The influence of date of flowering on certain seed and fiber properties of pope cotton

This study was undertaken to investigate the effect of date of flowering with subsequent attendant environmental conditions on certain seed and fiber properties

Evaluation of Multitask Feature in Storage and Virtualization

Nowadays all the computing devices manufactured come with high computational power and storage. But these resources are never utilized to its maximum potential. Hence virtualization is at most important in all the components of a computing device. Simultaneously tasks can be processed using such resources which means multitasking can be done. Here only storage and virtualization are considered for evaluating the feature of multitasking. Hypervisors play an important role in managing efficiently the compute resources. Virtualization has become the most developing technology. Terms virtualization and multitasking can be used alternatively

Angular distributions of protons scattered by 40 Ar nuclei with excitation of the 2 + (1.46 MeV) and 3 − (3.68 MeV) collective levels for incident energies of 25.1, 32.5, and 40.7 MeV

Elastic and inelastic scattering of unpolarized and polarized protons by 40Ar nuclei for incident energies between 20 and 50 MeV has been studied by reanalyzing experimental scattering spectra for the 2+(1.46 MeV) and 3-(3.68 MeV) levels in the angular range 30º–160º for incident protons of energies of 25.1, 32.5, and 40.7 MeV. An isospin dependent soft-rotator coupled-channels optical model with the potential containing a dispersive term with a nonlocal contribution is used to analyze the data

Particularized protection: UNSC mandates and the protection of civilians in armed conflict

The protection of civilians at risk in armed conflict has, since the late 1990s, become institutionalized at the United Nations (UN), gaining acceptance as a normative rationale for UN peacekeeping. However, the bulk of civilians in need of protection in armed conflict are unlikely to attain it. The article develops an argument on ‘particularized protection’ - particularized in that UN Security Council (SC) mandates are formulated and adjusted over time to direct mission protection to specific subsets of civilian populations, that is, those relevant to the UN itself, the host state, other states, NGOs and the media, leaving most local civilians receiving little effective protection. Particularized protection, we argue, is a result of the institutional dynamics involving actors producing mandates - the UNSC - and those providing protection - peacekeeping missions - whereby mandates are specified to direct mission protection to selected, particularized groups. We demonstrate these dynamics in two cases, Côte d’Ivoire and Somalia

A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies

Microtubule severing enzymes implement a diverse range of tissue-specific molecular functions throughout development and into adulthood. Although microtubule severing is fundamental to many dynamic neural processes, little is known regarding the role of the family member Katanin p60 subunit A-like 1, KATNAL1, in central nervous system (CNS) function. Recent studies reporting that microdeletions incorporating the KATNAL1 locus in humans result in intellectual disability and microcephaly suggest that KATNAL1 may play a prominent role in the CNS; however, such associations lack the functional data required to highlight potential mechanisms which link the gene to disease symptoms. Here we identify and characterise a mouse line carrying a loss of function allele in Katnal1. We show that mutants express behavioural deficits including in circadian rhythms, sleep, anxiety and learning/memory. Furthermore, in the brains of Katnal1 mutant mice we reveal numerous morphological abnormalities and defects in neuronal migration and morphology. Furthermore we demonstrate defects in the motile cilia of the ventricular ependymal cells of mutants, suggesting a role for Katnal1 in the development of ciliary function. We believe the data we present here are the first to associate KATNAL1 with such phenotypes, demonstrating that the protein plays keys roles in a number of processes integral to the development of neuronal function and behaviour.Molecular Psychiatry advance online publication, 4 April 2017; doi:10.1038/mp.2017.54

Loss of PTB or Negative Regulation of Notch mRNA Reveals Distinct Zones of Notch and Actin Protein Accumulation in Drosophila Embryo

Polypyrimidine Tract Binding (PTB) protein is a regulator of mRNA processing and translation. Genetic screens and studies of wing and bristle development during the post-embryonic stages of Drosophila suggest that it is a negative regulator of the Notch pathway. How PTB regulates the Notch pathway is unknown. Our studies of Drosophila embryogenesis indicate that (1) the Notch mRNA is a potential target of PTB, (2) PTB and Notch functions in the dorso-lateral regions of the Drosophila embryo are linked to actin regulation but not their functions in the ventral region, and (3) the actin-related Notch activity in the dorso-lateral regions might require a Notch activity at or near the cell surface that is different from the nuclear Notch activity involved in cell fate specification in the ventral region. These data raise the possibility that the Drosophila embryo is divided into zones of different PTB and Notch activities based on whether or not they are linked to actin regulation. They also provide clues to the almost forgotten role of Notch in cell adhesion and reveal a role for the Notch pathway in cell fusions

Systematic evaluation of immune regulation and modulation

Cancer immunotherapies are showing promising clinical results in a variety of malignancies. Monitoring the immune as well as the tumor response following these therapies has led to significant advancements in the field. Moreover, the identification and assessment of both predictive and prognostic biomarkers has become a key component to advancing these therapies. Thus, it is critical to develop systematic approaches to monitor the immune response and to interpret the data obtained from these assays. In order to address these issues and make recommendations to the field, the Society for Immunotherapy of Cancer reconvened the Immune Biomarkers Task Force. As a part of this Task Force, Working Group 3 (WG3) consisting of multidisciplinary experts from industry, academia, and government focused on the systematic assessment of immune regulation and modulation. In this review, the tumor microenvironment, microbiome, bone marrow, and adoptively transferred T cells will be used as examples to discuss the type and timing of sample collection. In addition, potential types of measurements, assays, and analyses will be discussed for each sample. Specifically, these recommendations will focus on the unique collection and assay requirements for the analysis of various samples as well as the high-throughput assays to evaluate potential biomarkers

NEOGENE-RECENT SEDIMENTATION AND DEVELOPMENT OF THE ADANACILICIAN BASIN

The Adana-Cilician basin formed by interaction between the African, Arabian, and Anatolian plates. The basin has been filled asymmetrically from the north and northeast with the northeastern extremity having been completely filled to form the Adana basin beneath the plain of the Seyhan delta. There is no direct borehole evidence from the submarine areas, but coastal boreholes have revealed the presence of at least 6 km of Neogene sediment. The Burdigalian-Serravalian interval is dominated by turbidites and deep-water shales in the center of the Adana basin, with shallow-water clastics and carbonates around the margins. A layer of Messinian evaporite appears to underlie much of the basin. The Serravalian-Pleistocene sedimentation was dominated by shallow marine and terrestrial sedimentation in the Adana basin, the only part known. Today, the Turkish rivers have built up several deltaic complexes. Quaternary sea level and climatic changes and the movement of river mouths have complicated the pattern of shelf sediments. Away from the immediate vicinity of river mouths, the sediments are rich in the remains of macrobenthos and microbenthos, and on tectonically controlled highs coralline algal mounds occur. The sediments of the deeper water areas (/approx/ 1,000 m) show evidence of downslope movement of shelf sediments and anoxic periods, and they contain an impoverished molluscan and foraminiferal fauna. Sediment dispersal appears to have been confined by submarine tectonic barriers. Continuous uplift and faulting along some margins together with flow of evaporites away from the depocenters on the Turkish coast appear to be actively affecting the most recently deposited sediments