Information Seek and Retrieval Mechanisms Based on Interactive Dynamics Linking Technology

The paper discusses the approach to dynamic hypertext technology used for query expansion and development. Two schemes of links creation on the fly are presented. The first one, System controlled scheme, generates (computes) hypertext links on retrieved documents output phase. In the second one, User controlled scheme, terms in viewed document are highlighted (and can be further used as a query in selected resource by one click) in accordance with user profile. The link creation mechanism is specified parametrically through the specification of the resource and selected (i.e. controlled) by the user. Linking mechanism is considered as a component of IR&S process, well controlled by user thought graphic interface.     Keywords: Information Retrieval Interface; Dynamic Linking; Hypertext Technology; System-Human Information Processing; Dynamic Query Reformulation

Creation of e-learning resources for Web-oriented disciplines

The experiences of development and using e-learning resources 'World information resources' and 'Network Economy' for web-oriented disciplines at Wikibooks platform are described © 2013 IEEE

Applied Ontologies Formation Based on Subject Area Texts

The problems of the formation of applied conceptual systems based on ontologies constructed automatically from the texts of the subject area documents are considered. Algorithms of operations on ontologies using the thesaurus as a general conceptual basis, unifying the terminology of the subject area, are proposed. Experiments with ontology collection obtained from the texts of design documentation showed that the semantic similarity of the resulting concepts of the system can be increased through the use of thesaurus links.     Keywords: ontologies, thesaurus, operations on ontologies, graph theory, semantic similarity, Neo4j, Jav

Clinically applicable artificial intelligence system for dental diagnosis with CBCT

Abstract In this study, a novel AI system based on deep learning methods was evaluated to determine its real-time performance of CBCT imaging diagnosis of anatomical landmarks, pathologies, clinical effectiveness, and safety when used by dentists in a clinical setting. The system consists of 5 modules: ROI-localization-module (segmentation of teeth and jaws), tooth-localization and numeration-module, periodontitis-module, caries-localization-module, and periapical-lesion-localization-module. These modules use CNN based on state-of-the-art architectures. In total, 1346 CBCT scans were used to train the modules. After annotation and model development, the AI system was tested for diagnostic capabilities of the Diagnocat AI system. 24 dentists participated in the clinical evaluation of the system. 30 CBCT scans were examined by two groups of dentists, where one group was aided by Diagnocat and the other was unaided. The results for the overall sensitivity and specificity for aided and unaided groups were calculated as an aggregate of all conditions. The sensitivity values for aided and unaided groups were 0.8537 and 0.7672 while specificity was 0.9672 and 0.9616 respectively. There was a statistically significant difference between the groups (p = 0.032). This study showed that the proposed AI system significantly improved the diagnostic capabilities of dentists

A nonlinear problem for the Laplace equation with a degenerating Robin condition

We investigate the behavior of the solutions of a mixed problem for the Laplace equation in a domain ?. On a part of the boundary ??, we consider a Neumann condition, whereas in another part, we consider a nonlinear Robin condition, which depends on a positive parameter ? in such a way that for ??=?0 it degenerates into a Neumann condition. For ? small and positive, we prove that the boundary value problem has a solution u(?,?). We describe what happens to u(?,?) as ??0 by means of representation formulas in terms of real analytic maps. Then, we confine ourselves to the linear case, and we compute explicitly the power series expansion of the solutionpublishersversionPeer reviewe

The probability of developing acute renal injury in patients with concomitant cardiovascular pathology hospitalized with COVID-19

The aim of the study - to assess the incidence of AKI in COVID-19 patients with a history of cardiovascular disease.Цель исследования - оценить частоту возникновения ОПП у пациентов при COVID-19, имеющих сердечно-сосудистую патологию в анамнез

НЕПОЛИОМИЕЛИТНЫЕ ЭНТЕРОВИРУС Ы, ОБУСЛОВИВШИЕ ПОДЪЕМ ЗАБОЛЕВАЕМОСТИ ЭНТЕРОВИРУСНОЙ ИНФЕКЦИЕЙ НА РЯДЕ ТЕРРИТОРИЙ РОССИИ В 2016 Г.

Aim: Characteristics of the peculiarities and the etiological factor of enterovirus infection on some territories of Russia in 2016. Materials and methods: We investigated 2138 samples from the patients with enterovirus infection. The isolation and identification of enteroviruses were conducted by the virological method and by partial sequencing of the genome region VP1. Phylogenic trees were constructed according to the method of Bayesian Monte Carlo Markov Chain. Results: Epidemic peaks of enterovirus infection were fixed on some territories of Russia. In Saratov region the morbidity index of enterovirus infection in 2016 was twice as high as the median morbidity index over previous years. The morbidity level of enterovirus meningitis – 3, 21 for 100000 of the population (77% from all the cases of enterovirus infection) was higher than on the other territories. In Kostroma region the morbidity index of enterovirus infection in 2016 was 11 times higher than the index of the previous year. On both territories the rise of morbidity depends on the active circulation of enterovirus ЕСНО30. Enteroviruses ECHO30 from Saratov region belonged to two phylogenic groups of genotype h. To one of them belonged viruses ECHO30 from Kostroma region. In Murmansk and Leningrad regions in 2016 most cases of enterovirus infection were represented by hand, foot and mouth disease (HFMD). The grouped foci of infection were registered in some preschool institutions. The etiological factor of this clinical form was Coxsackieviruses A6 belonging to different genetic variants. Conclusion: Epidemic peaks of enterovirus infection with the prevalence of different clinical forms of the disease were provoked by different etiological factors. On territories where enterovirus meningitis prevailed strains of enterovirus ECHO30 belonging to different variants of genotype h were detected. In patients with clinical picture of HFMD from territories where this form was leading the etiological factor of infection was Coxsackievirus A6 of different genetic variants.Цель: характеристика особенностей заболеваемости и этиологического фактора энтеровирусной инфекции (ЭВИ) на ряде территорий России в 2016 г. Материалы и методы: исследовано 2138 проб фекалий от больных ЭВИ. Выделение и идентификацию энтеровирусов проводили вирусологическим методом и путём частичного секвенирования области генома VP1. Филогенетические деревья были построены методом Bayesian Monte Carlo Markov Chain. Результаты: Эпидемические подъемы заболеваемости ЭВИ в 2016 г. были отмечены на ряде территорий России. В Саратовской области средний многолетний показатель заболеваемости ЭВИ был превышен в два раза. Показатель заболеваемости энтеровирусным менингитом – 3,21 на 100 000 населения (77% от всех случаев ЭВИ) – был выше, чем на других территориях. В Костромской области показатель заболеваемости ЭВИ в 2016 г. был превышен в 11 раз по сравнению с предыдущим годом. На обеих территориях рост заболеваемости был связан с активным включением в циркуляцию энтеровируса ECHO30. Вирусы ЕСНО30 из Саратовской области принадлежали генотипу h и относились к двум филогенетическим группам, в одну из которых вошли также штаммы, изолированные от больных ЭВИ в Костромской области. В Мурманской и Ленинградской областях в 2016 г. заболевания протекали в основном в видевирусной экзантемы полости рта и конечностей, были зарегистрированы групповые очаги в детских дошкольных учреждениях. Этиологическим фактором оказались вирусы Коксаки A6, которые относились к разным генетическим вариантам. Заключение: эпидемические подъемы заболеваемости энтеровирусной инфекцией с преобладанием различных клинических форм заболевания были обусловлены разными этиологическими факторами. На территориях, где превалировала клиника энтеровирусного менингита, в качестве этиологического агента были детектированы энтеровирусы ЕСНО 30, которые принадлежали к разным вариантам генотипа h. У больных с клиникой вирусной экзантемы полости рта и конечностей на территориях, где эта клиническая форма была ведущей, основным этиологическим фактором были вирусы Коксаки A6 разных генетических вариантов

РОЛЬ ЭНТЕРОВИРУСА ECHO 30 В ЭТИОЛОГИИ ЭНТЕРОВИРУСНОЙ ИНФЕКЦИИ НА СЕВЕРО -ЗАПАДЕ РОССИИ В 2013 г

In 2013 after two previous years when the situation had been calm the incidence rates of enterovirus infection significantly increased on certain territories of the North-West of Russia. In Novgorod and Vologda regions and in Saint-Petersburg enterovirus meningitis group cases were registered. The etiology of enterovirus infection was studied by virological and molecular methods. Enterovirus ECHO30 was identified as the principal etiological agent of the cases. Molecular study revealed that enteroviruses ECHO30 isolated in the North-West of Russia belonged to the genotype H and formed two subtypes inside this genotype. Phylogenetic analysis has shown that enteroviruses ECHO30 of both subtypes were closely related to the strains detected in different provinces of China in 2010-2013. Probably enteroviruses ECHO30 of the genotype H which largely circulated in Russia in 2013 and practically had not been detected in the country earlier had been imported on the territory of Russia from South-East Asia. Enteroviruses ECHO30 isolated in  Arkhangelsk and Novgorod regions in 2008-2009 belonged to another genotype Ec2. Enteroviruses of this genotype had circulated at that time in the European countries.В 2013 г. после относительно спокойной ситуации в течение двух предыдущих лет заболеваемость энтеровирусной инфекцией на ряде территорий Северо-Западного федерального округа резко возросла. Были зарегистрированы групповые заболевания энтеровирусным менингитом в Новгородской, Вологодской областях и в Санкт-Петербурге. Проведена расшифровка этиологии заболеваний энтеровирусной инфекцией с использованием вирусологического и молекулярно- генетического методов исследования. В качестве основного этиологического агента был идентифицирован энтеровирус ЕСНО 30. Установлено, что изолированные на Северо-Западе России вирусы ЕСНО 30 относились к генотипу Н и сформировали две филогенетические группы. Филогенетический анализ показал, что энтеровирусы ЕСНО 30 обоих субтипов были наиболее близко родственны штаммам, выделенным в разных провинциях Китая в 2010–2013 гг. Вероятно, энтеровирусы ЕСНО 30 генотипа Н, которые широко циркулировали в России в 2013 г. и ранее практически не выявлялись в стране, были импортированы на территорию России из Юго-Восточной Азии. Энтеровирусы ЕСНО 30, изолированные в 2008–2009 гг. в Архангельской и Новгородской областях, относились к другому генотипу Ес2, энтеровирусы этого генотипа циркулировали в тот период в странах Европы

ЗАБОЛЕВАЕМОСТЬ ЭНТЕРОВИРУСНОЙ ИНФЕКЦИЕЙ И ОСОБЕННОСТИ ЦИРКУЛЯЦИИ НЕПОЛИОМИЕЛИТНЫХ ЭНТЕРОВИРУСОВ НА НЕКОТОРЫХ ТЕРРИТОРИЯХ РОССИИ В 2017 ГОДУ

Aim: Characteristics of enterovirus infection morbidity and study of peculiarities of enterovirus circulation on some territories of Russia in 2017. Materials and methods: We investigated more than 5000 samples from the patients with enterovirus infection. The isolation and identification of enteroviruses were conducted by virological method and by partial sequencing of the genome region VP1. Phylogenic trees were constructed according to the method of Bayesian Monte Carlo Markov Chain. Results: Epidemic process and clinical picture of enterovirus infection were not the same on different territories. Peculiarities of the circulation of different types of enteroviruses on the territories were also different. In Saratov region 65% of cases were represented by enterovirus meningitis. In Murmansk region and in the Komi Republic enterovirus infection with exanthema prevailed, 95% and 60% correspondingly. In Saratov region enterovirus ECHO18 was the etiological agent of enterovirus meningitis. In Murmansk region and in the Komi Republic the cases were connected mainly with Coxsackieviruses A6. The strains of enterovirus ECHO18 were distributed to three clusters. The strains which provoked enterovirus meningitis in Saratov region belonged to cluster 3, they were formed separately from other strains of this enterovirus type and differed from the stains of ECHO18 which circulated in the North-West of Russia. The strains of Coxsackieviruses A6 identified in the North-West of Russia belonged to three sub-genotypes 5, 6, 8 of pandemic genotype of CoxsackievirusesA6. The majority of the strains belonged to sub-genotypes 6 and 8 which in 2017 dominated in the structure of Coxsackieviruses A6 in the North-West of Russia and in Russia. Conclusion: Epidemic peaks of enterovirus infection represented by different clinical forms of the disease were provoked by different types of enteroviruses. Enterovirus ECHO18 was the etiological agent of enterovirus meningitis. The main etiological factors of enterovirus infection with exanthema were Coxsackieviruses A6 of different sub-genotypes.Цель: характеристика заболеваемости энтеровирусной инфекцией и изучение особенностей циркуляции неполиомиелитных энтеровирусов на ряде территорий России в 2017 г. Материалы и методы: исследовано более 5000 проб фекалий от больных энтеровирусной инфекцией. Выделение и идентификацию энтеровирусов проводили вирусологическим методом и путём частичного секвенирования области генома VP1. Филогенетические деревья были построены методом Bayesian Monte Carlo Markov Chain. Результаты: течение эпидемического процесса и клинические проявления энтеровирусной инфекции на разных территориях отличались. Особенности циркуляции энтеровирусов разных типов на территориях также были разными. В Саратовской области 65% заболеваний были представлены энтеровирусным менингитом. В Мурманской области и в Республике Коми преобладали экзантемные формы энтеровирусной инфекции, составившие 95% и 60% соответственно. В Саратовской области этиологическим фактором энтеровирусного менингита оказался энтеровирус ЕСНО 18. В Мурманской области и в Республике Коми заболевания были обусловлены в основном Coxsackievirus А6. Штаммы энтеровируса ЕСНО 18 распределились по трем кластерам. Штаммы, обусловившие заболевания энтеровирусным менингитом в Саратовской области, вошли в кластер 3, они сформировались отдельно от штаммов этого типа вируса и отличались от штаммов ЕСНО18, которые циркулировали на северо-западе России. Штаммы вируса Coxsackievirus А6, идентифицированные на северо-западе России, относились к трем субгенотипам пандемического генотипа вируса Coxsackievirus А6 – 5, 6 и 8. Большинство штаммов относились к субгенотипам 6 и 8, которые в 2017 г. доминировали в структуре Coxsackieviruses А6 на северо-западе России и в Российской Федерации в целом. Заключение: эпидемические подъемы заболеваемости энтеровирусной инфекцией, представленной различными клиническими формами, были обусловлены разными типами энтеровирусов. Этиологическим агентом энтеровирусного менингита были энтеровирусы ЕСНО 18. Основным этиологическим фактором экзантемных форм заболевания были Coxsackieviruses A6 разных субгенотипов

Enterovirus infection in the Socialist Republic of Vietnam [ЭНТЕРОВИРУСНАЯ ИНФЕКЦИЯ В СОЦИАЛИСТИЧЕСКОЙ РЕСПУБЛИКЕ ВЬЕТНАМ]

Human enterovirus infections comprise a group of infectious diseases caused by viruses of Enterovirus A-D species (genus Enterovirus, family Picornaviridae). Enterovirus infections can vary in clinical manifestations and severity, from asymptomatic infection to serious multisystem diseases. During evolution, enterovirus strains with increased neurovirulence or atypical pathogenicity may emerge exhibiting an epidemic potential. Recently, outbreaks of enterovirus infection with an increased rate of neurological manifestations, a significant percentage of severe cases and lethal outcomes have been observed worldwide, which were associated with enteroviruses EV-A71, EV-D68 etc. The World Health Organization has included EV-A71 and EV-D68 enterovirus infection together with some other dangerous viral diseases considered for inclusion in the List of Blueprint Priority Diseases. In connection with this, global enterovirus surveillance is important for controlling emergence and spread of epidemic enterovirus variants, prediction of establishing epidemic situation, timely conduction of preventive measures and vaccine development. A growing multi-field cooperation between Russia and Vietnam leads to increased two-way population migration, which actualizes scientific and practical collaboration in surveillance and control of infectious disease spread, including enterovirus infection. Currently, epidemiological surveillance of enterovirus infection in Vietnam is based on monitoring hand, foot and mouth disease (HFMD) rate, laboratory diagnostics of enterovirus infection and identification of enterovirus strains, mainly detected in severe patients. In 2001-2016, 34 non-polio virus types were identified in patients with enterovirus infection, largely represented by viruses EV-A71, CVA6, CVA10, and CVA16. Moreover, the peak incidence of enterovirus infection and related mortality rate were associated with the increased activity of EV-A71 virus. In Vietnam, EVA71 enterovirus of genotypes C1, C4, C5 and B5 circulated at different times. Over the last years, a new pandemic genotype virus CVA6 has been dominating as a causative agent of enterovirus infection in Vietnam as well as the majority of other countries. The data on phylogenetic relation between Vietnamese epidemic EV-A71 and CVA6 strains allowed to find that they underwent multiple between-country spreads, whereas their subsequent in-country dissemination resulted in 2011-2012 enterovirus outbreak and sustained high-level HFMD morbidity. © 2019 Saint Petersburg Pasteur Institute. All rights reserved