Le medicine partenenti alle infermità delle donne di Giovanni Marinello «opera a beneficio e conservatione delle donne […] così esse la leggano & vedano volentieri»

This paper briefly introduces the venetian physician Giovanni Marinello and his vernacular treatise Le medicine partenenti alle infermità delle donne. This popular and widely circulated book can be taken as an example of the growing number of works devoted to women's health and diseases that were published in Europe between xvi and the first half of xvii centuries. Although controversial, the new attention for gynecological subjects in early modern medical literature emphasizes the specificity of female bodies and contributes to challenge the conventional view of woman as imperfect male, monster or error of nature.Questo articolo introduce brevemente il trattato in volgare dal titolo Le medicine partenenti alle infermità delle donne, scritto dal medico erudito Giovanni Marinello e pubblicato per la prima volta a Venezia nel 1536. Si tratta di un testo di grande successo che può essere preso ad esempio di quel ricco corpo di trattati e manuali dedicati alle malattie delle donne che circolano in Europa nel xvi secolo e fino alla prima metà del xvii e che, tra contraddizioni e controversie, testimoniano un rinnovato e forte interesse della medicina per la specificità del corpo femminile iniziando a prendere le distanze dalla visione scolastica della donna come maschio imperfetto, mostro o errore di natura

Effetto antiossidante o pro-ossidante di sostanze naturali in condizioni di ossidazione forzata

Questo lavoro di tesi si prefigge l'obiettivo di valutare l'effetto antiossidante o pro-ossidante di sostanze naturali in condizioni di ossidazione accelerata addizionate ad un olio di girasole commerciale. Il metodo di analisi si basa sull’OXITEST®️: test ad ossidazione accelerata che permette di determinare la stabilità di una matrice rispetto a delle condizioni di deterioramento (temperatura e pressione di ossigeno) ben definite. La valutazione della stabilità ossidativa viene espressa attraverso il tempo di induzione (IP). Dai risultati ottenuti si nota come i tempi di induzione varino in funzione dell’antiossidante addizionato e delle quantità aggiunte. Partendo da un olio di girasole commerciale con IP di 11:49 ore, hanno mostrato un incremento significativo i campioni aggiunti di phenolea. Al contrario, invece, i campioni arricchiti con estratto di rosmarino hanno mostrato valori di IP significativamente uguali a quello ottenuto per l’olio di girasole tal quale, il motivo potrebbe essere la scarsa solubilità di questo estratto nell’olio stesso. L’aggiunta di WGO ha mostrato valori (11:17 ore) non significativamente differenti da quelli dell’olio tal quale. Per poter stilare delle considerazioni, invece, sull’utilizzo della frazione insaponificabile del WGO sarebbero necessarie prove che prevedano l’aggiunta di percentuali maggiori. In conclusione, gli aspetti benefici legati al consumo dell’olio di germe di grano e la sua applicabilità industriale sono le ragioni per tentare di raggiungere una migliore utilizzazione del prodotto, meritevole sotto tanti aspetti

Caseous calcification of the mitral annulus: A multi-modality imaging perspective.

Mitral annulus calcification is a common echocardiographic finding, particularly in the elderly and in end-stage renal disease patients under chronic dialysis. Caseous calcification or liquefaction necrosis of mitral annulus calcification is a rare evolution of mitral annular calcification. Early recognition of this entity avoids an invasive diagnostic approach, since it is benign and, unlike intracardiac tumors and abscesses, has a favorable prognosis. The authors present the case of an 84-year-old woman with a suspicious large, echodense mass at the level of the posterior mitral leaflet with associated severe mitral regurgitation. Cardiac magnetic resonance imaging demonstrated a hypoperfused mass with strong peripheral enhancement 10 minutes after gadolinium administration. Multislice computed tomography showed the calcified nature of the mass. A multi-modality imaging approach confirmed the diagnosis of caseous calcification of the posterior mitral annulus. The patient refused surgical treatment

Echocardiographic History of an Asymptomatic Congenital Cardiac Tumor

n/

Yeast-Derived Formulations Are Differentially Fermented by the Canine and Feline Microbiome As Assessed in a Novel in Vitro Colonic Fermentation Model

The current study evaluated the effect of five yeast-derived formulations (T1-T5) on microbial metabolism and composition of the canine and feline gut microbiota using a novel in vitro colonic incubation approach. This novel in vitro model allowed for growth of the entire spectrum of dog- and cat-derived bacteria from the inoculum, thus offering an excellent platform to evaluate effects of nutritional interventions on the gut microbiota. Further, yeast-derived ingredients differentially increased production of acetate, propionate, butyrate, ammonium, and branched short-chain fatty acids, with T5 and T1 consistently stimulating propionate and butyrate, respectively. 16S-targeted Illumina sequencing coupled with flow cytometry provided unprecedented high-resolution quantitative insights in canine and feline microbiota modulation by yeast-derived ingredients, revealing that effects on propionate production were related to Prevotellaceae, Tannerellaceae, Bacteroidaceae, and Veillonellaceae members, while effects on butyrate production were related to Erysipelotrichaceae, Lachnospiraceae, Ruminococcaceae, and Fusobacteriaceae. Overall, these findings strengthen the health-promoting potential of yeast-derived ingredients

Comparison of the therapeutic effect of treatment with antibiotics or nutraceuticals on clinical activity and the fecal microbiome of dogs with acute diarrhea

Dogs with acute diarrhea are often presented to clinical practice and, although this generally represents a self-limiting condition, antibiotics are still frequently used as treatment. The aim of this study was to evaluate the effects in dogs with acute non-hemorrhagic diarrhea of the administration of an antibiotic combination in comparison to a nutraceutical product. Thirty dogs were enrolled and randomly assigned to two groups: 15 dogs (group A) received a nutraceutical commercial product while 15 dogs (group B) received an antimicrobial combination of metronidazole and spiramycin. For each dog, the Canine Acute Diarrhea Severity Index, the fecal microbiota and the Dysbiosis Index were assessed. Both stool consistency and frequency decreased on day 2 in the dogs of group A compared to baseline, while in group B, these parameters significantly decreased at days 3 and 4. The global concern for rising antibiotic resistance associated with indiscriminate use of antimicrobials, in both humans and animals, suggests the necessity of avoiding empirical and injudicious use of these molecules in diarrheic dogs. These results suggest that the nutraceutical treatment had a similar clinical effect compared to the antibiotic formulation, representing a valid antibiotic-sparing therapeutic approach in canine acute diarrhea