Open Data in London: What Is It and How Is It Used?

The intent of the open data movement is to provide freely available online data for analysis and innovation by scholars and the public. It recently has made some notable achievements, such as last year\u27s decision by the World Bank to provide all its data for free. Last fall, the City of London (Ontario) launched an open data beta web site, following in the tracks of other Canadian municipalities

The Grizzly, September 5, 2002

143 Students Call Richter / North Hall Home • Under Construction Again: Field House Floor to be Redone • Orientation 2002 a Success for Freshmen and OAs • Bridge Program Unique and Important at Ursinus • Y100 at Ursinus • Freshmen Give Three Thumbs Up to Their So-Called Overcrowded Rooms • Opinions: Dirty Rooms Make Move-in Extra Grungy; What\u27s it Liked to be Named Bart?; Enemy Combatant Declarations: Wrong Policy for America • Bored? Get Some Brotherly Love in Your Life • Comparative Pricing Report: Snack Foods • Field Hockey Makes a Move to Centennial Conference • X-Country Boys and Girls Ranked 8th in Conference • Volleyball Jumps Out to Positive Start • Men\u27s Soccer Regroups with New Coach • Women\u27s Soccer go 2-0 in First Weekend of Play • Bearcock\u27s Rugby Returns for Second Season • Football Team Prepares for big Season Opener Against Washington & Jefferson • Roller Hockey Club to Play in PCRHL • Dougherty Sets Course Record in Brian Dennis Memorial X-Country Meethttps://digitalcommons.ursinus.edu/grizzlynews/1517/thumbnail.jp

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1beta Activation

Published: November 27, 2018Intrinsic apoptosis resulting from BAX/BAK-mediated mitochondrial membrane damage is regarded as immunologically silent. We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase-8-mediated activation of IL-1β. Furthermore, BAX/BAK signaling induces a parallel pathway to NLRP3 inflammasome-mediated caspase-1-dependent IL-1β maturation that requires potassium efflux. Remarkably, following BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NLRP3-induced IL-1β maturation and secretion. Conversely, the pyroptotic cell death effectors gasdermin D and gasdermin E are not essential for BAX/BAK-induced IL-1β release. These findings highlight that innate immune cells undergoing BAX/BAK-mediated apoptosis have the capacity to generate pro-inflammatory signals and provide an explanation as to why IL-1β activation is often associated with cellular stress, such as during chemotherapy.James E. Vince, Dominic De Nardo, Wenqing Gao, Angelina J. Vince, Cathrine Hall, Kate McArthur, Daniel Simpson, Swarna Vijayaraj, Lisa M. Lindqvist, Philippe Bouillet, Mark A. Rizzacasa, Si Ming Man, John Silke, Seth L. Masters, Guillaume Lessene, David C.S. Huang, Daniel H.D. Gray, Benjamin T. Kile, Feng Shao, and Kate E. Lawlo

Learning about managing the business in the hospitality industry

This research examines the learning experiences of General Managers (GMs) in the hospitality industry, a sector much neglected in terms of research into management learning and human resource development. Our research focused on four large hospitality organizations (two hotels and two contract catering companies) and adopted an approach that integrates multiple data collection strategies in supporting our qualitative case studies. Data were collected by using document analysis plus detailed, qualitative interviews with 21 general managers, of whom seven were subsequently observed at work and observation notes generated. Data analysis revealed that the participants learned to manage the business primarily through experience, a process consisting of four key stages: Being Challenged, Information Searching, Information Transformation, and Testing. Reflective thinking plays a central role in their learning, taking the form of “actions” involving association, integration and validation, and of “products” involving content, process and context reflections. We argue that the way hospitality managers learn, while sharing the learning approaches taken by other professionals, differs in that these managers’ learning is more highly contextualized

CD5 Expression by Dendritic Cells Directs T Cell Immunity and Sustains Immunotherapy Responses

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c+CD5+ DCs are reduced in melanoma-affected lymph nodes, with CD5 expression on DCs correlating with patient survival. Activating CD5 on DCs enhanced T cell priming and improved survival after ICB therapy. CD5+ DC numbers increased during ICB therapy, and low interleukin-6 (IL-6) concentrations promoted their de novo differentiation. Mechanistically, CD5 expression by DCs was required to generate optimally protective CD5hi T helper and CD8+ T cells; further, deletion of CD5 from T cells dampened tumor elimination in response to ICB therapy in vivo. Thus, CD5+ DCs are an essential component of optimal ICB therapy

An Investigation into the Cognition Behind Spontaneous String Pulling in New Caledonian Crows

The ability of some bird species to pull up meat hung on a string is a famous example of spontaneous animal problem solving. The “insight” hypothesis claims that this complex behaviour is based on cognitive abilities such as mental scenario building and imagination. An operant conditioning account, in contrast, would claim that this spontaneity is due to each action in string pulling being reinforced by the meat moving closer and remaining closer to the bird on the perch. We presented experienced and naïve New Caledonian crows with a novel, visually restricted string-pulling problem that reduced the quality of visual feedback during string pulling. Experienced crows solved this problem with reduced efficiency and increased errors compared to their performance in standard string pulling. Naïve crows either failed or solved the problem by trial and error learning. However, when visual feedback was available via a mirror mounted next to the apparatus, two naïve crows were able to perform at the same level as the experienced group. Our results raise the possibility that spontaneous string pulling in New Caledonian crows may not be based on insight but on operant conditioning mediated by a perceptual-motor feedback cycle

Galaxy ecology: groups and low-density environments in the SDSS and 2dFGRS

We analyse the observed correlation between galaxy environment and Hα emission-line strength, using volume-limited samples and group catalogues of 24 968 galaxies at 0.05 < z < 0.095, drawn from the 2dF Galaxy Redshift Survey (M_(bJ) < −19.5) and the Sloan Digital Sky Survey (Mᵣ < −20.6). We characterize the environment by: (1) Σ₅, the surface number density of galaxies determined by the projected distance to the fifth nearest neighbour; and (2) ρ1.1 and ρ5.5, three-dimensional density estimates obtained by convolving the galaxy distribution with Gaussian kernels of dispersion 1.1 and 5.5 Mpc, respectively. We find that star-forming and quiescent galaxies form two distinct populations, as characterized by their Hα equivalent width, W₀(Hα). The relative numbers of star-forming and quiescent galaxies vary strongly and continuously with local density. However, the distribution of W₀(Hα) amongst the star-forming population is independent of environment. The fraction of star-forming galaxies shows strong sensitivity to the density on large scales, ρ5.5, which is likely independent of the trend with local density, ρ1.1.We use two differently selected group catalogues to demonstrate that the correlation with galaxy density is approximately independent of group velocity dispersion, for σ = 200–1000 km s⁻¹. Even in the lowest-density environments, no more than ∼70 per cent of galaxies show significant Hα emission. Based on these results, we conclude that the present-day correlation between star formation rate and environment is a result of short-time-scale mechanisms that take place preferentially at high redshift, such as starbursts induced by galaxy–galaxy interactions

Galaxy ecology: groups and low-density environments in the SDSS and 2dFGRS

We analyse the observed correlation between galaxy environment and Hα emission-line strength, using volume-limited samples and group catalogues of 24 968 galaxies at 0.05 < z < 0.095, drawn from the 2dF Galaxy Redshift Survey ( < −19.5) and the Sloan Digital Sky Survey (Mr < −20.6). We characterize the environment by: (1) Σ5, the surface number density of galaxies determined by the projected distance to the fifth nearest neighbour; and (2) ρ1.1 and ρ5.5, three-dimensional density estimates obtained by convolving the galaxy distribution with Gaussian kernels of dispersion 1.1 and 5.5 Mpc, respectively. We find that star-forming and quiescent galaxies form two distinct populations, as characterized by their Hα equivalent width, W0(Hα). The relative numbers of star-forming and quiescent galaxies vary strongly and continuously with local density. However, the distribution of W0(Hα) amongst the star-forming population is independent of environment. The fraction of star-forming galaxies shows strong sensitivity to the density on large scales, ρ5.5, which is likely independent of the trend with local density, ρ1.1. We use two differently selected group catalogues to demonstrate that the correlation with galaxy density is approximately independent of group velocity dispersion, for σ= 200-1000 km s-1. Even in the lowest-density environments, no more than ∼70 per cent of galaxies show significant Hα emission. Based on these results, we conclude that the present-day correlation between star formation rate and environment is a result of short-time-scale mechanisms that take place preferentially at high redshift, such as starbursts induced by galaxy-galaxy interaction

Further development and feasibility randomised controlled trial of a digital programme for adolescent depression, MoodHwb: study protocol

Introduction: A digital programme, MoodHwb, was codesigned with young people experiencing or at high risk of depression, parents/carers and professionals, to provide support for young people with their mood and well-being. A preliminary evaluation study provided support for the programme theory and found that MoodHwb was acceptable to use. This study aims to refine the programme based on user feedback, and to assess the acceptability and feasibility of the updated version and study methods. Methods and analysis: Initially, this study will refine MoodHwb with the involvement of young people, including in a pretrial acceptability phase. This will be followed by a multicentre feasibility randomised controlled trial comparing MoodHwb plus usual care with a digital information pack plus usual care. Up to 120 young people aged 13–19 years with symptoms of depression and their parents/carers will be recruited through schools, mental health services, youth services, charities and voluntary self-referral in Wales and Scotland. The primary outcomes are the feasibility and acceptability of the MoodHwb programme (including usage, design and content) and of trial methods (including recruitment and retention rates), assessed 2 months postrandomisation. Secondary outcomes include potential impact on domains including depression knowledge and stigma, help-seeking, well-being and depression and anxiety symptoms measured at 2 months postrandomisation. Ethics and dissemination: The pretrial acceptability phase was approved by the Cardiff University School of Medicine Research Ethics Committee (REC) and the University of Glasgow College of Medicine, Veterinary and Life Sciences REC. The trial was approved by Wales NHS REC 3 (21/WA/0205), the Health Research Authority(HRA), Health and Care Research Wales (HCRW), university health board Research and Development (R&amp;D) departments in Wales, and schools in Wales and Scotland. Findings will be disseminated in peer-reviewed open-access journals, at conferences and meetings, and online to academic, clinical, and educational audiences and the wider public. Trial registration number ISRCTN12437531