Comunicación efectiva y su influencia en la satisfacción del cliente en la empresa Data Tools S.A, Callao, año 2018

El objetivo de la investigación fue determinar la influencia de la Comunicación efectiva en la satisfacción del cliente en la empresa Data Tools S.A, Callao, año 2018. La investigación fue básica, hipotético-deductivo, del tipo descriptivo, correlacional - causal, con diseño no experimental, transversal; la muestra fue igual a la población, siendo un total de 50 clientes. Se aplicó la encuesta de 20 preguntas de tipo Likert, asimismo los resultados se procesaron con el programa estadístico SPSS 24. Los resultados de la investigación, se realizaron mediante el análisis descriptivo de las variables y dimensiones, el análisis inferencial para conocer el nivel de correlación mediante la prueba de Rho de spearman. También se realizó la prueba de influencia, con la cual se llegó a la conclusión que si existe influencia significativa de la Comunicación efectiva en la satisfacción del cliente en la empresa Data Tools S.A, en la provincia constitucional del callao, año 2018

ECMO for COVID-19 patients in Europe and Israel

Since March 15th, 2020, 177 centres from Europe and Israel have joined the study, routinely reporting on the ECMO support they provide to COVID-19 patients. The mean annual number of cases treated with ECMO in the participating centres before the pandemic (2019) was 55. The number of COVID-19 patients has increased rapidly each week reaching 1531 treated patients as of September 14th. The greatest number of cases has been reported from France (n = 385), UK (n = 193), Germany (n = 176), Spain (n = 166), and Italy (n = 136) .The mean age of treated patients was 52.6 years (range 16–80), 79% were male. The ECMO configuration used was VV in 91% of cases, VA in 5% and other in 4%. The mean PaO2 before ECMO implantation was 65 mmHg. The mean duration of ECMO support thus far has been 18 days and the mean ICU length of stay of these patients was 33 days. As of the 14th September, overall 841 patients have been weaned from ECMO support, 601 died during ECMO support, 71 died after withdrawal of ECMO, 79 are still receiving ECMO support and for 10 patients status n.a. . Our preliminary data suggest that patients placed on ECMO with severe refractory respiratory or cardiac failure secondary to COVID-19 have a reasonable (55%) chance of survival. Further extensive data analysis is expected to provide invaluable information on the demographics, severity of illness, indications and different ECMO management strategies in these patients

Comunicación efectiva y su influencia en la satisfacción del cliente en la empresa Data Tools S.A, Callao, año 2018

El objetivo de la investigación fue determinar la influencia de la Comunicación efectiva en la satisfacción del cliente en la empresa Data Tools S.A, Callao, año 2018. La investigación fue básica, hipotético-deductivo, del tipo descriptivo, correlacional - causal, con diseño no experimental, transversal; la muestra fue igual a la población, siendo un total de 50 clientes. Se aplicó la encuesta de 20 preguntas de tipo Likert, asimismo los resultados se procesaron con el programa estadístico SPSS 24. Los resultados de la investigación, se realizaron mediante el análisis descriptivo de las variables y dimensiones, el análisis inferencial para conocer el nivel de correlación mediante la prueba de Rho de spearman. También se realizó la prueba de influencia, con la cual se llegó a la conclusión que si existe influencia significativa de la Comunicación efectiva en la satisfacción del cliente en la empresa Data Tools S.A, en la provincia constitucional del callao, año 2018

Quantifying memory in spin glasses

10 pages, 8 figuresRejuvenation and memory, long considered the distinguishing features of spin glasses, have recently been proven to result from the growth of multiple length scales. This insight, enabled by simulations on the Janus~II supercomputer, has opened the door to a quantitative analysis. We combine numerical simulations with comparable experiments to introduce two coefficients that quantify memory. A third coefficient has been recently presented by Freedberg et al. We show that these coefficients are physically equivalent by studying their temperature and waiting-time dependence

Quantifying memory in spin glasses

10 pages, 8 figuresRejuvenation and memory, long considered the distinguishing features of spin glasses, have recently been proven to result from the growth of multiple length scales. This insight, enabled by simulations on the Janus~II supercomputer, has opened the door to a quantitative analysis. We combine numerical simulations with comparable experiments to introduce two coefficients that quantify memory. A third coefficient has been recently presented by Freedberg et al. We show that these coefficients are physically equivalent by studying their temperature and waiting-time dependence

Superposition principle and nonlinear response in spin glasses

International audienceThe extended principle of superposition has been a touchstone of spin-glass dynamics for almost 30 years. The Uppsala group has demonstrated its validity for the metallic spin glass, CuMn, for magnetic fields H up to 10 Oe at the reduced temperature Tr=T/Tg=0.95, where Tg is the spin-glass condensation temperature. For H>10 Oe, they observe a departure from linear response which they ascribe to the development of nonlinear dynamics. The thrust of this paper is to develop a microscopic origin for this behavior by focusing on the time development of the spin-glass correlation length, ξ(t,tw;H). Here, t is the time after H changes, and tw is the time from the quench for T>Tg to the working temperature T until H changes. We connect the growth of ξ(t,tw;H) to the barrier heights Δ(tw) that set the dynamics. The effect of H on the magnitude of Δ(tw) is responsible for affecting differently the two dynamical protocols associated with turning H off (TRM, or thermoremanent magnetization) or on (ZFC, or zero-field-cooled magnetization). This difference is a consequence of nonlinearity based on the effect of H on Δ(tw). Superposition is preserved if Δ(tw) is linear in the Hamming distance Hd (proportional to the difference between the self-overlap qEA and the overlap q[Δ(tw)]). However, superposition is violated if Δ(tw) increases faster than linear in Hd. We have previously shown, through experiment and simulation, that the barriers Δ(tw) do increase more rapidly than linearly with Hd through the observation that the growth of ξ(t,tw;H) slows down as ξ(t,tw;H) increases. In this paper, we display the difference between the zero-field-cooled ξZFC(t,tw;H) and the thermoremanent magnetization ξTRM(t,tw;H) correlation lengths as H increases, both experimentally and through numerical simulations, corresponding to the violation of the extended principle of superposition in line with the finding of the Uppsala Group

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

International audienceThe posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is SUMOylated in the tumor sections of patients with hepatocellular carcinoma in contrast to the surrounding tissue, as well as in human cell line and mouse models of the disease. SUMOylation of HuR promotes major cancer hallmarks, namely proliferation and invasion, whereas the absence of HuR SUMOylation results in a senescent phenotype with dysfunctional mitochondria and endoplasmic reticulum. Mechanistically, SUMOylation induces a structural rearrangement of the RNA recognition motifs that modulates HuR binding affinity to its target RNAs, further modifying the transcriptomic profile toward hepatic tumor progression. Overall, SUMOylation constitutes a mechanism of HuR regulation that could be potentially exploited as a therapeutic strategy for liver cancer