Re:Chicago

https://via.library.depaul.edu/museum-publications/1012/thumbnail.jp

A longitudinal cohort study of malaria exposure and changing serostatus in a malaria endemic area of rural Tanzania.

BACKGROUND: Measurements of anti-malarial antibodies are increasingly used as a proxy of transmission intensity. Most serological surveys are based on the use of cross-sectional data that, when age-stratified, approximates historical patterns of transmission within a population. Comparatively few studies leverage longitudinal data to explicitly relate individual infection events with subsequent antibody responses. METHODS: The occurrence of seroconversion and seroreversion events for two Plasmodium falciparum asexual stage antigens (MSP-1 and AMA-1) was examined using three annual measurements of 691 individuals from a cohort of individuals in a malaria-endemic area of rural east-central Tanzania. Mixed-effect logistic regression models were employed to determine factors associated with changes in serostatus over time. RESULTS: While the expected population-level relationship between seroprevalence and disease incidence was observed, on an individual level the relationship between individual infections and the antibody response was complex. MSP-1 antibody responses were more dynamic in response to the occurrence and resolution of infection events than AMA-1, while the latter was more correlated with consecutive infections. The MSP-1 antibody response to an observed infection seemed to decay faster over time than the corresponding AMA-1 response. Surprisingly, there was no evidence of an age effect on the occurrence of a conversion or reversion event. CONCLUSIONS: While the population-level results concur with previously published sero-epidemiological surveys, the individual-level results highlight the more complex relationship between detected infections and antibody dynamics than can be analysed using cross-sectional data. The longitudinal analysis of serological data may provide a powerful tool for teasing apart the complex relationship between infection events and the corresponding immune response, thereby improving the ability to rapidly assess the success or failure of malaria control programmes

The Art of George Ames Aldrich

A highly regarded impressionist-style artist, George Ames Aldrich drew on his years of experience living and studying in Europe to create beautiful landscape paintings. His life and work are explored in this gorgeous book. Many of the artist\u27s finest creations, some representing French subjects and others depicting the midwestern steel industry and American landscapes, are included in this book. It features color reproductions, along with other archival and contextual images. Essays by Michael Wright and Wendy Greenhouse explore in detail Aldrich\u27s life, influences, sources of inspiration, and art historical context. Exploiting a wide variety of sources, Wright and Greenhouse have discovered exciting new information about the artist and his times

At the Edge of Extinction: Useful Plants of the Border States of the United States and Mexico

Volume: 46Start Page: 37End Page: 4