Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses.

Decades of behavioral science research have documented functional shifts in attitudes and ideological adherence in response to various challenges, but little work to date has illuminated the neural mechanisms underlying these dynamics. This paper describes how continuous theta burst transcranial magnetic stimulation may be employed to experimentally assess the causal contribution of cortical regions to threat-related ideological shifts. In the example protocol provided here, participants are exposed to a threat prime-an explicit reminder of their own inevitable death and bodily decomposition-following a downregulation of the posterior medial frontal cortex (pMFC) or a sham stimulation. Next, disguised within a series of distracter tasks, participants' relative degree of ideological adherence is assessed-in the present example, with regard to coalitional prejudice and religious belief. Participants for whom the pMFC has been downregulated exhibit less coalitionally biased responses to an immigrant critical of the participants' national in-group, and less conviction in positive afterlife beliefs (i.e., God, angels, and heaven), despite having recently been reminded of death. These results complement prior findings that continuous theta burst stimulation of the pMFC influences social conformity and sharing and illustrate the feasibility of investigating the neural basis of high-level social cognitive shifts using transcranial magnetic stimulation

Hidden in plain sight: a massive, dusty starburst in a galaxy protocluster at z=5.7 in the COSMOS field

We report the serendipitous discovery of a dusty, starbursting galaxy at $z=5.667$ (hereafter called CRLE) in close physical association with the "normal" main-sequence galaxy HZ10 at $z=5.654$. CRLE was identified by detection of [CII], [NII] and CO(2-1) line emission, making it the highest redshift, most luminous starburst in the COSMOS field. This massive, dusty galaxy appears to be forming stars at a rate of at least 1500$\,M_\odot$ yr$^{-1}$ in a compact region only $\sim3$ kpc in diameter. The dynamical and dust emission properties of CRLE suggest an ongoing merger driving the starburst, in a potentially intermediate stage relative to other known dusty galaxies at the same epoch. The ratio of [CII] to [NII] may suggest that an important ($\sim15\%$) contribution to the [CII] emission comes from a diffuse ionized gas component, which could be more extended than the dense, starbursting gas. CRLE appears to be located in a significant galaxy overdensity at the same redshift, potentially associated with a large-scale cosmic structure recently identified in a Lyman Alpha Emitter survey. This overdensity suggests that CRLE and HZ10 reside in a protocluster environment, offering the tantalizing opportunity to study the effect of a massive starburst on protocluster star formation. Our findings support the interpretation that a significant fraction of the earliest galaxy formation may occur from the inside out, within the central regions of the most massive halos, while rapidly evolving into the massive galaxy clusters observed in the local Universe.Comment: 16 pages, 9 figures, 4 tables, final version to appear on ApJ (accepted May 19, 2018

Multimodal Music Perception Engages Motor Prediction: A TMS Study

Corticospinal excitability (CSE) in humans measured with Transcranial Magnetic Stimulation (TMS) is generally increased by the perception of other people’s actions. This perception can be unimodal (visual or auditory) or multimodal (visual and auditory). The increase in TMS-measured CSE is typically prominent for muscles involved in the perceived action (muscle specificity). There are two main classes of accounts for this phenomenon. One suggests that the motor system mirrors the actions that the observer perceives (the resonance account). The other suggests that the motor system predicts the actions that the observer perceives (the predictive account). To test these accounts (which need not be mutually exclusive), subjects were presented with four versions of three-note piano sequences: sound only, sight only, audiovisual, and audiovisual with sound lagging behind (the prediction violation condition). CSE was measured in two hand muscles used to play the notes. CSE increased reliably in one muscle only for the prediction violation condition, in line with the predictive account, while the other muscle demonstrated CSE increase for all conditions, in line with the resonance account. This finding supports both predictive coding accounts as well as resonance accounts of motor facilitation during action perception

Language processing skills linked to FMR1 variation: A study of gaze-language coordination during rapid automatized naming among women with the FMR1 premutation

This work is licensed under a Creative Commons Attribution 4.0 International License.The FMR1 premutation (PM) is relatively common in the general population. Evidence suggests that PM carriers may exhibit subtle differences in specific cognitive and language abilities. This study examined potential mechanisms underlying such differences through the study of gaze and language coordination during a language processing task (rapid automatized naming; RAN) among female carriers of the FMR1 PM. RAN taps a complex set of underlying neuropsychological mechanisms, with breakdowns implicating processing disruptions in fundamental skills that support higher order language and executive functions, making RAN (and analysis of gaze/language coordination during RAN) a potentially powerful paradigm for revealing the phenotypic expression of the FMR1 PM. Forty-eight PM carriers and 56 controls completed RAN on an eye tracker, where they serially named arrays of numbers, letters, colors, and objects. Findings revealed a pattern of inefficient language processing in the PM group, including a greater number of eye fixations (namely, visual regressions) and reduced eye-voice span (i.e., the eyes’ lead over the voice) relative to controls. Differences were driven by performance in the latter half of the RAN arrays, when working memory and processing load are the greatest, implicating executive skills. RAN deficits were associated with broader social-communicative difficulties among PM carriers, and with FMR1-related molecular genetic variation (higher CGG repeat length, lower activation ratio, and increased levels of the fragile X mental retardation protein; FMRP). Findings contribute to an understanding of the neurocognitive profile of PM carriers and indicate specific gene-behavior associations that implicate the role of the FMR1 gene in language-related processes.NIH R01DC010191NIH R01MH091131NIH P30 HD0311

Making Room for Zoom in Focus Group Methods: Opportunities and Challenges for Novice Researchers (During and Beyond COVID-19)

Als die COVID-19-Pandemie über die Welt hereinbrach, waren viele Menschen gezwungen, sich auf online-basierte Routinen einzustellen, darunter auch qualitative Forscher*innen, die nach alternativen Möglichkeiten zur Erhebung aussagekräftiger Daten suchten. Während Fokusgruppen traditionell Face to Face durchgeführt werden, bieten Fortschritte bei Online-Videokonferenzanwendungen neue Methoden zur Datenerhebung, die jedoch bisher nur selten untersucht wurden. In diesem Artikel berichten wir über die Erfahrungen von 12 Doktorand*innen mit der Durchführung von Fokusgruppen unter Verwendung von Zoom im Rahmen eines Kurses zu qualitativen Interviewmethoden. Wir reflektieren Chancen und Herausforderungen, die wir als Moderator*innen und Teilnehmer*innen bei der Nutzung von Zoom erlebten z.B. bei der Vorbereitung oder in Bezug auf Rapport, die Einbindung anderer digitaler Tools und von Internetverbindungen. Zusammenfassend lässt sich sagen, dass die Durchführung von Online-Fokusgruppen unter Verwendung von Zoom insgesamt eine positive Erfahrung war und mit Face-to-Face-Fokusgruppen vergleichbar ist. Möglichkeiten der Teilnehmer*innenrekrutierung, die Sicherheitsmerkmale von Zoom und die Nutzung von Zoom und allgemeiner neuen Technologien sollten auch jenseits der Pandemie weiter erforscht werden.As the COVID-19 pandemic swept through the world, it forced many people to adapt to an online-based routine, including qualitative researchers looking for alternative ways to collect meaningful data. While focus groups are traditionally conducted in-person, advances with online videoconferencing applications present a new method to collect data, however, few studies have explored this. In this article we present 12 doctoral students' experiences with conducting focus groups using the videoconferencing application Zoom during a qualitative methods course on interviewing methods. Through this self-study qualitative analysis, participants reflected on the opportunities and challenges experienced as both moderators and participants using Zoom including: preparation, rapport, incorporating other digital tools, and internet connectivity. In conclusion, doing focus groups online using Zoom was a positive experience overall and comparable to in-person focus groups for collecting qualitative data, despite the introduction of technology. More research on participant recruitment, new technology, Zoom's security features, and Zoom's use outside of a pandemic should be further explored

ALMA Reveals Weak [N II] Emission in "Typical" Galaxies and Intense Starbursts at z = 5–6

We report interferometric measurements of [N II] 205 μm fine-structure line emission from a representative sample of three galaxies at z = 5–6 using the Atacama Large (sub)Millimeter Array (ALMA). These galaxies were previously detected in [C II] and far-infrared continuum emission and span almost two orders of magnitude in star formation rate (SFR). Our results show at least two different regimes of ionized interstellar medium properties for galaxies in the first billion years of cosmic time, separated by their L_([C II])/L_([N II]) ratio. We find extremely low [N II] emission compared to [C II] (L_([C II])/L_([N II]) = 68^(+200)_(-28)) from a "typical" ~L_*(UV) star-forming galaxy, likely directly or indirectly (by its effect on the radiation field) related to low dust abundance and low metallicity. The infrared-luminous modestly star-forming Lyman-break galaxy (LBG) in our sample is characterized by an ionized-gas fraction (L_([C II])/L_([N II]) ≾ 20) typical of local star-forming galaxies and shows evidence for spatial variations in its ionized-gas fraction across an extended gas reservoir. The extreme SFR, warm and compact dusty starburst AzTEC-3 shows an ionized fraction higher than expected given its SFR surface density (L_([C II])/L_([N II]) = 22 ± 8) suggesting that [N II] dominantly traces a diffuse ionized medium rather than star-forming H II regions in this type of galaxy. This highest redshift sample of [N II] detections provides some of the first constraints on ionized and neutral gas modeling attempts and on the structure of the interstellar medium at z = 5–6 in "normal" galaxies and starbursts

Hidden in Plain Sight: A Massive, Dusty Starburst in a Galaxy Protocluster at z = 5.7 in the COSMOS Field

We report the serendipitous discovery of a dusty, starbursting galaxy at z = 5.667 (hereafter called CRLE) in close physical association with the "normal" main-sequence galaxy HZ10 at z = 5.654. CRLE was identified by detection of [C II], [N II], and CO(2–1) line emission, making it the highest-redshift, most luminous starburst in the COSMOS field. This massive, dusty galaxy appears to be forming stars at a rate of at least 1500 M⊙ yr^(−1) in a compact region only ~3 kpc in diameter. The dynamical and dust emission properties of CRLE suggest an ongoing merger driving the starburst, which is in a potentially intermediate stage relative to other known dusty galaxies at the same epoch. The ratio of [C II] to [N II] may suggest that an important (~15%) contribution to the [C II] emission comes from a diffuse ionized gas component, which could be more extended than the dense, starbursting gas. CRLE appears to be located in a significant galaxy overdensity at the same redshift, potentially associated with a large-scale cosmic structure recently identified in a Lyman α-emitter survey. This overdensity suggests that CRLE and HZ10 reside in a protocluster environment, offering the tantalizing opportunity to study the effect of a massive starburst on protocluster star formation. Our findings support the interpretation that a significant fraction of the earliest galaxy formation may occur from the inside out, within the central regions of the most massive halos, while rapidly evolving into the massive galaxy clusters observed in the local universe