Vibrational Satellites of C2_2S, C3_3S, and C4_4S: Microwave Spectral Taxonomy as a Stepping Stone to the Millimeter-Wave Band

We present a microwave spectral taxonomy study of several hydrocarbon/CS$_2$ discharge mixtures in which more than 60 distinct chemical species, their more abundant isotopic species, and/or their vibrationally excited states were detected using chirped-pulse and cavity Fourier-transform microwave spectroscopies. Taken together, in excess of 85 unique variants were detected, including several new isotopic species and more than 25 new vibrationally excited states of C$_2$S, C$_3$S, and C$_4$S, which have been assigned on the basis of published vibration-rotation interaction constants for C$_3$S, or newly calculated ones for C$_2$S and C$_4$S. On the basis of these precise, low-frequency measurements, several vibrationally exited states of C$_2$S and C$_3$S were subsequently identified in archival millimeter-wave data in the 253--280 GHz frequency range, ultimately providing highly accurate catalogs for astronomical searches. As part of this work, formation pathways of the two smaller carbon-sulfur chains were investigated using $^{13}$C isotopic spectroscopy, as was their vibrational excitation. The present study illustrates the utility of microwave spectral taxonomy as a tool for complex mixture analysis, and as a powerful and convenient `stepping stone' to higher frequency measurements in the millimeter and submillimeter bands.Comment: Accepted in PCC

A Multi-Area Stochastic Model for a Covert Visual Search Task

Decisions typically comprise several elements. For example, attention must be directed towards specific objects, their identities recognized, and a choice made among alternatives. Pairs of competing accumulators and drift-diffusion processes provide good models of evidence integration in two-alternative perceptual choices, but more complex tasks requiring the coordination of attention and decision making involve multistage processing and multiple brain areas. Here we consider a task in which a target is located among distractors and its identity reported by lever release. The data comprise reaction times, accuracies, and single unit recordings from two monkeys’ lateral interparietal area (LIP) neurons. LIP firing rates distinguish between targets and distractors, exhibit stimulus set size effects, and show response-hemifield congruence effects. These data motivate our model, which uses coupled sets of leaky competing accumulators to represent processes hypothesized to occur in feature-selective areas and limb motor and pre-motor areas, together with the visual selection process occurring in LIP. Model simulations capture the electrophysiological and behavioral data, and fitted parameters suggest that different connection weights between LIP and the other cortical areas may account for the observed behavioral differences between the animals

QCD thermodynamics with two flavors of Wilson quarks at N_t=6

We report on a study of hadron thermodynamics with two flavors of Wilson quarks on 12^3x6 lattices. We have studied the crossover between the high and low temperature regimes for three values of the hopping parameter, kappa=0.16, 0.17, and 0.18. At each of these values of kappa we have carried out spectrum calculations on 12^3x24 lattices for two values of the gauge coupling in the vicinity of the crossover in order to set an energy scale for our thermodynamics calculations and to determine the critical value of the gauge coupling for which the pion and quark masses vanish. For kappa=0.17 and 0.18 we find coexistence between the high and low temperature regimes over 1,000 simulation time units indicating either that the equilibration time is extremely long or that there is a possibility of a first order phase transition. The pion mass is large at the crossover values of the gauge coupling, but the crossover curve has moved closer to the critical curve along which the pion and quark masses vanish, than it was on lattices with four time slices. In addition, values of the dimensionless quantity T_c/m_rho are in closer agreement with those for staggered quarks than was the case at N_t=4. (A POSTSCRIPT VERSION OF THIS PAPER IS AVAILABLE BY ANONYMOUS FTP FROM sarek.physics.ucsb.edu (128.111.8.250) IN THE FILE pub/wilson_thermo.ps)Comment: 24 page

A Laboratory Study of C_3H^+ and the C_3H Radical in Three New Vibrationally Excited ^2Σ States Using a Pin-Hole Nozzle Discharge Source

Rotational lines of the positive molecular ion C_3H^+ and of the neutral C_3H radical in three new vibrationally excited states with ^2Σ symmetry have been detected in a supersonic molecular beam in the centimeter-wave band. The fundamental rotational line of the ion is quite weak, but is observed with similar intensity in a dc discharge through several different hydrocarbon gases when helium is the buffer gas. Under these conditions, the fractional abundance of C_3H^+ relative to C_3H is estimated to be of order 10^(−4), i.e., toward the lower end of the ratio (10^(−3)–10^(−4)) found for protonated ions using the same discharge nozzle. For each new ^2Σ state of the C_3H radical, spectroscopic constants, including those describing hydrogen hyperfine structure, have been determined to high precision. Lines of one ^2Σ state (B = 11271 MHz) are particularly intense in our molecular beam; for this state and a second one (B = 11306 MHz), millimeter-wave transitions have also been observed between 180 and 340 GHz using a long path dc glow absorption spectrometer. On the basis of intensity measurements with this spectrometer, the inferred rotation–vibration constant α, and theoretical calculations, the state with B = 11271 MHz is tentatively assigned to the ν_5 bending mode, predicted to lie ~300 cm^(−1) above ground

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes.

Low-dose antithymocyte globulin (ATG) plus pegylated granulocyte colony-stimulating factor (G-CSF) preserves β-cell function for at least 12 months in type 1 diabetes. Herein, we describe metabolic and immunological parameters 24 months following treatment. Patients with established type 1 diabetes (duration 4-24 months) were randomized to ATG and pegylated G-CSF (ATG+G-CSF) (N = 17) or placebo (N = 8). Primary outcomes included C-peptide area under the curve (AUC) following a mixed-meal tolerance test (MMTT) and flow cytometry. "Responders" (12-month C-peptide ≥ baseline), "super responders" (24-month C-peptide ≥ baseline), and "nonresponders" (12-month C-peptide < baseline) were evaluated for biomarkers of outcome. At 24 months, MMTT-stimulated AUC C-peptide was not significantly different in ATG+G-CSF (0.49 nmol/L/min) versus placebo (0.29 nmol/L/min). Subjects treated with ATG+G-CSF demonstrated reduced CD4+ T cells and CD4+/CD8+ T-cell ratio and increased CD16+CD56hi natural killer cells (NK), CD4+ effector memory T cells (Tem), CD4+PD-1+ central memory T cells (Tcm), Tcm PD-1 expression, and neutrophils. FOXP3+Helios+ regulatory T cells (Treg) were elevated in ATG+G-CSF subjects at 6, 12, and 18 but not 24 months. Immunophenotyping identified differential HLA-DR expression on monocytes and NK and altered CXCR3 and PD-1 expression on T-cell subsets. As such, a group of metabolic and immunological responders was identified. A phase II study of ATG+G-CSF in patients with new-onset type 1 diabetes is ongoing and may support ATG+G-CSF as a prevention strategy in high-risk subjects

Hadron Spectrum in QCD with Valence Wilson Fermions and Dynamical Staggered Fermions at $6/g^2=5.6

We present an analysis of hadronic spectroscopy for Wilson valence quarks with dynamical staggered fermions at lattice coupling $6/g^2 = \beta=5.6$ at sea quark mass $am_q=0.01$ and 0.025, and of Wilson valence quarks in quenched approximation at $\beta=5.85$ and 5.95, both on $16^3 \times 32$ lattices. We make comparisons with our previous results with dynamical staggered fermions at the same parameter values but on $16^4$ lattices doubled in the temporal direction.Comment: 32 page

Field strength correlators in full QCD

We study, by numerical simulations on a lattice, the behaviour of the gauge-invariant two-point correlation functions of the gauge field strengths in the QCD vacuum with dynamical fermions.Comment: 11 pages, LaTeX file, + 2 PS figure

Initial Virological and Immunologic Response to Highly Active Antiretroviral Therapy Predicts Long-Term Clinical Outcome

Little is known about the long-term clinical outcomes for human immunodeficiency virus (HIV)-infected patients who have received highly active antiretroviral therapy (HAART). Determining factors associated with long-term clinical outcomes early in the course of treatment may allow modifications to be made for patients who are at a greater risk of treatment failure. To evaluate these factors, we studied 213 HIV-infected patients who had received HAART for at least 115 weeks. In the univariate analysis, virological response, which was measured as the change in virus load from baseline at month 3 of treatment, was the single best predictor of clinical outcome (relative hazard, 0.722; P = .001), independent of virological suppression. In the multivariate analysis, virological response and immunologic response, which was measured as an increase in CD4 cell count of >200 cells/mm^3, resulted in better prediction of clinical outcomes than did use of either variable alone (P = .02). Our results indicate that changes in virus load and immunologic response together are good predictors of clinical outcome and can be assessed after the initiation of HAART, which would allow clinicians to identify patients early in the course of therapy who are at greater risk of negative outcome

ROTATIONAL SPECTRA OF THE MOLECULAR IONS H2_2NCO+^+ AND NCO−^-

Author Institution: Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138, and School of Engineering and Applied Science, Harvard University, Cambridge, MA 02138; Max-Planck-Institut fur Radioastronomie, Bonn, Germany, and I. Physikalisches Institut, Universitat zu Koln, GermanyWe report the first high resolution spectroscopic detection of H$_2$NCO$^+$, the protonated cation of isocyanic acid, in a discharge through HNCO heavily diluted in hydrogen in the throat of a supersonic nozzle. Spectroscopic constants derived from the two lowest rotational transitions agree very well with theoretical structure calculations of the ground state isomer, in which protonation occurs at the nitrogen atom, yielding an isomer of C$_{2v}$ symmetry. In the same molecular beam, the fundamental rotational transition of NCO$^-$ was observed with well-resolved nitrogen quadrupole hyperfine structure. Detection of NCO$^-$ in our beam was subsequently confirmed by observation of several millimeter-wave transitions in a low pressure discharge through cyanogen and water. The spectroscopic constants of NCO$^-$ obtained earlier by infrared laser spectroscopy nderline{\textbf{86}}, 6631, (1987).} are in good agreement with the highly accurate constants derived here. Owing to the high abundance of HNCO in many galactic molecular sources, both ions are excellent candidates for astronomical detection in the radio band. %The rotational spectrum of H$_2$NCO$^+$ has been recently detected in a supersonic molecular beam. through the discharge of isocyanic acid heavily diluted in a hydrogen expansion. Under the same experimental conditions, the fundamental rotational transition of NCO$^-$ has also been observed, showing the expected hyperfine structure from the presence of the nitrogen nucleus. The laboratory search has been guided by high level quantum chemical calculations and the rotational constant derived by infrared laser spectroscopy nderline{\textbf{86}}(12), 6631 June 1987.} for the anion. Due to the high abundance of HNCO in several interstellar medium regions, these two molecular ions represent serious candidates for detection through radio-astronomical techniques. %By means of high resolution microwave techniques, the spectra of NCO$^-$ and H$_2$NCO$^+$ has been recently detected. The laboratory search of the cation has been guided by theoretical structure calculations performed at the CCSD(T)/cc-pwCVQZ level of theory corrected for zero-point vibrational effects at the CCSD(T)/cc-pVQZ level. The anion search has been based on the rotational constant derived by infrared laser spectroscopy nderline{\textbf{86}}(12), 6631 June 1987.} and the nitrogen quadrupole coupling constant calculated at the CCSD(T)/aug-cc-pwCVQZ level of theory. Both species have produced using isocyanic acid heavily diluted in a hydrogen expansion. The spectrum of both ions shows expected hyperfine structure from the presence of the nitrogen nucleus, providing a crucial confirmation of the discovery. Due to the large and ubiquitous presence of isocyanic acid in several interstellar medium regions, these two molecular ions represent serious candidates for detection through radio-astronomical techniques