The McMaster Family Assessment Device (FAD) dimensions involved in the prediction of adolescent depressive symptoms and their mediating role in regard to socioeconomic status

Family functioning plays an important role in explaining the high prevalence of depressive symptoms in adolescents and it is necessary to identify the family functioning characteristics responsible for this relationship. In turn, while socioeconomic status (SES) is associated with adolescent depressive symptoms, the mechanisms that explain this relationship are largely unknown. In this study, we used the McMaster Family Assessment Device (FAD) to obtain a picture of the family functioning dimensions that genuinely contribute to explaining the relationship between family functioning and adolescent depressive symptoms and analyzed the mediating effect of family functioning on the impact of SES on depressive symptoms. Regression-based conditional process analysis was used with a sample of 636 adolescents aged 12–17 years. Pratt's measures in regression analyses showed that 95% of the variance in depressive symptoms was accounted for by three of the six FAD dimensions: the ability to experience and express emotions appropriately—Affective Responsiveness— the ability to maintain adequate involvement among family members—Affective Involvement—and the ability to set and abide by rules and standards of behavior— Behavioral Control. Results also showed that the impact of SES on depressive symptoms was mediated by the existence of clear expectations about standards of behavior and behavioral patterns for handling family tasks—Behavioral Control and Roles—and, for the boys, by experiencing and expressing emotions appropriately. The results emphasize the importance of affect and clear-cut family rules to prevent adolescent depressive symptoms and suggest that the existence of family rules and roles buffer the impact of SES on adolescent wellbeingFunding for open access charge: University of Malaga/CBU

Climate and construction delays: case study in Chile

Purpose – Construction projects usually suffer delays, and the causes of these delays and its cost overruns have been widely discussed, the weather being one of the most recurrent. The purpose of this paper is to analyze the influence of climate on standard construction work activities through a case study. Design/methodology/approach – By studying the extent at which some weather variables impede outdoor work from being effectively executed, new maps and tables for planning for delays are presented. In addition, a real case regarding the construction of several bridges in southern Chile is analyzed. Findings – Few studies have thoroughly addressed the influences of major climatic agents on the most common outdoor construction activities. The method detailed here provides a first approximation for construction planners to assess to what extent construction productivity will be influenced by the climate. Research limitations/implications – Although this study was performed in Chile, the simplified method proposed is entirely transferable to any other country, however, other weather or combinations of weather variables could be needed in other environments or countries. Practical implications – The implications will help reducing the negative social, economic and environmental outcomes that usually emerge from project delays. Originality/value – Climatic data were processed using extremely simple calculations to create a series of quantitative maps and tables that would be useful for any construction planner to decide the best moment of the year to start a project and, if possible, where to build it

Dietary fatty acids and lipoproteins on progression of age-related macular degeneration

Age-related macular degeneration (AMD) is a medical condition of central loss vision and blindness. Numerous studies have revealed that changes on certain dietary fatty acids (FAs) could have useful for AMD management. This review summarizes the effects of dietary omega-3 long-chain PUFAs, MUFAs, and SFAs, and lipoproteins on AMD. Findings are consistent with the beneficial role of dietary omega-3 long-chain PUFAs, while the effects of dietary MUFAs and SFAs appeared to be ambiguous with respect to the possible protection from MUFAs and to the possible adverse impact from SFAs on AMD. Some of the pathological mechanisms associated with lipoproteins on AMD share those observed previously in cardiovascular diseases. It was also noticed that the effects of FAs in the diet and lipoprotein on AMD could be modulated by genetic variants. From a population health perspective, the findings of this review are in favour of omega-3 long-chain FAs recommendations in a preventive and therapeutic regimen to attain lower AMD occurrence and progression rates. Additional long-term and short-term nutrigenomic studies are required to clearly establish the role and the relevance of interaction of dietary FAs, lipoproteins, and genes in the genesis and progression of AMD

Procedimientos en caso de incumplimiento de las garantias explicitas de salud en Chile: garantia de oportunidad

77 p.La Reforma al Sistema de Salud en Chile, tiene por finalidad mejorar la Salud de la población y reducir las desigualdades en Salud, a través de varias iniciativas legales, una de las cuales es la Ley Nº 19.966, que establece un Régimen de Garantías en Salud, el cual contempla las Garantías Explícitas en Salud, como un mecanismo destinado a brindar certeza y equidad al Sistema. Transformando en Derechos exigibles, para el Sistema público y privado, el acceso, calidad, oportunidad y asequibilidad de las prestaciones asociadas a las enfermedades decretadas como cubiertas. La Reforma contribuye a la realización del Derecho a la Salud y otorga a las personas la titularidad de Derechos, de los que derivan obligaciones para otros. Frente al incumplimiento de las Garantías, las personas pueden y deben demandar su cumplimiento. El incumplimiento sólo se configurará al momento en que se accione por parte del titular del Derecho./ ABSTRACT: The Reform of Health System in Chile, has as aim to improve the Health of the population and reduce the disparity of Health, through several legal initiatives, among them, the Law number 19.996, that establishes a Regime of Health Guarantees, including the Explicit Guarantees in Health, as a mechanism used to bring certainty and equity to the System. The Explicit Guarantees have become requirable Rights, for the public system and the private one, the access, quality, opportunity and attainability of the services associated to the diseases decrees as covered. The Reform contributes to execute de Right to Health and gives people the entitlement of rights, causing obligations for others. In front of the non-fulfilment of any of the Guarantees, the people can and must demand its fulfilment. The nonfulfilment only gets shaped in the moment of the legal action from the person entitled by the la

Tradução espanhola do questionário para o diagnóstico de transtorno do desenvolvimento da coordenação

El trastorno del desarrollo de la coordinación se reconoce por dificultades motoras que afectan el rendimiento en actividades cotidianas y escolares; por tanto, se hace necesario un diagnóstico precoz para iniciar una intervención oportuna. Un cuestionario para diagnosticar es el Developmental coordination disorder questionnaire’07, DCDQ’07. Objetivo: realizar la traducción y adaptación transcultural al español del DCDQ’07. Materiales y métodos: tres traductores independientes tradujeron el cuestionario, clasificando sus ítems como equivalentes, con problemas en algunas palabras y sin equivalencia, y desde su equivalencia experiencial, semántica, conceptual e idiomática. Resultados: el artículo presenta los resultados preliminares de la investigación, la cual culminó su primera fase de traducción de los quince ítems del cuestionario. Ocho de ellos fueron clasificados como equivalentes, seis con problemas en algunas palabras y uno sin equivalencia. Diez ítems correspondieron a traducción por equivalencia experiencial, cuatro se clasificaron como equivalentes semánticas y uno se consideró con doble equivalencia. La autora del cuestionario original valoró positivamente la versión en español. La percepción de los padres frente al cuestionario fue positiva. Conclusiones: la mayoría de los ítems del cuestionario no tuvo dificultad en su traducción, facilitando su adaptación transcultural al español y la continuidad del proceso de validación y confiabilidad.The developmental coordination disorder can be recognized by motor difficulties that affect the performance in daily and school activities; therefore, it is necessary to get its early diagnosis in order to initiate early intervention. A tool for diagnosis is the Developmental coordination disorder questionnaire’07, DCDQ’07. Objective: the translation and cultural adaptation of the DCDQ’07 into Spanish. Materials and methods: three independent translators translated the questionnaire into Spanish. Its items were classified according to their equivalent or non-equivalent problems in some words, and also according to their experiential, semantic, conceptual or idioms equivalence. Results: 8 items out of 15 questionnaire items were classified as equivalent 8, 6 of them presented problems in a few words and only one was classified as non-equivalent, 10 items correspond to experiential equivalence translation, 4 items were classified as semantic equivalent and only one got two equivalents. The author agreed the Spanish version. Also, the parent´s opinions about the questionnaire were positive. Conclusions: most of the items of the questionnaire did not have translation difficulties. It allowed its translation and cultural adaptation into Spanish as well asits validation continuity and reliability process.Reconhece-se o transtorno do desenvolvimento da coordenação pelas dificuldades motoras que afetam o rendimento em atividades cotidianas e escolares, portanto precisa-se de um diagnóstico precoce para começar uma intervenção oportuna. Um questionário para tal diagnóstico é o Developmental coordination disorder questionnaire’07 (DCDQ’07). Objetivo: a tradução e adaptação transcultural do DCDQ’07 ao espanhol. Materiais e métodos: três tradutores independentes fizeram a tradução do questionário e classificaram seus items como equivalentes, com problemas em algumas palavras e sem equivalência, como também desde a equivalência experiencial, semântica, conceitual e idiomática. Resultados: dos 15 items do questionário, 8 foram classificados como equivalentes, 6 com problemas em algumas palavras e só um foi classificado sem equivalência,10 items corresponderam à tradução por equivalência experiencial, 4 foram classificados como equivalentes semânticos e só um foi classificado com dupla equivalência. A autora do questionárioapreciou positivamente a versão em espanhol. A apreciação dos pais à frente do questionário é positiva. Conclusões: a tradução da maioria dos items do questionário foi fácil. Isto facilitou a adaptação transcultural ao espanhol e a continuidade do processo de validação e confiabilidade

Validade e confiabilidade do questionário do transtorno do desenvolvimento da coordenação em versão em espanhol

El trastorno del desarrollo de la coordinación se caracteriza por dificultades en el desarrollo psicomotor que generan consecuencias en el desempeño en actividades de la vida diaria y escolares y requiere un diagnóstico precoz. Una herramienta para diagnosticarlo es el Cuestionario del Trastorno del Desarrollo de la Coordinación (CTDC), en su versión en español y por el cual se realiza esta investigación, cuyo objetivo fue determinar las propiedades psicométricas del CTDC. Metodología. Estudio descriptivo y de validación de instrumento, con una muestra de 41 niños de 6 a 12 años de edad, escolarizados, en quienes se aplicó el CTDC y la Batería Da Fonseca. Se analizó la confiabilidad por consistencia interna, intraevaluador y la validez concurrente entre ambos instrumentos. Resultados. Se obtuvieron resultados positivos, la confiabilidad para el cuestionario completo por consistencia interna mediante el coeficiente alfa de Cronbach de 0,92 y la confiabilidad intraevaluador mediante el índice de Kappa de 0,82 con un p<0,001 y para ítems independientes valores Kappa por encima de 0,5, la validez concurrente a través del coeficiente de correlación de Spearman Rho fue de 0,6 con un p<0,01. Conclusiones. El CTDC cuenta con adecuadas y fuertes propiedades psicométricas para su aplicación y uso clínico.O Transtorno do Desenvolvimento da Coordenação caracteriza-se por dificuldades no desenvolvimento psicomotor as quais geram consequências no desempenhodas atividades da vida diária e escolares, requerendo um diagnóstico precoce. Um questionário utilizado para diagnosticar oTDC é o Questionário do Transtorno do Desenvolvimento da Coordenação (CTDC). O objetivo da pesquisa consistiu em determinar as propriedades psicométricas do CTDC. Metodologia. Estudodescritivo e de validação de instrumento, com uma amostra de 41 crianças com uma faixa etária entre 6 e 12 anos, escolarizados, aos quais foram aplicadoso CTDC e a BateriaVitor da Fonseca.Analisou-se a confiabilidade pela consistência interna, intra-avaliador e a validade concorrente entre os dois instrumentos. Resultados. Os resultados foram positivos, com a confiabilidade para o questionário completo por consistência internamediante o coeficiente alfa de Cronbach de 0,92 e a confiabilidade intra-avaliadormediante o Índice Kappa acima de 0,5, com um p<0,001. Para os itens independentes, valores Kappa acima de 0,5, a validade concorrente através da correlação de SpermannRho foi de 0,5, com um p<0,01. Conclusões. O CTDC conta com propriedades psicométricas adequadas e sólidas para sua aplicação e uso clinico.The Developmental Coordination Disorder is characterized by difficulties that produce consequences on the psychomotor performance in daily and school activities, and requires early diagnosis. The Developmental Coordination Disorder Questionnaire CTDC is used for its diagnosis.The objective of the study was to determinate the psychometric properties of CTDC. Methodology. Descriptive study and instrument validation, with a sample of 41 children aged between 6 to 12 years old, at school, with the application of the CTDC and the Da Fonseca Psychomotor Battery. The study analyzed internal consistency reliability, and intra-rater and concurrent validity through the two instruments. Results. Positive results were obtained: the reliability for the full internal consistency using Cronbach’s alpha coefficient was 0.92, and the intra-rater reliability using Kappa index was 0.82 with ap<0.001, independent items showed values above 0.5; concurrent validity through the Spearman correlation coefficient Rho was 0.6, with ap<0.01. Conclusions. The CTDC has appropriate and strong psychometric properties for its application and clinical use

Small Molecules as Dream Modulators: New Avenues for the Search of Drugs for Neurodegenerative Diseases

Trabajo presentado en el 9th drug Design and Medicinal Chemistry, celebrado en Berlín (Alemania) del 05 al 06 de mayo de 2015.Altered neuronal calcium homeostasis and early compensatory changes in transcriptional programs are common features of many neurodegenerative pathologies including Alzheimer¿s disease, Down syndrome and Huntington¿s disease. DREAM (Downstream Regulatory Element Antagonist Modulator), also known as calsenilin or KChIP-3 (potassium channel interacting protein-3), is a multifunctional calcium binding protein that controls the expression level and/or the activity of several proteins related to calcium homeostasis, neuronal excitability and neuronal survival. This protein is widely expressed in the brain and, depending on the cell type and physiological conditions, shows multiple subcellular localizations, in the nucleus, cytosol or cell membrane. The interest in DREAM is based on its key role in the regulation of intracellular calcium levels. As a calcium-dependent transcriptional repressor, DREAM is a master regulator of activity-dependent gene expression and controls genes important for calcium homeostasis such as the sodium/calcium exchanger-3 (NCX3), IP3R and L-type calcium channels. As an auxiliary protein in the plasma membrane, DREAM interacts with and regulates the gating of Kv4 potassium channels, L- and T-type voltage-dependent calcium channels and NMDA receptors. These findings suggest that DREAM could be a novel and versatile target for therapeutic intervention in neurodegeneration and that molecules able to bind to DREAM and block its physiological functions could be candidates for drugs to treat neurodegenerative diseases. Moreover, up to now, only two DREAM-binding molecules have been identified. In this communication we report the rational design and the synthesis of novel DREAM-binding molecules and their effects on the modulation of DREAM/protein interactions

Género y espacio público: nueve ensayos

I. PERFILES: CAPÍTULO 1. Rocío Orsi Portalo (Universidad Carlos III de Madrid): Vírgenes y mártires. Dos escenarios premodernos.- CAPÍTULO 2. Cinta Canterla (Universidad Pablo de Olavide): La filosofía y la ciencia en el s. XVIII, a propósito de la biopolítica y la categorización de lo público y lo privado.- CAPÍTULO 3. Carmen González Marín (Universidad Carlos III de Madrid): La ansiedad de la diferencia.- CAPÍTULO 4. Laura Calvo Valdivieso (Editorial Impedimenta): Mujeres renacentistas en la “res publica litterarum”.- CAPÍTULO 5. María Jesús Fuente (Universidad Autónoma de Madrid): Cruzando el umbral. Mujeres en el proceso de paso del espacio privado al público -- II. HACIA LA CONTEMPORANEIDAD: CAPÍTULO 6. Laura Branciforte (Universidad Carlos III de Madrid): El “singular” recorrido de las mujeres en los espacios públicos contemporáneos.- CAPÍTULO 7. Montserrat Huguet Santos (Universidad Carlos III de Madrid): Espacios de papel: vidas domésticas y escrituras burguesas.- CAPÍTULO 8. Leticia Naranjo Gálvez (Universidad del Rosario): Opresión y representación de lo femenino. Apuntes sobre la capacidad de agencia y la fortuna moral.- CAPÍTULO 9. Rocío Navarro (Universidad Carlos III de Madrid): Mujeres españolas en el siglo XX: asociacionismo y activismo político (Estado de la cuestión

Metodología para la realización de la teleconferencia. Methodology for the performance of a Telelecture

Se elaboró una metodología para impartir las tele conferencias con el objetivo de unificar criterios partiendo de la revisión de la bibliografía y de la experiencia práctica de los profesores del Policlínico Universitario "Turcios Lima". Se plantea un orden metodológico que sirve de guía para impartir esta actividad, definiendo tres etapas que son la fase preparatoria, el desarrollo y las conclusiones o reflexiones, destacando a su vez que la etapa de desarrollo se subdivide en introducción, desarrollo propiamente dicho y conclusiones. Se hace mención a las principales ventajas de esta actividad. Palabras claves: Enseñanza/Métodos, Educación Médica, Centros de salud, Universidades, Cuba, Medios Audiovisuales, Médicos de Familia, Telecomunicaciones. ABSTRACT A methodology to teach a telelecture was prepared, aimed at reaching into agreements from the literature revision and practical experience of professors at "Turcios Lima" University Outpatient Clinic. The methodological order that is to be used as a guide to teach this activity is described in three stages: preparatory, development, conclusions or reflections, highlighting at the same time the stage of development that is subdivided in introduction, development and conclusions. The main advantages of this activity are mentioned. Key words: Teaching/Methods, Medical Education, Health Institutions, Universities, Cuba, Audiovisual Aids, Family Doctors, Telecommunications

Metodología para la realización de la teleconferencia. Methodology for the performance of a Telelecture

Se elaboró una metodología para impartir las tele conferencias con el objetivo de unificar criterios partiendo de la revisión de la bibliografía y de la experiencia práctica de los profesores del Policlínico Universitario "Turcios Lima". Se plantea un orden metodológico que sirve de guía para impartir esta actividad, definiendo tres etapas que son la fase preparatoria, el desarrollo y las conclusiones o reflexiones, destacando a su vez que la etapa de desarrollo se subdivide en introducción, desarrollo propiamente dicho y conclusiones. Se hace mención a las principales ventajas de esta actividad. Palabras claves: Enseñanza/Métodos, Educación Médica, Centros de salud, Universidades, Cuba, Medios Audiovisuales, Médicos de Familia, Telecomunicaciones. ABSTRACT A methodology to teach a telelecture was prepared, aimed at reaching into agreements from the literature revision and practical experience of professors at "Turcios Lima" University Outpatient Clinic. The methodological order that is to be used as a guide to teach this activity is described in three stages: preparatory, development, conclusions or reflections, highlighting at the same time the stage of development that is subdivided in introduction, development and conclusions. The main advantages of this activity are mentioned. Key words: Teaching/Methods, Medical Education, Health Institutions, Universities, Cuba, Audiovisual Aids, Family Doctors, Telecommunications