Can ultrastrong coupling change ground state chemical reactions?

Recent advancements on the fabrication of organic micro- and nanostructures have permitted the strong collective light-matter coupling regime to be reached with molecular materials. Pioneering works in this direction have shown the effects of this regime in the excited state reactivity of molecular systems and at the same time has opened up the question of whether it is possible to introduce any modifications in the electronic ground energy landscape which could affect chemical thermodynamics and/or kinetics. In this work, we use a model system of many molecules coupled to a surface-plasmon field to gain insight on the key parameters which govern the modifications of the ground-state Potential Energy Surface (PES). Our findings confirm that the energetic changes per molecule are determined by single-molecule-light couplings which are essentially local, in contrast with those of the electronically excited states, for which energetic corrections are of a collective nature. Still, we reveal some intriguing quantum-coherent effects associated with pathways of concerted reactions, where two or more molecules undergo reactions simultaneously, and which can be of relevance in low-barrier reactions. Finally, we also explore modifications to nonadiabatic dynamics and conclude that, for this particular model, the presence of a large number of dark states yields negligible changes. Our study reveals new possibilities as well as limitations for the emerging field of polariton chemistry

Plausible explanation of the Δ5/2+(2000)\Delta_{5/2^{+}}(2000) puzzle

From a Faddeev calculation for the $\pi-(\Delta\rho)_{N_{5/2^{-}}(1675)}$ system we show the plausible existence of three dynamically generated $I(J^{P})=3/2 (5/2^{+})$ baryon states below 2.3 GeV whereas only two resonances, $\Delta_{5/2^{+}}(1905)(\ast\ast\ast\ast)$ and $\Delta_{5/2^{+}}(2000)(\ast\ast),$ are cataloged in the Particle Data Book Review. Our results give theoretical support to data analyses extracting two distinctive resonances, $\Delta_{5/2^{+}}(\sim1740)$ and $\Delta_{5/2^{+}}(\sim2200),$ from which the mass of $\Delta_{5/2^{+}}(2000)(\ast\ast)$ is estimated. We propose that these two resonances should be cataloged instead of $\Delta_{5/2^{+}}(2000).$ This proposal gets further support from the possible assignment of the other baryon states found in the approach in the $I=1/2,3/2$ with $J^{P}=1/2^{+},3/2^{+},5/2^+$ sectors to known baryonic resonances. In particular, $\Delta_{1/2^{+}}(1750)(\ast)$ is naturally interpreted as a $\pi N_{1/2^{-}}(1650)$ bound state.Comment: 13 pages, 7 figure

AIP and MEN1 mutations and AIP immunohistochemistry in pituitary adenomas in a tertiary referral center.

Background: Pituitary adenomas have a high disease burden due to tumor growth/ invasion and disordered hormonal secretion. Germline mutations in genes such as MEN1 and AIP are associated with early onset of aggressive pituitary adenomas that can be resistant to medical therapy. Aims: We performed a retrospective screening study using published risk criteria to assess the frequency of AIP and MEN1 mutations in pituitary adenoma patients in a tertiary referral center. Methods: Pituitary adenoma patients with pediatric/adolescent onset, macroadenomas occurring ≤30 years of age, familial isolated pituitary adenoma (FIPA) kindreds and acromegaly or prolactinoma cases that were uncontrolled by medical therapy were studied genetically. We also assessed whether immunohistochemical staining for AIP (AIP-IHC) in somatotropinomas was associated with somatostatin analogs (SSA) response. Results: Fifty-five patients met the study criteria and underwent genetic screening for AIP/MEN1 mutations. No mutations were identified and large deletions/duplications were ruled out using MLPA. In a cohort of sporadic somatotropinomas, low AIP-IHC tumors were significantly larger (P = 0.002) and were more frequently sparsely granulated (P = 0.046) than high AIP-IHC tumors. No significant relationship between AIP-IHC and SSA responses was seen. Conclusions: Germline mutations in AIP/MEN1 in pituitary adenoma patients are rare and the use of general risk criteria did not identify cases in a large tertiary-referral setting. In acromegaly, low AIP-IHC was related to larger tumor size and more frequent sparsely granulated subtype but no relationship with SSA responsiveness was seen. The genetics of pituitary adenomas remains largely unexplained and AIP screening criteria could be significantly refined to focus on large, aggressive tumors in young patients

On the void explanation of the Cold Spot

The integrated Sachs-Wolfe (ISW) contribution induced on the cosmic microwave background by the presence of a supervoid as the one detected by Szapudi et al. (2015) is reviewed in this letter in order to check whether it could explain the Cold Spot (CS) anomaly. Two different models, previously used for the same purpose, are considered to describe the matter density profile of the void: a top hat function and a compensated profile produced by a Gaussian potential. The analysis shows that, even enabling ellipticity changes or different values for the dark-energy equation of state parameter $\omega$, the ISW contribution due to the presence of the void does not reproduce the properties of the CS. Finally, the probability of alignment between the void and the CS is also questioned as an argument in favor of a physical connection between these two phenomena