La inteligencia lingüística y su influencia con el entorno social en los alumnos del 3ero de secundaria de la I.E.T.I. Pedro E. Paulet Moztajo – Huacho

Objetivo: conocer la influencia que tienen ambas variables como es la inteligencia lingüística y el entorno social.El desarrollo de la inteligencia lingüística en la educación básica regular por los docentes del área de comunicación es importante y fundamental, permite motivar orientar a los alumnos el hábito por la lectura, siendo esta una base fundamental para una buena formación académica de los alumnos del nivel secundario. Terman (2006), en su investigación desarrollada sobre el desarrollo de la inteligencia lingüística en el nivel secundario es importante, los docentes del área de comunicación deben aplicar y desarrollar buenas estrategias metodológicas asertiva en aula, permite motivar orientar y lograr un aprendizaje significativo, generando en los alumnos el hábito por la lectura y que comprendan lo que leen, El logro de la inteligencia lingüística les genera a los alumnos, seguridad, ganas de seguir estudiando, reflejado directamente en su concentración, la atención y la memoria, fundamentales en el proceso de aprendizaje, (p.17)

Proceso de formación de profesores en el diseño de Ambientes Virtuales de Aprendizaje incluyentes

El Grupo de Investigación en Enseñanza de las Ciencias Experimentales (GREECE) diseñó e implementó un curso en formación inicial para profesores de ciencias de la Universidad Distrital Francisco José de Caldas (UDFJC), haciendo énfasis en el diseño didáctico para la generación y adaptación de objetos virtuales de aprendizaje (OVA) como parte de un ambiente virtual de aprendizaje (AVA) que tiene como finalidad la inclusión de población sorda y población ciega en procesos de enseñanza aprendizaje. Dentro de la ruta metodológica se trabajan diferentes herramientas pensadas en términos de accesibilidad para las necesidades educativas especiales. Los resultados del curso se hacen tangibles con los nuevos cursos creados en la plataforma ATutor por parte de los estudiantes en formación, contando así con material inclusivo en aras de aportar a otros docentes en aulas diversas

Proceso de formación de profesores en el diseño de Ambientes Virtuales de Aprendizaje incluyentes

El Grupo de Investigación en Enseñanza de las Ciencias Experimentales (GREECE) diseñó e implementó un curso en formación inicial para profesores de ciencias de la Universidad Distrital Francisco José de Caldas (UDFJC), haciendo énfasis en el diseño didáctico para la generación y adaptación de objetos virtuales de aprendizaje (OVA) como parte de un ambiente virtual de aprendizaje (AVA) que tiene como finalidad la inclusión de población sorda y población ciega en procesos de enseñanza aprendizaje. Dentro de la ruta metodológica se trabajan diferentes herramientas pensadas en términos de accesibilidad para las necesidades educativas especiales. Los resultados del curso se hacen tangibles con los nuevos cursos creados en la plataforma ATutor por parte de los estudiantes en formación, contando así con material inclusivo en aras de aportar a otros docentes en aulas diversas

Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)

Sm16, also known as SPO-1 and SmSLP, is a low molecular weight protein (~16kDa) secreted by the digenean trematode parasite Schistosoma mansoni, one of the main causative agents of human schistosomiasis. The molecule is secreted from the acetabular gland of the cercariae during skin invasion and is believed to perform an immune-suppressive function to protect the invading parasite from innate immune cell attack. We show that Sm16 homologues of the Schistosomatoidea family are phylogenetically related to the helminth defence molecule (HDM) family of immunomodulatory peptides first described in Fasciola hepatica. Interrogation of 69 helminths genomes demonstrates that HDMs are exclusive to trematode species. Structural analyses of Sm16 shows that it consists predominantly of an amphipathic alpha-helix, much like other HDMs. In S. mansoni, Sm16 is highly expressed in the cercariae and eggs but not in adult worms, suggesting that the molecule is of importance not only during skin invasion but also in the pro-inflammatory response to eggs in the liver tissues. Recombinant Sm16 and a synthetic form, Sm16 (34-117), bind to macrophages and are internalised into the endosomal/lysosomal system. Sm16 (34-117) elicited a weak pro-inflammatory response in macrophages in vitro but also suppressed the production of bacterial lipopolysaccharide (LPS)-induced inflammatory cytokines. Evaluation of the transcriptome of human macrophages treated with a synthetic Sm16 (34-117) demonstrates that the peptide exerts significant immunomodulatory effects alone, as well as in the presence of LPS. Pathways most significantly influenced by Sm16 (34-117) were those involving transcription factors peroxisome proliferator-activated receptor (PPAR) and liver X receptors/retinoid X receptor (LXR/RXR) which are intricately involved in regulating the cellular metabolism of macrophages (fatty acid, cholesterol and glucose homeostasis) and are central to inflammatory responses. These results offer new insights into the structure and function of a well-known immunomodulatory molecule, Sm16, and places it within a wider family of trematode-specific small molecule HDM immune-modulators with immuno-biotherapeutic possibilities.JS was supported by a fellowship provided by the Department for the Economy through Queen’s University Belfast, Northern Ireland, UK. KT, SC, BGS and JPD were supported by a Canadian Institute of Health Research (CIHR) Chair (Tier 1) in Infectious Diseases awarded to JPD (https://cihr-irsc.gc.ca/e/193.html). KC and JPD were funded by the Science Foundation Ireland (SFI, Republic of Ireland) Research Professorship grant 17/RP/5368 (https://www.sfi.ie/). RA, JT and SD were supported by an NHMRC project grant APP1142006 (https://www.nhmrc.gov.au/). CCT and SW are supported by the Medical Research Council, UK (https://mrc.ukri.org/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.peer-reviewe

Matrix stiffness mechanically conditions EMT and migratory behavior of oral squamous cell carcinoma

Tumors are composed of heterogeneous phenotypes, each having different sensitivities to the microenvironment. One microenvironment characteristic – matrix stiffness – helps to regulate malignant transformation and invasion in mammary tumors, but its influence on oral squamous cell carcinoma (OSCC) is unclear. We observed that, on stiff matrices, a highly invasive OSCC cell line (SCC25) comprising a low E-cad toN-cad ratio (InvH/E:NL; SCC25) had increasedmigration velocity and decreased adhesion strength compared to a less invasive OSCC cell line (Cal27) with high E-cad to N-cad ratio (InvL/E:NH; Cal27). However, InvL/E:NH cells acquire a mesenchymal signature and begin to migrate faster when exposed to prolonged time on a stiff niche, suggesting that cells can be mechanically conditioned.Owing to increased focal adhesion assembly, InvL/E:NH cells migrated faster, which could be reduced when increasing integrin affinity with high divalent cation concentrations.Mirroring these data in human patients, we observed that collagen organization, an indicator of matrix stiffness, was increased with advanced disease and correlated with early recurrence. Consistent with epithelial tumors, our data suggest that OSCC cells are mechanically sensitive and that their contribution to tumor progression is mediated in part by this sensitivity

Analysis of ELISA results using FhCL1 antigen and anti-total-IgG as secondary antibody.

<p>A) Histogram of control and <i>Fasciola-</i>positive serum samples. B) Histogram of normalized total IgG for negative control and <i>Fasciola</i> positive samples. Dash line represents cut-off for negative samples.</p

Analysis of ELISA data using FhCL1 antigen and secondary antibodies specific for IgG1, IgG2 and IgG4+IgG1 isotypes.

<p>Histograms of ELISA data obtained for Fasciola-positive and control patient sera using A) anti-IgG1, B) anti-IgG2, and C) IgG4+IgG1 secondary antibodies. Black bars represent sera from control patients while white bars represent sera from positive patients.</p

Box plots of ELISA data using sera from non-infected control patients, <i>F. hepatica</i>-infected patients, and patients with various parasitic diseases.

<p>A: ELISA using anti-total IgG as secondary antibody and B: ELISA using anti-IgG4 as secondary antibody. The dashed line represents the cut-off for negative samples. <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0002414#s3" target="_blank">Results</a> are obtained from three independent experiments conducted in duplicate.</p

Comparison of ELISA data obtained using secondary antibodies specific for various isotypes.

<p>Absorbance between positive infected sera and negative control sera using anti-total IgG and the different serotypes.</p

Scattergraphs for ELISA data using various secondary antibodies.

<p>Data obtained using secondary antibodies specific for anti-IgG4 (A), anti-IgG2 (B) and anti-IgG1 (C) compared to data obtained using anti-total IgG. Blue circles represent sera from control patients while green circles represent Fasciola-positive patients.</p