Role of resonances in rho^0 -> pi^+ pi^- gamma

We study the effect of the sigma(600) and a_1(1260) resonances in the rho^0 -> pi^+ pi^- gamma decay, within the meson dominance model. Major effects are driven by the mass and width parameters of the sigma(600), and the usually neglected contribution of the a_1(1260), although small by itself, may become sizable through its interference with pion bremsstrahlung, and the proper relative sign can favor the central value of the experimental branching ratio. We present a procedure, using the gauge invariant structure of the resonant amplitudes, to kinematically enhance the resonant effects in the angular and energy distribution of the photon. We also elaborate on the coupling constants involved.Comment: 5 pages, 5 figures, accepted for publication in PR

Physics and Mathematics of Calogero particles

We give a review of the mathematical and physical properties of the celebrated family of Calogero-like models and related spin chains.Comment: Version to appear in Special Issue of Journal of Physics A: Mathematical and Genera

Genome-wide association study identifies multiple susceptibility loci for glioma

Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10−8), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10−11), 12q21.2 (rs12230172, P=7.53 × 10−11) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10−9). Our findings provide further insights into the genetic basis of the different glioma subtypes

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Analyses of pig genomes provide insight into porcine demography and evolution

For 10,000 years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model

Where are the resonances in the ρ0→π+π -γ decay?

We consider the ρ0→π+π -γ decay to study the σ(600) and a1(1260) resonances. Using the meson dominance model we find that major effects are driven by the mass and width parameters of the σ(600), and the usually neglected contribution of the a1(1260), although small by itself, may become sizable through its interference with pion bremsstrahlung. We present a procedure to kinematically enhance the resonant effects in the angular and energy distribution of the photon. © 2008 American Institute of Physics

Widespread of ESBL- and carbapenemase GES-type genes on carbapenem-resistant Pseudomonas aeruginosa clinical isolates: A multicenter study in Mexican hospitals

We consider the ?0??+? -? decay to study the ?(600) and a1(1260) resonances. Using the meson dominance model we find that major effects are driven by the mass and width parameters of the ?(600), and the usually neglected contribution of the a1(1260), although small by itself, may become sizable through its interference with pion bremsstrahlung. We present a procedure to kinematically enhance the resonant effects in the angular and energy distribution of the photon. " 2008 American Institute of Physics.",,,,,,"10.1063/1.2965044",,,"http://hdl.handle.net/20.500.12104/45729","http://www.scopus.com/inward/record.url?eid=2-s2.0-51149105028&partnerID=40&md5=18ccaed5721448a08e459e33b4d74c69",,,,,,,,"AIP Conference Proceedings",,"18