Review of the Books: Eribon, Didier. 2013. Returning to Reims, Los Angeles/CA, Semiotext(e). Louis, Édouard. 2017. The End of Eddy. London, Harvill Secker

Eribon, Didier. 2009. Retour à Reims. Une théorie du sujet, Paris: Librairie Arthème Fayard.Louis, Édouard. 2014. En finir avec Eddy Bellegueule, Paris, Éditions du Seuil.Eribon, Didier. 2016. Rückkehr nach Reims. Berlin, Suhrkamp Verlag.Louis, Édouard. 2016. Das Ende von Eddy, Frankfurt am Main, S. Fischer Verlag

Análise de livros didáticos de biologia com foco na educação ambiental

The present work presents an analysis made in Didactic Books (LD) of Biology of High School (MS) used by teachers and students (of a public school) in a classroom with a look at the theme of Environmental Education (EA) And / or the relationship with the content addressed. Although the National Curricular Parameters (NCP) on Environment focus on EE with a transforming principle of environmental care, there are still difficulties among educators in relating the theme to the content of the curricular component. In this way, it is important that we study LD more, a sometimes guiding tool used by teachers in their teaching planning. In order to do this, a documentary research was done referring to some documents and Laws, as well as an analysis in three LD distributed to schools through the National Program of Didactic Book (PNLD) used by teachers and students of high school. To do so, we draw up a table for each LD highlighting the excerpts on the theme EA. The results obtained showed little insertion of the EA, which requires a problematization to integrate the specific contents in the LD, which need to be reviewed and discussed, such as the content: nutrition, respective to question about the reduction of the induced consumption of canned products and Artificially manufactured, for example.O presente trabalho apresenta uma análise feita em Livros Didáticos (LD) de Biologia do Ensino Médio (EM) utilizados pelos professores e alunos (de uma escola pública) em sala de aula com olhar para a temática da Educação Ambiental (EA) visto a inserção e/ou a relação com os conteúdos abordados. Mesmo que os Parâmetros Curriculares Nacionais (PCN) sobre Meio Ambiente foquem na EA com princípio transformador de cuidado ambiental, ainda assim existem dificuldades entre os educadores em relacionar a temática com o conteúdo do componente curricular. Desta forma, é importante que estudemos mais o LD, uma ferramenta por vezes norteadora utilizada pelos professores em seu planejamento de ensino. Para isso foi realizada uma pesquisa documental referenciando alguns documentos e Leis, bem como uma analise em três LD distribuídos as escolas por intermédio do Programa Nacional do Livro Didático (PNLD) utilizados por professores e alunos do ensino médio. Para tanto elaboramos uma tabela para cada LD destacando os excertos sobre a temática EA. Os resultados obtidos mostraram pouca inserção da EA, o que requer uma problematização para integração dos conteúdos específicos nos LD, os quais precisam ser revistos e discutidos, a exemplo do conteúdo: nutrição, respectivo a problematizar sobre a diminuição do consumo induzido de produtos enlatados e fabricados artificialmente, por exemplo

Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells

Background: Mtss1 encodes an actin-binding protein, dysregulated in a variety of tumors, that interacts with sonic hedgehog/Gli signaling in epidermal cells. Given the prime importance of this pathway for cerebellar development and tumorigenesis, we assessed expression of Mtss1 in the developing murine cerebellum and human medulloblastoma specimens. Results: During development, Mtss1 is transiently expressed in granule cells, from the time point they cease to proliferate to their synaptic integration. It is also expressed by granule cell precursor-derived medulloblastomas. In the adult CNS, Mtss1 is found exclusively in cerebellar Purkinje cells. Neuronal differentiation is accompanied by a switch in Mtss1 splicing. Whereas immature granule cells express a Mtss1 variant observed also in peripheral tissues and comprising exon 12, this exon is replaced by a CNS-specific exon, 12a, in more mature granule cells and in adult Purkinje cells. Bioinformatic analysis of Mtss1 suggests that differential exon usage may affect interaction with Fyn and Src, two tyrosine kinases previously recognized as critical for cerebellar cell migration and histogenesis. Further, this approach led to the identification of two evolutionary conserved nuclear localization sequences. These overlap with the actin filament binding site of Mtss1, and one also harbors a potential PKA and PKC phosphorylation site. Conclusion: Both the pattern of expression and splicing of Mtss1 is developmentally regulated in the murine cerebellum. These findings are discussed with a view on the potential role of Mtss1 for cytoskeletal dynamics in developing and mature cerebellar neurons

Brief Depression Screening with the PHQ-2 Associated with Prognosis Following Percutaneous Coronary Intervention with Paclitaxel-Eluting Stenting

BACKGROUND: Depression is associated with adverse prognosis in cardiac patients, warranting the availability of brief and valid instruments to identify depressed patients in clinical practice. OBJECTIVES: We examined whether the two-item Patient Health Questionnaire (PHQ-2) was associated with adverse events in percutaneous coronary intervention (PCI) patients treated with paclitaxel-eluting stenting (using the continuous score and various cutoffs), overall and by gender. DESIGN: Prospective follow-up study. PARTICIPANTS: Consecutive PCI patients (n=796) seen at a university medical centre. MEASUREMENTS: PHQ-2 at baseline. The study end-point was an adverse event, defined as a combination of death or non-fatal myocardial infarction (MI) at follow-up (mean of 1.4 years). RESULTS: At follow-up, 47 patients had experienced an adverse event. Using the continuous score of the PHQ-2 and the recommended cutoff >= 3, depressive symptoms were not associated with adverse events (ps>0.05). Using a cutoff >= 2, depressive symptoms were significantly associated with adverse events (HR: 1.89; 95% CI: 1.06-3.35) and remained significant in adjusted analysis (HR: 1.90; 95% CI: 1.05-3.44). Depressive symptoms were associated with an increased risk of adverse events in men (HR: 2.69; 95% CI: 1.36-5.32) but not in women (HR: 0.76; 95% CI: 0.24-2.43); these results remained in adjusted analysis. CONCLUSIONS: Depression screening with a two-item scale and a cutoff score of >= 2 was independently associated with adverse events at follow-up. The PHQ-2 is a brief and valid measure that can easily be used post PCI to identify patients at risk for adverse health outcomes

Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control

Missing in Metastasis (MIM), or Metastasis Suppressor 1 (MTSS1), is a highly conserved protein, which links the plasma membrane to the actin cytoskeleton. MIM has been implicated in various cancers, however, its modes of action remain largely enigmatic. Here, we performed an extensive in silico characterisation of MIM to gain better understanding of its function. We detected previously unappreciated functional motifs including adaptor protein (AP) complex interaction site and a C-helix, pointing to a role in endocytosis and regulation of actin dynamics, respectively. We also identified new functional regions, characterised with phosphorylation sites or distinct hydrophilic properties. Strong negative selection during evolution, yielding high conservation of MIM, has been combined with positive selection at key sites. Interestingly, our analysis of intra-molecular co-evolution revealed potential regulatory hotspots that coincided with reduced potentially\ua0pathogenic polymorphisms. We explored databases for the mutations and expression levels of MIM in cancer. Experimentally, we focused on chronic lymphocytic leukaemia (CLL), where MIM showed high overall expression, however, downregulation on poor prognosis samples. Finally, we propose strong conservation of MTSS1 also on the transcriptional level and predict novel transcriptional regulators. Our data highlight important targets for future studies on the role of MIM in different tissues and cancers