Late Gas accretion onto Primordial Minihalos: a Model for Leo T, Dark Galaxies and Extragalactic High-Velocity Clouds

In this letter we revisit the idea of reionization feedback on dwarf galaxy formation. We show that primordial minihalos with v_cir<20 km/s stop accreting gas after reionization, as it is usually assumed, but in virtue of their increasing concentration and the decreasing temperature of the intergalactic medium as redshift decreases below z=3, they have a late phase of gas accretion and possibly star formation. We expect that pre-reionization fossils that evolved on the outskirts of the Milky Way or in isolation show a bimodal star formation history with 12 Gyr old and <10 Gyr old population of stars. Leo T fits with this scenario. Another prediction of the model is the possible existence of a population of gas rich minihalos that never formed stars. More work is needed to understand whether a subset of compact high-velocity clouds can be identified as such objects or whether an undiscovered population exists in the voids between galaxies.Comment: 5 pages, 4 figures, accepted version MNRAS 392, L4

Where are the Fossils of the First Galaxies? I. Local Volume Maps and Properties of the Undetected Dwarfs

We present a new method for generating initial conditions for LCDM N-body simulations which provides the dynamical range necessary to follow the evolution and distribution of the fossils of the first galaxies on Local Volume, 5-10 Mpc, scales. The initial distribution of particles represents the position, velocity and mass distribution of the dark and luminous halos extracted from pre-reionization simulations. We confirm previous results that ultra-faint dwarfs have properties compatible with being well preserved fossils of the first galaxies. However, because the brightest pre-reionization dwarfs form preferentially in biased regions, they most likely merge into non-fossil halos with circular velocities >20-30 km/s. Hence, we find that the maximum luminosity of true-fossils in the Milky Way is L_V<10^5 L_solar, casting doubts on the interpretation that some classical dSphs are true-fossils. In addition, we argue that most ultra-faints at small galactocentric distance, R<50 kpc, had their stellar properties modified by tides, while a large population of fossils is still undetected due to their extremely low surface brightness log(Sigma_V) < -1.4. We estimate that the region outside R_50 (~ 400 kpc) up to 1 Mpc from the Milky Way contains about a hundred true fossils of the first galaxies with V-band luminosities 10^3 - 10^5 L_solar and half-light radii, r_hl ~ 100-1000 pc.Comment: published in ApJ October 2011 with minor revisions V. 741 article ID. 1

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Co-Designing Wearable Devices for Sports: The Case Study of Sport Climbing

This paper presents the co-design process of a wearable device for rock climbing, an extreme sport that requires high physical, emotional, and cognitive involvement. From the preliminary investigation of climbers’ needs, it emerged that their acceptance of wearables is mainly influenced by climbing sport-specific values like self-efficacy, trust, and adventure. Such values highlight the importance of the role technology should have beyond its functional purpose, i.e. how wearables should support climbers. Based on these insights, we designed and deployed a vibrotactile wearable device aimed at augmenting the communication between instructor and trainees and assessed its usefulness, usability, and pleasantness during an indoor climbing lesson. Finally, we conclude the paper discussing how the wearable we implemented meets the design criteria emerged from climbers’ values and reflecting on the importance to gain new perspectives on the design of wearables for sports in general

Relationship between Body Composition and Cardiac Autonomic Regulation in a Large Population of Italian Olympic Athletes

Athletic performance is determined by many factors, such as cardiorespiratory fitness, muscular strength and psychological features, which all interact simultaneously. The large Italian National Olympic Committee database of Olympic athletes offers a unique healthy population to verify the strength of the interplay among a number of major elements of training, including autonomic nervous system (ANS) modulation, biochemical indicators and body composition, in a system medicine approach. This observational, retrospective study involved 583 individuals. As part of the yearly precompetitive examination, cardiac autonomic (heart rate variability), psychological, physical (cycloergometer stress test), biochemical and body composition (BOD POD) evaluations were performed. In subsequent analysis, we first considered the relationship between body composition and single individual variables in a simple correlation matrix, including a multitude of variables; then, Exploratory Factor Analysis (EFA) restricted the information to six latent domains, each combining congruent information in relation to body composition. Finally, we employed a multiple quantile regression model to evaluate possible relationships between ANSIs (index capable of synthetizing ANS regulation) and the latent domains indicated by EFA reflecting body composition. We observed a clear relationship between ANS and body mass composition parameters, as indicated by both bivariate correlations and the quantile regression result of ANSIs versus the latent domain aggregating mainly body composition data expressed in % (p = 0.002). In conclusion, these results suggest that specific training may elicit parallel adaptation of ANS control and body composition. The analysis of Olympic athletes&rsquo; data allowed us to obtain a better understanding of the complex, multidimensional factors involved in determining sport performance. The latter appears to be determined by the simultaneous interaction not only of cardiorespiratory fitness, muscular strength and psychological features, but also of ANS cardiovascular modulation and body composition

Progressive Additive Benefits of Prehabilitation and Subsequent Bariatric Surgery on Cardiac Autonomic Regulation as Assessed by Means of a Simple Unitary Composite Index: Preliminary Data from an Observational Study

Obesity is associated with an increased risk of several chronic comorbidities, which may also be determined by dysfunctional autonomic nervous system (ANS). The influence of bariatric surgery (BS) on ANS balance was explored in previous studies, but with high heterogeneity in both the assessment timing and methods employed. In the present observational study, we applied a clinical protocol which considers two subsequent phases. Twenty-nine non-diabetic obese subjects were studied at baseline (T0), after one month of lifestyle modification (prehabilitation) (phase 1-T1), and after eight months following BS (phase 2-T2). ANS regulation was assessed across the three study epochs by means of ANSI, a single composite percent-ranked proxy of autonomic balance, being free of gender and age bias, economical and simple to apply in a clinical setting. The aim of the present study was to investigate the effects of the clinical protocol based on prehabilitation and subsequent BS on the ANS regulation by means of ANSI. Potential intertwined correlations with metabolic parameters were also investigated. Notably, we observed a progressive improvement in ANS control, even by employing ANSI. Moreover, the reduction in the markers of sympathetic overactivity was found to significantly correlate with the amelioration in some metabolic parameters (fasting glucose, insulin levels, and waist circumference), as well as in stress and tiredness perception. In conclusion, this study provides convincing evidence that a unitary proxy of cardiac autonomic regulation (CAR) may reflect the progressive improvement in autonomic regulation following behavioral and surgical interventions in obese patients. Intriguingly, this might contribute to reducing cardiovascular and metabolic risk