Pin-on-Disc Testing of Low-Metallic Friction Material Sliding Against HVOF Coated Cast Iron: Modelling of the Contact Temperature Evolution

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Low molecular weight Adiponectin increases the mortality risk in very old patients

Despite its beneficial role on insulin resistance and atherosclerosis, adiponectin has been frequently reported as an independent positive predictor of cardiovascular mortality. Very few information is available regarding adiponectin isoforms and mortality, in particular in advanced aging. Baseline serum levels of Total Adiponectin and its circulating isoforms (HMW-, MMW-, LMW-Adiponectin) were measured in 97 old patients (mean age: 79 years). Patients were followed up for all-cause mortality (study end-point) for an average of 76.4 ±37.3 months. A positive association was observed for LMW-Ad and all-cause mortality (HR: 1.13, 95% CI: 1.05-1,22, p: 0.002). After multivariate adjustment for age, sex and a previous history of myocardial infarction, higher levels of LMW-Ad were significantly associated with all-cause mortality (HR: 1.11, 95% CI: 1.02-1.21; p: 0.017). Interestingly neither total adiponectin neither the other two circulating isoforms (MMW- and HMW-Ad) showed any significant association with the study end-point. Our data suggest that the association between high serum adiponectin levels and increased mortality rate in elderly is contingent to an unbalanced circulating levels of adiponectin isoforms. The present results support the hypothesis that high levels of Low Molecular Weight adiponectin are a biomarker for mortality risk in very old patients

Programa de intervención y prevención en el riesgo psicosocial para ejecutivos de ventas en una empresa del sector i.t de Lima Metropolitana

El objetivo general del presente trabajo de suficiencia profesional fue evidenciar el riesgo psicosocial al que eran expuestos un grupo de vendedores del sector IT. Para este fin se presentó un diagnóstico situacional de los factores de riesgo psicosocial a los que se venían expuestos los colaboradores de acuerdo a estos resultados y basándose en otros procesos de intervención se elaboró un plan de intervención con el objetivo de identificar el nivel de riesgo psicosocial y se elaboraron los correspondientes indicadores de evaluación. Se trabajó con un grupo de 13 ejecutivos de ventas de una empresa dedicada al sector I.T. Los resultados del proceso de diagnóstico mostraron que esta población sufría de riesgo psicosocial al presentar indicadores elevados e intermedios en la escala ISTAS 21, el Focus Group y entrevista semiestructurada, por lo que el plan de intervención tuvo como objetivo diseñar un sistema de reducción, control y prevención para la organización, este se elaboró en base al modelo de intervención propuesto por Superintendencia de seguridad social de España y sus principales características es que propone un modelo dinámico y participativo, que integra todas las áreas de la organización permitiendo no solo la eliminación del riesgo psicosocial sino que creando una cultura de prevención dentro de este . Se espera tener como resultados a corto y mediano plazo la disminución y control de los riesgos psicosociales en el trabajo y a largo plazo la eliminación de estos, este se evaluó mediante el re test con el método ISTAS 21.The general objective of this work on professional sufficiency was to show the psychosocial risk to which a group of vendors from the IT sector were exposed. For this purpose, a situational diagnosis of the psychosocial risk factors to which the collaborators were exposed was presented according to these results and based on other intervention processes, an intervention plan was elaborated with the objective to identify the level of psychosocial risk and the corresponding indicators of evaluation. We worked with a group of 13 sales executives from a company dedicated to the I.T. The results of the diagnostic process showed that this population did suffer from psychosocial risk by presenting high and intermediate indicators on the ISTAS 21 scale, the Focus Group and a semi-structured interview, so the intervention plan aimed to design a reduction system, control and prevention for the organization, this was developed in passing to the intervention model proposed by the Superintendency of social security of Spain and its main characteristics is that it proposes a dynamic and participatory model, which integrates all areas of the organization allowing not only the elimination psychosocial risk but creating a culture of prevention within it. It is expected to have as short and medium term results the reduction and control of psychosocial risks at work and in the long term the elimination of these, this was evaluated through a re test with the ISTAS 21 meth

Application of machine learning techniques to derive sea water turbidity from Sentinel-2 imagery

Earth Observation (EO) from satellites has the potential to provide comprehensive, rapid and inexpensive information about water bodies, integrating in situ measurements. Traditional methods to retrieve optically active water quality parameters from satellite data are based on semiempirical models relying on few bands, which often revealed to be site and season specific. The use of machine learning (ML) for remotely sensed water quality estimation has spread in recent years thanks to the advances in algorithm development and computing power. These models allow to exploit the wealth of spectral information through more flexible relationships and are less affected by atmospheric and other background factors. The present study explores the use of Sentinel-2 MultiSpectral Instrument (MSI) Level-1C Top of Atmosphere spectral radiance to derive water turbidity, through application of machine learning techniques. A dataset of 222 combination of turbidity measurements, collected in the North Tyrrhenian Sea – Italy from 2015 to 2021, and values of the 13 spectral bands in the pixel corresponding to the sample location was used. Two regression techniques were tested and compared: a Stepwise Linear Regression (SLR) and a Polynomial Kernel Regression. The two models show accurate and similar performance (R2 = 0.736, RMSE = 2.03 NTU, MAE = 1.39 NTU for the SLR and R2 = 0.725, RMSE = 2.07 NTU, MAE = 1.40 NTU for the Kernel). A band importance analysis revealed the contribution of the different spectral bands and the main role of the red-edge range. The work shows that it is possible to reach a good accuracy in turbidity estimation from MSI TOA reflectance using ML models, fed by the whole spectrum of available bands, although the possible generation of errors related to atmospheric effect in turbidity estimates was not evaluated. Comparison between turbidity estimates obtained from the models with turbidity data from Copernicus CMEMS dataset named ‘Mediterranean Sea, Bio-Geo-Chemical, L3, daily observation’ produced consistent results. Finally, turbidity maps from satellite imagery were produced for the study area, showing the ability of the models to catch extreme events

Bacterial composition, genotoxicity, and cytotoxicity of fecal samples from individuals consuming omnivorous or vegetarian diets

This study analyzes the composition of viable fecal bacteria and gut toxicology biomarkers of 29 healthy volunteers, who followed omnivorous, lacto-ovo-vegetarian, or vegan diets. In particular, the research was focused on the prevalence of some representative viable bacteria from the four dominant phyla (Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria) commonly present in human feces, in order to evaluate the relationship between microorganisms selected by the habitual dietary patterns and the potential risk due to fecal water (FW) genotoxicity and cytotoxicity, considered as biomarkers for cancer risk and protective food activity. The relative differences of viable bacteria among dietary groups were generally not statistically significant. However, compared to omnivores, lacto-ovo-vegetarians showed low levels of total anaerobes. Otherwise, vegans showed total anaerobes counts similar to those of omnivores, but with lower number of bifidobacteria and the highest levels of bacteria from the Bacteroides-Prevotella genera. FW genotoxicity of lacto-ovo-vegetarians resulted significantly lower either in relation to that of omnivores and vegans. Lacto-ovo-vegetarians also showed the lowest levels of cytotoxicity, while the highest were found for vegans. These results highlighted that lacto-ovo-vegetarian diet was particularly effective in a favorable modulation of microbial activity, thus contributing to a significant reduction of the genotoxic and cytotoxic risk in the gut

Overground walking training with the i-Walker, a robotic servo-assistive device, enhances balance in patients with subacute stroke: a randomized controlled trial

Background: Patients affected by mild stroke benefit more from physiological overground walking training than walking-like training performed in place using specific devices. The aim of the study was to evaluate the effects of overground robotic walking training performed with the servo-assistive robotic rollator (i-Walker) on walking, balance, gait stability and falls in a community setting in patients with mild subacute stroke. Methods: Forty-four patients were randomly assigned to two different groups that received the same therapy in two daily 40-min sessions 5 days a week for 4 weeks. Twenty sessions of standard therapy were performed by both groups. In the other 20 sessions the subjects enrolled in the i-Walker-Group (iWG) performed with the i-Walker and the Control-Group patients (CG) performed the same amount of conventional walking oriented therapy. Clinical and instrumented gait assessments were made pre- and post-treatment. The follow-up observation consisted of recording the number of fallers in the community setting after 6 months. Results: Treatment effectiveness was higher in the iWG group in terms of balance improvement (Tinetti: 68.4 ± 27.6 % vs. 48.1 ± 33.9 %, p= 0.033) and 10-m and 6-min timed walking tests (significant interaction between group and time: F(1,40) = 14.252, p = 0.001; and F (1,40) = 7.883, p = 0.008, respectively). When measured, latero-lateral upper body accelerations were reduced in iWG (F= 4.727, p= 0.036), suggesting increased gait stability, which was supported by a reduced number of falls at home. Conclusions: A robotic servo-assisted i-Walker improved walking performance and balance in patients affected by mild/moderate stroke, leading to increased gait stability and reduced falls in the community.Peer ReviewedPostprint (published version

Temperature adaptation of glutathione S-transferase P1-1. A case for homotropic regulation of substrate binding.

Human glutathione S-transferase P1-1 (GST P1-1) is a homodimeric enzyme expressed in several organs as well as in the upper layers of epidermis, playing a role against carcinogenic and toxic compounds. A sophisticated mechanism of temperature adaptation has been developed by this enzyme. In fact, above 35 degrees C, glutathione (GSH) binding to GST P1-1 displays positive cooperativity, whereas negative cooperativity occurs below 25 degrees C. This binding mechanism minimizes changes of GSH affinity for GST P1-1 because of temperature fluctuation. This is a likely advantage for epithelial skin cells, which are naturally exposed to temperature variation and, incidentally, to carcinogenic compounds, always needing efficient detoxifying systems. As a whole, GST P1-1 represents the first enzyme which displays a temperature-dependent homotropic regulation of substrate (e.g. GSH) binding

Clinical features of headache patients with fibromyalgia comorbidity

Our previous study assessed the prevalence of fibromyalgia (FM) syndrome in migraine and tension-type headache. We aimed to update our previous results, considering a larger cohort of primary headache patients who came for the first time at our tertiary headache ambulatory. A consecutive sample of 1,123 patients was screened. Frequency of FM in the main groups and types of primary headaches; discriminating factor for FM comorbidity derived from headache frequency and duration, age, anxiety, depression, headache disability, allodynia, pericranial tenderness, fatigue, quality of life and sleep, and probability of FM membership in groups; and types of primary headaches were assessed. FM was present in 174 among a total of 889 included patients. It prevailed in the tension-type headache main group (35%, p < 0.0001) and chronic tension-type headache subtype (44.3%, p < 0.0001). Headache frequency, anxiety, pericranial tenderness, poor sleep quality, and physical disability were the best discriminating variables for FM comorbidity, with 81.2% sensitivity. Patients presenting with chronic migraine and chronic tension-type headache had a higher probability of sharing the FM profile (Bonferroni test, p < 0.01). A phenotypic profile where headache frequency concurs with anxiety, sleep disturbance, and pericranial tenderness should be individuated to detect the development of diffuse pain in headache patients

Preliminary work about the basis data for monitoring youth soccer team planning training

The youth soccer is always important especially for the assessment and the data of development of skills. The monitoring of them it could be important for the trainer to reorganize the planning of training and for the adaptation to individual athlete Aim of the study is to recruit the quantitative data about the anthropometric and performance aspects for reutilize to rearrangement of training planning. Method is experimental and has to carry out the usual parameters for monitoring the trainings. Anthropometric data are weight, height, BMI and performance data are Vo2max (Cooper) speed triangle test (three corner run) and speed test with (dribbling) on a sample are 13 athletes of 13 years old that play championship under 14 . BMI Data shows 6 weight, 4 in overweight risk and 3 in overweight. Cooper test data shows 2 above- average, 5 average, 5 below average and 1 poor. Mean speed triangle test 32.38 seconds, mean dibbling test 25.39 seconds. The results have to be useful for tool method of training

Association of Urinary and Plasma Levels of Trimethylamine N-Oxide (TMAO) with Foods

Introduction: Trimethylamine N-oxide (TMAO) may play a key mediator role in the relationship between the diet, gut microbiota and cardiovascular diseases, particularly in people with kidney failure. The aim of this review is to evaluate which foods have a greater influence on blood or urinary trimethylamine N-oxide (TMAO) levels. Methods: 391 language articles were screened, and 27 were analysed and summarized for this review, using the keywords "TMAO" AND "egg" OR "meat" OR "fish" OR "dairy" OR "vegetables" OR "fruit" OR "food" in December 2020. Results: A strong correlation between TMAO and fish consumption, mainly saltwater fish and shellfish, but not freshwater fish, has been demonstrated. Associations of the consumption of eggs, dairy and meat with TMAO are less clear and may depend on other factors such as microbiota or cooking methods. Plant-based foods do not seem to influence TMAO but have been less investigated. Discussion: Consumption of saltwater fish, dark meat fish and shellfish seems to be associated with an increase in urine or plasma TMAO values. Further studies are needed to understand the relationship between increased risk of cardiovascular disease and plasma levels of TMAO due to fish consumption. Interventions coupled with long-term dietary patterns targeting the gut microbiota seem promising