The self in autism and its relation to memory

This chapter begins with some definitions of memory and the self and continues to explain their relation on the psychological level along with their facets. It considers the relevance of these theories to autism spectrum disorder (ASD). The chapter provides a critical review of relevant research on the self in autism, followed by some hypotheses concerning how diminished sense of self might predict and explain the unique memory profile in the ASD population. Although there are a considerable number of studies showing typical performance on some types of “self” task among people with ASD on balance, existing evidence suggests that individuals with ASD have atypical me‐selves. There is a considerable amount of evidence to suggest that individuals with ASD have impaired episodic memory. Strikingly, the study of prospective memory in ASD is an emergent research field with a handful of studies published to date. Two forms of prospective memory are commonly distinguished: event‐based and time‐based

Apps-olutely fabulous? - The quality of PFMT smartphone app content and design rated using the Mobile App Rating Scale, Behaviour Change Taxonomy, and guidance for exercise prescription

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordICS 2019: International Continence Society 49th Annual Meeting, 3-6 September 2019, Gothenburg, SwedenDunedin School of MedicineNational Institute for Health Research (NIHR

Masked priming and ERPs dissociate maturation of orthographic and semantic components of visual word recognition in children

This study examined the time-course of reading single words in children and adults using masked repetition priming and the recording of event-related potentials. The N250 and N400 repetition priming effects were used to characterize form- and meaning-level processing, respectively. Children had larger amplitude N250 effects than adults for both shorter and longer duration primes. Children did not differ from adults on the N400 effect. The difference on the N250 suggests that automaticity for form processing is still maturing in children relative to adults, while the lack of differentiation on the N400 effect suggests that meaning processing is relatively mature by late childhood. The overall similarity in the children's repetition priming effects to adults' effects is in line with theories of reading acquisition, according to which children rapidly transition to an orthographic strategy for fast access to semantic information from print.Ellison Medical FoundationF32HD06118

Age Deficits in Facial Affect Recognition : The Influence of Dynamic Cues

Funding This work was supported by the Australian Research Council, Australia (DP150100302) and the Leverhulme Trust, U.K. (F/00152/W).Peer reviewedPostprin

Data-in-Place: Thinking through the Relations Between Data and Community

We present findings from a year-long engagement with a street and its community . The work is targeted at exploring how the production and use of data is bound up with place, both in terms of physical and social geography. We detail three strands of the project. First, we consider how residents have sought to curate existing data about the street in the form of an archive with physical and digital components. Second, we report endeavours to capture data about the street’s environment, especially of traffic moving through it. Third, we draw on the possibilities afforded by technologies for polling opinion. We reflect on how these engagements have: materialised distinctive relations between the community and their data; surfaced flows and contours of data , and spatial, temporal and social boundaries ;and enacted a multiplicity of ‘small worlds’. We consider how such a conceptualisation of data-in-place is relevant to the design of data technologies

Investigations in Bantry Bay following the Betelgeuse oil tanker disaster

About 30,000 tons of Arabian light crude oil plus some bunker oil was lost from the tanker Betelgeuse in Bantry Bay following an explosion and fire in January 1971. Most of the oil was burnt, and in the intense heat was polymerised into an asphalt-like material which coated the shoreline or sank, disrupting fishing activity. Oil leaked intermittently from the wreck for over a year during the salvage operation, and some of this was treated very effectively by spraying concentrated dispersant from an aircraft. Evidence of residual circulation suggested that the northern side of the inner Bay would have been most threatened by the dispersed oil. Several species of fish spawned in the Bay in the months following the disaster and larvae and post-larvae were not seriously affected. Fishing activity was disrupted but, apart from periwinkles Littorina littorea (L.), no commercial stocks were observed to suffer mortality as a result of the spillage. There was some very minor contamination of escallops Pecten maximus (L.) but this did not prevent escallop spatfalls in 1979 or 1980

In vitro Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells

The brain is the most complex organ in the body, controlling our highest functions, as well as regulating myriad processes which incorporate the entire physiological system. The effects of prospective therapeutic entities on the brain and central nervous system (CNS) may potentially cause significant injury, hence, CNS toxicity testing forms part of the “core battery” of safety pharmacology studies. Drug-induced seizure is a major reason for compound attrition during drug development. Currently, the rat ex vivo hippocampal slice assay is the standard option for seizure-liability studies, followed by primary rodent cultures. These models can respond to diverse agents and predict seizure outcome, yet controversy over the relevance, efficacy, and cost of these animal-based methods has led to interest in the development of human-derived models. Existing platforms often utilize rodents, and so lack human receptors and other drug targets, which may produce misleading data, with difficulties in inter-species extrapolation. Current electrophysiological approaches are typically used in a low-throughput capacity and network function may be overlooked. Human-derived induced pluripotent stem cells (iPSCs) are a promising avenue for neurotoxicity testing, increasingly utilized in drug screening and disease modeling. Furthermore, the combination of iPSC-derived models with functional techniques such as multi-electrode array (MEA) analysis can provide information on neuronal network function, with increased sensitivity to neurotoxic effects which disrupt different pathways. The use of an in vitro human iPSC-derived neural model for neurotoxicity studies, combined with high-throughput techniques such as MEA recordings, could be a suitable addition to existing pre-clinical seizure-liability testing strategies