224 research outputs found
From Sociology and Economics to World History
World History has only recently emerged as a distinctive and vibrant field of study. Its origins arose from a cross-fertilization of economics, history, and comparative sociology, and from particular conjunctions of people and places in the 1980s and 1990s. World historians now, thanks to unprecedented access to quantitative historical data and international networks of scholars, can develop increasingly precise, formal, and detailed accounts of changes and comparisons across historical periods. However, our goal is not to create new master narratives or theories that predict a grand historical trajectory for mankind; rather we seek to better understand the similarities and differences among societies, and the likely consequences of those similarities and differences.World History has only recently emerged as a distinctive and vibrant field of study. Its origins arose from a cross-fertilization of economics, history, and comparative sociology, and from particular conjunctions of people and places in the 1980s and 1990s. World historians now, thanks to unprecedented access to quantitative historical data and international networks of scholars, can develop increasingly precise, formal, and detailed accounts of changes and comparisons across historical periods. However, our goal is not to create new master narratives or theories that predict a grand historical trajectory for mankind; rather we seek to better understand the similarities and differences among societies, and the likely consequences of those similarities and differences
The Once and Future Middle Kingdom: Chinaâs Return to Dominance in the Global Economy
Im 16. und 17. Jahrhundert fĂŒhrten alle Wege nach China. Die Nachfrage Europas nach chinesischer Seide, Keramik und Tee fĂŒhrte die europĂ€ischen Kaufleute in den Orient. Als Europa industrialisiert war, dominierten die EuropĂ€er den Welthandel, indem sie eine Reihe von StĂŒtzpunkten und Kolonien in Afrika, im Indischen Ozean und in China errichteten. Heute versucht China, diesen âdeviantenâ Trend umzukehren und China wieder zu seiner ânormalenâ Position als fĂŒhrende Wirtschaftsmacht zu verhelfen. China strebt nach einer FĂŒhrungsrolle in den Bereichen Wind- und Sonnenenergie, kĂŒnstlicher Intelligenz, ElektromobilitĂ€t und Quantencomputer, um die beherrschende Macht unter den Volkswirtschaften des 21. Jahrhunderts zu werden. AuĂerdem errichtet China eigene StĂŒtzpunkte quer durch den Indischen Ozean und nach SĂŒdeuropa, um seine Kontrolle ĂŒber diese Handelsrouten wiederherzustellen. Wenn China Erfolghat, wird es die letzten zweihundert Jahre der Weltwirtschaftsgeschichte umkehren und seine frĂŒhere Rolle als Hauptakteur in der globalen Wirtschaft wiederherstellen.In the sixteenth and seventeenth centuries, all roads led to China. Europeâs demand for Chinese silks, ceramics, and tea led European traders to the Orient. Then as Europe industrialized, Europeans came to dominate world trade, building a string of bases and colonies around Africa, across the Indian Ocean, and in China. Today, China is seeking to reverse this âdeviantâ trend and restore China to its ânormalâ position as the worldâs dominant economy. Seeking leadership in wind and solar power, artificial intelligence, electric vehicles, and quantum computing to become the dominant power among twenty-first century economies, China is also building its own set of bases across the Indian Ocean and into southern Europe to reassert its control of these trade routes. If China succeeds, it will reverse the last two hundred years of world economic history and reassert its earlier role as the core actor in the global economy
Diazoxide choline extendedârelease tablet in people with PraderâWilli syndrome: results from longâterm openâlabel study
Objective:
This study assessed the effect of 1-year administration of diazoxide choline extended-release tablet (DCCR) on hyperphagia and other complications of Prader-Willi syndrome (PWS).
Methods:
The authors studied 125 participants with PWS, ageââ„â4âyears, who were enrolled in the DESTINY PWS Phase 3 study and who received DCCR for up to 52âweeks in DESTINY PWS and/or its open-label extension. The primary efficacy endpoint was Hyperphagia Questionnaire for Clinical Trials (HQ-CT) score. Other endpoints included behavioral assessments, body composition, hormonal measures, and safety.
Results:
DCCR administration resulted in significant improvements in HQ-CT (mean [SE] â9.9 [0.77], pâ<â0.0001) and greater improvements in those with more severe baseline hyperphagia (HQ-CTâ>â22). Improvements were seen in aggression, anxiety, and compulsivity (all pâ<â0.0001). There were reductions in leptin, insulin, and insulin resistance, as well as a significant increase in adiponectin (all pâ<â0.004). Lean body mass was increased (pâ<â0.0001). Disease severity was reduced as assessed by clinician and caregiver (both pâ<â0.0001). Common treatment-emergent adverse events included hypertrichosis, peripheral edema, and hyperglycemia. Adverse events infrequently resulted in discontinuation (7.2%).
Conclusions:
DCCR administration to people with PWS was well tolerated and associated with broad-ranging improvements in the syndrome. Sustained administration of DCCR has the potential to reduce disease severity and the burden of care for families
Where you look matters for body perception: Preferred gaze location contributes to the body inversion effect
The Body Inversion Effect (BIE; reduced visual discrimination performance for inverted compared to upright bodies) suggests that bodies are visually processed configurally; however, the specific importance of head posture information in the BIE has been indicated in reports of BIE reduction for whole bodies with fixed head position and for headless bodies. Through measurement of gaze patterns and investigation of the causal relation of fixation location to visual body discrimination performance, the present study reveals joint contributions of feature and configuration processing to visual body discrimination. Participants predominantly gazed at the (body-centric) upper body for upright bodies and the lower body for inverted bodies in the context of an experimental paradigm directly comparable to that of prior studies of the BIE. Subsequent manipulation of fixation location indicates that these preferential gaze locations causally contributed to the BIE for whole bodies largely due to the informative nature of gazing at or near the head. Also, a BIE was detected for both whole and headless bodies even when fixation location on the body was held constant, indicating a role of configural processing in body discrimination, though inclusion of the head posture information was still highly discriminative in the context of such processing. Interestingly, the impact of configuration (upright and inverted) to the BIE appears greater than that of differential preferred gaze locations
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