2,450 research outputs found
A Study of Technology Implementation in Two School Districts: The Dynamics of Leadership and Change
This qualitative case study investigated the role administrative leadership plays in organizational change related to the infusion of technology into district programs and pedagogical practices. School districts have been engaged in a struggle to incorporate new generations of technological advancements in meaningful ways for their students. Instructional reform and measurable performance-based outcomes are frequently conflated with the pressure to implement effective technology programs that ensure the No Child Left Behind federal mandates are met while ensuring judicious use of district funds. While technology has the potential to transform the educational process, it must align with the cultural uniqueness of the local learning community. This study investigated how educators, who are committed to technology programs in schools, dealt with differing attitudes, beliefs, interests, and aptitudes for change. The study used leadership research to examine two school districts, one rural and one suburban, that have undergone significant changes by infusing technology into their curriculum. It examined their staff development approaches and garnered insight about how to accomplish such a change in a responsible, forward-thinking way. Qualitative research methods were used to examine how leadership, change, and staff development might be related and how individuals dealt with change. The findings suggested that: (a) educators should understand that there is more than one way to implement successful technology programs, (b) leadership can play a significant role in the change and staff development efforts, and (c) staff development programs should involve support activities among the members of the learning community. This case study provides the basis for further investigation into how supportive relationships and collaborative efforts help individuals create learning communities that can effectively embrace organizational changes
Finite-size and correlation-induced effects in Mean-field Dynamics
The brain's activity is characterized by the interaction of a very large
number of neurons that are strongly affected by noise. However, signals often
arise at macroscopic scales integrating the effect of many neurons into a
reliable pattern of activity. In order to study such large neuronal assemblies,
one is often led to derive mean-field limits summarizing the effect of the
interaction of a large number of neurons into an effective signal. Classical
mean-field approaches consider the evolution of a deterministic variable, the
mean activity, thus neglecting the stochastic nature of neural behavior. In
this article, we build upon two recent approaches that include correlations and
higher order moments in mean-field equations, and study how these stochastic
effects influence the solutions of the mean-field equations, both in the limit
of an infinite number of neurons and for large yet finite networks. We
introduce a new model, the infinite model, which arises from both equations by
a rescaling of the variables and, which is invertible for finite-size networks,
and hence, provides equivalent equations to those previously derived models.
The study of this model allows us to understand qualitative behavior of such
large-scale networks. We show that, though the solutions of the deterministic
mean-field equation constitute uncorrelated solutions of the new mean-field
equations, the stability properties of limit cycles are modified by the
presence of correlations, and additional non-trivial behaviors including
periodic orbits appear when there were none in the mean field. The origin of
all these behaviors is then explored in finite-size networks where interesting
mesoscopic scale effects appear. This study leads us to show that the
infinite-size system appears as a singular limit of the network equations, and
for any finite network, the system will differ from the infinite system
The interplay of intrinsic and extrinsic bounded noises in genetic networks
After being considered as a nuisance to be filtered out, it became recently
clear that biochemical noise plays a complex role, often fully functional, for
a genetic network. The influence of intrinsic and extrinsic noises on genetic
networks has intensively been investigated in last ten years, though
contributions on the co-presence of both are sparse. Extrinsic noise is usually
modeled as an unbounded white or colored gaussian stochastic process, even
though realistic stochastic perturbations are clearly bounded. In this paper we
consider Gillespie-like stochastic models of nonlinear networks, i.e. the
intrinsic noise, where the model jump rates are affected by colored bounded
extrinsic noises synthesized by a suitable biochemical state-dependent Langevin
system. These systems are described by a master equation, and a simulation
algorithm to analyze them is derived. This new modeling paradigm should enlarge
the class of systems amenable at modeling.
We investigated the influence of both amplitude and autocorrelation time of a
extrinsic Sine-Wiener noise on: the Michaelis-Menten approximation of
noisy enzymatic reactions, which we show to be applicable also in co-presence
of both intrinsic and extrinsic noise, a model of enzymatic futile cycle
and a genetic toggle switch. In and we show that the
presence of a bounded extrinsic noise induces qualitative modifications in the
probability densities of the involved chemicals, where new modes emerge, thus
suggesting the possibile functional role of bounded noises
Induced hyperlipaemia and immune challenge in locusts
Injections of immunogens, such as ÎČ-1,3-glucan or lipopolysaccharide (LPS), bring about a marked hyperlipaemia with associated changes in lipophorins and apolipophorin-III in the haemolymph of Locusta migratoria. These changes are similar to those observed after injection of adipokinetic hormone (AKH). The possibility that endogenous AKH is released as part of the response to these immunogens is investigated using passive immunisation against AKH-I, and measurement of AKH-I titre in the haemolymph after injection of immunogens. The data presented show that, despite the similarity of the changes brought about by the presence of immunogens in the haemolymph to those brought about by AKH, there is no release of endogenous AKH after injection of laminarin or LPS. A direct effect of the immunogens on release of neutral lipids by the fat body cannot be demonstrated in vitro, and the mechanism by which hyperlipaemia is induced during immune challenge remains uncertain
Experiences of men who have sex with men when initiating, implementing, and persisting with HIV pre-exposure prophylaxis
Abstract Introduction HIV preâexposure prophylaxis (PrEP) involves the use of antiretroviral medication in HIVânegative individuals considered to be at risk of acquiring HIV. It has been shown to prevent HIV and has been available in Wales since July 2017. Measuring and understanding adherence to PrEP is complex as it relies on the simultaneous understanding of both PrEP use and sexual activity. We aimed to understand the experiences of men who have sex with men (MSM) living in Wales initiating, implementing and persisting with HIV PrEP. Methods We conducted semistructured interviews with MSM PrEP users in Wales who participated in a cohort study of PrEP use and sexual behaviour. Following completion of the cohort study, participants were invited to take part in a semistructured interview about their experiences of taking PrEP. We aimed to include both individuals who had persisted with and discontinued PrEP during the study. The interview topic guide was informed by the ABC taxonomy for medication adherence and the theory of planned behaviour. We analysed our data using reflexive thematic analysis. Results Twentyâone participants were interviewed, five having discontinued PrEP during the cohort study. The developed themes focused on triggers for initiating PrEP, habitual behaviour, drivers for discontinuation and engagement with sexual health services. Stigma surrounding both PrEP and HIV permeated most topics, acting as a driver for initiating PrEP, an opportunity to reduce discrimination against people living with HIV, but also a concern around the perception of PrEP users. Conclusion This is the first study to investigate PrEPâtaking experiences incorporating established medication adherence taxonomy. We highlight key experiences regarding the initiation, implementation and persistence with PrEP and describe how taking PrEP may promote positive engagement with sexual health services. These findings may be useful for informing PrEP rollout programmes and need to be explored in other key populations. Patient and Public Contribution PrEP users, in addition to PrEP providers and representatives of HIV advocacy and policy, were involved in developing the topic guide for this study
Between- and within-individual sociodemographic and psychological determinants of PrEP adherence among men who have sex with men prescribed a daily PrEP regimen in Wales
We investigated the determinants of daily PrEP use and coverage of condomless anal sex (CAS) by PrEP among men who
have sex with men in Wales, UK. We measured PrEP use by electronic monitors and CAS by secure online surveys. We
defned PrEP use based on daily medication cap openings and coverage as CAS episodes preceded byâ„3 days of PrEP use
and followed byâ„2 days of PrEP use. We included 57 participants (5463 observations). An STI diagnosis was associated
with lower PrEP use but also lower PrEP coverage. Older adults had higher PrEP use. A belief that other PrEP users took
PrEP as prescribed was associated with lower PrEP coverage. An STI diagnosis is an important cue for an intervention,
refecting episodes of high-risk sexual behaviour and low PrEP coverage. Other results provide a basis for the development
of an evidence-informed intervention for promoting coverage of PrE
Determination of the vacuum optomechanical coupling rate using frequency noise calibration
The strength of optomechanical interactions in a cavity optomechanical system
can be quantified by a vacuum coupling rate \vcr analogous to cavity quantum
electrodynamics. This single figure of merit removes the ambiguity in the
frequently quoted coupling parameter defining the frequency shift for a given
mechanical displacement, and the effective mass of the mechanical mode. Here we
demonstrate and verify a straightforward experimental technique to derive the
vacuum optomechanical coupling rate. It only requires applying a known
frequency modulation of the employed electromagnetic probe field and knowledge
of the mechanical oscillator's occupation. The method is experimentally
verified for a micromechanical mode in a toroidal whispering-gallery-resonator
and a nanomechanical oscillator coupled to a toroidal cavity via its near
field.Comment: 11 pages, 2 figure
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