47 research outputs found
Quantum Rod Emission Coupled to Plasmonic Lattice Resonances: A Collective Directional Source of Polarized Light
We demonstrate that an array of optical antennas may render a thin layer of
randomly oriented semiconductor nanocrystals into an enhanced and highly
directional source of polarized light. The array sustains collective plasmonic
lattice resonances which are in spectral overlap with the emission of the
nanocrystals over narrow angular regions. Consequently, different photon
energies of visible light are enhanced and beamed into definite directions.Comment: 4 pages, 3 figure
Characterizing the Epidemiology of the 2009 Influenza A/H1N1 Pandemic in Mexico
Gerardo Chowell and colleagues address whether school closures and other social
distancing strategies were successful in reducing pandemic flu transmission in
Mexico by analyzing the age- and state-specific incidence of influenza morbidity
and mortality in 32 Mexican states
Development of dissolution test method for a telmisartan/amlodipine besylate combination using synchronous derivative spectrofluorimetry
The dissolution process is considered an important in vitro tool to evaluate product quality and drug release behavior. Single dissolution methods for the analysis of combined dosage forms are preferred to simplify quality control testing. The objective of the present work was to develop and validate a single dissolution test for a telmisartan (TEL) and amlodipine besylate (AML) combined tablet dosage form. The sink conditions, stability and specificity of both drugs in different dissolution media were tested to choose a discriminatory dissolution method, which uses an USP type-II apparatus with a paddle rotating at 75 rpm, with 900 mL of simulated gastric fluid (SGF without enzymes) as the dissolution medium. This dissolution methodology provided good dissolution profiles for both TEL and AML and was able to discriminate changes in the composition and manufacturing process. To quantify both drugs simultaneously, a synchronous first derivative spectrofluorimetric method was developed and validated. Drug release was analyzed by a fluorimetric method at 458 nm and 675 nm for AML and TEL, respectively. The dissolution method was validated as per ICH guidance