Shuttle LOX loading transient study. Task 2 milestone report. National space and technology laboratories (NSTL) LOX loading facility analysis

Transient thermodynamic analyses were made of the LOX loading system proposed for the space shuttle main propulsion test article (MPTA). This system is made up of a LOX replenish system and a main LOX line which include the barge tank, the lines, pumps, and valves between the barge and the orbiter (ORB) ground service equipment (GSE) interface, the MPTA fill system, the space shuttle main engine (SSME) chilldown bleed system, and the GSE vent system. System analyses include predictions of system performance sensitivity to operating sequence and LOX flowrate, temperature, and quality at the ORB/GSE interface. The transient thermodynamic conditions at the SSME feed line entrance, ET entrance (tank bottom), and the SSME bleed/GSE vent TEE are also included. The analyses are based on continuous SSME bleed flow during GSE facility chilldown

Shuttle LOX Loading Transient Study

The configuration and operation of the LOX loading facilities to be used for the space shuttle main propulsion test article at the National Space and Technology Laboratories (NSTL), and for the space shuttle launch facilities at John F. Kennedy Space Center (KSC) was investigated. The acceptability of these LOX loading facilities for each application was determined along with the degree of similarity between the systems with respect to the applicability of data developed during operations at NSTL a to the launch site operations at KSC. Results are summarized and final data comparisons, conclusions, and recommendations are presented

Investigation of Statistical and Imaging Methods for Luminescence Detection of Irradiated Ingredients

This project investigated two potential approaches to improving the reliability of lumines-cence methods for detecting minor irradiated ingredients in foods. Whereas in the 1980’s there were no validated methods for laboratory detection of irradiated foods, work conducted in the UK and elsewhere by the mid 1990’s had resulted in the development of a series of physical, chemical and biological methods capable of detecting a range of irradiated food classes. Of these the luminescence methods embodied in EN1788 (Thermoluminescence) and EN13751 (Photostimulated luminescence) standards have been applied to detection of a vari-ety of products including herbs and spices, and seafood. In common with the other EN stan-dard methods almost all validation work had been originally conducted using pure irradiated or unirradiated ingredients. Yet application experience had shown the presence of mixed products containing both irradiated and unirradiated ingredients. A short study was commis-sioned by MAFF to investigate the impact of blending on standard EN1788 methods, and on the provisional draft EN13751 (the standard having been published in the meantime) method. This showed the impact of dilution of irradiated material between 10% and 0.1% concentra-tions on detection rates, which unsurprisingly are reduced by extreme dilution. UK labelling regulation, both before and after adoption of the European Directive on Food Irradiation, call for labelling of all irradiated ingredients regardless of concentration or origin within the final product. This study was therefore motivated by the recognition of the long term need for im-proved methods to improve reliability at low concentrations. Two complementary approaches were investigated. The project first examined whether TL data collected using the EN1788 method could be enhanced using advanced statistical proce-dures. Data sets from the SURRC TL archive, and from project CSA4790 were used both to define the characteristics of irradiated and unirradiated end members, and to assess classifica-tion methods using the controlled blending experimental data sets of CSA 4790. Multivariate analyses, based on principal components analysis and discriminant analysis of glow curve data; kinetic deconvolution approaches coupled to PCA and DA, and neural analyses were investigated and compared with detection rates achieved using expert visual classification. To complement this experiments were undertaken to explore the potential of using focussed laser stimulation to produce spatially resolved measurements from mineral grains separated from foods. Two systems were evaluated based on IR and visible band lasers. Work was under-taken to explore sample presentation and to assess the ability of this approach to distinguish mixtures of irradiated and unirradiated grains. The statistical work was successful in developing three approaches which could be used for objective identification of irradiated materials. Pure irradiated and unirradiated data sets from 150 sample pairs were obtained having searched the SUERC archive of more than 3500 lu-minescence analyses. These were used to set up multivariate analyses based on the ap-proaches outlined above. Performance in recognising irradiated ingredients using these meth-ods was then assessed with data drawn from the MAFF blending investigation, comprising 160 permutations of irradiated and unirradiated herbs and spices at 10%, 1% and 0.1% con-centrations. It was possible to achieve good detection rates with alatistical approaches, the best approaches inigated being the use of glow curve deconvolution coupwith li discrimination, and the use of neural appros. The absolute performance achieved matched that opert visual clfication utilising the revised EN1788 criterwhich were adopted within the international standauring course of this project. The use of ad-vancedtistical methods, while not adding performance, can pde objective support to visual classifications. During performance assessment it was aloted that theformance of all methods wasficiently close to infer that detections rates are most dependent on the statistical presence or absence of irradiated grains within the extracted samples used for TL analysis. This raises practical suggestions for improving detection rates at low concentrations based on the use of larger samples and more specific mineral separation approaches. These may be worth investigating further. Laser scanning approaches were also investigated using highly focussed laser beams to stimulated luminescence sequentially from different parts of separated mineral samples. Work was conducted using a system which had been developed in earlier work at SUERC, and then followed by additional investigation using an improved instrument built during the project. Initial work confirmed the feasibility of using laser scanning approaches to obtain spatially resolved luminescence data at or near the dimensions of individual mineral grains. Practical obstacles included the recognition that laser scattering from surfaces coated with mineral grains introduced an element of cross-talk between different parts of the sample, and difficulties in accurate re-positioning of the sample using the first generation prototype in-strument. Work was conducted to investigate a series of different sample presentation media to improve the former, and to incorporate high precision mechanical and optoelectronic means of re-positioning samples between initial measurements, external irradiation, and sub-sequent re-measurement. Both IR and visible band semiconductor lasers were investigated with successful production of single grain images. The short and medium term reliability of the lasers used was acceptable. The lasers used both however eventually failed, which sug-gests that long term lifetime may be an issue for further work. Of the two lasers the IR laser in particular gave a good signal to background ratio for discriminating between irradiated and unirradiated grains. Quantitative analysis of the grain resolved images confirms the potential of this approach in identifying minor irradiated components. The overall conclusions of the work are that both statistical approaches and imaging instru-ments are able to enhance current methods. The observation that visual classification can match the performance even of deconvolution or neural approaches suggests that future effort should be directed more towards improvement of grain statistics in conventional measure-ments, and in further development and investigation of imaging approaches. In these ways it can anticipated that the performance of standard luminescence methods for detecting dilute mixtures of irradiated and unirradiated food ingredients could be significantly improved. To do so would further enhance work conducted by FSA and other bodies to ensure that regula-tions governing the use of irradiation in food processing and the labelling of imported foods are followed

Assessing Organizational Readiness for Depression Care Quality Improvement: Relative Commitment and Implementation Capability

Background: Depression is a major cause of morbidity and cost in primary care patient populations. Successful depression improvement models, however, are complex. Based on organizational readiness theory, a practice’s commitment to change and its capability to carry out the change are both important predictors of initiating improvement. We empirically explored the links between relative commitment (i.e., the intention to move forward within the following year) and implementation capability. Methods: The DIAMOND initiative administered organizational surveys to medical and quality improvement leaders from each of 83 primary care practices in Minnesota. Surveys preceded initiation of activities directed at implementation of a collaborative care model for improving depression care. To assess implementation capability, we developed composites of survey items for five types of organizational factors postulated to be collaborative care barriers and facilitators. To assess relative commitment for each practice, we averaged leader ratings on an identical survey question assessing practice priorities. We used multivariable regression analyses to assess the extent to which implementation capability predicted relative commitment. We explored whether relative commitment or implementation capability measures were associated with earlier initiation of DIAMOND improvements. Results: All five implementation capability measures independently predicted practice leaders’ relative commitment to improving depression care in the following year. These included the following: quality improvement culture and attitudes (p = 0.003), depression culture and attitudes (p \u3c0.001), prior depression quality improvement activities (p \u3c0.001), advanced access and tracking capabilities (p = 0.03), and depression collaborative care features in place (p = 0.03). Higher relative commitment (p = 0.002) and prior depression quality improvement activities appeared to be associated with earlier participation in the DIAMOND initiative. Conclusions: The study supports the concept of organizational readiness to improve quality of care and the use of practice leader surveys to assess it. Practice leaders’ relative commitment to depression care improvement may be a useful measure of the likelihood that a practice is ready to initiate evidence-based depression care changes. A comprehensive organizational assessment of implementation capability for depression care improvement may identify specific barriers or facilitators to readiness that require targeted attention from implementers

Crocodiles and grey nomads: a deadly combination?

Increasing numbers of retirees seek individual, extended, unstructured activities in remote, non-commercial locations. Travel is predominantly by self-drive 4WD vehicle towing a caravan/campervan. These ‘grey nomads’ often prefer remote bush camping sites/caravan parks to commercial resorts. The tropics – a popular destination – are inhabited by Australia’s only large semi-terrestrial carnivore, the estuarine crocodile Crocodylus porosus. Conservation programmes of recent decades have resulted in a substantial increase in numbers. With naive grey nomads increasingly encroaching on crocodile territory, attacks are expected to increase. Review of conservation programmes to incorporate awareness education targeting grey nomads is therefore required

Randomized controlled trial of a web-based computer-tailored smoking cessation program as a supplement to nicotine patch therapy

Aim  To assess the efficacy of World Wide Web-based tailored behavioral smoking cessation materials among nicotine patch users. Design  Two-group randomized controlled trial. Setting  World Wide Web in England and Republic of Ireland. Participants  A total of 3971 subjects who purchased a particular brand of nicotine patch and logged-on to use a free web-based behavioral support program. Intervention  Web-based tailored behavioral smoking cessation materials or web-based non-tailored materials. Measurements  Twenty-eight-day continuous abstinence rates were assessed by internet-based survey at 6-week follow-up and 10-week continuous rates at 12-week follow-up. Findings  Using three approaches to the analyses of 6- and 12-week outcomes, participants in the tailored condition reported clinically and statistically significantly higher continuous abstinence rates than participants in the non-tailored condition. In our primary analyses using as a denominator all subjects who logged-on to the treatment site at least once, continuous abstinence rates at 6 weeks were 29.0% in the tailored condition versus 23.9% in the non-tailored condition (OR = 1.30; P  = 0.0006); at 12 weeks continuous abstinence rates were 22.8% versus 18.1%, respectively (OR = 1.34; P  = 0.0006). Moreover, satisfaction with the program was significantly higher in the tailored than in the non-tailored condition. Conclusions  The results of this study demonstrate a benefit of the web-based tailored behavioral support materials used in conjunction with nicotine replacement therapy. A web-based program that collects relevant information from users and tailors the intervention to their specific needs had significant advantages over a web-based non-tailored cessation program.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72486/1/j.1360-0443.2005.01093.x.pd

Cost Effectiveness of Internet Interventions: Review and Recommendations

10.1007/s12160-009-9131-6Annals of Behavioral Medicine38140-45ABME

What research impacts do Australian primary health care researchers expect and achieve?

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Background Funding for research is under pressure to be accountable in terms of benefits and translation of research findings into practice and policy. Primary health care research has considerable potential to improve health care in a wide range of settings, but little is known about the extent to which these impacts actually occur. This study examines the impact of individual primary health care research projects on policy and practice from the perspective of Chief Investigators (CIs). Methods The project used an online survey adapted from the Buxton and Hanney Payback Framework to collect information about the impacts that CIs expected and achieved from primary health care research projects funded by Australian national competitive grants. Results and Discussion Chief Investigators (CIs) provided information about seventeen completed projects. While no CI expected their project to have an impact in every domain of the framework used in the survey, 76% achieved at least half the impacts they expected. Sixteen projects had published and/or presented their work, 10 projects included 11 doctorate awards in their research capacity domain. All CIs expected their research to lead to further research opportunities with 11 achieving this. Ten CIs achieved their expectation of providing information for policy making but only four reported their research had influenced policy making. However 11 CIs achieved their expectation of providing information for organizational decision making and eight reported their research had influenced organizational decision making. Conclusion CIs reported that nationally funded primary health care research projects made an impact on knowledge production, staff development and further research, areas within the realm of influence of the research team and within the scope of awareness of the CIs. Some also made an impact on policy and organizational decision-making, and on localized clinical practice and service delivery. CIs reported few broader economic benefits from their research. Routine use of an instrument of this type would facilitate primary health care research funders' determination of the payback for funding of research in this sector