891 research outputs found

    Casimir effect in 2+1 dimensional noncommutative theories

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    We study the Dirichlet Casimir effect for a complex scalar field on two noncommutative spatial coordinates plus a commutative time. To that end, we introduce Dirichlet-like boundary conditions on a curve contained in the spatial plane, in such a way that the correct commutative limit can be reached. We evaluate the resulting Casimir energy for two different curves: (a) Two parallel lines separated by a distance LL, and (b) a circle of radius RR. In the first case, the resulting Casimir energy agrees exactly with the one corresponding to the commutative case, regardless of the values of LL and of the noncommutativity scale θ\theta, while for the latter the commutative behaviour is only recovered when R>>θR >> \sqrt{\theta}. Outside of that regime, the dependence of the energy with RR is substantially changed due to noncommutative corrections, becoming regular for R0R \to 0.Comment: 12 pages, 3 figure

    Representation of the Lagrange reconstructing polynomial by combination of substencils

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    The Lagrange reconstructing polynomial [Shu C.W.: {\em SIAM Rev.} {\bf 51} (2009) 82--126] of a function f(x)f(x) on a given set of equidistant (\Delta x=\const) points {xi+Δx;  {M,...,+M+}}\bigl\{x_i+\ell\Delta x;\;\ell\in\{-M_-,...,+M_+\}\bigr\} is defined [Gerolymos G.A.: {\em J. Approx. Theory} {\bf 163} (2011) 267--305] as the polynomial whose sliding (with xx) averages on [x12Δx,x+12Δx][x-\tfrac{1}{2}\Delta x,x+\tfrac{1}{2}\Delta x] are equal to the Lagrange interpolating polynomial of f(x)f(x) on the same stencil. We first study the fundamental functions of Lagrange reconstruction, show that these polynomials have only real and distinct roots, which are never located at the cell-interfaces (half-points) xi+n12Δxx_i+n\tfrac{1}{2}\Delta x (nZn\in\mathbb{Z}), and obtain several identities. Using these identities, by analogy to the recursive Neville-Aitken-like algorithm applied to the Lagrange interpolating polynomial, we show that there exists a unique representation of the Lagrange reconstructing polynomial on {iM,...,i+M+}\{i-M_-,...,i+M_+\} as a combination of the Lagrange reconstructing polynomials on the Ks+1M:=M+M+>1K_\mathrm{s}+1\leq M:=M_-+M_+>1 substencils {iM+ks,...,i+M+Ks+ks}\{i-M_-+k_\mathrm{s},...,i+M_+-K_\mathrm{s}+k_\mathrm{s}\} (ks{0,...,Ks}k_\mathrm{s}\in\{0,...,K_\mathrm{s}\}), with weights σR1,M,M+,Ks,ks(ξ)\sigma_{R_1,M_-,M_+,K_\mathrm{s},k_\mathrm{s}}(\xi) which are rational functions of ξ\xi (x=xi+ξΔxx=x_i+\xi\Delta x) [Liu Y.Y., Shu C.W., Zhang M.P.: {\em Acta Math. Appl. Sinica} {\bf 25} (2009) 503--538], and give an analytical recursive expression of the weight-functions. We then use the analytical expression of the weight-functions σR1,M,M+,Ks,ks(ξ)\sigma_{R_1,M_-,M_+,K_\mathrm{s},k_\mathrm{s}}(\xi) to obtain a formal proof of convexity (positivity of the weight-functions) in the neighborhood of ξ=12\xi=\tfrac{1}{2}, under the condition that all of the substencils contain either point ii or point i+1i+1 (or both).Comment: final corrected version; in print J. Comp. Appl. Mat

    A novel HIV vaccine adjuvanted by IC31 induces robust and persistent humoral and cellular immunity.

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    The HIV vaccine strategy that, to date, generated immune protection consisted of a prime-boost regimen using a canarypox vector and an HIV envelope protein with alum, as shown in the RV144 trial. Since the efficacy was weak, and previous HIV vaccine trials designed to generate antibody responses failed, we hypothesized that generation of T cell responses would result in improved protection. Thus, we tested the immunogenicity of a similar envelope-based vaccine using a mouse model, with two modifications: a clade C CN54gp140 HIV envelope protein was adjuvanted by the TLR9 agonist IC31®, and the viral vector was the vaccinia strain NYVAC-CN54 expressing HIV envelope gp120. The use of IC31® facilitated immunoglobulin isotype switching, leading to the production of Env-specific IgG2a, as compared to protein with alum alone. Boosting with NYVAC-CN54 resulted in the generation of more robust Th1 T cell responses. Moreover, gp140 prime with IC31® and alum followed by NYVAC-CN54 boost resulted in the formation and persistence of central and effector memory populations in the spleen and an effector memory population in the gut. Our data suggest that this regimen is promising and could improve the protection rate by eliciting strong and long-lasting humoral and cellular immune responses

    Approximation error of the Lagrange reconstructing polynomial

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    The reconstruction approach [Shu C.W.: {\em SIAM Rev.} {\bf 51} (2009) 82--126] for the numerical approximation of f(x)f'(x) is based on the construction of a dual function h(x)h(x) whose sliding averages over the interval [x12Δx,x+12Δx][x-\tfrac{1}{2}\Delta x,x+\tfrac{1}{2}\Delta x] are equal to f(x)f(x) (assuming an homogeneous grid of cell-size Δx\Delta x). We study the deconvolution problem [Harten A., Engquist B., Osher S., Chakravarthy S.R.: {\em J. Comp. Phys.} {\bf 71} (1987) 231--303] which relates the Taylor polynomials of h(x)h(x) and f(x)f(x), and obtain its explicit solution, by introducing rational numbers τn\tau_n defined by a recurrence relation, or determined by their generating function, gτ(x)g_\tau(x), related with the reconstruction pair of ex{\rm e}^x. We then apply these results to the specific case of Lagrange-interpolation-based polynomial reconstruction, and determine explicitly the approximation error of the Lagrange reconstructing polynomial (whose sliding averages are equal to the Lagrange interpolating polynomial) on an arbitrary stencil defined on a homogeneous grid.Comment: 31 pages, 1 table; revised version to appear in J. Approx. Theor

    Extreme Ultra-Violet Spectroscopy of the Lower Solar Atmosphere During Solar Flares

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    The extreme ultraviolet portion of the solar spectrum contains a wealth of diagnostic tools for probing the lower solar atmosphere in response to an injection of energy, particularly during the impulsive phase of solar flares. These include temperature and density sensitive line ratios, Doppler shifted emission lines and nonthermal broadening, abundance measurements, differential emission measure profiles, and continuum temperatures and energetics, among others. In this paper I shall review some of the advances made in recent years using these techniques, focusing primarily on studies that have utilized data from Hinode/EIS and SDO/EVE, while also providing some historical background and a summary of future spectroscopic instrumentation.Comment: 34 pages, 8 figures. Submitted to Solar Physics as part of the Topical Issue on Solar and Stellar Flare

    Clinical utility of vinblastine therapeutic drug monitoring for the treatment of infantile myofibroma patients:A case series

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    Infantile myofibroma is a rare, benign tumour of infancy typically managed surgically. In a minority of cases, more aggressive disease is seen and chemotherapy with vinblastine and methotrexate may be used, although evidence for this is limited. Chemotherapy dosing in infants is challenging, and vinblastine disposition in infants is unknown. We describe the use of vinblastine therapeutic drug monitoring in four cases of infantile myofibroma. Marked inter- and intrapatient variability was observed, highlighting the poorly understood pharmacokinetics of vinblastine in children, the challenges inherent in treating neonates, and the role of adaptive dosing in optimising drug exposure in challenging situations.</p

    The Imaging Magnetograph eXperiment (IMaX) for the Sunrise balloon-borne solar observatory

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    The Imaging Magnetograph eXperiment (IMaX) is a spectropolarimeter built by four institutions in Spain that flew on board the Sunrise balloon-borne telesocope in June 2009 for almost six days over the Arctic Circle. As a polarimeter IMaX uses fast polarization modulation (based on the use of two liquid crystal retarders), real-time image accumulation, and dual beam polarimetry to reach polarization sensitivities of 0.1%. As a spectrograph, the instrument uses a LiNbO3 etalon in double pass and a narrow band pre-filter to achieve a spectral resolution of 85 mAA. IMaX uses the high Zeeman sensitive line of Fe I at 5250.2 AA and observes all four Stokes parameters at various points inside the spectral line. This allows vector magnetograms, Dopplergrams, and intensity frames to be produced that, after reconstruction, reach spatial resolutions in the 0.15-0.18 arcsec range over a 50x50 arcsec FOV. Time cadences vary between ten and 33 seconds, although the shortest one only includes longitudinal polarimetry. The spectral line is sampled in various ways depending on the applied observing mode, from just two points inside the line to 11 of them. All observing modes include one extra wavelength point in the nearby continuum. Gauss equivalent sensitivities are four Gauss for longitudinal fields and 80 Gauss for transverse fields per wavelength sample. The LOS velocities are estimated with statistical errors of the order of 5-40 m/s. The design, calibration and integration phases of the instrument, together with the implemented data reduction scheme are described in some detail.Comment: 17 figure
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