40 research outputs found
Relativistic Mean-Field Theory and the High-Density Nuclear Equation of State
The properties of high-density nuclear and neutron matter are studied using a
relativistic mean-field approximation to the nuclear matter energy functional.
Based on ideas of effective field theory, nonlinear interactions between the
fields are introduced to parametrize the density dependence of the energy
functional. Various types of nonlinearities involving scalar-isoscalar
(), vector-isoscalar (), and vector-isovector () fields
are studied. After calibrating the model parameters at equilibrium nuclear
matter density, the model and parameter dependence of the resulting equation of
state is examined in the neutron-rich and high-density regime. It is possible
to build different models that reproduce the same observed properties at normal
nuclear densities, but which yield maximum neutron star masses that differ by
more than one solar mass. Implications for the existence of kaon condensates or
quark cores in neutron stars are discussed.Comment: 26 pages in RevTex, 12 PostScript figure
Acute and chronic lung inflammation drives changes in epithelial glycans
IntroductionAsthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally referring to collagen deposition and epithelial hyperplasia. Changes in hyaluronin production have also been demonstrated, while mutations in fucosyltransferases reportedly limit asthmatic inflammation.MethodsGiven the importance of glycans in cellular communication and to better characterize tissue glycosylation changes associated with asthma, we performed a comparative glycan analysis of normal and inflamed lungs from a selection of murine asthma models.ResultsWe found that among other changes, the most consistent was an increase in fucose-α1,3-N-acetylglucosamine (Fuc-α1,3-GlcNAc) and fucose-α1,2-galactose (Fuc-α1,2-Gal) motifs. Increases in terminal galactose and N-glycan branching were also seen in some cases, whereas no overall change in O-GalNAc glycans was observed. Increased Muc5AC was found in acute but not chronic models, and only the more human-like triple antigen model yielded increased sulfated galactose motifs. We also found that human A549 airway epithelial cells stimulated in culture showed similar increases in Fuc-α1,2-Gal, terminal galactose (Gal), and sulfated Gal, and this matched transcriptional upregulation of the α1,2-fucosyltransferase Fut2 and the α1,3-fucosyltransferases Fut4 and Fut7.ConclusionsThese data suggest that airway epithelial cells directly respond to allergens by increasing glycan fucosylation, a known modification important for the recruitment of eosinophils and neutrophils
Hydrogen Epoch of Reionization Array (HERA)
The Hydrogen Epoch of Reionization Array (HERA) is a staged experiment to
measure 21 cm emission from the primordial intergalactic medium (IGM)
throughout cosmic reionization (), and to explore earlier epochs of our
Cosmic Dawn (). During these epochs, early stars and black holes
heated and ionized the IGM, introducing fluctuations in 21 cm emission. HERA is
designed to characterize the evolution of the 21 cm power spectrum to constrain
the timing and morphology of reionization, the properties of the first
galaxies, the evolution of large-scale structure, and the early sources of
heating. The full HERA instrument will be a 350-element interferometer in South
Africa consisting of 14-m parabolic dishes observing from 50 to 250 MHz.
Currently, 19 dishes have been deployed on site and the next 18 are under
construction. HERA has been designated as an SKA Precursor instrument.
In this paper, we summarize HERA's scientific context and provide forecasts
for its key science results. After reviewing the current state of the art in
foreground mitigation, we use the delay-spectrum technique to motivate
high-level performance requirements for the HERA instrument. Next, we present
the HERA instrument design, along with the subsystem specifications that ensure
that HERA meets its performance requirements. Finally, we summarize the
schedule and status of the project. We conclude by suggesting that, given the
realities of foreground contamination, current-generation 21 cm instruments are
approaching their sensitivity limits. HERA is designed to bring both the
sensitivity and the precision to deliver its primary science on the basis of
proven foreground filtering techniques, while developing new subtraction
techniques to unlock new capabilities. The result will be a major step toward
realizing the widely recognized scientific potential of 21 cm cosmology.Comment: 26 pages, 24 figures, 2 table
Phase Transitions in Warm, Asymmetric Nuclear Matter
A relativistic mean-field model of nuclear matter with arbitrary proton
fraction is studied at finite temperature. An analysis is performed of the
liquid-gas phase transition in a system with two conserved charges (baryon
number and isospin) using the stability conditions on the free energy, the
conservation laws, and Gibbs' criteria for phase equilibrium. For a binary
system with two phases, the coexistence surface (binodal) is two-dimensional.
The Maxwell construction through the phase-separation region is discussed, and
it is shown that the stable configuration can be determined uniquely at every
density. Moreover, because of the greater dimensionality of the binodal
surface, the liquid-gas phase transition is continuous (second order by
Ehrenfest's definition), rather than discontinuous (first order), as in
familiar one-component systems. Using a mean-field equation of state calibrated
to the properties of nuclear matter and finite nuclei, various phase-separation
scenarios are considered. The model is then applied to the liquid-gas phase
transition that may occur in the warm, dilute matter produced in energetic
heavy-ion collisions. In asymmetric matter, instabilities that produce a
liquid-gas phase separation arise from fluctuations in the proton concentration
(chemical instability), rather than from fluctuations in the baryon density
(mechanical instability).Comment: Postscript file, 50 pages including 23 figure
Optimizing Sparse RFI Prediction using Deep Learning
Radio Frequency Interference (RFI) is an ever-present limiting factor among
radio telescopes even in the most remote observing locations. When looking to
retain the maximum amount of sensitivity and reduce contamination for Epoch of
Reionization studies, the identification and removal of RFI is especially
important. In addition to improved RFI identification, we must also take into
account computational efficiency of the RFI-Identification algorithm as radio
interferometer arrays such as the Hydrogen Epoch of Reionization Array grow
larger in number of receivers. To address this, we present a Deep Fully
Convolutional Neural Network (DFCN) that is comprehensive in its use of
interferometric data, where both amplitude and phase information are used
jointly for identifying RFI. We train the network using simulated HERA
visibilities containing mock RFI, yielding a known "ground truth" dataset for
evaluating the accuracy of various RFI algorithms. Evaluation of the DFCN model
is performed on observations from the 67 dish build-out, HERA-67, and achieves
a data throughput of 1.6 HERA time-ordered 1024 channeled
visibilities per hour per GPU. We determine that relative to an amplitude only
network including visibility phase adds important adjacent time-frequency
context which increases discrimination between RFI and Non-RFI. The inclusion
of phase when predicting achieves a Recall of 0.81, Precision of 0.58, and
score of 0.75 as applied to our HERA-67 observations.Comment: 11 pages, 7 figure
HI 21cm Cosmology and the Bi-spectrum: Closure Diagnostics in Massively Redundant Interferometric Arrays
New massively redundant low frequency arrays allow for a novel investigation
of closure relations in interferometry. We employ commissioning data from the
Hydrogen Epoch of Reionization Array to investigate closure quantities in this
densely packed grid array of 14m antennas operating at 100 MHz to 200 MHz. We
investigate techniques that utilize closure phase spectra for redundant triads
to estimate departures from redundancy for redundant baseline visibilities. We
find a median absolute deviation from redundancy in closure phase across the
observed frequency range of about 4.5deg. This value translates into a
non-redundancy per visibility phase of about 2.6deg, using prototype
electronics. The median absolute deviations from redundancy decrease with
longer baselines. We show that closure phase spectra can be used to identify
ill-behaved antennas in the array, independent of calibration. We investigate
the temporal behavior of closure spectra. The Allan variance increases after a
one minute stride time, due to passage of the sky through the primary beam of
the transit telescope. However, the closure spectra repeat to well within the
noise per measurement at corresponding local sidereal times (LST) from day to
day. In future papers in this series we will develop the technique of using
closure phase spectra in the search for the HI 21cm signal from cosmic
reionization.Comment: 32 pages. 11 figures. Accepted to Radio Scienc
Mitigating Internal Instrument Coupling for 21 cm Cosmology. II. A Method Demonstration with the Hydrogen Epoch of Reionization Array
We present a study of internal reflection and cross-coupling systematics in Phase I of the Hydrogen Epoch of Reionization Array (HERA). In a companion paper, we outlined the mathematical formalism for such systematics and presented algorithms for modeling and removing them from the data. In this work, we apply these techniques to data from HERA's first observing season as a method demonstration. The data show evidence for systematics that, without removal, would hinder a detection of the 21 cm power spectrum for the targeted Epoch of Reionization (EoR) line-of-sight modes in the range 0.2 h −1 Mpc−1 < < 0.5 h −1 Mpc−1. In particular, we find evidence for nonnegligible amounts of spectral structure in the raw autocorrelations that overlaps with the EoR window and is suggestive of complex instrumental effects. Through systematic modeling on a single night of data, we find we can recover these modes in the power spectrum down to the integrated noise floor, achieving a dynamic range in the EoR window of 106 in power (mK2 units) with respect to the bright galactic foreground signal. Future work with deeper integrations will help determine whether these systematics can continue to be mitigated down to EoR levels. For future observing seasons, HERA will have upgraded analog and digital hardware to better control these systematics in the field