7,281 research outputs found
The group structure of non-Abelian NS-NS transformations
We study the transformations of the worldvolume fields of a system of
multiple coinciding D-branes under gauge transformations of the supergravity
Kalb-Ramond field. We find that the pure gauge part of these NS-NS
transformations can be written as a U(N) symmetry of the underlying Yang-Mills
group, but that in general the full NS-NS variations get mixed up non-trivially
with the U(N). We compute the commutation relations and the Jacobi identities
of the bigger group formed by the NS-NS and U(N) transformations.Comment: Latex, 11 pages. v2: Typos corrected; version to appear in JHEP
Fast non-negative deconvolution for spike train inference from population calcium imaging
Calcium imaging for observing spiking activity from large populations of
neurons are quickly gaining popularity. While the raw data are fluorescence
movies, the underlying spike trains are of interest. This work presents a fast
non-negative deconvolution filter to infer the approximately most likely spike
train for each neuron, given the fluorescence observations. This algorithm
outperforms optimal linear deconvolution (Wiener filtering) on both simulated
and biological data. The performance gains come from restricting the inferred
spike trains to be positive (using an interior-point method), unlike the Wiener
filter. The algorithm is fast enough that even when imaging over 100 neurons,
inference can be performed on the set of all observed traces faster than
real-time. Performing optimal spatial filtering on the images further refines
the estimates. Importantly, all the parameters required to perform the
inference can be estimated using only the fluorescence data, obviating the need
to perform joint electrophysiological and imaging calibration experiments.Comment: 22 pages, 10 figure
Unitarity Bounds for Gauged Axionic Interactions and the Green-Schwarz Mechanism
We analyze the effective actions of anomalous models in which a
four-dimensional version of the Green-Schwarz mechanism is invoked for the
cancellation of the anomalies, and we compare it with those models in which
gauge invariance is restored by the presence of a Wess-Zumino term. Some issues
concerning an apparent violation of unitarity of the mechanism, which requires
Dolgov-Zakharov poles, are carefully examined, using a class of amplitudes
studied in the past by Bouchiat-Iliopoulos-Meyer (BIM), and elaborating on
previous studies. In the Wess-Zumino case we determine explicitly the unitarity
bound using a realistic model of intersecting branes (the Madrid model) by
studying the corresponding BIM amplitudes. This is shown to depend
significantly on the St\"uckelberg mass and on the coupling of the extra
anomalous gauge bosons and allows one to identify Standard-Model-like regions
(which are anomaly-free) from regions where the growth of certain amplitudes is
dominated by the anomaly, separated by an inflection point which could be
studied at the LHC. The bound can even be around 5-10 TeV's for a mass
around 1 TeV and varies sensitively with the anomalous coupling. The results
for the WZ case are quite general and apply to all the models in which an
axion-like interaction is introduced as a generalization of the Peccei-Quinn
mechanism, with a gauged axion.Comment: 50 pages, 28 figure
Hepatic Transcriptomic and Metabolic Responses of Hybrid Striped Bass (Morone saxatilis × Morone chrysops) to Acute and Chronic Hypoxic Insult
Striped bass (Morone saxatilis), white bass (Morone chrysops), and their hybrid are an important group of fish prized for recreational angling in the United States, and there and abroad as a high-value farmed fish. Regardless of habitat, it is not uncommon for fish of the genus Morone to encounter and cope with conditions of scarce oxygen availability. Previously, we determined that hybrid striped bass reared under conditions of chronic hypoxia exhibited reduced feed intake, lower lipid and nutrient retention, and poor growth. To better understand the molecular mechanisms governing these phenotypes, in the present study, we examined the transcriptomic profiles of hepatic tissue in hybrid striped bass exposed to chronic hypoxia (90 days at 25% oxygen saturation) and acute hypoxia (6 h at 25% oxygen saturation). Using high-throughput RNA-seq, we found that over 1400 genes were differentially expressed under disparate oxygen conditions, with the vast majority of transcriptional changes occurring in the acute hypoxia treatment. Gene pathway and bioenergetics analyses revealed hypoxia-mediated perturbation of genes and gene networks related to lipid metabolism, cell death, and changes in hepatic mitochondrial content and cellular respiration. This study offers a more comprehensive view of the temporal and tissue-specific transcriptional changes that occur during hypoxia, and reveals new and shared mechanisms of hypoxia tolerance in teleosts
The relationship between fragility, configurational entropy and the potential energy landscape of glass forming liquids
Glass is a microscopically disordered, solid form of matter that results when
a fluid is cooled or compressed in such a fashion that it does not crystallise.
Almost all types of materials are capable of glass formation -- polymers, metal
alloys, and molten salts, to name a few. Given such diversity, organising
principles which systematise data concerning glass formation are invaluable.
One such principle is the classification of glass formers according to their
fragility\cite{fragility}. Fragility measures the rapidity with which a
liquid's properties such as viscosity change as the glassy state is approached.
Although the relationship between features of the energy landscape of a glass
former, its configurational entropy and fragility have been analysed previously
(e. g.,\cite{speedyfr}), an understanding of the origins of fragility in these
features is far from being well established. Results for a model liquid, whose
fragility depends on its bulk density, are presented in this letter. Analysis
of the relationship between fragility and quantitative measures of the energy
landscape (the complicated dependence of energy on configuration) reveal that
the fragility depends on changes in the vibrational properties of individual
energy basins, in addition to the total number of such basins present, and
their spread in energy. A thermodynamic expression for fragility is derived,
which is in quantitative agreement with {\it kinetic} fragilities obtained from
the liquid's diffusivity.Comment: 8 pages, 3 figure
Detection of a glitch in the pulsar J1709-4429
We report the detection of a glitch event in the pulsar J17094429 (also
known as B170644) during regular monitoring observations with the Molonglo
Observatory Synthesis Telescope (UTMOST). The glitch was found during timing
operations, in which we regularly observe over 400 pulsars with up to daily
cadence, while commensally searching for Rotating Radio Transients, pulsars,
and FRBs. With a fractional size of ,
the glitch reported here is by far the smallest known for this pulsar,
attesting to the efficacy of glitch searches with high cadence using UTMOST.Comment: 3 pages, 1 figur
S-wave eta'-proton FSI; phenomenological analysis of near-threshold production of pi0, eta, and eta' mesons in proton-proton collisions
We describe a novel technique for comparing total cross sections for the
reactions pp --> pp pi(0), pp --> pp eta, and pp --> pp eta' close to
threshold. The initial and final state proton-proton interactions are factored
out of the total cross section, and the dependence of this reduced cross
section on the volume of phase space is discussed. Different models of the
proton-proton interaction are compared. We argue that the scattering length of
the S-wave eta'-proton interaction is of the order of 0.1 fm.Comment: 10 pages, 5 figure
Therapeutic targeting of integrin αvβ6 in breast cancer
BACKGROUND: Integrin ?v?6 promotes migration, invasion, and survival of cancer cells; however, the relevance and role of ?v?6 has yet to be elucidated in breast cancer.METHODS: Protein expression of integrin subunit beta6 (?6) was measured in breast cancers by immunohistochemistry (n > 2000) and ITGB6 mRNA expression measured in the Molecular Taxonomy of Breast Cancer International Consortium dataset. Overall survival was assessed using Kaplan Meier curves, and bioinformatics statistical analyses were performed (Cox proportional hazards model, Wald test, and Chi-square test of association). Using antibody (264RAD) blockade and siRNA knockdown of ?6 in breast cell lines, the role of ?v?6 in Human Epidermal Growth Factor Receptor 2 (HER2) biology (expression, proliferation, invasion, growth in vivo) was assessed by flow cytometry, MTT, Transwell invasion, proximity ligation assay, and xenografts (n ? 3), respectively. A student's t-test was used for two variables; three-plus variables used one-way analysis of variance with Bonferroni's Multiple Comparison Test. Xenograft growth was analyzed using linear mixed model analysis, followed by Wald testing and survival, analyzed using the Log-Rank test. All statistical tests were two sided.RESULTS: High expression of either the mRNA or protein for the integrin subunit ?6 was associated with very poor survival (HR = 1.60, 95% CI = 1.19 to 2.15, P = .002) and increased metastases to distant sites. Co-expression of ?6 and HER2 was associated with worse prognosis (HR = 1.97, 95% CI = 1.16 to 3.35, P = .01). Monotherapy with 264RAD or trastuzumab slowed growth of MCF-7/HER2-18 and BT-474 xenografts similarly (P < .001), but combining 264RAD with trastuzumab effectively stopped tumor growth, even in trastuzumab-resistant MCF-7/HER2-18 xenografts.CONCLUSIONS: Targeting ?v?6 with 264RAD alone or in combination with trastuzumab may provide a novel therapy for treating high-risk and trastuzumab-resistant breast cancer patients.<br/
Report of a workshop on technical approaches to construction of a seafloor geomagnetic observatory
This report considers the technical issues on sensors, data recording and transmission, control and timing, power, and
packaging associated with constricting a seafloor geomagnetic observatory. Existing technologies either already in use for
oceanographic purposes or adapted from terrestral geomagnetic observatories could be applied to measure the vector
magnetic field components and absolute intensity with minimal development. The major technical challenge arises in
measuring absolute direction on the seafloor because terrestral techniques are not transferrable to the deep ocean. Two
solutions to this problem were identified. The first requires the development of an instrument which measures the
instantaneous declination and inclination of the magnetic field relative to a north-seeking gyroscope and the local vertical.
The second is a straightforward extension of a precision acoustic method for determining absolute position on the seafloor.Funding was provided by the National Science Foundation under grant EAR94-21712 and the
National Aeronautics and Space Administration
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