RNA content in spinal cord motoneurons during hypokinesia

The effect of a diminished motor activity of rats upon the ribonucleic and (RNA) content in a single isolated motoneuron of frontal of their spinal cord was studied. Within a 1 to 30 day exposure of rats to the hypokinetic conditions, RNA content was found to decrease on the 1st, 3rd, and 5th day and to return to the initial level by the 7th day. No changes in RNA content were observed during the subsequent stages of the xperiments. The volume of the nerve cells declined on the 3rd and 5th day, whereas RNA concentration reduced on the 1st, 3rd, 5th, and 30th day

Effect of restricted mobility on RNA content and nucleotide composition and on protein content in motoneurons of spinal cord anterior horns

An investigation into the effect of hypokinesia on the ribonucleic acid (RNA) content, the nucleotide composition, and dynamics of protein content in the motoneuron of the rat spinal cord anterior horns is described. Methodology and findings are presented. The study results showed that the nucleotide composition of the total cellular RNA at all the studied periods of hypokinesia remained unchanged and is characteristic for the cytoplasmic, high polymer ribosomal RNA. This means that with a change in the functional state of the neuron the newly formed RNA of the nerve cell has the same composition of bases as the original RNA that belongs to the ribosomal type

Management of food cold chains traceability amid the COVID-19 pandemic

The present article considers the functioning of food supply chains and their major component — a continuous cold chain of perishable food products, including meat products, under the conditions of COVID‑19 pandemic. The issues of the impact of the pandemic on production, processing and commercial supply of meat and meat products in Russia and worldwide are being considered. The traceability of temperature fluctuations in meat processing plants is relevant; it becomes an increasingly important factor for efficient logistics to provide the best supply and to keep the food safe in the current conditions. Research data is presented here. The results of the research show that frozen foods serve as carriers and distributors of SARS-CoV‑2 infection without any contact between people. This conclusion highlights additional challenges in controlling the spread of COVID‑19 worldwide, and reveals the mechanism of the disease transmission, taking into account the peculiarities of temperature modes during storage and transportation of perishable meat products. The risks of food cold chains functioning under the conditions of pandemic, the adaptive strategies for their mitigation and logistical systems of tracking are considered, in particular, the application of various data technologies

Career guidance and professional mobility оf the highly skilled worker

The approaches to career-oriented work in different countries in terms of professional mobility of workers in today's economyРассмотрены подходы к профориентационной работе в разных странах с точки зрения обеспечения профессиональной мобильности рабочего в современных экономических условия

Trabajo creativo musical en computadora en el sistema de educación vocacional inicial ruso

The development of new music technologies necessitates changes in the content of music education. Musical pedagogy is faced with the task of educating creative musicians who are capable of innovative activities and inventive musical thinking. Therefore, primary music education should introduce creative learning technologies aimed at developing students’ creative abilities. This article analyzes the content of students’ musical and creative activities in the field of music computer technologies (MCT) illustrated by the subject “Computer Music Creative Work.” The theoretical and experimental study led us to conclude that this course not only develops creative abilities but also establishes conditions for the comprehensive and harmonious development of students’ personalities.El desarrollo de nuevas tecnologías musicales requiere cambios en el contenido de la educación musical. La pedagogía musical se enfrenta a la tarea de educar a músicos creativos que sean capaces de actividades innovadoras y pensamiento musical inventivo. Por lo tanto, la educación musical primaria debe introducir tecnologías de aprendizaje creativo destinadas a desarrollar las habilidades creativas de los estudiantes. Este artículo analiza el contenido de las actividades musicales y creativas de los estudiantes en el campo de las tecnologías informáticas de música (MCT) ilustradas por el tema “Trabajo creativo de música de computadora”. El estudio teórico y experimental nos llevó a concluir que este curso no solo desarrolla habilidades creativas sino que también establece condiciones para el desarrollo integral y armonioso de las personalidades de los estudiantes

Computer Musical Creative Work in the Russian Initial Vocational Education System

The development of new music technologies necessitates changes in the content of music education. Musical pedagogy is faced with the task of educating creative musicians who are capable of innovative activities and inventive musical thinking. Therefore, primary music education should introduce creative learning technologies aimed at developing students’ creative abilities. This article analyzes the content of students’ musical and creative activities in the field of music computer technologies (MCT) illustrated by the subject “Computer Music Creative Work.” The theoretical and experimental study led us to conclude that this course not only develops creative abilities but also establishes conditions for the comprehensive and harmonious development of students’ personalities.The development of new music technologies necessitates changes in the content of music education. Musical pedagogy is faced with the task of educating creative musicians who are capable of innovative activities and inventive musical thinking. Therefore, primary music education should introduce creative learning technologies aimed at developing students’ creative abilities. This article analyzes the content of students’ musical and creative activities in the field of music computer technologies (MCT) illustrated by the subject “Computer Music Creative Work.” The theoretical and experimental study led us to conclude that this course not only develops creative abilities but also establishes conditions for the comprehensive and harmonious development of students’ personalities

Assessment of causes and consequences of food and agricultural raw material loss and opportunities for its reduction

The article summarizes and systematizes the causes and consequences of food loss and waste. The uncontrolled accumulation and inefficient management of loss and waste is a serious problem of food security in many countries. Moreover, the world annually loses or wastes about a third of food produced while natural resources are inefficiently used. A significant number of definitions and terms in the field of food loss and waste cause international inconsistency in management systems. So, systematization of terms and research methods for food loss and waste has been carried out. The review analyzes the stages of food supply chain, i.e. the production of agricultural raw materials, their collection, processing, transportation and consumption, where the largest loss and waste occur. Furthermore, environmental, social and other problems associated with the accumulation of loss and waste are considered. Prevention of food loss and waste has been shown to be a potential strategy to improve the balance of food supply and demand and is essential for improving food security while reducing environmental impact and providing economic benefits to various participants in the food supply chain. Separately, the actions taken by the Russian Federation in the field of waste management and reduction of food loss are considered. Attention is drawn to the fact that the difficulties in solving these problems are associated with insufficient progress in legislation and low funding of relevant research projects. Possible approaches for simulation and optimization of actions to support specific strategies to reduce loss and waste are considered, taking into account the following factors: improving the management of various inventories; developing a clear strategy for planning and allocating resources; forming the supply chain based on variability (uncertainty) of customer demand and supply. Knowledge comparison and integration, as well as optimization of food supply chain management are essential for development of strategies and decisions about where and how to focus efforts to most effectively ensure the reduction of loss and waste at each stage of food supply chain. The main decisions and practices for FLW prevention and management have been systematized.The article summarizes and systematizes the causes and consequences of food loss and waste. The uncontrolled accumulation and inefficient management of loss and waste is a serious problem of food security in many countries. Moreover, the world annually loses or wastes about a third of food produced while natural resources are inefficiently used. A significant number of definitions and terms in the field of food loss and waste cause international inconsistency in management systems. So, systematization of terms and research methods for food loss and waste has been carried out. The review analyzes the stages of food supply chain, i.e. the production of agricultural raw materials, their collection, processing, transportation and consumption, where the largest loss and waste occur. Furthermore, environmental, social and other problems associated with the accumulation of loss and waste are considered. Prevention of food loss and waste has been shown to be a potential strategy to improve the balance of food supply and demand and is essential for improving food security while reducing environmental impact and providing economic benefits to various participants in the food supply chain. Separately, the actions taken by the Russian Federation in the field of waste management and reduction of food loss are considered. Attention is drawn to the fact that the difficulties in solving these problems are associated with insufficient progress in legislation and low funding of relevant research projects. Possible approaches for simulation and optimization of actions to support specific strategies to reduce loss and waste are considered, taking into account the following factors: improving the management of various inventories; developing a clear strategy for planning and allocating resources; forming the supply chain based on variability (uncertainty) of customer demand and supply. Knowledge comparison and integration, as well as optimization of food supply chain management are essential for development of strategies and decisions about where and how to focus efforts to most effectively ensure the reduction of loss and waste at each stage of food supply chain. The main decisions and practices for FLW prevention and management have been systematized

STUDY DATA OF KRAS- AND RAS-UNMUTATED (WILD) TYPE OF COLORECTAL CANCER

Analysis of latest trials, comparing treatment schemes including chemotherapy with anti-EGFR monoclonal antibodies or bevacizumab is presented in this article. The data in these trials is inconsistent, but detailed analysis of FIRE-3 trial allows to distinguish a wild-type RAS patient group that benefits most from chemotherapy with cetuximab or panitumumab as 1st line metastatic colorectal cancer treatment. A final analysis of this patient group in CALGB/SWOG 80 405 trial is pending. The RAS analysis is pivotal for choice of 1st line chemotherapy