Labores de Lagartera

En número dedicado a: La provincia de Toled

Improving I/O performance through an in-kernel disk simulator

This paper presents two mechanisms that can significantly improve the I/O performance of both hard and solid-state drives for read operations: KDSim and REDCAP. KDSim is an in-kernel disk simulator that provides a framework for simultaneously simulating the performance obtained by different I/O system mechanisms and algorithms, and for dynamically turning them on and off, or selecting between different options or policies, to improve the overall system performance. REDCAP is a RAM-based disk cache that effectively enlarges the built-in cache present in disk drives. By using KDSim, this cache is dynamically activated/deactivated according to the throughput achieved. Results show that, by using KDSim and REDCAP together, a system can improve its I/O performance up to 88% for workloads with some spatial locality on both hard and solid-state drives, while it achieves the same performance as a ‘regular system’ for workloads with random or sequential access patterns.Peer ReviewedPostprint (author's final draft

Prediction of non-genotoxic carcinogenicity based on genetic profiles of short term exposure assays

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be applied to develop early identifiers for long term phenotypes. In this study, we used rat liver expression profiles from the NTP (National Toxicology Program, Research Triangle Park, USA) DrugMatrix Database to construct a gene classifier that can distinguish between non-genotoxic carcinogens and other chemicals. The model was based on short term exposure assays (3 days) and the training was limited to oxidative stressors, peroxisome proliferators and hormone modulators. Validation of the predictor was performed on independent toxicogenomic data (TG-GATEs, Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System, Osaka, Japan). To build our model we performed Random Forests together with a recursive elimination algorithm (VarSelRF). Gene set enrichment analysis was employed for functional interpretation. A total of 770 microarrays comprising 96 different compounds were analyzed and a predictor of 54 genes was built. Prediction accuracy was 0.85 in the training set, 0.87 in the test set and increased with increasing concentration in the validation set: 0.6 at low dose, 0.7 at medium doses and 0.81 at high doses. Pathway analysis revealed gene prominence of cellular respiration, energy production and lipoprotein metabolism. The biggest target of toxicogenomics is accurately predict the toxicity of unknown drugs. In this analysis, we presented a classifier that can predict non-genotoxic carcinogenicity by using short term exposure assays. In this approach, dose level is critical when evaluating chemicals at early time points.Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria ; Argentin

Protección penal de los daños al patrimonio histórico (tras la reforma del Código Penal operada por la LO 1/2015)

Se analizan los tipos penales que protegen los daños sobre el patrimonio histórico tras la reforma del Código Penal operada por LO 1/2015, destacando especialmente algunos defectos de técnica legislativa que impiden proteger correctamente este tipo de bienes y proponiendo posibles mejoras que deben hacer hincapié en la protección penal de estos bienes frente a los atentados en la segunda fase, esto es, el tráfico ilícito posterior a la conducta delictiva de robo o daños a los mismosI analyze the existing penal provisions regarding criminal damage in the protection of historic patrimony after the reform of the Criminal Code operated by the Organic Law 1/2015, highlighting especially those defects in legislative technique that prevent the proper protection of such goods, and proposing possible improvements needed to emphasize the penal protections against these attacks in the second phase, that is, in the illicit traffic after the original criminal conduct of theft or damage to these propertie