages & Linkages

Varney documents the processes of organizing and mounting an exhibition of over 200 contemporary British Columbia artists. Includes artist's statements