196 research outputs found
Entrepreneurial Passion: Sources and Sustenance
Entrepreneurial passion helps coordinate cognition and behavior of entrepreneurs, providing the fire that fuels innovation, persistence, and ultimate success. But where does entrepreneurial passion come from? Using a phenomenological approach, we conduct a qualitative study of 80 entrepreneurs and analyze their oral histories to explore the sources of entrepreneurial passion, as experienced by entrepreneurs. Our discovery process in the interviews suggests six major sources of entrepreneurial passion: passion for building/developing the venture, passion for people, passion for the product or service, passion for inventing, passion for competition, and passion for a social cause
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Treatment of infantile spasms: emerging insights from clinical and basic science perspectives.
Infantile spasms is an epileptic encephalopathy of early infancy with specific clinical and electroencephalographic (EEG) features, limited treatment options, and a poor prognosis. Efforts to develop improved treatment options have been hindered by the lack of experimental models in which to test prospective therapies. The neuropeptide adrenocorticotropic hormone (ACTH) is effective in many cases of infantile spasms, although its mechanism(s) of action is unknown. This review describes the emerging candidate mechanisms that can underlie the therapeutic effects of ACTH in infantile spasms. These mechanisms can ultimately help to improve understanding and treatment of the disease. An overview of current treatments of infantile spasms, novel conceptual and experimental approaches to infantile spasms treatment, and a perspective on remaining clinical challenges and current research questions are presented here. This summary derives from a meeting of specialists in infantile spasms clinical care and research held in New York City on June 14, 2010
The nature of point source fringes in mid-infrared spectra acquired with the James Webb Space Telescope
The constructive and destructive interference in different layers of the
James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) detector
arrays modulate the detected signal as a function of wavelength. Additionally,
sources of different spatial profiles show different fringe patterns. Dividing
by a static fringe flat could hamper the scientific interpretation of sources
whose fringes do not match that of the fringe flat. We find point source
fringes measured by the MIRI Medium-Resolution Spectrometer (MRS) to be
reproducible under similar observing conditions. We want, thus, to identify the
variables, if they exist, that would allow for a parametrization of the signal
variations induced by point source fringe modulations. We do this by analyzing
MRS detector plane images acquired on the ground. We extracted the fringe
profile of multiple point source observations and studied the amplitude and
phase of the fringes as a function of field position and pixel sampling of the
point spread function of the optical chain. A systematic variation in the
amplitude and phase of the point source fringes is found over the wavelength
range covered by the test sources (4.9-5.8 m). The variation depends on
the fraction of the point spread function seen by the detector pixel. We
identify the non-uniform pixel illumination as the root cause of the reported
systematic variation. We report an improvement after correction of 50% on the
1 standard deviation of the spectral continuum. A 50% improvement is
also reported in line sensitivity for a benchmark test with a spectral
continuum of 100 mJy. The improvement in the shape of weak lines is illustrated
using a T Tauri model spectrum. Consequently, we verify that fringes of
extended sources and potentially semi-extended sources and crowded fields can
be simulated by combining multiple point source fringe transmissions.Comment: 17 pages, 31 figure
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Cognitive dysfunction in Adult Congenital Heart Disease with different structural complexity
We carried out a cross-sectional study to assess cognitive function in a sample of adult CHD patients, within the Functioning in Adult Congenital Heart Disease study London. The association between cognitive functioning and disease complexity was examined.
A total of 310 patients participated in this study. Patients were classified into four structural complexity groups – tetralogy of Fallot, transposition of the great arteries, single ventricle, and simple conditions. Each patient underwent neuropsychological assessment to evaluate cognitive function, including memory and executive function, and completed questionnaires to assess depression and anxiety.
Among all, 41% of the sample showed impaired performance (>1.5 SD below the normative mean) on at least three tests of cognitive function compared with established normative data. This was higher than the 8% that was expected in a normal population. The sample exhibited significant deficits in divided attention, motor function, and executive functioning. There was a significant group difference in divided attention (F=5.01, p=0.002) and the mean total composite score (F=5.19, p=0.002) between different structural complexity groups, with the simple group displaying better cognitive function.
The results indicate that many adult CHD patients display impaired cognitive function relative to a healthy population, which differs in relation to disease complexity. These findings may have implications for clinical decision making in this group of patients during childhood. Possible mechanisms underlying these deficits and how they may be reduced or prevented are discussed; however, further work is needed to draw conclusive judgements
International Veterinary Epilepsy Task Force Consensus Proposal: Outcome of therapeutic interventions in canine and feline epilepsy
Common criteria for the diagnosis of drug resistance and the assessment of outcome are needed urgently as a prerequisite for standardized evaluation and reporting of individual therapeutic responses in canine epilepsy. Thus, we provide a proposal for the definition of drug resistance and partial therapeutic success in canine patients with epilepsy. This consensus statement also suggests a list of factors and aspects of outcome, which should be considered in addition to the impact on seizures. Moreover, these expert recommendations discuss criteria which determine the validity and informative value of a therapeutic trial in an individual patient and also suggest the application of individual outcome criteria. Agreement on common guidelines does not only render a basis for future optimization of individual patient management, but is also a presupposition for the design and implementation of clinical studies with highly standardized inclusion and exclusion criteria. Respective standardization will improve the comparability of findings from different studies and renders an improved basis for multicenter studies. Therefore, this proposal provides an in-depth discussion of the implications of outcome criteria for clinical studies. In particular ethical aspects and the different options for study design and application of individual patient-centered outcome criteria are considered
Early Switch from Intravenous to Oral Antibiotics in Skin- and Soft-tissue Infections: An Algorithm-based Prospective Multicentre Pilot Trial.
BACKGROUND: In hospitalized patients with skin and soft tissue infections (SSTIs), intravenous (IV) empiric antibiotic treatment is initiated. The best time point for switching from IV to oral treatment is unknown. We used an algorithm-based decision tree for the switch from IV to oral antibiotics within 48 hours and aimed to investigate the treatment outcome of this concept. METHODS: In a nonrandomized trial, we prospectively enrolled 128 patients hospitalized with SSTI from July 2019 to May 2021 at 3 institutions. Clinical and biochemical response data during the first week and at follow-up after 30 days were analyzed. Patients fulfilling criteria for the switch from IV to oral antibiotics were assigned to the intervention group. The primary outcome was a composite definition consisting of the proportion of patients with clinical failure or death of any cause. RESULTS: Ninety-seven (75.8%) patients were assigned to the intervention group. All of them showed signs of clinical improvement (ie, absence of fever or reduction of pain) within 48 hours of IV treatment, irrespective of erythema finding or biochemical response. The median total antibiotic treatment duration was 11 (interquartile range [IQR], 9–13) days in the invention group and 15 (IQR, 11–24) days in the nonintervention group (P < .001). The median duration of hospitalization was 5 (IQR, 4–6) days in the intervention group and 8 (IQR, 6–12) days in the nonintervention group (P < .001). There were 5 (5.2%) failures in the intervention group and 1 (3.2%) in the nonintervention group after a median follow-up of 37 days. CONCLUSIONS: In this pilot trial, the proposed decision algorithm for early switch from IV to oral antibiotics for SSTI treatment was successful in 95% of cases. Clinical Trials Registration. ISRCTN1524549
JWST MIRI flight performance: The Medium-Resolution Spectrometer
The Medium-Resolution Spectrometer (MRS) provides one of the four operating
modes of the Mid-Infrared Instrument (MIRI) on board the James Webb Space
Telescope (JWST). The MRS is an integral field spectrometer, measuring the
spatial and spectral distributions of light across the 5-28 wavelength
range with a spectral resolving power between 3700-1300. We present the MRS's
optical, spectral, and spectro-photometric performance, as achieved in flight,
and we report on the effects that limit the instrument's ultimate sensitivity.
The MRS flight performance has been quantified using observations of stars,
planetary nebulae, and planets in our Solar System. The precision and accuracy
of this calibration was checked against celestial calibrators with well-known
flux levels and spectral features. We find that the MRS geometric calibration
has a distortion solution accuracy relative to the commanded position of 8 mas
at 5 and 23 mas at 28 . The wavelength calibration is accurate
to within 9 km/sec at 5 and 27 km/sec at 28 . The uncertainty in
the absolute spectro-photometric calibration accuracy was estimated at 5.6 +-
0.7 %. The MIRI calibration pipeline is able to suppress the amplitude of
spectral fringes to below 1.5 % for both extended and point sources across the
entire wavelength range. The MRS point spread function (PSF) is 60 % broader
than the diffraction limit along its long axis at 5 and is 15 % broader
at 28 . The MRS flight performance is found to be better than prelaunch
expectations. The MRS is one of the most subscribed observing modes of JWST and
is yielding many high-profile publications. It is currently humanity's most
powerful instrument for measuring the mid-infrared spectra of celestial sources
and is expected to continue as such for many years to come.Comment: 16 pages, 21 figure
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