The NRF2 transcription factor plays a dual role in colorectal cancer : A systematic review

Background: Colorectal cancer is one of the most common cancers worldwide, and is influenced by the interplay of various factors, including a very strong genetic component. For instance, incorrect mitochondrial biogenesis is correlated with increased risk of developing colorectal cancer. Thus, it is important to understand the consequences of changes in both the expression and the correct function of the transcription factors that regulate mitochondrial biogenesis, namely NRF2. Objectives: The main objective of this paper is to characterise the relationship between NRF2 and colorectal cancer by compiling data from an exhaustive literature search. Methods: Information was obtained by defining specific search terms and searching in several databases. After a strict selection procedure, data were tabulated and the relationships between articles were assessed by measuring heterogeneity and by constructing conceptual maps. Results and discussion: We found a general consensus in the literature that the presence of oxidizing agents as well as the inhibition of the NRF2 repressor Keap1 maintain NRF2 expression at basal levels. This predominantly exerts a cytoprotective effect on cells and decreases risk of colorectal cancer. However, if NRF2 is inhibited, protection against external agents disappears and risk of colorectal cancer increases. Interestingly, colorectal cancer risk is also increased when NRF2 becomes overexpressed. In this case, the increased risk arises from NRF2-induced inflammation and resistance to chemotherapy. Conclusion: The proper basal function of NRF2 and Keap1 are essential for preventing oncogenic processes in the colon. Consequently, any disruption to the expression of these genes can promote the genesis and progression of colon cancer

Colección de jupyter notebooks para cursos de robótica móvil

Las expectativas de implantación de vehículos autónomos en nuestra sociedad (coches, UAVs, robots, etc.) está impulsando la demanda de profesionales en el campo de la robótica móvil. Dada la diversidad y complejidad de las materias que abarca la robótica, \eg probabilidad, álgebra lineal, cálculo diferencial, mecánica, programación, inteligencia artificial, etc., se hace necesario contar con material didáctico innovador que facilite el aprendizaje y posibilite el desarrollo de problemas prácticos soportados por sus correspondientes fundamentos teóricos. Este trabajo presenta una colección de documentos interactivos para el aprendizaje en robótica, basados en la novedosa tecnología Jupyter Notebook, la cual permite al docente incluir en el mismo documento texto, ecuaciones matemáticas, recursos visuales como imágenes o vídeos, enlaces externos, e implementación de código. De este modo, los documentos interactivos introducen temas fundamentales de la robótica móvil situando al estudiante en un mejor contexto, incorporando los conceptos necesarios de distintas materias, y permitiéndole interactuar y analizar los resultados obtenidos. Esta herramienta esta siendo integrada en diversos cursos de la Universidad de Málaga, entre ellos la asignatura obligatoria de Robótica del grado de Ingeniería Informática (Computación).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Diet quality and depression risk: A systematic review and dose-response meta-analysis of prospective studies

Stress-related psychiatric disorders across the life spa

Desocupación laboral en el subsector turismo frente a la pandemia (COVID-19)

El objetivo de este proyecto es exponer desde diferentes perspectivas el desarrollo del subsector turístico y la repercusión que tiene económica y socialmente en Colombia. Para el análisis de este sector se utilizaron documentos extraídos por el Departamento Administrativo Nacional de Estadística (DANE), Noticias y Procolombia en 2020; que permitieron dar un avance en el análisis de los factores externos para el subsector. El estudio está enmarcado en un diseño metodológico apoyado en las matrices PESTEL y Porter; así como en método de una investigación documental y descriptiva que permitió conocer factores fundamentales para el turismo en el cual se obtuvieron diferentes resultados de acuerdo con los análisis realizados al subsector evidenciando una desocupación importante derivada de la paralización de actividades en el subsector

Correction to: Dimensions of leisure-time physical activity and risk of depression in the “Seguimiento Universidad de Navarra” (SUN) prospective cohort

After publication of our article [1] we have been notified that Table 2 was incorrectly formatte

COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses

Stress and Psychopatholog

Exploring genetic diversity for grain partitioning traits to enhance yield in a high biomass spring wheat panel

© 2020 Breeding to raise yield potential through enhancing photosynthesis will have limited impact unless harvest index (HI: proportion of above-ground biomass as grain yield) is maintained or ideally increased. Boosting grain dry matter (DM) partitioning will require increased allocation of assimilates to sink organs to enhance spike growth. A high biomass spring wheat panel of 150 genotypes encompassing elite, landrace-derived and synthetic-derived lines was grown under yield potential conditions in two seasons in NW Mexico. Results showed that the incorporation of landrace-derived and synthetic-derived backgrounds into elite lines resulted in higher expression of above-ground biomass (AGDM), leaf lamina and stem DM partitioning at anthesis. However, no grain yield advantage was observed over elite lines, due to lower grain number per unit area (GN) and decreased harvest index (HI). Positive linear associations were found among spike fertility-related traits - fruiting efficiency (grains per unit of spike DM at anthesis; FE), GN and HI - which were, in turn, related positively with grain yield (GY). Stem-internode 3 length and internode 3 DM partioning were negatively associated with spike partitioning index (SPI: ratio of spike DM to total above-ground DM at anthesis) and GN, suggesting an enhanced competition for assimilates between the spike and stem internode 3 during stem elongation. Within-spike DM partitioning analysis (glume, lemma, palea, rachis, awn) showed decreased partitioning to awns was associated with increased FE and thousand grain weight (TGW). While the use of exotic material can enhance biomass, special attention needs to be paid in the selection for novel DM partitioning traits that raise HI and GN coming from the elite genepool. The selection for grain partitioning traits in wheat breeding combined with sources expressing high biomass can potentially allow breeders to increase grain carbon assimilation that will deliver higher yields

Self-perceived level of competitiveness, tension and dependency and depression risk in the SUN cohort

Background: Emerging evidence suggests a possible etiologic role of certain personality traits (not necessary dysfunctional) in the risk of depression, but the longitudinal long-term available evidence is currently scarce. We longitudinally assessed whether 3 common personality traits (competitiveness, tension and dependency) were associated with the risk of depression after a maximum follow-up of 15 years. Methods: We assessed 15,604 university graduates free of depression at baseline through a self-administered questionnaire including personality traits. Simple, Likert-type, questions with 11 possible answers ranging from 0 to 10 were used at baseline to assess the 3 personality traits. We compared participants with high scores (7–10) versus those with low scores (0–4). New medical diagnoses of depression during follow-up were used as the outcome. Results: During a median follow-up of 10.1 y, we prospectively identified 902 new medical diagnoses of depression. The multivariable-adjusted hazard ratios (95% confidence intervals) for depression were 1.85 (1.52–2.24) for participants with higher baseline tension (7–10 versus 0 to 4), P-trend < 0.001; and 1.23 (1.06–1.44) for high versus low baseline dependence levels, P-trend = 0.004. Higher levels of competitiveness were marginally associated with lower risk of depression, with hazard ratio = 0.78 (0.61–1.01), P-trend = 0.105. Conclusion: A simple scoring system of personality traits shows an independent association with the future occurrence of depression. This finding underscores, with now prospective evidence, the importance of personality traits in the aetiology of depression and can provide a clinically useful tool for gathering valid information about depression-related personality traits

A longitudinal analysis of diet quality scores and the risk of incident depression in the SUN project

Background: Some studies have pointed out that several dietary patterns could be associated with a reduced risk of depression among adults. This association seems to be consistent across countries, cultures and populations. The objective of the study was to compare and to establish the type of relationship between three diet quality scores and depression in the SUN (Seguimiento Universidad de Navarra) Cohort study. Methods: We performed a dynamic cohort study based on Spanish university graduates free of depression at baseline. Dietary intake was repeatedly assessed at baseline and after 10 years of follow-up with a validated semi-quantitative foodfrequency questionnaire. Three previously described diet quality scores: Mediterranean Diet Score (MDS), Pro-vegetarian Dietary Pattern (PDP) and Alternative Healthy Eating Index-2010 (AHEI-2010) were built. Participants were classified as having depression if they reported a new clinical diagnosis of depression by a physician or initiated the use of an antidepressant drug during follow-up. Time-dependent Cox regression models with cumulative averages of diet and restricted cubic splines were used to estimate hazard ratios of depression according to quintiles of adherence to the MDS, PDP and AHEI-2010. Results: One thousand and fifty one incident cases of depression were observed among 15,093 participants from the SUN Cohort after a median follow-up of 8.5 years. Inverse and significant associations were observed between the three diet quality scores and depression risk. The hazard ratios and 95 % confidence intervals for extreme quintiles (fifth versus first) of updated adherence to MDS, PDP and AHEI-2010 were 0.84 (0.69–1.02), 0.74 (0.61–0.89) and 0.60 (0.49–0.72), respectively. The dose–response analyses showed non-linear associations, suggesting that suboptimal adherence to these dietary patterns may partially be responsible for increased depression risk. Conclusions: Better adherence to the MDS, PDP and AHEI-2010 was associated with a reduced risk of depression among Spanish adults. However, our data suggested a threshold effect so that although the risk of depression was reduced when comparing moderate versus lower adherence, there was not much extra benefit for the comparison between moderate and high or very high adherence