Photodissociation of pernitric acid (HO2NO2) at 248 nm

The photodissociation of pernitric acid (PNA) was studied at 248 nm. The quantum yield for production of OH radicals is 34 + or - 16 percent. The yield of OH from PNA was measured relative to that of H2O2. The translational and rotational energy content of the OH photofragment from PNA was characterized. A fluorescent emission was also observed and characterized. It is attributed to electronically excited NO2 produced in the PNA photodissociation. A maximum yield of 30 percent for NO2 production was determined. The intensity of this emission, and a mass spectrometric peak at m/e = 33, were found to be useful means of characterizing the purity of the PNA sample

Heterogeneous chemistry related to Antarctic ozone depletion: Reaction of ClONO2 and N2O5 on ice surfaces

Laboratory studies of heterogeneous reactions of possible importance for Antarctic ozone depletion were performed. In particular, the reactions of chlorine nitrate (ClONO2) and dinitrogen pentoxide (N2O5) were investigated on ice and HCl/ice surfaces. These reactions occur on the surfaces of polar stratospheric clouds (PSCs) over Antarctica. One reaction transforms the stable chlorine reservoir species (ClONO2 and HCl) into photochemically active chlorine in the form of HOCl and Cl2. Condensation of HNO3 in the reactions removes odd nitrogen from the stratosphere, a requirement in nearly all models of Antarctic ozone depletion. Other reactions may also be important for Antarctic ozone depletion. Like the reactions of chlorine nitrate, these reactions deplete odd nitrogen through HNO3 condensation. In addition, one reaction converts a stable chlorine reservior species (HCl) into photochemically active chlorine (ClNO2). These reactions were studied with a modified version of a Knudsen cell flow reactor

Quantifying the volunteer effort of scientific peer reviewing

A survey of 310 reviewers for Monthly Weather Review addresses how much time and effort goes into the peer-review process and provides insight into how reviewers function. Using these data, the individual and collective contributions of volunteer peer reviewers to the peer-review process can be determined. Individually, respondents to the survey review an average of 2 manuscripts a year for Monthly Weather Review, 4 manuscripts a year for AMS journals, and 8 manuscripts a year in total, although some review more than 20 manuscripts a year. Each review takes an average of 9.6 h. Summing the individual contributions of the reviewers, respondents averaged 18 h yr−1 performing reviews for Monthly Weather Review, 36 h yr−1 for AMS journals, and 63 h yr−1 for all journals. The collective time that all of the reviewers put into the peer-review process for all manuscripts submitted to Monthly Weather Review for each year amounts to 362,179 h, or more than 4 years of voluntary labor valued at over $2.34 million. Nearly all respondents (95%) are comfortable with their current load, but only 30% said that they would be willing to perform more reviews. Because the number of submissions to journals has been increasing over time and is unlikely to decrease in the near future, this burden is anticipated to grow. Options for reducing the burden include using fewer reviewers per manuscript, increasing the number of unilateral decisions made by editors, and increasing the size of the reviewer pool (particularly from active retired and early-career scientists).</jats:p

Regulation of alveolar macrophage p40phox: hierarchy of activating kinases and their inhibition by PGE2

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141717/1/jlb0219.pd

Oxidized quinones signal onset of darkness directly to the cyanobacterial circadian oscillator

Synchronization of the circadian clock in cyanobacteria with the day/night cycle proceeds without an obvious photoreceptor, leaving open the question of its specific mechanism. The circadian oscillator can be reconstituted in vitro,where the activities of two of its proteins, KaiA and KaiC, are affected by metabolites that reflect photosynthetic activity: KaiC phosphorylation is directly influenced by the ATP/ADP ratio, and KaiA stimulation of KaiC phosphorylation is blocked by oxidized, but not reduced, quinones. Manipulation of the ATP/ADP ratio can reset the timing of KaiC phosphorylation peaks in the reconstituted in vitro oscillator. Here, we show that pulses of oxidized quinones reset the cyanobacterial circadian clock both in vitro and in vivo. Onset of darkness causes an abrupt oxidation of the plastoquinone pool in vivo, which is in contrast to a gradual decrease in the ATP/ADP ratio that falls over the course of hours until the onset of light. Thus, these twometabolicmeasures of photosynthetic activity act in concert to signal both the onset and duration of darkness to the cyanobacterial clock

Little Higgses from an Antisymmetric Condensate

We construct an SU(6)/Sp(6) non-linear sigma model in which the Higgses arise as pseudo-Goldstone bosons. There are two Higgs doublets whose masses have no one-loop quadratic sensitivity to the cutoff of the effective theory, which can be at around 10 TeV. The Higgs potential is generated by gauge and Yukawa interactions, and is distinctly different from that of the minimal supersymmetric standard model. At the TeV scale, the new bosonic degrees of freedom are a single neutral complex scalar and a second copy of SU(2)xU(1) gauge bosons. Additional vector-like pairs of colored fermions are also present.Comment: 13 page

Natural variants of photosystem II subunit D1 tune photochemical fitness to solar intensity

Background: Cyanobacteria use multiple PSII-D1 isoforms to adapt to environmental conditions. Results: D1:2 achieves higher quantum efficiency of water oxidation and biomass accumulation rate at high light versus D1:1; the latter is more efficient at low light due to less charge recombination. Conclusion: A functional advantage for D1:1 is revealed for the first time. Significance: Improved photochemical efficiency at low light suggests an evolutionary advantage to retain D1:1. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc

Differential regulation by leukotrienes and calcium of Fcγ receptorâ induced phagocytosis and Syk activation in dendritic cells versus macrophages

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141597/1/jlb1234.pd

EP4 and EP2 Receptor Activation of Protein Kinase A by Prostaglandin E 2 Impairs Macrophage Phagocytosis of Clostridium sordellii

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102186/1/aji12153.pd

Effectiveness of structured patient-clinician communication with a solution focused approach (DIALOG+) in community treatment of patients with psychosis - a cluster randomised controlled trial

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited