The Ursinus Weekly, November 12, 1951

Second Forum features talk on philosophy • MSGA compiles roster of minimum penalties • Campus Chest combines all campaigns for money • Library records show big increase • Chem society lists speaker • Marriage discussion held at Y fireside chats • Students offered cheap rates for The River • Kenneth Graham read at meeting • Cast listed for group production • Large crowd hears pianist in local recital Thursday • Jones, Pettit write Ursinus spirit song • Newman Club plans events • Four new members join pre-legal group • Dr. Garrett pens article for language journal • Editorials: Dreamers wanted; Korean interest lags • Letters to the editor • YM-YW plan spoken grace • Adelphi tallies 39-19 win over Ursinus grid team • Junior Bearettes defeat Beaver • Forty men start basketball practice • Bruin eleven to meet undefeated Crusaders • Lehigh booters down Grizzlies; Beaver beats Snell\u27s hockeyites • Junior bazaar hailed success • Lois Johnson represents Red Cross at meeting • Polish refugee lectures in several classeshttps://digitalcommons.ursinus.edu/weekly/1527/thumbnail.jp

Rab3-GEF controls active zone development at the Drosophila neuromuscular junction

Synaptic signaling involves the release of neurotransmitter from presynaptic active zones (AZs). Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). At the Drosophila neuromuscular junction (NMJ), the small GTPase Rab3 controls the distribution of CAZ proteins across release sites, thereby regulating the efficacy of individual AZs. Here we identify Rab3-GEF as a second protein that acts in conjunction with Rab3 to control AZ protein composition. At rab3-GEF mutant NMJs, Bruchpilot (Brp) and Ca(2+) channels are enriched at a subset of AZs, leaving the remaining sites devoid of key CAZ components in a manner that is indistinguishable from rab3 mutant NMJs. As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis elegans AEX-3, Rab3-GEF is a guanine nucleotide exchange factor (GEF) for Rab3 that stimulates GDP to GTP exchange. Mechanistic studies reveal that although Rab3 and Rab3-GEF act within the same mechanism to control AZ development, Rab3-GEF is involved in multiple roles. We show that Rab3-GEF is required for transport of Rab3. However, the synaptic phenotype in the rab3-GEF mutant cannot be fully explained by defective transport and loss of GEF activity. A transgenically expressed GTP-locked variant of Rab3 accumulates at the NMJ at wild-type levels and fully rescues the rab3 mutant but is unable to rescue the rab3-GEF mutant. Our results suggest that although Rab3-GEF acts upstream of Rab3 to control Rab3 localization and likely GTP-binding, it also acts downstream to regulate CAZ development, potentially as a Rab3 effector at the synapse

Extreme magnetic field-boosted superconductivity

Applied magnetic fields underlie exotic quantum states, such as the fractional quantum Hall effect and Bose-Einstein condensation of spin excitations. Superconductivity, on the other hand, is inherently antagonistic towards magnetic fields. Only in rare cases can these effects be mitigated over limited fields, leading to reentrant superconductivity. Here, we report the unprecedented coexistence of multiple high-field reentrant superconducting phases in the spin-triplet superconductor UTe2. Strikingly, we observe superconductivity in the highest magnetic field range identified for any reentrant superconductor, beyond 65 T. These extreme properties reflect a new kind of exotic superconductivity rooted in magnetic fluctuations and boosted by a quantum dimensional crossover

Training of Instrumentalists and Development of New Technologies on SOFIA

This white paper is submitted to the Astronomy and Astrophysics 2010 Decadal Survey (Astro2010)1 Committee on the State of the Profession to emphasize the potential of the Stratospheric Observatory for Infrared Astronomy (SOFIA) to contribute to the training of instrumentalists and observers, and to related technology developments. This potential goes beyond the primary mission of SOFIA, which is to carry out unique, high priority astronomical research. SOFIA is a Boeing 747SP aircraft with a 2.5 meter telescope. It will enable astronomical observations anywhere, any time, and at most wavelengths between 0.3 microns and 1.6 mm not accessible from ground-based observatories. These attributes, accruing from the mobility and flight altitude of SOFIA, guarantee a wealth of scientific return. Its instrument teams (nine in the first generation) and guest investigators will do suborbital astronomy in a shirt-sleeve environment. The project will invest $10M per year in science instrument development over a lifetime of 20 years. This, frequent flight opportunities, and operation that enables rapid changes of science instruments and hands-on in-flight access to the instruments, assure a unique and extensive potential - both for training young instrumentalists and for encouraging and deploying nascent technologies. Novel instruments covering optical, infrared, and submillimeter bands can be developed for and tested on SOFIA by their developers (including apprentices) for their own observations and for those of guest observers, to validate technologies and maximize observational effectiveness.Comment: 10 pages, no figures, White Paper for Astro 2010 Survey Committee on State of the Professio

Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort

OBJECTIVES To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc). METHODS We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, valid mRSS at 12±3 months after baseline and ≥1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and ≥25% from baseline to 12±3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. Associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. RESULTS Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. Survival analyses indicated that skin progressors had a significantly higher probability of FVC decline ≥10% (53.6% vs 34.4%; p<0.001) and all-cause death (15.4% vs 7.3%; p=0.003) than non-progressors. These significant associations were also found in subgroup analyses of patients with either low baseline mRSS (≤22/51) or short disease duration (≤15 months). In multivariable analyses, skin progression within 1 year was independently associated with FVC decline ≥10% (HR 1.79, 95% CI 1.20 to 2.65) and all-cause death (HR 2.58, 95% CI 1.31 to 5.09). CONCLUSIONS Progressive skin fibrosis within 1 year is associated with decline in lung function and worse survival in dcSSc during follow-up. These results confirm mRSS as a surrogate marker in dcSSc, which will be helpful for cohort enrichment in future trials and risk stratification in clinical practice

Investigating the Bivalve Tree of Life -- an exemplar-based approach combining molecular and novel morphological characters.

To re-evaluate the relationships of the major bivalve lineages, we amassed detailed morpho-anatomical, ultrastructural and molecular sequence data for a targeted selection of exemplar bivalves spanning the phylogenetic diversity of the class. We included molecular data for 103 bivalve species (up to five markers) and also analysed a subset of taxa with four additional nuclear protein-encoding genes. Novel as well as historically employed morphological characters were explored, and we systematically disassembled widely used descriptors such as gill and stomach ‘types’. Phylogenetic analyses, conducted using parsimony direct optimisation and probabilistic methods on static alignments (maximum likelihood and Bayesian inference) of the molecular data, both alone and in combination with morphological characters, offer a robust test of bivalve relationships. A calibrated phylogeny also provided insights into the tempo of bivalve evolution. Finally, an analysis of the informativeness of morphological characters showed that sperm ultrastructure characters are among the best morphological features to diagnose bivalve clades, followed by characters of the shell, including its microstructure. Our study found support for monophyly of most broadly recognised higher bivalve taxa, although support was not uniform for Protobranchia. However, monophyly of the bivalves with protobranchiate gills was the best-supported hypothesis with incremental morphological and/or molecular sequence data. Autobranchia, Pteriomorphia, Heteroconchia, Palaeoheterodonta, Archiheterodonta, Euheterodonta, Anomalodesmata and Imparidentia new clade ( = Euheterodonta excluding Anomalodesmata) were recovered across analyses, irrespective of data treatment or analytical framework. Another clade supported by our analyses but not formally recognised in the literature includes Palaeoheterodonta and Archiheterodonta, which emerged under multiple analytical conditions. The origin and diversification of each of these major clades is Cambrian or Ordovician, except for Archiheterodonta, which diverged from Palaeoheterodonta during the Cambrian, but diversified during the Mesozoic. Although the radiation of some lineages was shifted towards the Palaeozoic (Pteriomorphia, Anomalodesmata), or presented a gap between origin and diversification (Archiheterodonta, Unionida), Imparidentia showed steady diversification through the Palaeozoic and Mesozoic. Finally, a classification system with six major monophyletic lineages is proposed to comprise modern Bivalvia: Protobranchia, Pteriomorphia, Palaeoheterodonta, Archiheterodonta, Anomalodesmata and Imparidentia

The Tito-Stalin Split 70 Years After

The goal of the Zagreb conference “The Tito-Stalin Split: 70 Years Later”, Zagreb-Goli Otok, 28-30 June 2018, as well as of the papers presented, was to show not only&nbsp;the new interpretations and takes on the subject, but to present the Yugoslav 1948 as a&nbsp;global event, one that touched lives of so many people around the world. It had a very&nbsp;significant impact not only on politics, international relations, prisoners, army cooperation and army relations, ideology, but also cultural life and production, especially&nbsp;in Yugoslavia and the Soviet Union.&nbsp;Most of the papers presented at the Faculty of Humanities and Social Sciences,&nbsp;University of Zagreb, which co-organized the whole event with colleagues from the&nbsp;University of Ljubljana, Slovenia, are published in this volume. A few papers were presented but the authors did not contribute the text (those were: Mark Kramer, Peter Ruggenthaler, Ondřej Vojtěchovský, Klaus Buchenau, Andreii Edemskii, Boris Stamenić,&nbsp;and Marie-Janine Calic). Also, one paper on China was not presented, but the text is&nbsp;here. We hope this volume will be an important contribution to the continuous dialogue&nbsp;that should be not only regional, but global. It should also be ongoing, since there is&nbsp;hardly an event in the history of the Cold War whose consequences were as important&nbsp;and as global as this one’s. (from the Preface)The book is co-published by the University of Zagreb, Faculty of Humanities and Social Sciences – Department of History (Postgraduate Doctoral Studies “Modern and Contemporary Croatian History In European and World Context”)&nbsp;&amp; the&nbsp;University of Ljubljana Faculty of Arts – Department of History, as a volume 31 in the Historia series.&nbsp;The goal of the Zagreb conference “The Tito-Stalin Split: 70 Years Later”, Zagreb-Goli Otok, 28-30 June 2018, as well as of the papers presented, was to show not only&nbsp;the new interpretations and takes on the subject, but to present the Yugoslav 1948 as a&nbsp;global event, one that touched lives of so many people around the world. It had a very&nbsp;significant impact not only on politics, international relations, prisoners, army cooperation and army relations, ideology, but also cultural life and production, especially&nbsp;in Yugoslavia and the Soviet Union.Most of the papers presented at the Faculty of Humanities and Social Sciences,&nbsp;University of Zagreb, which co-organized the whole event with colleagues from the&nbsp;University of Ljubljana, Slovenia, are published in this volume. A few papers were presented but the authors did not contribute the text (those were: Mark Kramer, Peter Ruggenthaler, Ondřej Vojtěchovský, Klaus Buchenau, Andreii Edemskii, Boris Stamenić,&nbsp;and Marie-Janine Calic). Also, one paper on China was not presented, but the text is&nbsp;here. We hope this volume will be an important contribution to the continuous dialogue&nbsp;that should be not only regional, but global. It should also be ongoing, since there is&nbsp;hardly an event in the history of the Cold War whose consequences were as important&nbsp;and as global as this one’s. (from the Preface)The book is co-published by the University of Zagreb, Faculty of Humanities and Social Sciences – Department of History (Postgraduate Doctoral Studies “Modern and Contemporary Croatian History In European and World Context”)&nbsp;&amp; the&nbsp;University of Ljubljana Faculty of Arts – Department of History, as a volume 31 in the Historia series.&nbsp

Asymmetric phase diagram and dimensional crossover in a system of spin-spin- 1/2 dimers under applied hydrostatic pressure

We present the magnetic and structural properties of [Cu(pyrazine)0.5 (glycine)]ClO4 under applied pressure. As previously reported, at ambient pressure this material consists of quasi-two-dimensional layers of weakly coupled antiferromagnetic dimers which undergo Bose-Einstein condensation of triplet excitations between two magnetic field-induced quantum critical points (QCPs). The molecular building blocks from which the compound is constructed give rise to exchange strengths that are considerably lower than those found in other S=1/2 dimer materials, which allows us to determine the pressure evolution of the entire field-temperature magnetic phase diagram using radio-frequency magnetometry. We find that a distinct phase emerges above the upper field-induced transition at elevated pressures and also show that an additional QCP is induced at zero-field at a critical pressure of pc=15.7(5),kbar. Pressure-dependent single-crystal X-ray diffraction and density functional theory calculations indicate that this QCP arises primarily from a dimensional crossover driven by an increase in the interdimer interactions between the planes. While the effect of quantum fluctuations on the lower field-induced transition is enhanced with applied pressure, quantum Monte Carlo calculations suggest that this alone cannot explain an unconventional asymmetry that develops in the phase diagram