Geocoding health data in submunicipal scale : some Brazilian experiences

Neste trabalho, são relatadas experiências de georreferenciamento de dados de saúde em alguns Municípios brasileiros, analisadas segundo a disponibilidade e atualização de bases cartográficas e o tratamento de dados de endereço nos sistemas de informações em saúde (SIS). A diversidade de estratégias de georreferenciamento de dados no Brasil é resultado das condições particulares de desenvolvimento desses projetos nos Municípios, o que influi na eficiência e precisão da localização dos eventos de saúde. São sugeridas estratégias para captação e armazenamento de dados de endereço nos SIS e sua compatibilização com os cadastros de logradouros existentes, bem como o desenvolvimento de programas e aplicativos que permitam buscas e relacionamentos entre essas duas bases de dados. ____________________________________________________________________________________ ABSTRACTThis work describes experiences in geocoding health data in Brazilian municipalities, analyzed according to the availability and update of cartographic databases and the treatment given to addresses data in health information systems (SIS). The diversity of current geocoding strategies in Brazil results of local conditions on which these projects are developed, presenting variable efficiency and accuracy for health event location. The authors suggest strategies to capture and store addresses data in SIS, compatible with the existent street registries, as well as the development of programs and scripts to search and link these two databases

Ecoepidemiology of American Visceral Leishmaniasis in Tocantins State, Brazil: Factors Associated with the Occurrence and Spreading of the Vector Lutzomyia (Lutzomyia) longipalpis (Lutz & Neiva, 1912) (Diptera: Psychodidae: Phlebotominae)

Leishmaniases are considered serious public health problems, and their geographical expansion has enabled their establishment in urban areas of medium and large cities in Brazil. Continuous processes of deforestation, construction of dams, and hydroelectric plants, among others, cause environmental impact and may favor the increase in the number of human cases of leishmaniases, as well as the establishment of epidemic outbreaks. This scenario reflects the reality of some regions of Brazil, such as Tocantins State, which in recent years has recorded high levels of American visceral leishmaniasis (AVL). This study is aimed to analyze environmental and epidemiological factors related with the spatial and temporal distribution of AVL and with the occurrence of Lutzomyia (Lutzomyia) longipalpis, the main vector of AVL, in the state of Tocantins. The results indicate that the vector is adapted to all environments, especially the ones under human influence, and that anthropogenic environmental impacts can support the development and adaptation of AVL in Brazil. Such information could be applied in control strategies aimed at decreasing AVL incidence

Heterogeneidade espacial da dengue em estudos locais, Niterói, RJ

OBJECTIVE: To analyze the spatial and temporal occurrence of dengue fever and its association with the heterogeneity of urban environment characteristics. METHODS: A total of 1,212 dengue cases, recorded in the Information System for Notifiable Diseases (Sinan) between 1998 and 2006, in the city of Niterói, Southeastern Brazil, were georeferenced according to census tracts. These tracts were classified into homogeneous areas for the occurrence of the disease: slum, shipyard and urban area. Cases were grouped into five periods - two inter-epidemic periods (1998-2000 and 2003-2005) and three epidemic periods (2001, 2002 and 2006) - and analyzed using operations between layers in a geographic information system (GIS) environment. The kernel method was used to identify clusters of cases. Kulldorff's spatial scan statistic was used to confirm these clusters statistically. RESULTS: Of all cases, 57% were females. Age groups with the highest number of cases were 20-29-years (20.5%) and 30-39-years (17.7%). The hill slum sector showed only 11% of households covered by garbage collection service, the highest percentage of illiterate individuals (8.7%) and head of families with income lower than one monthly minimum wage (29.5%). Cases remained in the slum sectors. In the first epidemic year and in the inter-epidemic periods, the highest number of cases was found in the hill and flatland slum sectors; in the second and third epidemic years, in the flatland slum sector. CONCLUSIONS: The economically active portion of the population was that most affected in the study area. Census tracts show spatial heterogeneity in relation to life conditions. In addition, in some tracts, there are differences in spatial and temporal distribution of the risk of occurrence of dengue fever.OBJETIVO: Analizar ocurrencia espacial y temporal del dengue y su asociación con la heterogeneidad de características del ambiente urbano. MÉTODOS: Fueron georeferenciados 1.212 casos de dengue registrados en el Sistema de Información de Agravios de Notificación entre 1998 y 2006, en el municipio de Niteroi, Sureste de Brasil, según sectores censitarios. Los sectores fueron clasificados en áreas homogéneas para la ocurrencia de la enfermedad: barrio, astillero y urbano. Los casos fueron agrupados en cinco períodos: dos interepidémicos 1998-2000 y 2003-2005; tres epidémicos 2001, 2002 y 2006 y analizados por medio de operaciones entre camadas en ambiente sistema de información geográfica. Para identificación de conglomerados con mayor intensidad de casos, se utilizó el método de kernel. El método de barredura espacial de Kulldorff fue usado para confirmación estadística de esos clusters. RESULTADOS: Del total de casos, 57% eran del sexo femenino. Los grupos etarios con mayor concentración de casos fueron de 20-29 años (20,5%) y de 30-39 años (17,7%). El sector barrio morro presentó solamente 11% de los domicilios atendidos por servicio de colecta de basura, el mayor porcentaje de no alfabetizados (8,7%) y de jefes de familia con rendimientos menores de 1 salario mínimo (29,5%). Los casos permanecieron en los sectores denominados barrios. En el primer año epidémico y en los períodos interepidémicos el mayor número de casos estaba situado en los sectores barrios morro y barrio plano; en el segundo y tercero año de epidemia, se situaban en el sector barrio plano. CONCLUSIONES: La parcela económicamente activa fue la más afectada en el área de estudio. Los sectores censitarios muestran heterogeneidad espacial con relación a las condiciones de vida y dentro de algunos sectores, hay diferencias en la distribución espacial y temporal de riesgo de ocurrencia del dengue.OBJETIVO: Analisar a ocorrência espacial e temporal da dengue e sua associação com a heterogeneidade de características do ambiente urbano. MÉTODOS: Foram georreferenciados 1.212 casos de dengue registrados no Sistema de Informação de Agravos de Notificação entre 1998 e 2006, no município de Niterói, RJ, segundo setores censitários. Os setores foram classificados em áreas homogêneas para a ocorrência da doença: favela, estaleiro e urbano. Os casos foram agrupados em cinco períodos: dois interepidêmicos 1998-2000 e 2003-2005; três epidêmicos 2001, 2002 e 2006 e analisados por meio de operações entre camadas em ambiente sistema de informação geográfica. Para identificação de conglomerados com maior intensidade de casos, utilizou-se o método de kernel. O método de varredura espacial de Kulldorff foi usado para confirmação estatística desses clusters. RESULTADOS: Do total de casos, 57% eram do sexo feminino. As faixas etárias com maior concentração de casos foram de 20-29 anos (20,5%) e de 30-39 anos (17,7%). O setor favela morro apresentou somente 11% dos domicílios atendidos por serviço de coleta de lixo, o maior percentual de não alfabetizados (8,7%) e de chefes de família com rendimentos menores de 1 salário mínimo (29,5%). Os casos permaneceram nos setores denominados favelas. No primeiro ano epidêmico e nos períodos interepidêmicos o maior número de casos estava situado nos setores favelas morro e favela plana; no segundo e terceiro ano de epidemia, situavam-se no setor favela plana. CONCLUSÕES: A parcela economicamente ativa foi a mais atingida na área de estudo. Os setores censitários mostram heterogeneidade espacial em relação às condições de vida e dentro de alguns setores, há diferenciais na distribuição espacial e temporal do risco de ocorrência da dengue

Relato de tristeza/depressão, nervosismo/ansiedade e problemas de sono na população adulta brasileira durante a pandemia de COVID-19

Objective. To analyze the frequency of sadness, nervousness, and sleep disorders during the COVID-19 pandemic in Brazil, identifying the most affected demographic segments. Methods. It is a cross-sectional study, with a questionnaire applied via the web to adults and the elderly, collecting information on living conditions, health and health behaviors. Prevalence and prevalence ratios were adjusted for age and sex. Results. With data from 45,161 respondents, it was found that during the pandemic 40.4% (95%CI 41,4; 46,7) of Brazilians often felt sad or depressed and 52.6% (95%CI 51,2; 54,1) often anxious or nervous; 43.5% (95%CI 41,8; 45,3) started to have a sleep problem and 48.0% (95%CI 45,6; 50,5) had a previous sleep problem aggravated. The frequencies of sadness, nervousness and change in sleep were higher in young adults, women and those with a history of depression. Conclusion. The high prevalence found indicates the need to guarantee the provision of services for mental health and quality of sleep that are adapted to the pandemic context.Objetivo. Analisar a frequência de tristeza, nervosismo e alterações do sono durante a pandemia de COVID-19 no Brasil, identificando os segmentos demográficos mais afetados. Métodos. Estudo transversal, com questionário aplicado via web a adultos e idosos, coletando informações sobre condições de vida, saúde e comportamentos de saúde. Foram estimadas prevalências e razões de prevalência ajustadas por idade e sexo. Resultados. Com dados de 45.161 respondentes, verificou-se que, durante a pandemia, 40,4% (IC95% 39,0; 41,8) dos brasileiros sentiram-se frequentemente tristes ou deprimidos e 52,6% (IC95% 51,2; 54,1) frequentemente ansiosos ou nervosos; 43,5% (IC95% 41,8; 45,3) relataram início de problemas de sono e 48,0% (IC95% 45,6; 50,5) problema de sono prévio agravado. A tristeza e o nervosismo frequentes e as alterações do sono estiveram mais presentes entre adultos jovens, mulheres e pessoas com antecedente de depressão. Conclusão. As elevadas prevalências encontradas indicam a necessidade de garantir a provisão de serviços de atenção à saúde mental e à qualidade do sono de forma adaptada ao contexto pandêmico

Mudanças nas condições socioeconômicas e de saúde dos brasileiros durante a pandemia de covid-19

Objective: To describe changes in socioeconomic and health conditions of Brazilians during the COVID-19 pandemic. Methodology: Cross-sectional study with data from a web-based behavioral survey data carried out from April 24 to May 24, 2020 with 45,161 participants recruited by chain sampling procedure. A descriptive analysis of the survey topics was performed: adherence to social restriction measures, diagnosis of the new coronavirus, work situation and income, difficulties in routine activities, presence of comorbidities, psychological issues, and access to health services. Prevalence and respective 95% confidence intervals were estimated. Results: Approximately 74% of Brazilians adhered to social restrictions. As for flu symptoms, 28.1% reported having at least one flu symptom, but only 5.9% underwent testing for covid-19. Regarding the socioeconomic impact, 55.1% reported a decrease in family income, and 7.0% were left without income; 25.8% of people lost their jobs, with the group of informal workers being the most affected (50.6%). As for health conditions, 29.4% reported worsening of health status; 45% having sleep problems; 40% frequently presented feelings of sadness and 52.5% of anxiety; 21.7% sought health care, and among them, 13.9% did not get care. Conclusion: The findings show the importance of controlling the covid-19 pandemic in Brazil, to mitigate the adverse effects on the socioeconomic and health conditions related to social restriction measures.Objetivo: Descrever as mudanças nas condições socioeconômicas e de saúde dos brasileiros durante a pandemia de covid-19. Metodologia: Estudo transversal com dados de pesquisa de comportamentos realizada pela internet de 24 de abril a 24 de maio, 2020 com 45.161 participantes recrutados por amostragem em cadeia. Foi realizada uma análise descritiva de temas abordados na pesquisa: adesão às medidas de restrição social, diagnóstico do novo coronavírus, situação de trabalho e rendimentos, dificuldades nas atividades de rotina, presença de comorbidades, estado de ânimo e acesso aos serviços de saúde. Foram estimadas as prevalências e intervalos de 95% de confiança. Resultados: Aproximadamente 74% dos brasileiros aderiram à restrição social. Quanto aos sintomas de gripe, 28,1% relatou ter apresentado algum sintoma, mas apenas 5,9% realizou teste para covid-19. Em relação à situação socioeconômica, 55,1% relataram diminuição do rendimento familiar, e 7,0% ficaram sem rendimento; 25,8% dos indivíduos ficaram sem trabalhar, sendo o grupo de trabalhadores informais o mais afetado (50,6%). Quanto às condições de saúde, 29,4% avaliaram que a sua saúde piorou; 45% tiveram problemas no sono, 40% apresentou, frequentemente, sentimento de tristeza e 52,5% de ansiedade/nervosismo; 21,7% procurou serviço de saúde, e, entre esses, 13,9% não conseguiu atendimento. Conclusão: Os achados mostram a importância do controle da pandemia de covid-19, no Brasil, para mitigar os efeitos adversos na situação socioeconômica e nas condições de saúde relacionados às medidas de restrição social

A pandemia da COVID-19 e as mudanças no estilo de vida dos brasileiros adultos: um estudo transversal, 2020

Objective. To describe the changes in lifestyles, regarding to the consumption of tobacco and alcohol, food intake and physical activity, in the period of social restriction resulting from the pandemic of the disease by the coronavirus 2019 (COVID-19). Methods. This is a cross-sectional study conducted in Brazil with data from the virtual health survey ConVid (Behavior Survey). Changes in lifestyles were analyzed. The data were expressed in relative frequencies and a 95% confidence interval. Results. 45,161 individuals aged 18 years or more participated. During the period of social restriction, a decrease in the practice of physical activity and an increase in time in front of screens, ingestion of ultra-processed foods, the number of cigarettes smoked and the consumption of alcoholic beverages were reported. Differences were observed according to sex and age group. Conclusion. The results indicate a worsening of lifestyles and an increase in health risk behaviors.Objetivo. Descrever as mudanças nos estilos de vida, quanto ao consumo de tabaco, álcool, alimentação e atividade física, no período de restrição social consequente à pandemia da COVID-19. Métodos. Estudo transversal realizado com dados do inquérito ConVid sobre comportamentos em saúde. Os dados foram coletados por meio de questionário online autopreenchido pelos participantes. Procedimentos de pós-estratificação foram empregados para o cálculo das prevalências e intervalos de confiança de 95%. Resultados. Participaram 45.161 indivíduos com 18 ou mais anos de idade. Durante o período de restrição social, foi relatada diminuição da prática de atividade física e aumento do tempo em frente a telas, da ingestão de alimentos ultraprocessados, do número de cigarros fumados e do consumo de bebidas alcóolicas. Foram observadas diferenças segundo sexo e faixa etária. Conclusão. Os resultados apontam uma piora dos estilos de vida e aumento de comportamentos de risco à saúde

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Background A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. Methods This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. Findings Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0–75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4–97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8–80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3–4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. Interpretation ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

BACKGROUND: A safe and efficacious vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), if deployed with high coverage, could contribute to the control of the COVID-19 pandemic. We evaluated the safety and efficacy of the ChAdOx1 nCoV-19 vaccine in a pooled interim analysis of four trials. METHODS: This analysis includes data from four ongoing blinded, randomised, controlled trials done across the UK, Brazil, and South Africa. Participants aged 18 years and older were randomly assigned (1:1) to ChAdOx1 nCoV-19 vaccine or control (meningococcal group A, C, W, and Y conjugate vaccine or saline). Participants in the ChAdOx1 nCoV-19 group received two doses containing 5 × 1010 viral particles (standard dose; SD/SD cohort); a subset in the UK trial received a half dose as their first dose (low dose) and a standard dose as their second dose (LD/SD cohort). The primary efficacy analysis included symptomatic COVID-19 in seronegative participants with a nucleic acid amplification test-positive swab more than 14 days after a second dose of vaccine. Participants were analysed according to treatment received, with data cutoff on Nov 4, 2020. Vaccine efficacy was calculated as 1 - relative risk derived from a robust Poisson regression model adjusted for age. Studies are registered at ISRCTN89951424 and ClinicalTrials.gov, NCT04324606, NCT04400838, and NCT04444674. FINDINGS: Between April 23 and Nov 4, 2020, 23 848 participants were enrolled and 11 636 participants (7548 in the UK, 4088 in Brazil) were included in the interim primary efficacy analysis. In participants who received two standard doses, vaccine efficacy was 62·1% (95% CI 41·0-75·7; 27 [0·6%] of 4440 in the ChAdOx1 nCoV-19 group vs71 [1·6%] of 4455 in the control group) and in participants who received a low dose followed by a standard dose, efficacy was 90·0% (67·4-97·0; three [0·2%] of 1367 vs 30 [2·2%] of 1374; pinteraction=0·010). Overall vaccine efficacy across both groups was 70·4% (95·8% CI 54·8-80·6; 30 [0·5%] of 5807 vs 101 [1·7%] of 5829). From 21 days after the first dose, there were ten cases hospitalised for COVID-19, all in the control arm; two were classified as severe COVID-19, including one death. There were 74 341 person-months of safety follow-up (median 3·4 months, IQR 1·3-4·8): 175 severe adverse events occurred in 168 participants, 84 events in the ChAdOx1 nCoV-19 group and 91 in the control group. Three events were classified as possibly related to a vaccine: one in the ChAdOx1 nCoV-19 group, one in the control group, and one in a participant who remains masked to group allocation. INTERPRETATION: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials. FUNDING: UK Research and Innovation, National Institutes for Health Research (NIHR), Coalition for Epidemic Preparedness Innovations, Bill & Melinda Gates Foundation, Lemann Foundation, Rede D'Or, Brava and Telles Foundation, NIHR Oxford Biomedical Research Centre, Thames Valley and South Midland's NIHR Clinical Research Network, and AstraZeneca