Neonatal Transport Nursing is an Interpretive Practice

In this paper, we offer a personal account of a neonatal transport nurse (TRN) and the interpretive nature of the TRN’s work. Beginning at the start of a shift, the reader encounters the many ways in which the neonatal transport nurse interprets her surroundings, colleagues, patients, and circumstances, lending to how these factors are consciously and subconsciously engaged in the TRN’s practice throughout a day’s work

Synthesis, biological evaluation, and utility of fluorescent ligands targeting the μ-opioid receptor

Fluorescently labeled ligands are useful pharmacological research tools for studying receptor localization, trafficking, and signaling processes via fluorescence imaging. They are also employed in fluorescent binding assays. This study is centered on the design, synthesis, and pharmacological evaluation of fluorescent probes for the opioid receptors, for which relatively few non-peptidic fluorescent probes currently exist. The known μ-opioid receptor (MOR) partial agonist, buprenorphine, was structurally elaborated to include an amidoalkylamine linker moiety that was coupled with a range of fluorophores to afford new fluorescent probes. All compounds proved to be selective MOR antagonists. Confocal fluorescence microscopy studies revealed that the probe incorporating a sulfonated cyanine-5 fluorophore was the most appropriate for imaging studies. This ligand was subsequently employed in an automated fluorescence-based competition binding assay, allowing the pKi values of several well-known opioid ligands to be determined. Thus, this new probe will prove useful in future studies of MOR receptor pharmacology

Daily mood, partner support, sexual interest, and sexual activity among adolescent women

This is a post print version of the article. The official published version can be accessed from the link below.Objective: to examine day-to-day associations of coitus, sexual interest, partner emotional support, negative mood and positive mood among adolescent women. Methods: Women (ages 14 – 17 at enrollment; N=146) enrolled from one of three adolescent primary care clinics completed up to five 84-day diaries over a 27-month period. The diaries assessed partner interactions, sexual activity, substance use and mood. Partner-specific measures assessed on each day included partner emotional support (4 items; alpha = 0.94), argument with a partner (no/yes) and coitus (no/yes). Within-day measures assessed marijuana use (no/yes), Positive Mood (3-items; alpha = 0. 86); Negative Mood (3-items; alpha = 0.82) and Sexual Interest (1-item). Lagged measures of mood and sexual activity were included in multivariate models to control for recent mood and sexual behavior effects on current day mood and coitus. Two main analyses were conducted: coitus as a predictor of positive and negative mood; and the role of positive and negative mood as predictors of coitus. Analyses were conducted by multivariate mixed effect regression and mixed effect logistic regression models. Results: Data represent 28,376 days from 146 participants. The average number of diary days was 194 days per participant. Sexual activity was reported on 8.3% of days, with condoms used for 27.0% of these coital events. Marijuana was used on 11% of days. Significant predictors of positive mood on a given day included partner support, marijuana use, and coitus. Negative mood was associated with having an argument with a partner and with prior day coitus. Predictors of coitus on a given day included age (Odds ratio = 1.22), increased coital frequency in previous week (OR = 1.49), coitus on the previous day (1.21), increased same-day sexual interest (OR = 2.8) and decreased same-day negative mood (OR = 0.92). Conclusions: The data demonstrate complex associations of sexual interest, mood, partner interactions and sexual activity

Gravity in the 3+1-Split Formalism II: Self-Duality and the Emergence of the Gravitational Chern-Simons in the Boundary

We study self-duality in the context of the 3+1-split formalism of gravity with non-zero cosmological constant. Lorentzian self-dual configurations are conformally flat spacetimes and have boundary data determined by classical solutions of the three-dimensional gravitational Chern-Simons. For Euclidean self-dual configurations, the relationship between their boundary initial positions and initial velocity is also determined by the three-dimensional gravitational Chern-Simons. Our results imply that bulk self-dual configurations are holographically described by the gravitational Chern-Simons theory which can either viewed as a boundary generating functional or as a boundary effective action.Comment: 25 pages; v2: minor improvements, references adde

Gravity in the 3+1-Split Formalism I: Holography as an Initial Value Problem

We present a detailed analysis of the 3+1-split formalism of gravity in the presence of a cosmological constant. The formalism helps revealing the intimate connection between holography and the initial value formulation of gravity. We show that the various methods of holographic subtraction of divergences correspond just to different transformations of the canonical variables, such that the initial value problem is properly set up at the boundary. The renormalized boundary energy momentum tensor is a component of the Weyl tensor.Comment: 28 pages; v2: minor improvements, references adde

Asymptotic generators of fermionic charges and boundary conditions preserving supersymmetry

We use a covariant phase space formalism to give a general prescription for defining Hamiltonian generators of bosonic and fermionic symmetries in diffeomorphism invariant theories, such as supergravities. A simple and general criterion is derived for a choice of boundary condition to lead to conserved generators of the symmetries on the phase space. In particular, this provides a criterion for the preservation of supersymmetries. For bosonic symmetries corresponding to diffeomorphisms, our prescription coincides with the method of Wald et al. We then illustrate these methods in the case of certain supergravity theories in $d=4$. In minimal AdS supergravity, the boundary conditions such that the supercharges exist as Hamiltonian generators of supersymmetry transformations are unique within the usual framework in which the boundary metric is fixed. In extended ${\mathcal N}=4$ AdS supergravity, or more generally in the presence of chiral matter superfields, we find that there exist many boundary conditions preserving ${\mathcal N}=1$ supersymmetry for which corresponding generators exist. These choices are shown to correspond to a choice of certain arbitrary boundary ``superpotentials,'' for suitably defined ``boundary superfields.'' We also derive corresponding formulae for the conserved bosonic charges, such as energy, in those theories, and we argue that energy is always positive, for any supersymmetry-preserving boundary conditions. We finally comment on the relevance and interpretation of our results within the AdS-CFT correspondence.Comment: 45 pages, Latex, no figures, v2: extended discussion of positive energy theorem and explicit form of fermionic generators, references adde

Correlation Functions of Operators and Wilson Surfaces in the d=6, (0,2) Theory in the Large N Limit

We compute the two and three-point correlation functions of chiral primary operators in the large N limit of the (0,2), d=6 superconformal theory. We also consider the operator product expansion of Wilson surfaces in the (0,2) theory and compute the OPE coefficients of the chiral primary operators at large N from the correlation functions of surfaces.Comment: 34 pages, using utarticle.cls (included), array.sty, amsmath.sty, amsfonts.sty, latexsym.sty, epsfig. Bibtex style: utphys.bst (.bbl file included

An action for the (2,0) self-dual tensor multiplet in a conformal supergravity background

We present the action for a self-dual tensor in six dimensions, coupled to a (2,0) conformal supergravity background. This action gives rise to the expected equations of motion. An alternative look upon one of the gauge symmetries clarifies its role in the supersymmetry transformation rules and the realisation of the algebra.Comment: 14 pages, accepted by Class. Quant. Gra

The HST/ACS Coma Cluster Survey. II. Data Description and Source Catalogs

The Coma cluster was the target of a HST-ACS Treasury program designed for deep imaging in the F475W and F814W passbands. Although our survey was interrupted by the ACS instrument failure in 2007, the partially completed survey still covers ~50% of the core high-density region in Coma. Observations were performed for 25 fields that extend over a wide range of cluster-centric radii (~1.75 Mpc) with a total coverage area of 274 arcmin^2. The majority of the fields are located near the core region of Coma (19/25 pointings) with six additional fields in the south-west region of the cluster. In this paper we present reprocessed images and SExtractor source catalogs for our survey fields, including a detailed description of the methodology used for object detection and photometry, the subtraction of bright galaxies to measure faint underlying objects, and the use of simulations to assess the photometric accuracy and completeness of our catalogs. We also use simulations to perform aperture corrections for the SExtractor Kron magnitudes based only on the measured source flux and half-light radius. We have performed photometry for ~73,000 unique objects; one-half of our detections are brighter than the 10-sigma point-source detection limit at F814W=25.8 mag (AB). The slight majority of objects (60%) are unresolved or only marginally resolved by ACS. We estimate that Coma members are 5-10% of all source detections, which consist of a large population of unresolved objects (primarily GCs but also UCDs) and a wide variety of extended galaxies from a cD galaxy to dwarf LSB galaxies. The red sequence of Coma member galaxies has a constant slope and dispersion across 9 magnitudes (-21<M_F814W<-13). The initial data release for the HST-ACS Coma Treasury program was made available to the public in 2008 August. The images and catalogs described in this study relate to our second data release.Comment: Accepted for publication in ApJS. A high-resolution version is available at http://archdev.stsci.edu/pub/hlsp/coma/release2/PaperII.pd

Extinction times in the subcritical stochastic SIS logistic epidemic

Many real epidemics of an infectious disease are not straightforwardly super- or sub-critical, and the understanding of epidemic models that exhibit such complexity has been identified as a priority for theoretical work. We provide insights into the near-critical regime by considering the stochastic SIS logistic epidemic, a well-known birth-and-death chain used to model the spread of an epidemic within a population of a given size $N$. We study the behaviour of the process as the population size $N$ tends to infinity. Our results cover the entire subcritical regime, including the "barely subcritical" regime, where the recovery rate exceeds the infection rate by an amount that tends to 0 as $N \to \infty$ but more slowly than $N^{-1/2}$. We derive precise asymptotics for the distribution of the extinction time and the total number of cases throughout the subcritical regime, give a detailed description of the course of the epidemic, and compare to numerical results for a range of parameter values. We hypothesise that features of the course of the epidemic will be seen in a wide class of other epidemic models, and we use real data to provide some tentative and preliminary support for this theory.Comment: Revised; 34 pages; 6 figure