Distinguishing the Mélange-forming processes in subduction-accretion complexes: constraints from the Anisotropy of Magnetic Susceptibility (AMS).

The strong morphological similitude of the block-in-matrix fabric of chaotic rock units (mélanges and broken formations) makes problematic the recognition of their primary forming-processes. We present results of the comparison between magnetic fabric and mesoscale structural investigations of non-metamorphic tectonic, sedimentary, and polygenetic mélanges in the exhumed Late Cretaceous to early Eocene Ligurian accretionary complex and overlying wedge-top basin succession in the Northern Apennines (northwest Italy). Our findings show that the magnetic fabric reveals diagnostic configurations of principal anisotropy of magnetic susceptibility (AMS) axes orientation that are well comparable with the mesoscale block-in-matrix fabric of mélanges formed by different processes. Broken formations and tectonic mélanges show prolate and neutral-to-oblate ellipsoids, respectively, with magnetic fabric elements being consistent with those of the mesoscale anisotropic “structurally ordered” block-in-matrix fabric. Sedimentary mélanges show an oblate ellipsoid with a clear sedimentary magnetic fabric related to downslope gravitational emplacement. Polygenetic mélanges show the occurrence of a cumulative depositional and tectonic magnetic fabric. The comparison of field and laboratory investigations validate the analysis of magnetic features as a diagnostic tool suitable to analytically distinguish the contribution of different mélange forming-processes and their mutual superposition, and to better understand the geodynamic evolution of subduction-accretion complexes

Time-resolved prompt-gamma activation analysis at spallation neutron sources and applications to cultural heritage, security, and radiation protection

Abstract The present and future developments of time-resolved prompt-gamma activation analysis (T-PGAA) at pulsed neutron sources is discussed in the framework of the successful history of neutron-activation techniques. A brief description of the state of the art and the most important user facilities using standard prompt-gamma activation analysis (PGAA) is provided. Then, we discuss the challenges and the opportunities for T-PGAA at pulsed neutron sources, and the potential impact for applications to cultural heritage, radiation protection, and security. We notice some inversions of trend needed for the further development of T-PGAA with epithermal and fast neutrons, such as the possibility to use fast and high-efficiency γ-ray scintillators with lower energy resolution (compared to usual high-purity germanium detectors) when the signal from neutron capture resonance is selected. We also suggest how detection systems often used in other fields, such as medical physics, can be of interest and inspiration also in the case of neutron-based investigations. Finally, we present new data of T-PGAA measurements on VESUVIO using neutron energies up to the keV using the scintillators available on the instrument, for samples of gold (of interest in cultural heritage), cadmium (for environmental safety), and tantalum (a material used in biomedical implants)

SiO2 nanoparticles as new repairing treatments toward the Pietraforte sandstone in Florence renaissance buildings

In this work, the consolidation efficiency of SiO2 nanoparticles (synthesized in the Chemistry laboratories at the Tor Vergata University of Roma) was tested on Pietraforte sandstone surfaces belonging to the bell tower of San Lorenzo (Florence, Italy) and was fully investigated. Nanoparticles (synthesized in large-scale mass production) have been characterized by XRD—X-Ray Diffraction; Raman and FTIR—Fourier Transform Infrared spectroscopy; SEM—Scanning Electron Microscopy; while the Pietraforte sandstone morphology was examined by Porosimetry, capillary absorption test, surface hardness test, drilling resistance and tensile strength. The colorimetric measurements were also performed to characterize the optical modification exhibited by Pietraforte sandstones, especially after the SiO2 treatments. Our results show that applying to the Pietraforte, the new consolidating agent based on SiO2 nanoparticles, has several advantages, as they are more resistant to perforation, wear, and abrasion even long range (for long times of exposure and consolidating exercise against Florentine sandstone), compared to the CaCO3 nanoparticles (tested in our previous paper), which instead show excellent performance but only close to their first application. This means that over time, their resistance to drilling decreases, they wear much more easily (compared to SiO2 -treated sandstone), and tend to exhibit quite a significant surface abrasion phenomena. The experimental results highlight that the SiO2 consolidation efficiency on this kind of Florentine Pietraforte sandstone (having low porosity and a specific calcitic texture) seems to be higher in terms of water penetration protection, superficial cohesion forces, and an increase in surface resistance. Comparing the performance of SiO2 nanoparticles with commercial consolidants in solvents such as Estel 1000 (tested here), we demonstrate that: (A) the restorative effects are obtained with a consolidation time over one week, significantly shorter when compared to the times of Estel 1000, exceeding 21 days; (B) SiO2 nanoparticles perform better than Estel 1000 in terms of cohesion forces, also ensuring excellent preservation of the optical and color properties of the parent rock (without altering it after application)

Expression of high- and low-affinity epidermal growth factor receptors in human hepatoma cell lines

AbstractData are presented from a comparative research on expression of epidermal growth factor (EGF) receptors and response to EGF of six independently established cell lines derived from human hepatoma. These lines differ in terms of the degree of differentiation, presence of hepatitis B virus (HBV) DNA copies in integrated form and expression of HBV genes. Our results indicate differential expression of membrane EGF receptors and differential response to EGF under serum- and hormone-free culture conditions. Furthermore, a significant difference in affinity could be detected between EGF receptors of the two highly dedifferentiated cell lines (HA22T/VGH and Li7A) whose replication is inhibited by EGF concentrations capable of stimulating more differentiated phenotypes

How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March-April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients' management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons' personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon-patient/family communication. From the Italian surgeons' perspective, COVID-related measures will continue to influence future surgical clinical practice

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Neutron-based imaging applied to cultural heritage

La scoperta di oggetti antichi solleva una serie di questioni quali la corretta determinazione del contesto storico-culturale, la provenienza ed il metodo di lavorazione, oltre alla scelta dei trattamenti e delle condizioni di restauro e conservazione. Vengono qui presentati risultati riguardo l’applicazione di tecnologie neutroniche nel campo dei beni culturali e promettenti prospettive future nel binomio scienza-tecnologia per lo studio di oggetti archeologici. Vengono discusse attività relative allo sviluppo di strumentazione ad hoc quali un sistema di posizionamento successivamente integrato nello strumento Prompt Gamma Activation Imaging/Neutron Tomography (PGAI/NT) e l’utilizzo del fotomoltiplicatore al silicio (SiPM) accoppiato con un cristallo scintillante YAP come rivelatore di neutroni e gamma al fine di ottenere un sistema di rivelazione di piccole dimensioni, compatto e a basso costo. Vengono poi presentati quattro risultati significativi riguardo l’utilizzo di tecniche neutroniche ‘standard’ su oggetti di reale interesse archeologico. Da ultimo, alcuni risultati preliminari riguardanti l’applicazione della nuova tecnica di Prompt Gamma Activation Imaging (PGAI) combinata con la Neutron Radiography (NR) su due preziosi pezzi, quali due teste in bronzo dorato provenienti dalle porte del Battistero di Firenze del Ghiberti, completeranno lo studio.The discovery of ancient artefacts often raises a variety of questions such as the correct determination of its historical and cultural time-frame, the place and method of production, the choice of treatments and conditions for restoration and preservation. Research results about the application of neutron technology in the field of cultural heritage are presented together with promising perspectives for the future of science and technology within cultural heritage studies. Activities on neutron instrumentation such as sample positioning system for Prompt Gamma Activation Imaging/Neutron Tomography (PGAI/NT) instrument and the use of silicon-photomultiplier (SiPM) as neutrons and gammas detector coupled by YAP crystal to obtain small and compact, low cost, portable detector system, are discussed. The systematic assessment of neutron diffraction application to the study of archaeological objects is also carried out. Four significant results from the use of ‘standard’ techniques on real archaeological objects are reported. Finally, results about first preliminary measurement by the new Prompt Gamma Activation Imaging (PGAI) combined with Neutron Radiography (NR) on two precious gilded bronze heads from the monumental doors of the Florence Baptistery by Lorenzo Ghiberti will complete the study