Long-term characterization of landfill leachate: impacts of the tropical climate on its composition

The disposal of Municipal Solid Waste (MSW) in sanitary landfills produces leachate, whose composition changes depending on the microbial community and the environmental conditions. However, these changes cannot be observed in sanitary landfill because of the superposition of cells, which makes it difficult to determinate the relationship among the phases of biodegradation of MSW, the composition of the leachate and the time required for complete stabilization of the waste. This illustrates the importance of building experimental cells that simulate landfill to monitor the leachate over a long period. This study aimed to analyze the composition of the leachate generated from an experimental cell built on the Delta A sanitary landfill of Campinas City, Brazil, over 945 days. The leachate showed a transition from an acidic anaerobic phase to a methanogenic phase within approximately 100 days. By the one-hundredth day, the leachate showed a characteristically low pH, between 5.0 and 6.0 and a high Chemical Oxygen Demand (COD) and Biochemical Oxygen Demand (BOD) such as a young leachate with high biodegradability. Moreover, there was an intense leaching of the metals Cd, Fe, Pb and Mn, with concentrations higher than those allowed for the release in water bodies, according to Brazilian law. After the one-hundredth day, the leachate was characterized as stabilized. The pH increased and the concentration of volatile fatty acid, COD and BOD decreased. Co, Zn, Ni and Cu were leached. The potentially toxic metal concentrations found in the leachate also were above the values allowed by Brazilian law13211612

Diagnóstico del déficit de alfa-1 antitripsina en atención primaria

Alpha-1 antitrypsin deficiency; Primary careDèficit d'alfa-1 antitripsina; Atenció primàriaDéficit de alfa-1 antitripsina; Atención primariaThe World Health Organization and respiratory societies such as the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR)3 and the Europeran Respiratory Society (ERS)4 recommend testing of all COPD patients. Due to its great variability in the clinical expression of pulmonary disease, they also recommend testing for AATD adults with non-completely reversible asthma or with bronchiectasis of unknown etiolog

Saturated hydraulic conductivity of municipal solid waste considering the influence of biodegradation

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOMunicipal solid waste (MSW) permeability is influenced mainly by compaction, unit weight, overburden pressure, composition, and biodegradation of the waste. However, the variation of hydraulic conductivity with MSW biodegrading over time has not yet been14491449FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2010/18560-

Biogas production from the landfilled easily degradable fraction of municipal solid waste: mining strategy for energy recovery

The growing demand for space and fnancial resources to manage current and new municipal solid waste (MSW) landflls has become a massive challenge for several countries. Additionally, landflls contribute to adverse environmental impacts such as pollution and CO2 (carbon dioxide) and CH4 (methane) emissions. This paper has analyzed the possibility of producing biogas from landflled MSW. An easily degradable fraction of landflled MSW with 8 years of landflling was mined and subjected to chemical characterization and elemental composition analysis. The abbreviation for the study sample was called ED8 – Mined. The low values of lignin (24.5%) and nitrogen content (0.7%) and high values of holocellulose (75.9%) and C/N (46.1%) on dry basis were obtained resulting in materials with the potential to be used for biogas generation. Recal‑citrant materials were found in greater amounts than easily biodegradable fresh MSW fractions. The reuse of energy from landflled MSW can contribute positively to the country’s environment and economy, reducing environmental liabilities and generating energy in a controlled way. In Delta A Sanitary Landfll, Southeastern Brazil, the recovery of the ED8 – Mined would refect a signifcant recovery of about 100,000 tonnes of landflled materials for annual MSW cells of about 450,000 tonnes, allowing recovery of materials and space expansion for rejects.Campus Lima Su

The MONARCH high-resolution reanalysis of desert dust aerosol over Northern Africa, the Middle East and Europe (2007–2016)

One of the challenges in studying desert dust aerosol along with its numerous interactions and impacts is the paucity of direct in situ measurements, particularly in the areas most affected by dust storms. Satellites typically provide column-integrated aerosol measurements, but observationally constrained continuous 3D dust fields are needed to assess dust variability, climate effects and impacts upon a variety of socio-economic sectors. Here, we present a high-resolution regional reanalysis data set of desert dust aerosols that covers Northern Africa, the Middle East and Europe along with the Mediterranean Sea and parts of central Asia and the Atlantic and Indian oceans between 2007 and 2016. The horizontal resolution is 0.1◦ latitude × 0.1◦ longitude in a rotated grid, and the temporal resolution is 3 h. The reanalysis was produced using local ensemble transform Kalman filter (LETKF) data assimilation in the Multiscale Online Nonhydrostatic AtmospheRe CHemistry model (MONARCH) developed at the Barcelona Supercomputing Center (BSC). The assimilated data are coarse-mode dust optical depth retrieved from the Moderate Resolution Imaging Spectroradiometer (MODIS) Deep Blue Level 2 products. The reanalysis data set consists of upper-air variables (dust mass concentrations and the extinction coefficient), surface variables (dust deposition and solar irradiance fields among them) and total column variables (e.g. dust optical depth and load). Some dust variables, such as concentrations and wet and dry deposition, are expressed for a binned size distribution that ranges from 0.2 to 20 µm in particle diameter. Both analysis and first-guess (analysis-initialized simulation) fields are available for the variables that are diagnosed from the state vector. A set of ensemble statistics is archived for each output variable, namely the ensemble mean, standard deviation, maximum and median. The spatial and temporal distribution of the dust fields follows well-known dust cycle features controlled by seasonal changes in meteorology and vegetation cover. The analysis is statistically closer to the assimilated retrievals than the first guess, which proves the consistency of the data assimilation method. Independent evaluation using Aerosol Robotic Network (AERONET) dust-filtered optical depth retrievals indicates that the reanalysis data set is highly accurate (mean bias = −0.05, RMSE = 0.12 and r = 0.81 when compared to retrievals from the spectral de-convolution algorithm on a 3-hourly basis). Verification statistics are broadly homogeneous in space and time with regional differences that can be partly attributed to model limitations (e.g. poor representation of small-scale emission processes), the presence of aerosols other than dust in the observations used in the evaluation and differences in the number of observations among seasons. Such a reliable high-resolution historical record of atmospheric desert dust will allow a better quantification of dust impacts upon key sectors of society and economy, including health, solar energy production and transportation. The reanalysis data set (Di Tomaso et al., 2021) is distributed via Thematic Real-time Environmental Distributed Data Services (THREDDS) at BSC and is freely available at http://hdl.handle.net/21.12146/c6d4a608-5de3-47f6-a004-67cb1d498d98 (last access: 10 June 2022).This research has been supported by the DustClim project, which is part of ERA4CS, an ERA-NET programme co-funded by the European Union’s Horizon 2020 research and innovation programme (grant no. 690462); the European Research Council (FRAGMENT (grant no. 773051)); grant no. RYC-2015- 18690 funded by MCIN/AEI/10.13039/501100011033 and ESF Investing in your future; grant no. CGL2017-88911-R funded by MCIN/AEI/10.13039/501100011033 and ERDF A way of making Europe; the AXA Research Fund (AXA Chair on Sand and Dust Storms); the European Commission, Horizon 2020 Framework Programme (grant no. 792103 (SOLWARIS)); and ATMO-ACCESS (Access to Atmospheric Research Facilities) funded in the frame of the programme H2020-EU.1.4.1.2 (grant no. 101008004, 1 April 2021–31 March 2025). Jerónimo Escribano and Martina Klose have received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreements H2020-MSCACOFUND-2016-754433 and H2020-MSCA-IF-2017-789630, respectively. Martina Klose received further support through the Helmholtz Association’s Initiative and Networking Fund (grant no. VH-NG-1533). This work has been partially funded by the contribution agreement between AEMET and BSC to carry out development and improvement activities of the products and services supplied by the World Meteorological Organization (WMO) Barcelona Dust Regional Center (i.e. the WMO Sand and Dust Storm Warning Advisory and Assessment System (SDS-WAS) Regional Center for Northern Africa, the Middle East and Europe).Peer ReviewedArticle signat per 24 autors/es: Enza Di Tomaso (1) , Jerónimo Escribano (1) , Sara Basart (1) , Paul Ginoux (2) , Francesca Macchia (1) , Francesca Barnaba (3) , Francesco Benincasa (1), Pierre-Antoine Bretonnière (1), Arnau Buñuel (1), Miguel Castrillo (1), Emilio Cuevas (4) , Paola Formenti (5) , María Gonçalves (1,6), Oriol Jorba (1), Martina Klose (1,7), Lucia Mona (8), Gilbert Montané Pinto (1) , Michail Mytilinaios (8), Vincenzo Obiso (1,a), Miriam Olid (1), Nick Schutgens (9) , Athanasios Votsis (10,11), Ernest Werner (12), and Carlos Pérez García-Pando (1,13) // (1) Barcelona Supercomputing Center (BSC), Barcelona, Spain; (2) NOAA Geophysical Fluid Dynamics Laboratory, Princeton, New Jersey, USA; (3) Consiglio Nazionale delle Ricerche–Istituto di Scienze dell’Atmosfera e del Clima (CNR–ISAC), Rome, Italy; (4) Izaña Atmospheric Research Center (IARC), Agencia Estatal de Meteorología (AEMET), Santa Cruz de Tenerife, Spain; (5) Université Paris Cité and Univ Paris-Est Créteil, CNRS, LISA, 75013 Paris, France; (6) Department of Project and Construction Engineering, Universitat Politècnica de Catalunya – BarcelonaTech (UPC), Terrassa, Spain; (7) Department Troposphere Research, Institute of Meteorology and Climate Research (IMK-TRO), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany; (8) Consiglio Nazionale delle Ricerche–Istituto di Metodologie per l’Analisi Ambientale (CNR–IMAA), Tito Scalo (PZ), Italy; (9) Department of Earth Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; (10) Section of Governance and Technology for Sustainability (BMS-CSTM), University of Twente, Enschede, the Netherlands; (11) Weather and Climate Change Impact Research, Finnish Meteorological Institute (FMI), Helsinki, Finland; (12) Agencia Estatal de Meteorología (AEMET), Barcelona, Spain; (13) ICREA, Catalan Institution for Research and Advanced Studies, Barcelona, Spain anow at: NASA Goddard Institute for Space Studies (GISS), New York, New York, USAObjectius de Desenvolupament Sostenible::13 - Acció per al Clima::13.3 - Millorar l’educació, la conscienciació i la capacitat humana i institucional en relació amb la mitigació del canvi climàtic, l’adaptació a aquest, la reducció dels efectes i l’alerta primerencaObjectius de Desenvolupament Sostenible::13 - Acció per al ClimaPostprint (published version

Gender Dysphoria: Concepts, Diagnosis and Clinical Management

Gender dysphoria is defined as a condition characterized by mental suffering associated with the incongruence between one’s experienced gender and their birth-assigned sex. Gender as a construct and gender dysphoria as a condition in need of multidisciplinary intervention have developed as swiftly as their visibility in society, making it mandatory to promote the literacy and education of all healthcare professionals in this area. This article aims to review information based on scientific evidence on people with gender dysphoria and its clinical approach, while contributing to a safe, inclusive, and non-discriminatory practice of healthcare

Jovens Solistas da Metropolitana

Brochura de sala do concerto realizado pelos Jovens Solistas da Metropolitana a 7 de Abril de 2022 no MUSEU DO ORIENTE em Lisboa no âmbito da Temporada 2021/2022 da Metropolitana dedicada a 30º aniversário da instituição. O programa do concerto foi preenchido com obras de Maurer, Ewald, Forsythe, Taffanel e Borodin. Desenvolvendo uma ponte pedagógica inédita entre a prática e o ensino musical, a ANSO é a única escola do país que forma maestros, instrumentistas de orquestra e pianistas vocacionados para música de câmara. Ao longo dos seus quase 30 anos, mudou o panorama cultural em Portugal, sendo muitos os seus alunos a entrar nas mais exigentes instituições de ensino e formações internacionais. Mais premiada escola nacional desta área, as novas gerações de intérpretes e diretores musicais que lança são reconhecidas pela qualidade. A música de câmara é uma das vertentes fundamentais da Academia Nacional Superior de Orquestra, que todos os anos apresenta o ciclo Jovens Solistas da Metropolitana.N/

The MONARCH high-resolution reanalysis of desert dust aerosol over Northern Africa, the Middle East and Europe (2007-2016)

One of the challenges in studying desert dust aerosol along with its numerous interactions and impacts is the paucity of direct in-situ measurements, particularly in the areas most affected by dust storms. Satellites typically provide columnintegrated aerosol measurements, but observationally-constrained continuous 3D dust fields are needed to assess dust variability, climate effects and impacts upon a variety of socio-economic sectors. Here, we present a high resolution regional reanalysis data set of desert dust aerosols that covers Northern Africa, the Middle East and Europe along with the Mediterranean sea and parts of Central Asia, and the Atlantic and Indian Oceans between 2007 and 2016. The horizontal resolution is 0.1° latitude × 0.1° longitude, and the temporal resolution is 3 hours. The reanalysis was produced using Local Ensemble Transform Kalman Filter (LETKF) data assimilation in the Multiscale Online Non-hydrostatic AtmospheRe CHemistry model (MONARCH) developed at the Barcelona Supercomputing Center (BSC). The assimilated data are coarse-mode dust optical depth retrieved from the Moderate Resolution Imaging Spectroradiometer (MODIS) Deep Blue Level 2 products. The reanalysis data set consists of upper air (dust mass concentrations and extinction coefficient), surface (dust deposition and solar irradiance fields, among them) and total column (e.g., dust optical depth and load) variables. Some dust variables, such as concentrations and wet and dry deposition, are expressed for a binned size distribution that ranges from 0.2 to 20 μm in particle diameter. Both analysis and first-guess (analysis-initialized simulation) fields are available for the variables that are diagnosed from the state vector.We acknowledge the DustClim project which is part of ERA4CS, an ERA-NET initiated by JPI Climate, and funded by FORMAS (SE), DLR (DE), BMWFW (AT), IFD (DK), MINECO (ES), ANR (FR) with co-funding by the European Union’s Horizon 2020 research and innovation programme (Grant n. 690462)

Evaluation of the potential association of SOHLH2 polymorphisms with non-obstructive azoospermia susceptibility in a large European population

Non-obstructive azoospermia (NOA) or spermatogenic failure is a complex disease with an important genetic component that causes infertility in men. Known genetic factors associated with NOA include AZF microdeletions of the Y chromosome or karyotype abnormalities; however, most causes of NOA are idiopathic. During the last decade, a large list of associations between single-nucleotide polymorphisms (SNP) and NOA have been reported. However, most of the genetic studies have been performed only in Asian populations. We aimed to evaluate whether the previously described association in Han Chinese between NOA and two SNPs of the SOHLH2 gene (involved in the spermatogenesis process) may also confer risk for NOA in a population of European ancestry. We genotyped a total of 551 NOA patients (218 from Portugal and 333 from Spain) and 1,050 fertile controls (226 from Portugal and 824 from Spain) for the genetic variants rs1328626 and rs6563386 using TaqMan assays. To test for association, we compared the allele and genotype frequencies between cases and controls using an additive model. A haplotype analysis and a meta-analysis using the inverse variance method with our data and those of the original Asian study were also performed. No statistically significant differences were observed in any of the analyses described above. Therefore, considering the high statistical power of our study, it is not likely that the two analysed SOHLH2 genetic variants are related with an increase susceptibility to NOA in the European population.info:eu-repo/semantics/publishedVersio