ILC2s chew the fat.

In this issue of JEM, Rana et al. (https://doi.org/10.1084/jem.20190689) report that adipose tissue multipotent stromal cells (MSCs) provide multifaceted support for adipose tissue-resident ILC2s through contact-mediated proliferation and IL-33-mediated stress-induced activation

Modeling heat exchange characteristics of long term space operations: Role of skin wettedness and exercise

The problems of heat exchange during rest and exercise during long term space operations are covered in this report. Particular attention is given to the modeling and description of the consequences of requirement to exercise in a zero-g atmosphere during Space Shuttle flights, especially long term ones. In space environments, there exists no free convection therefore only forced convection occurring by movement, such as pedalling on a cycle ergometer, augments required heat dissipation necessary to regulate body temperature. The requirement to exercise at discrete periods of the day is good practice in order to resist the deleterious consequences of zero-gravity problems and improve distribution of body fluids. However, during exercise (ca. 180 to 250W), in zero-g environments, the mass of eccrine sweating rests as sheets on the skin surface and the sweat cannot evaporate readily. The use of exercise suits with fabrics that have hydrophobic or outwicking properties somewhat distributes the mass of sweat to a larger surface from which to evaporate. However, with no free convection, increased skin wettedness throughout the body surface induces increasing thermal discomfort, particularly during continuous exercise. This report presents several alternatives to aid in this problem: use of intermittent exercise, methods to quantify local skin wettedness, and introduction of a new effective temperature that integrates thermal stress and heat exchange avenues in a zero-g atmosphere

Dicer is required for female reproductive tract development and fertility in the mouse.

Dicer encodes a riboendonuclease required for microRNA biosynthesis. Dicer was inactivated in Müllerian duct mesenchyme-derived tissues of the reproductive tract of the mouse, using an Amhr2-Cre allele. Although Amhr2-Cre; Dicer conditional mutant males appeared normal and were fertile, mutant females were infertile. In adult mutant females, there was a reduction in the size of the oviducts and uterine horns. The oviducts were less coiled compared to controls and cysts formed at the isthmus near the uterotubal junction. Unfertilized, degenerate oocytes were commonly found within these cysts, indicating a defect in embryo transit. Beads transferred into the mutant oviduct failed to migrate into the uterus. In addition, blastocysts transferred directly into the mutant uterus did not result in pregnancy. Histological analysis demonstrated that the mutant uterus contained less glandular tissue and often the few glands that remained were found within the myometrium, an abnormal condition known as adenomyosis. In adult mutants, there was ectopic expression of Wnt4 and Wnt5a in the luminal epithelium (LE) and glandular epithelium (GE) of the uterus, and Wnt11 was ectopically expressed in GE. These results demonstrate that Dicer is necessary for postnatal differentiation of Müllerian duct mesenchyme-derived tissues of the female reproductive tract, suggesting that microRNAs are important regulators of female reproductive tract development and fertility

Evidence-based design heuristics for idea generation

How do product designers create multiple concepts to consider? To address this question, we combine evidence from four empirical studies of design process and outcomes, including award-winning products, multiple concepts for a project by an experienced industrial designer, and concept sets from 48 industrial and engineering designers for a single design problem. This compilation of over 3450 design process outcomes is analyzed to extract concept variations evident across design problems and solutions. The resulting set of patterns, in the form of 77 Design Heuristics, catalog how designers appear to introduce intentional variation into conceptual product designs. These heuristics provide ‘cognitive shortcuts’ that can help designers generate more, and more varied, candidate concepts to consider in the early phases of design

Hydration and blood volume effects on human thermoregulation in the heat: Space applications

Astronauts exposed to prolonged weightlessness will experience deconditioning, dehydration, and hypovolemia which all adversely affect thermoregulation. These thermoregulatory problems can be minimized by several countermeasures that manipulate body water and vascular volumes. USARIEM scientists have extensively studied dehydration effects and several possible countermeasures including hyperhydration, plasma and erythrocyte volume expansion. This paper reviews USARIEM research into these areas

Design Heuristics in Engineering Concept Generation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94902/1/j.2168-9830.2012.tb01121.x.pd

Spitzer and Hubble Constraints on the Physical Properties of the z~7 Galaxy Strongly Lensed by Abell 2218

We report the detection of a z~7 galaxy strongly lensed by the massive galaxy cluster Abell 2218 (z=0.175) at 3.6 and 4.5 um using the Spitzer Observatory and at 1.1 um using the Hubble Space Telescope. The new data indicate a refined photometric redshift in the range of 6.6-6.8 depending on the presence of Ly-alpha emission. The spectral energy distribution is consistent with having a significant Balmer break, suggesting that the galaxy is in the poststarburst stage with an age of at least ~50 Myr and quite possibly a few hundred Myr. This suggests the possibility that a mature stellar population is already in place at such a high redshift. Compared with typical Lyman break galaxies at z~3-4, the stellar mass is an order of magnitude smaller (~10^{9} Msun), but the specific star formation rate (star formation rate/M_{star}) is similarly large (> 10^{-9} yr^{-1}), indicating equally vigorous star-forming activity.Comment: 11 pages, 2 figures, 2 tables; Accepted for publication in ApJ

Prediction modeling of physiological responses and human performance in the heat with application to space operations

This institute has developed a comprehensive USARIEM heat strain model for predicting physiological responses and soldier performance in the heat which has been programmed for use by hand-held calculators, personal computers, and incorporated into the development of a heat strain decision aid. This model deals directly with five major inputs: the clothing worn, the physical work intensity, the state of heat acclimation, the ambient environment (air temperature, relative humidity, wind speed, and solar load), and the accepted heat casualty level. In addition to predicting rectal temperature, heart rate, and sweat loss given the above inputs, our model predicts the expected physical work/rest cycle, the maximum safe physical work time, the estimated recovery time from maximal physical work, and the drinking water requirements associated with each of these situations. This model provides heat injury risk management guidance based on thermal strain predictions from the user specified environmental conditions, soldier characteristics, clothing worn, and the physical work intensity. If heat transfer values for space operations' clothing are known, NASA can use this prediction model to help avoid undue heat strain in astronauts during space flight

Testing Hall-Post Inequalities With Exactly Solvable N-Body Problems

The Hall--Post inequalities provide lower bounds on $N$-body energies in terms of $N'$-body energies with $N'<N$. They are rewritten and generalized to be tested with exactly-solvable models of Calogero-Sutherland type in one and higher dimensions. The bound for $N$ spinless fermions in one dimension is better saturated at large coupling than for noninteracting fermions in an oscillatorComment: 7 pages, Latex2e, 2 .eps figure

Tissue signals imprint ILC2 identity with anticipatory function.

Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP). Transcriptional profiling of ILC2s from different tissues, however, grouped ILC2s according to their tissue of origin, even in the setting of combined IL-25-, IL-33-receptor-, and TSLP-receptor-deficiency. Single-cell profiling confirmed a tissue-organizing transcriptome and identified ILC2 subsets expressing distinct activating receptors, including the major subset of skin ILC2s, which were activated preferentially by IL-18. Tissue ILC2 subsets were unaltered in number and expression in germ-free mice, suggesting that endogenous, tissue-derived signals drive the maturation of ILC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life